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The map label for this gene is pdp [H]

Identifier: 125623891

GI number: 125623891

Start: 1020886

End: 1022178

Strand: Direct

Name: pdp [H]

Synonym: llmg_1060

Alternate gene names: 125623891

Gene position: 1020886-1022178 (Clockwise)

Preceding gene: 125623890

Following gene: 125623892

Centisome position: 40.36

GC content: 39.83

Gene sequence:

>1293_bases
ATGACCTATCGAATGGTTGATCTCATTCAAAAGAAGAGAGACGGCGGAGCATTTAGCAAGTCTGAAATCGATTGGATGAT
TGAAAATTATGTCAATGGAACTGTGCCAGATTATCAAATGTCGGCTTTGGCCATGGCAATTTATTTTAAAGGAATGACGA
CACAAGAGACTGCCTATCTCACGATGGCTATGGTTCATTCAGGTAAAGAATTTGATTTGTCAACTATATCTGGTATCAAA
GTCGACAAACATTCTACCGGAGGGGTGGGCGACAAGGTCACGCTGATTTTGGCGCCTTTAGTTGCTTCATTCGGTGTTCC
AGTTGCCAAAATGTCAGGACGAGGTCTTGGACATACTGGGGGAACACTTGATAAATTAGAATCTATTCCAGGTTTCAAGT
TTGAAAAAACAGAAGAAGAATTTATCAAACAAGTTAAAGAAACTGGAATTGCCATCATCGGCCAATCCGATGAATTAGTT
AAAGCTGATAAGTTGCTCTATGCTCTTCGAGATGTCACGGCGACTGTTGATATTATCCCTTTAATTGCAAGTTCGGTCAT
GTCTAAAAAAATTGCTGCAGGCTCTGACGCTATTTTACTGGATGTCACAGTGGGCGATGGTGCCTTCATGAAATCAGTAG
ATGATGCACGACTTCTGGCTCAAACAATGGTCGACCTTGGAAAATCTGTCGGTCGTGAAACCGTGGCTGTTATTACTAAT
ATGAGTCAGCCGCTTGGTTTTGCAATTGGGAATCGGAATGAAATGACAGAAGCAGTTAATACTTTGCAGGGAAATGCACC
AAAAGAATTCCAAGTCTTTATCGCTGAGCTTGCTCAAATTATGCTGCAACTTGCGGGACTTGAAAAATCAATAACTGAAA
TTTTAGAGCATTTTAATAATGGCTTAGCTTACAAAAAGTTTGTTGAAATGGTTAAAGCCCAAGGTGGTGACCCATATGCT
TTTGAACAGCTGACAGCTCCTCTTAAAGTGAAATATCAAGTTGATATTCATGCCAAAGCATCAGGATTTATTTCTGAGGA
AAAAGCATTAGGAATCGGCTTGCTTGCCATGAAATTAGGTGCTGGACGGGCAACTAAAGCAGATGAAATTGATTTTGAAG
CAGGTGTTACCTTGACCAAAAAAGTAGGAGATCGAGTTGAAGTAGGTGAGCTTATCGCCAGCCTCTATTCTAATCGAGAA
ATTACTGACGAATTAGTTGCTGAATTTAATGATAGCTTAGTCATTAGTGACCAGCAAATTGAGCAAAAAGAAATTATAGA
GATTATCAGATAA

Upstream 100 bases:

>100_bases
GTCTTTGGCAACTGTCAGCTAGTGGCAAGGGATAAAGGATACTTTATTCTTAGAAGTTATAAATGATTAATCACTGATTA
TATAAAATGAGGAGAAGTCT

Downstream 100 bases:

>100_bases
GATGAAAAATGATTTAAAAATTCCAACTCCAGTGATGGCTTTGCAAGTGATTCTGTCAGCTTTAGCTGGGGCAGCCACAA
AATTATATTTACAAAATTTG

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTYRMVDLIQKKRDGGAFSKSEIDWMIENYVNGTVPDYQMSALAMAIYFKGMTTQETAYLTMAMVHSGKEFDLSTISGIK
VDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEEEFIKQVKETGIAIIGQSDELV
KADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVDDARLLAQTMVDLGKSVGRETVAVITN
MSQPLGFAIGNRNEMTEAVNTLQGNAPKEFQVFIAELAQIMLQLAGLEKSITEILEHFNNGLAYKKFVEMVKAQGGDPYA
FEQLTAPLKVKYQVDIHAKASGFISEEKALGIGLLAMKLGAGRATKADEIDFEAGVTLTKKVGDRVEVGELIASLYSNRE
ITDELVAEFNDSLVISDQQIEQKEIIEIIR

