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The map label for this gene is czcD [H]

Identifier: 125623731

GI number: 125623731

Start: 858798

End: 859715

Strand: Reverse

Name: czcD [H]

Synonym: llmg_0887

Alternate gene names: 125623731

Gene position: 859715-858798 (Counterclockwise)

Preceding gene: 125623732

Following gene: 125623724

Centisome position: 33.99

GC content: 38.45

Gene sequence:

>918_bases
ATGAGTCTTAAAAATAAGAAAGCTCTCAAATTGGAGCACGAGCATGACCATTTGGACAAGCTAGTTTCTCAAAATGTGAC
GATTGTTTTTGCACTGAACCTCTTCTTTGCAATTTTAGAATTCATCTTTGGAGTCATTTTTAATTCAACTGCTATTTTGT
CTGATGCAGTGCATGACACCGGAGATGCCGTAGCCATTGGTTTGGCCTGGTTTTTCCAAAAATTTTCTAAACGTCGGGAG
GATAAACATTTCTCTTTTGGTTATCAACGTTTTAGTTTACTTGGCGCCTCACTGACCAGTGTAATTTTAATTACAGGGAG
TTTCATTGTCCTTTTCGAGGCTCTTCCTCGATTTTTTAACCCTCAACCTGTGGAAACAACAGGTATGCTCGGTTTGGCAA
TTTTTGCGATTGTTGCCAATGGCTTTGGGGCCTGGCTTTTGGCTCGTGGTTCCTCACGAAATGAAAGTATCTTAAATCTT
CACGCGCTTGAAGACGTTTTAGGTTGGTTAGGCGTTCTAATTGTTTCAATCGTCCTTCATTTTGTTGATTGGTACTGGTT
AGATCCTCTTCTTTCTATTTTAATTGCTTTGTTCATCTTATCTAAAGCCATTCCAAAATTCTGGGGCACTTTACGTATTC
TTTTGGAATCGGTTCCTGAAGATATTGATTACAAAAAACTCCTGATTGCTCTTGAAAAACTCCCAGAAGTACGTAGTGTT
ACTCAACTTATTATCTGGTCAATTGATGGAGAACAAAATGCGGCCATGATTCACATTGTAATTCCTGAAAATCAAGATTT
TTCTGAAGCAAAAATTGCTGTTCGCACGCTTTTGGAAAGTGAAAAAGTGTGCCGCTCAGCAATTGAACTTGACGAAACGG
TTGACGAACATAAAAAACACATGATTTATGAAGTCTAA

Upstream 100 bases:

>100_bases
AAAATTGGAAAAACAGTCACTTATAGTATTTATGACCGACATATTTTGCATCTTTTGAAAGACGTTGCAGAGCATCTGGA
CGAGCAAGAAGGAGGAAATC

Downstream 100 bases:

>100_bases
TTTACTGACAGCTTTTCATTAAATTTTTATAGATTACACCACTTCTGTCAGCTCAATGTGCTGATTTATGCACTTTGAAC
TGTCAAATAAAAGTTTTGAT

Product: cation transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSLKNKKALKLEHEHDHLDKLVSQNVTIVFALNLFFAILEFIFGVIFNSTAILSDAVHDTGDAVAIGLAWFFQKFSKRRE
DKHFSFGYQRFSLLGASLTSVILITGSFIVLFEALPRFFNPQPVETTGMLGLAIFAIVANGFGAWLLARGSSRNESILNL
HALEDVLGWLGVLIVSIVLHFVDWYWLDPLLSILIALFILSKAIPKFWGTLRILLESVPEDIDYKKLLIALEKLPEVRSV
TQLIIWSIDGEQNAAMIHIVIPENQDFSEAKIAVRTLLESEKVCRSAIELDETVDEHKKHMIYEV

Sequences:

