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The map label for this gene is purC [H]

Identifier: 125623812

GI number: 125623812

Start: 936865

End: 937587

Strand: Direct

Name: purC [H]

Synonym: llmg_0973

Alternate gene names: 125623812

Gene position: 936865-937587 (Clockwise)

Preceding gene: 125623811

Following gene: 125623813

Centisome position: 37.04

GC content: 32.37

Gene sequence:

>723_bases
ATGGAGGATATTGTGGAAAAAGAAACGCTGCTTTATGAAGGAAAAGCCAAAAAACTGTATTTTACAGACGATTCTAATGT
GCTTTGGGTTGAATATTGTGATCAAGCGACAGCTTTAAATGGTGCTCGTAAAGAACAAATTACTGGGAAAGGTGCTCTAA
ATAATCAAATTACTTCATTGATTTTTGAAAAATTAAATGCTGAAGGATTAGAAACGCATTTTATTAAAAAGTTATCAAAA
ACCGAACAATTGAATAAAAAAGTATCAATAATTCCTTTGGAAGTTGTTTTGCGAAATGTCGTTGCTGGGTCTTTTGCCAA
ACGATTTGGTCTTGAAGAAGGAATTGTTTTGGAAGAACCTATTGTTGAATTTTATTATAAAGATGATGCTTTAGATGACC
CATTTATCAATGATGAACATGTCAAATTCCTGAACATTGCAAGTGATTCTGAAATTGAGTTTCTAAAAAAAGAAACACGT
AAAATTAATAAGATTTTGAAAAAAATATGGACTGAAATTGGCTTAACTTTGGTTGATTTCAAACTTGAATTTGGTCGTCT
TGCTGACGGAAGTATTATTCTTGCTGACGAAATCTCACCAGATACTTCACGTCTTTGGGACGCGAAGGGGCAACACATGG
ATAAAGACGTTTTCAGGCGTAATATTGGAGATTTGATTGAAACTTATACTGAAGTTTTAAATCTATTGGAAAAGACAAAA
TAA

Upstream 100 bases:

>100_bases
ACCGAACAATAAAATGAAAAAGTTCTAGTTTTATCCGCTAGAGCTTTTTTTATTTGTCTCATTAGAATAGAATAAGAAGC
ATAAAGAATTCCTTAAAGGG

Downstream 100 bases:

>100_bases
GAATGTTCTAGTCTTTAGGGCAGGTCTCACATCTTATATAGAAAGAATTTAAAAATGACAAAAGTACGTGTTTACGTGGC
TTACAAAGCCTCAATTCTCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MEDIVEKETLLYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSLIFEKLNAEGLETHFIKKLSK
TEQLNKKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLEEPIVEFYYKDDALDDPFINDEHVKFLNIASDSEIEFLKKETR
KINKILKKIWTEIGLTLVDFKLEFGRLADGSIILADEISPDTSRLWDAKGQHMDKDVFRRNIGDLIETYTEVLNLLEKTK

Sequences:

>Translated_240_residues
MEDIVEKETLLYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSLIFEKLNAEGLETHFIKKLSK
TEQLNKKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLEEPIVEFYYKDDALDDPFINDEHVKFLNIASDSEIEFLKKETR
KINKILKKIWTEIGLTLVDFKLEFGRLADGSIILADEISPDTSRLWDAKGQHMDKDVFRRNIGDLIETYTEVLNLLEKTK
>Mature_240_residues
MEDIVEKETLLYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSLIFEKLNAEGLETHFIKKLSK
TEQLNKKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLEEPIVEFYYKDDALDDPFINDEHVKFLNIASDSEIEFLKKETR
KINKILKKIWTEIGLTLVDFKLEFGRLADGSIILADEISPDTSRLWDAKGQHMDKDVFRRNIGDLIETYTEVLNLLEKTK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=239, Percent_Identity=37.6569037656904, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI5453539, Length=239, Percent_Identity=37.6569037656904, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI119220559, Length=246, Percent_Identity=36.1788617886179, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1788820, Length=233, Percent_Identity=43.3476394849785, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17531275, Length=243, Percent_Identity=34.5679012345679, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18860083, Length=220, Percent_Identity=32.7272727272727, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24583917, Length=219, Percent_Identity=31.0502283105023, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27506; Mature: 27506

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDIVEKETLLYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSL
CCCHHHHHHHEECCCCCEEEEECCCCEEEEEECCCHHHCCCCHHHHCCCCCCHHHHHHHH
IFEKLNAEGLETHFIKKLSKTEQLNKKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLEEP
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
IVEFYYKDDALDDPFINDEHVKFLNIASDSEIEFLKKETRKINKILKKIWTEIGLTLVDF
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
KLEFGRLADGSIILADEISPDTSRLWDAKGQHMDKDVFRRNIGDLIETYTEVLNLLEKTK
EECCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDIVEKETLLYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSL
CCCHHHHHHHEECCCCCEEEEECCCCEEEEEECCCHHHCCCCHHHHCCCCCCHHHHHHHH
IFEKLNAEGLETHFIKKLSKTEQLNKKVSIIPLEVVLRNVVAGSFAKRFGLEEGIVLEEP
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
IVEFYYKDDALDDPFINDEHVKFLNIASDSEIEFLKKETRKINKILKKIWTEIGLTLVDF
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
KLEFGRLADGSIILADEISPDTSRLWDAKGQHMDKDVFRRNIGDLIETYTEVLNLLEKTK
EECCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471; 9683487 [H]