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The map label for this gene is proA [H]

Identifier: 125623730

GI number: 125623730

Start: 857316

End: 858560

Strand: Direct

Name: proA [H]

Synonym: llmg_0886

Alternate gene names: 125623730

Gene position: 857316-858560 (Clockwise)

Preceding gene: 125623729

Following gene: 125623733

Centisome position: 33.89

GC content: 38.63

Gene sequence:

>1245_bases
ATGATGATTGAAGAACTTGGATTAAAGGTAAAAACAGCGAGTAAAGAAGCGGCAAAGCTATCAACTGCTGAAAAAAACAC
ATTTTTGCAAAAATTGGCTGACAGTCTTGTCGAAAATACGGACAGAATTATCAGCGAAAATGCAAAGGATTTAGCAAAAG
CCAAAGGACATGGAATTTCTGAAATTATGGTTGACCGTTTACGCCTGACTGCTCAGAGAATCTCTGATATGGCGACAGGA
TTGAGACAAGTTGCGGAACTTCCTGATCCAATTGGGCAAGTCTTGCAAGGTTTCACTAATCTTGACGGACTTAAAATTGT
TCAAAAAAGAGTGCCACTTGGTACGGTCGGAATGATTTTTGAAAGTCGTCCAAATGTAACCATCGATGCTTTTTCACTTT
GTTTCAAAACAGGAAATTCTGTCTTGTTACGTGGTGGGTCTGATGCGATTTATTCCAATATGGTTTTAGTTGAAATTATT
AAGGAAAATTTGCTGTCAGCAAAAATTACTGACGGAGTGGTTGAACTTTTATCTGACACGAGTCATGCTGAAGCTGAAAA
GATGATGCAAGCTGATAAGTTCTTAGATGTTTTGATTCCACGTGGGTCGGCTAGATTGATTAATCGTGTCAAAGAAAAAG
CAACGGTCCCTGTCATTGAAACTGGGGTTGGAAATTGTACGATTTTTGTTGACGAATCGGCTGATTTGGATATGGCGACT
CGGATTGTGATTAATGCAAAAACACAGCGCCCAAGTGTTTGCAATGCGGCCGAAAGTTTAGTGGTTCATGCAAAAATTGC
TGACGAGTTTTTACCTAAACTCCAAAATGAAATCAATAAAGTCCATGAAGTTGAATTTCGTGCTGATGAACGATCGTTAA
AAGCTCTGTCAGCTGGAATTCCTGCAACTGACGAAGATTTTGGAATGGAATTTTTAGATTATATTCTGTCAGTAAAAACG
GTTGATAATTTGGATGAGGCAATCGAGCATATTAATACTTATTCAAGTCGTCATTCGGAAAGTATTGTTACTCATGATTA
TTTTAATGCACAAAAATTTCAAGATGAAATTGATGCGGCGGCCGTTTATGTCAATGCTTCAACCCGATTTACTGACGGCT
TTGTATTTGGTTTGGGTGCTGAAATTGGGATTTCAACTCAAAAACTTCATGCCAGAGGACCAATGGGCTTAGAGGCTCTA
ACCTCAACTAAATATCTGATTGATGGATGTGGACAAATTCGTTGA

Upstream 100 bases:

>100_bases
CTAAAAAGCAAAGCCGTTTTTGCGATGTGACTAGGTGTTTGAGCGACATAGCGAGCATGGTCAGCCTAGCAAAGCAGGCC
ACAAAGAAAGAAGGATAAAA

Downstream 100 bases:

>100_bases
AAATATTAAAAGACTCGGCTTATGAAAAGTCGAGTCTTTTGTTTATCAAGGATGCTGTCAGTAAATCCTTGAAATCATTG
TTTACCCATTTAATATTTAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MMIEELGLKVKTASKEAAKLSTAEKNTFLQKLADSLVENTDRIISENAKDLAKAKGHGISEIMVDRLRLTAQRISDMATG
LRQVAELPDPIGQVLQGFTNLDGLKIVQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEII
KENLLSAKITDGVVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLDMAT
RIVINAKTQRPSVCNAAESLVVHAKIADEFLPKLQNEINKVHEVEFRADERSLKALSAGIPATDEDFGMEFLDYILSVKT
VDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEAL
TSTKYLIDGCGQIR

Sequences:

>Translated_414_residues
MMIEELGLKVKTASKEAAKLSTAEKNTFLQKLADSLVENTDRIISENAKDLAKAKGHGISEIMVDRLRLTAQRISDMATG
LRQVAELPDPIGQVLQGFTNLDGLKIVQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEII
KENLLSAKITDGVVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLDMAT
RIVINAKTQRPSVCNAAESLVVHAKIADEFLPKLQNEINKVHEVEFRADERSLKALSAGIPATDEDFGMEFLDYILSVKT
VDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEAL
TSTKYLIDGCGQIR
>Mature_414_residues
MMIEELGLKVKTASKEAAKLSTAEKNTFLQKLADSLVENTDRIISENAKDLAKAKGHGISEIMVDRLRLTAQRISDMATG
LRQVAELPDPIGQVLQGFTNLDGLKIVQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEII
KENLLSAKITDGVVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLDMAT
RIVINAKTQRPSVCNAAESLVVHAKIADEFLPKLQNEINKVHEVEFRADERSLKALSAGIPATDEDFGMEFLDYILSVKT
VDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEAL
TSTKYLIDGCGQIR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=409, Percent_Identity=35.4523227383863, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI62912457, Length=409, Percent_Identity=35.4523227383863, Blast_Score=260, Evalue=2e-69,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=47.242206235012, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=35.9036144578313, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=35.9036144578313, Blast_Score=258, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=416, Percent_Identity=36.2980769230769, Blast_Score=262, Evalue=6e-71,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=35.4523227383863, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45291; Mature: 45291

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIEELGLKVKTASKEAAKLSTAEKNTFLQKLADSLVENTDRIISENAKDLAKAKGHGIS
CCHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
EIMVDRLRLTAQRISDMATGLRQVAELPDPIGQVLQGFTNLDGLKIVQKRVPLGTVGMIF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEE
ESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIKENLLSAKITDGVVELLSDT
ECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLDMAT
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCCEE
RIVINAKTQRPSVCNAAESLVVHAKIADEFLPKLQNEINKVHEVEFRADERSLKALSAGI
EEEEECCCCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PATDEDFGMEFLDYILSVKTVDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAA
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCE
AVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKYLIDGCGQIR
EEEEECCCEECCCEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMIEELGLKVKTASKEAAKLSTAEKNTFLQKLADSLVENTDRIISENAKDLAKAKGHGIS
CCHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHH
EIMVDRLRLTAQRISDMATGLRQVAELPDPIGQVLQGFTNLDGLKIVQKRVPLGTVGMIF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEE
ESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIKENLLSAKITDGVVELLSDT
ECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLDMAT
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCCEE
RIVINAKTQRPSVCNAAESLVVHAKIADEFLPKLQNEINKVHEVEFRADERSLKALSAGI
EEEEECCCCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PATDEDFGMEFLDYILSVKTVDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAA
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCE
AVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKYLIDGCGQIR
EEEEECCCEECCCEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]