Sequences:

>Translated_430_residues
MTYRMVDLIQKKRDGGAFSKSEIDWMIENYVNGTVPDYQMSALAMAIYFKGMTTQETAYLTMAMVHSGKEFDLSTISGIK
VDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEEEFIKQVKETGIAIIGQSDELV
KADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVDDARLLAQTMVDLGKSVGRETVAVITN
MSQPLGFAIGNRNEMTEAVNTLQGNAPKEFQVFIAELAQIMLQLAGLEKSITEILEHFNNGLAYKKFVEMVKAQGGDPYA
FEQLTAPLKVKYQVDIHAKASGFISEEKALGIGLLAMKLGAGRATKADEIDFEAGVTLTKKVGDRVEVGELIASLYSNRE
ITDELVAEFNDSLVISDQQIEQKEIIEIIR
>Mature_429_residues
TYRMVDLIQKKRDGGAFSKSEIDWMIENYVNGTVPDYQMSALAMAIYFKGMTTQETAYLTMAMVHSGKEFDLSTISGIKV
DKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTGGTLDKLESIPGFKFEKTEEEFIKQVKETGIAIIGQSDELVK
ADKLLYALRDVTATVDIIPLIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVDDARLLAQTMVDLGKSVGRETVAVITNM
SQPLGFAIGNRNEMTEAVNTLQGNAPKEFQVFIAELAQIMLQLAGLEKSITEILEHFNNGLAYKKFVEMVKAQGGDPYAF
EQLTAPLKVKYQVDIHAKASGFISEEKALGIGLLAMKLGAGRATKADEIDFEAGVTLTKKVGDRVEVGELIASLYSNREI
TDELVAEFNDSLVISDQQIEQKEIIEIIR

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=431, Percent_Identity=36.8909512761021, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4503445, Length=431, Percent_Identity=36.8909512761021, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI166158922, Length=431, Percent_Identity=36.8909512761021, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1790842, Length=402, Percent_Identity=40.7960199004975, Blast_Score=276, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46624; Mature: 46493

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRMVDLIQKKRDGGAFSKSEIDWMIENYVNGTVPDYQMSALAMAIYFKGMTTQETAYL
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
TMAMVHSGKEFDLSTISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTG
HHHHHHCCCCCCCHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
GTLDKLESIPGFKFEKTEEEFIKQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIP
CCHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVDDARLLAQTMVDLGKSVGRETVAVITN
HHHHHHHHHHHCCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHC
MSQPLGFAIGNRNEMTEAVNTLQGNAPKEFQVFIAELAQIMLQLAGLEKSITEILEHFNN
CCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
GLAYKKFVEMVKAQGGDPYAFEQLTAPLKVKYQVDIHAKASGFISEEKALGIGLLAMKLG
CCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHC
AGRATKADEIDFEAGVTLTKKVGDRVEVGELIASLYSNREITDELVAEFNDSLVISDQQI
CCCCCCCCCCCCCCCCEEHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECHHHC
EQKEIIEIIR
CHHHHHHHHC
>Mature Secondary Structure 
TYRMVDLIQKKRDGGAFSKSEIDWMIENYVNGTVPDYQMSALAMAIYFKGMTTQETAYL
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
TMAMVHSGKEFDLSTISGIKVDKHSTGGVGDKVTLILAPLVASFGVPVAKMSGRGLGHTG
HHHHHHCCCCCCCHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
GTLDKLESIPGFKFEKTEEEFIKQVKETGIAIIGQSDELVKADKLLYALRDVTATVDIIP
CCHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LIASSVMSKKIAAGSDAILLDVTVGDGAFMKSVDDARLLAQTMVDLGKSVGRETVAVITN
HHHHHHHHHHHCCCCCEEEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHC
MSQPLGFAIGNRNEMTEAVNTLQGNAPKEFQVFIAELAQIMLQLAGLEKSITEILEHFNN
CCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
GLAYKKFVEMVKAQGGDPYAFEQLTAPLKVKYQVDIHAKASGFISEEKALGIGLLAMKLG
CCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHC
AGRATKADEIDFEAGVTLTKKVGDRVEVGELIASLYSNREITDELVAEFNDSLVISDQQI
CCCCCCCCCCCCCCCCEEHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECHHHC
EQKEIIEIIR
CHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]