>Translated_305_residues
MSLKNKKALKLEHEHDHLDKLVSQNVTIVFALNLFFAILEFIFGVIFNSTAILSDAVHDTGDAVAIGLAWFFQKFSKRRE
DKHFSFGYQRFSLLGASLTSVILITGSFIVLFEALPRFFNPQPVETTGMLGLAIFAIVANGFGAWLLARGSSRNESILNL
HALEDVLGWLGVLIVSIVLHFVDWYWLDPLLSILIALFILSKAIPKFWGTLRILLESVPEDIDYKKLLIALEKLPEVRSV
TQLIIWSIDGEQNAAMIHIVIPENQDFSEAKIAVRTLLESEKVCRSAIELDETVDEHKKHMIYEV
>Mature_304_residues
SLKNKKALKLEHEHDHLDKLVSQNVTIVFALNLFFAILEFIFGVIFNSTAILSDAVHDTGDAVAIGLAWFFQKFSKRRED
KHFSFGYQRFSLLGASLTSVILITGSFIVLFEALPRFFNPQPVETTGMLGLAIFAIVANGFGAWLLARGSSRNESILNLH
ALEDVLGWLGVLIVSIVLHFVDWYWLDPLLSILIALFILSKAIPKFWGTLRILLESVPEDIDYKKLLIALEKLPEVRSVT
QLIIWSIDGEQNAAMIHIVIPENQDFSEAKIAVRTLLESEKVCRSAIELDETVDEHKKHMIYEV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=325, Percent_Identity=24.3076923076923, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI21359890, Length=274, Percent_Identity=29.1970802919708, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI21361112, Length=304, Percent_Identity=25.9868421052632, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI52352805, Length=260, Percent_Identity=24.2307692307692, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI289803013, Length=290, Percent_Identity=24.8275862068966, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI289803009, Length=290, Percent_Identity=24.8275862068966, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI289803007, Length=290, Percent_Identity=24.8275862068966, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI289803003, Length=290, Percent_Identity=24.8275862068966, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI64762489, Length=290, Percent_Identity=24.8275862068966, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=29.1338582677165, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=250, Percent_Identity=30, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI32564488, Length=295, Percent_Identity=23.728813559322, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=26.7515923566879, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17555794, Length=293, Percent_Identity=24.2320819112628, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17555796, Length=272, Percent_Identity=24.6323529411765, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34449; Mature: 34317

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKNKKALKLEHEHDHLDKLVSQNVTIVFALNLFFAILEFIFGVIFNSTAILSDAVHDT
CCCCCCCCCEECCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
GDAVAIGLAWFFQKFSKRREDKHFSFGYQRFSLLGASLTSVILITGSFIVLFEALPRFFN
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQPVETTGMLGLAIFAIVANGFGAWLLARGSSRNESILNLHALEDVLGWLGVLIVSIVLH
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FVDWYWLDPLLSILIALFILSKAIPKFWGTLRILLESVPEDIDYKKLLIALEKLPEVRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHH
TQLIIWSIDGEQNAAMIHIVIPENQDFSEAKIAVRTLLESEKVCRSAIELDETVDEHKKH
HHHHHEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIYEV
HCCCC
>Mature Secondary Structure 
SLKNKKALKLEHEHDHLDKLVSQNVTIVFALNLFFAILEFIFGVIFNSTAILSDAVHDT
CCCCCCCCEECCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
GDAVAIGLAWFFQKFSKRREDKHFSFGYQRFSLLGASLTSVILITGSFIVLFEALPRFFN
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQPVETTGMLGLAIFAIVANGFGAWLLARGSSRNESILNLHALEDVLGWLGVLIVSIVLH
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FVDWYWLDPLLSILIALFILSKAIPKFWGTLRILLESVPEDIDYKKLLIALEKLPEVRSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHH
TQLIIWSIDGEQNAAMIHIVIPENQDFSEAKIAVRTLLESEKVCRSAIELDETVDEHKKH
HHHHHEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIYEV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]