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The map label for this gene is dapA

Identifier: 125623718

GI number: 125623718

Start: 843396

End: 844289

Strand: Direct

Name: dapA

Synonym: llmg_0874

Alternate gene names: 125623718

Gene position: 843396-844289 (Clockwise)

Preceding gene: 125623717

Following gene: 125623720

Centisome position: 33.34

GC content: 37.36

Gene sequence:

>894_bases
ATGTCAGCAAAAGAAACAATTGAAAAATTAAAAAAAGCACGAATTATCACGGCTTTAGTGACACCCTTTAAAGAAAATGG
CCAAATTAATTTTGAAGCATTTCCAAAACTTGTTGAGGATTTGCTTGCCAGTCATACAGAAGGGCTTATTTTAGCAGGAA
CGACAGCCGAATCGCCAACGCTCACGCATGATGAAGAATTAGAAATTTTTGCCTCAATTAATCAGCTCGTAGATGGACGG
GTTCCTTTGATTGCCGGCATAGGAACTAATGATACTCGGGATTCAGTTGAGTTCATAAAAGAAGTTGCAAAATTAGGCTA
TATTGATGCAGGACTAGCGGTGACTCCTTATTACAATAAACCTTCCCAAGAAGGTATTTATCAGCATTTTAAAGCAATTG
CTACTGCCAGTGATTTGCCAATTATTTTGTATAATATTCCAGGACGAGTAGTGACTGAAATTCTACCAGATACAATTTTA
CGTTTGGCCCAGTTGGAAAATGTAATTGCAGTTAAAGAGTGTACAAGTACTGACAACCTAGCTTATCTCATTGAAAATGT
ACCAGAAGATTTTCTTGTTTATACTGGAGAAGATGGCTTAGCTTTTCATGCGAAAACTCTAGGAGGACAAGGAGTCATCT
CGGTTGCCAGCCATATCTTGGGGCAAGAATTTTTTGAAATGTTTGCTGAAATAGACCAGGGCTCGATTCAAAAGGCCGCA
ACTATTCAAAGAAAAATATTACCAAAAATCAATGCGCTCTTTAGTGTGACAAGTCCAGCACCAATTAAAACAGTTTTGAA
CAATAAAGGTTATGCAGTTGGAGGATTACGCTTACCACTTGTCGCTTGTACTGACCAGGAAGCAAAAATAATTATTGAAC
AAATTGAAAATTAA

Upstream 100 bases:

>100_bases
TATTTTTGACGAACTTTTGAGAACCTCTTTTGCATAAAAAGAGGTTCTTTTTGACCTCTTGACAGAAGCTTATCAATAAG
CTCACCCAAAAGGAGAAGAC

Downstream 100 bases:

>100_bases
AAATACCTTTAAAGGTATTTTTTTATTAAAATATTCTTGTCAGTATTCAATTGACTTAATTTTGCCGTTTGTTTCTAATA
AGTTTAGAATTGAAGTGATT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSAKETIEKLKKARIITALVTPFKENGQINFEAFPKLVEDLLASHTEGLILAGTTAESPTLTHDEELEIFASINQLVDGR
VPLIAGIGTNDTRDSVEFIKEVAKLGYIDAGLAVTPYYNKPSQEGIYQHFKAIATASDLPIILYNIPGRVVTEILPDTIL
RLAQLENVIAVKECTSTDNLAYLIENVPEDFLVYTGEDGLAFHAKTLGGQGVISVASHILGQEFFEMFAEIDQGSIQKAA
TIQRKILPKINALFSVTSPAPIKTVLNNKGYAVGGLRLPLVACTDQEAKIIIEQIEN

Sequences:

>Translated_297_residues
MSAKETIEKLKKARIITALVTPFKENGQINFEAFPKLVEDLLASHTEGLILAGTTAESPTLTHDEELEIFASINQLVDGR
VPLIAGIGTNDTRDSVEFIKEVAKLGYIDAGLAVTPYYNKPSQEGIYQHFKAIATASDLPIILYNIPGRVVTEILPDTIL
RLAQLENVIAVKECTSTDNLAYLIENVPEDFLVYTGEDGLAFHAKTLGGQGVISVASHILGQEFFEMFAEIDQGSIQKAA
TIQRKILPKINALFSVTSPAPIKTVLNNKGYAVGGLRLPLVACTDQEAKIIIEQIEN
>Mature_296_residues
SAKETIEKLKKARIITALVTPFKENGQINFEAFPKLVEDLLASHTEGLILAGTTAESPTLTHDEELEIFASINQLVDGRV
PLIAGIGTNDTRDSVEFIKEVAKLGYIDAGLAVTPYYNKPSQEGIYQHFKAIATASDLPIILYNIPGRVVTEILPDTILR
LAQLENVIAVKECTSTDNLAYLIENVPEDFLVYTGEDGLAFHAKTLGGQGVISVASHILGQEFFEMFAEIDQGSIQKAAT
IQRKILPKINALFSVTSPAPIKTVLNNKGYAVGGLRLPLVACTDQEAKIIIEQIEN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=277, Percent_Identity=24.5487364620939, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1788823, Length=273, Percent_Identity=39.5604395604396, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI87082415, Length=288, Percent_Identity=26.3888888888889, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1786463, Length=252, Percent_Identity=26.984126984127, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789620, Length=257, Percent_Identity=28.0155642023346, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_LACLM (A2RJL6)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032201.1
- ProteinModelPortal:   A2RJL6
- SMR:   A2RJL6
- STRING:   A2RJL6
- GeneID:   4798822
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_0874
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   SGEDMTA
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32321; Mature: 32189

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 172-172 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKETIEKLKKARIITALVTPFKENGQINFEAFPKLVEDLLASHTEGLILAGTTAESPT
CCHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
LTHDEELEIFASINQLVDGRVPLIAGIGTNDTRDSVEFIKEVAKLGYIDAGLAVTPYYNK
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCC
PSQEGIYQHFKAIATASDLPIILYNIPGRVVTEILPDTILRLAQLENVIAVKECTSTDNL
CCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AYLIENVPEDFLVYTGEDGLAFHAKTLGGQGVISVASHILGQEFFEMFAEIDQGSIQKAA
HHHHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TIQRKILPKINALFSVTSPAPIKTVLNNKGYAVGGLRLPLVACTDQEAKIIIEQIEN
HHHHHHHHHHHHHEECCCCCCHHHHHCCCCEEECCEEEEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure 
SAKETIEKLKKARIITALVTPFKENGQINFEAFPKLVEDLLASHTEGLILAGTTAESPT
CHHHHHHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
LTHDEELEIFASINQLVDGRVPLIAGIGTNDTRDSVEFIKEVAKLGYIDAGLAVTPYYNK
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCC
PSQEGIYQHFKAIATASDLPIILYNIPGRVVTEILPDTILRLAQLENVIAVKECTSTDNL
CCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AYLIENVPEDFLVYTGEDGLAFHAKTLGGQGVISVASHILGQEFFEMFAEIDQGSIQKAA
HHHHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TIQRKILPKINALFSVTSPAPIKTVLNNKGYAVGGLRLPLVACTDQEAKIIIEQIEN
HHHHHHHHHHHHHEECCCCCCHHHHHCCCCEEECCEEEEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA