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The map label for this gene is kinA [H]

Identifier: 125623752

GI number: 125623752

Start: 874950

End: 876440

Strand: Direct

Name: kinA [H]

Synonym: llmg_0909

Alternate gene names: 125623752

Gene position: 874950-876440 (Clockwise)

Preceding gene: 125623751

Following gene: 125623753

Centisome position: 34.59

GC content: 35.95

Gene sequence:

>1491_bases
GTGAACGCAAATAAAAAAATGAAAAAATTATTCACTTTCAACAAGAAAAAGGAAACGGTAGAAGAAAGTTCGGCTAAGCG
GTCTATTATGCTTAGGTGGGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTCTTTTTGCAACATTAACTTATC
AACTGACCATAAGTTCTTTCATCAAGGAGGAACAAAGGTTATTGACAGGTTCAATGGACAGCGCTGAAGAGGTATTAGAA
CAAGCGGATGCTCCTTTAAATTCAACTAATTTGAATACTTATATTGAAGCGACATCAAAGATTCAAAATGGGGAATCGGA
AGGAATGAGTCTGGGAAGTATCATCGGGACTCGGAAAGCATTTTATATTTATGATTTAAATCATAAATTACTATATTCAA
CTAATCGACATGATTTTGGATTTCAAAAGCAAGGCAATAATGAGATGAAAGAAATTCAAGGTGAGAATCCAGGTTATTTA
GTCCAAAGGAAGATTGTTTCTAAAGGGACGGGACAGGTTGTAGGCTATTTACAGGCATTTTATGACACGACAACTTATCA
TCGGATTTCCAATCTCCTTTTAGTCGTCTTGTTAATTTTAGAAATTGTCGCTTTAATCGTTGCGCAAATGATTGGTTATT
TTATGGCGAATTATTTTATGAAGCCTTTAGAAAAACTTTATCAGGGAATGCAGGAAATGGCGAGCGATCCCACGAATGAT
TTCAAACCTATCGAAATTGAAAGTGGTGATGAAATTGAAGAATTAGCTCATGTTTATAATGATATGATGCTGAAAATGAA
AGCATACCTTGAACAGCAAAATCGGTTTGTCTCTGATGTTTCACATGAATTAAGGACTCCGTTAGCAGTTTTGGACGGTC
ATATTAATCTCTTAAATCGTTGGGGAAAAAATGATCCAGAAGTTTTGGATGAATCTTTGCAGGCGAGTTTGGATGAAGTA
GACCGAATGAAGAAAATGCTTGAAGAAATGCTTGCTTTAGCTAGGCTTGAAAATGTAGATTTGTCCAGTGAAGAATTGGA
TTGTGACGTTGGTAAAGTATCTAATCATGCGCTTAAAAACTTCCAACTTCTACATGAGGATTTTGAGATTGTGCTTGATA
ATCAGCTTATCTACCCTGTCCATGCCCGGATATCTGAAAATCATTTTGAACAAGGATTACGCATTTTGTTAGATAATGCT
GTTAAGTATTCTCCGGATGATCGAAAGGAGATTGTGATTACTGTTTCAGAAGATGAACAGTTTGTCATTACTAGTGTTTC
TGATAAAGGAATCGGAATTGCCGAAGAAGATATTAATCATCTTTTTGAGCGATTCTTTCGAGCGGATAAGGCACGTAACC
GTGAGATTGGCGGAACTGGTTTAGGTTTACCAATTCTTGCTCGTTTAGCCGAAAATTATCAAGGGGAGATTGAAGTTAGT
TCTGAGCTTGGGATTGGTTCAACTTTTACCTTAAAATTTCCAAAAATGTGA

Upstream 100 bases:

>100_bases
AATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACAGCTATATTCAAACCGTTCG
TGGTTTGGGTTATGTGATGC

Downstream 100 bases:

>100_bases
TAAATAGGAATTATCTTTTAGATAATTCCTTTTTATCTGCTCATTCCATGTTATGTTATATAACATGGAATGAGTAAATG
ATTGACTTTAACAAAAAACT

Product: sensor protein kinase kinA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MNANKKMKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQRLLTGSMDSAEEVLE
QADAPLNSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHDFGFQKQGNNEMKEIQGENPGYL
VQRKIVSKGTGQVVGYLQAFYDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTND
FKPIEIESGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEV
DRMKKMLEEMLALARLENVDLSSEELDCDVGKVSNHALKNFQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNA
VKYSPDDRKEIVITVSEDEQFVITSVSDKGIGIAEEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVS
SELGIGSTFTLKFPKM

Sequences:

>Translated_496_residues
MNANKKMKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQRLLTGSMDSAEEVLE
QADAPLNSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHDFGFQKQGNNEMKEIQGENPGYL
VQRKIVSKGTGQVVGYLQAFYDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTND
FKPIEIESGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEV
DRMKKMLEEMLALARLENVDLSSEELDCDVGKVSNHALKNFQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNA
VKYSPDDRKEIVITVSEDEQFVITSVSDKGIGIAEEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVS
SELGIGSTFTLKFPKM
>Mature_496_residues
MNANKKMKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQRLLTGSMDSAEEVLE
QADAPLNSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHDFGFQKQGNNEMKEIQGENPGYL
VQRKIVSKGTGQVVGYLQAFYDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTND
FKPIEIESGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEV
DRMKKMLEEMLALARLENVDLSSEELDCDVGKVSNHALKNFQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNA
VKYSPDDRKEIVITVSEDEQFVITSVSDKGIGIAEEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVS
SELGIGSTFTLKFPKM

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=272, Percent_Identity=29.4117647058824, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786783, Length=321, Percent_Identity=27.1028037383178, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=31.0344827586207, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=27.3381294964029, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790346, Length=289, Percent_Identity=28.719723183391, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787894, Length=305, Percent_Identity=27.8688524590164, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790861, Length=290, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=26.431718061674, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=28.3636363636364, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=343, Percent_Identity=23.3236151603499, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=29.957805907173, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=28.1512605042017, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=282, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=25.3846153846154, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789808, Length=246, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=26.9565217391304, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56550; Mature: 56550

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANKKMKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSF
CCCCHHHHHHHHCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKEEQRLLTGSMDSAEEVLEQADAPLNSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKA
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCE
FYIYDLNHKLLYSTNRHDFGFQKQGNNEMKEIQGENPGYLVQRKIVSKGTGQVVGYLQAF
EEEEECCCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHH
YDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FKPIEIESGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNR
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WGKNDPEVLDESLQASLDEVDRMKKMLEEMLALARLENVDLSSEELDCDVGKVSNHALKN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHH
FQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNAVKYSPDDRKEIVITVSEDEQ
HHHHHHHHHEEECCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCE
FVITSVSDKGIGIAEEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVS
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEE
SELGIGSTFTLKFPKM
CCCCCCCEEEEECCCC
>Mature Secondary Structure
MNANKKMKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSF
CCCCHHHHHHHHCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKEEQRLLTGSMDSAEEVLEQADAPLNSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKA
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCE
FYIYDLNHKLLYSTNRHDFGFQKQGNNEMKEIQGENPGYLVQRKIVSKGTGQVVGYLQAF
EEEEECCCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHH
YDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FKPIEIESGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNR
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WGKNDPEVLDESLQASLDEVDRMKKMLEEMLALARLENVDLSSEELDCDVGKVSNHALKN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHH
FQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNAVKYSPDDRKEIVITVSEDEQ
HHHHHHHHHEEECCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCE
FVITSVSDKGIGIAEEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVS
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEE
SELGIGSTFTLKFPKM
CCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA