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The map label for this gene is uxuB [H]

Identifier: 125623703

GI number: 125623703

Start: 824842

End: 826476

Strand: Direct

Name: uxuB [H]

Synonym: llmg_0858

Alternate gene names: 125623703

Gene position: 824842-826476 (Clockwise)

Preceding gene: 125623701

Following gene: 125623704

Centisome position: 32.61

GC content: 35.96

Gene sequence:

>1635_bases
ATGGTGAAATTGCTTGATAATTACTTGGAAAAAAGCGAGAGATTTGCGGAGTCAAAGATTAATATTCCAAAGTTTGACCA
AGGAAAAGTCGCAGAATCAACAACAGATAATCCGGTCTGGGTTCATTTTGGTGGAGGAAATCTTTTTAGATGTTTTCATG
CGGTTGTCGCGCAAGACTTGTTAAATCAAGGAGAACTGAACTCTGGGATTATTGTTGCTGAAACTTATGATGATGAGGTC
ATTGAGAAAATCTATCATGCTTATGATAATCGTTTTCTATCAGTAACAATGAAATCGGATGGAACTTTTGATAAAGAATT
AATTGCTTCTGTTTCCGAAAGTTTTTATTTTAATTCTGAAAATACCGAAGGTTGGGCCCATTTAACAAAAGTATTTGAAA
ATCCATCTTTGCAATTCACAACTTTTTCAATTACAGAAAAAGGTTATTCACTTCGTGATTCCAAAGATCAATTGACGCCT
TTGGCACTTGAAGATATGCAAGGAAGAAGTAAGCCCAAAACCAATATGGGCGCAATTACTTATCTCCTTTATGCAAGATT
TAAAGCTGGTAAATTTCCAATTGCCATGGTCAGTACAGATAATTTTTCAGAAAATGGTTTGAAATTGCAGGAAGCGATTT
TGACCATTGCTAAGGCTTGGGTTGAAAATGAAATCGTAGAACAAGATTTCTATGATTACCTCATCAATCCTAAGAGAGTA
AGTTTTCCTTGGTCAATGATTGACCGAATCACTCCCAATCCGTCTGAAAAAGTAGCAGGATTACTGACAGCTGACGGTTT
TGAGGATACAGAAATTTTACATAGTCAAAAACATACAAATATCGCTCCTTTTGGCAATACGGAAGAAGTTCATTATTTGG
TGATTGAAGATGCCTTTCCAAACGGGAGACCTGCCTTAGAAAAAGCAGGAGTTATTTTGACTGACCGTGAAACGGTAAAT
GATGCTGACCAGATGAAAGTTACAGCTTGTTTGAATCCTCTTCATACTGCTTTAGCTATTTTTGGAAGTTTATTAGATTA
TCATTCAATTTGGGAAGAAGTTGCCAACCCAGATTTGTTAGCACTTATTAAGAATTTGGGCTATGGCGAGGCTTTGCCTG
TGGTTAAGAATCCGAAAATTATCAATCCGACAGAGTTTATTGACCAGTTACTGACTAAACGTTTACCAAATAAAAATATT
CCAGATACGCCACAAAGAATTGCAGCAGATAGCTCACAAAAAATTCCTGTTCGCTATGGGGTAACGATTGGCCACTATAT
TGCCAACCCAAGATTTTCTGTCAAAGAATTGGAATTTATTCCATTAGTCATTGCAGCTTGGTGTCGTTATTTAATCGGAA
TTAATGATGAGTTAGAAAGTTTTTCTCCAAGTCCTGACCCTCTTCTTGAAGAGTTACAAAGTTATCTTACCAAAGTAAAA
TTAGATGGTAGTCAAAAAGAAATTCATGAAATTTTGAAACCCATCTTATCTAATCATCAAATTTTCCCACATGAGATGTA
TCAAACGGGCTTAGCAGAAAAAATTGAGACTTACTTTGAAGAGATGATTCAAGGCAAAGGGGCTGTACTTGCGACGCTAC
AAATTGCTCTAAAAAAACATGGAAAAAATTACTGA

Upstream 100 bases:

>100_bases
CTTTTTTTAAATATATCCTTGACAACGGTTTCTTAAAAGTGATATACTAGTTTTTGTAAATAAGAAACTGATATATCACT
TTTGAATTAAAGGAGAAATA

Downstream 100 bases:

>100_bases
CAGAAAGTTTATGTAGGACCTGTCAGCAAAAAATACTGACAATATGAGTCAATTAAAAGAAAGGAAAGTAAATTCTGACA
CTGACAGAATTTGCAATGTA

Product: fructuronate reductase

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MVKLLDNYLEKSERFAESKINIPKFDQGKVAESTTDNPVWVHFGGGNLFRCFHAVVAQDLLNQGELNSGIIVAETYDDEV
IEKIYHAYDNRFLSVTMKSDGTFDKELIASVSESFYFNSENTEGWAHLTKVFENPSLQFTTFSITEKGYSLRDSKDQLTP
LALEDMQGRSKPKTNMGAITYLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKRV
SFPWSMIDRITPNPSEKVAGLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFPNGRPALEKAGVILTDRETVN
DADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLLALIKNLGYGEALPVVKNPKIINPTEFIDQLLTKRLPNKNI
PDTPQRIAADSSQKIPVRYGVTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQSYLTKVK
LDGSQKEIHEILKPILSNHQIFPHEMYQTGLAEKIETYFEEMIQGKGAVLATLQIALKKHGKNY

Sequences:

>Translated_544_residues
MVKLLDNYLEKSERFAESKINIPKFDQGKVAESTTDNPVWVHFGGGNLFRCFHAVVAQDLLNQGELNSGIIVAETYDDEV
IEKIYHAYDNRFLSVTMKSDGTFDKELIASVSESFYFNSENTEGWAHLTKVFENPSLQFTTFSITEKGYSLRDSKDQLTP
LALEDMQGRSKPKTNMGAITYLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKRV
SFPWSMIDRITPNPSEKVAGLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFPNGRPALEKAGVILTDRETVN
DADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLLALIKNLGYGEALPVVKNPKIINPTEFIDQLLTKRLPNKNI
PDTPQRIAADSSQKIPVRYGVTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQSYLTKVK
LDGSQKEIHEILKPILSNHQIFPHEMYQTGLAEKIETYFEEMIQGKGAVLATLQIALKKHGKNY
>Mature_544_residues
MVKLLDNYLEKSERFAESKINIPKFDQGKVAESTTDNPVWVHFGGGNLFRCFHAVVAQDLLNQGELNSGIIVAETYDDEV
IEKIYHAYDNRFLSVTMKSDGTFDKELIASVSESFYFNSENTEGWAHLTKVFENPSLQFTTFSITEKGYSLRDSKDQLTP
LALEDMQGRSKPKTNMGAITYLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKRV
SFPWSMIDRITPNPSEKVAGLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFPNGRPALEKAGVILTDRETVN
DADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLLALIKNLGYGEALPVVKNPKIINPTEFIDQLLTKRLPNKNI
PDTPQRIAADSSQKIPVRYGVTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQSYLTKVK
LDGSQKEIHEILKPILSNHQIFPHEMYQTGLAEKIETYFEEMIQGKGAVLATLQIALKKHGKNY

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=534, Percent_Identity=23.9700374531835, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1790779, Length=446, Percent_Identity=26.0089686098655, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787823, Length=535, Percent_Identity=25.2336448598131, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324401, Length=543, Percent_Identity=24.6777163904236, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320765, Length=543, Percent_Identity=24.6777163904236, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 61375; Mature: 61375

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLLDNYLEKSERFAESKINIPKFDQGKVAESTTDNPVWVHFGGGNLFRCFHAVVAQDL
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
LNQGELNSGIIVAETYDDEVIEKIYHAYDNRFLSVTMKSDGTFDKELIASVSESFYFNSE
HCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHEECCC
NTEGWAHLTKVFENPSLQFTTFSITEKGYSLRDSKDQLTPLALEDMQGRSKPKTNMGAIT
CCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHH
YLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKRV
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
SFPWSMIDRITPNPSEKVAGLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFP
CCCHHHHHCCCCCCHHHHHEEHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NGRPALEKAGVILTDRETVNDADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLL
CCCCCHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALIKNLGYGEALPVVKNPKIINPTEFIDQLLTKRLPNKNIPDTPQRIAADSSQKIPVRYG
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEC
VTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQSYLTKVK
CEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHEE
LDGSQKEIHEILKPILSNHQIFPHEMYQTGLAEKIETYFEEMIQGKGAVLATLQIALKKH
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GKNY
CCCC
>Mature Secondary Structure
MVKLLDNYLEKSERFAESKINIPKFDQGKVAESTTDNPVWVHFGGGNLFRCFHAVVAQDL
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
LNQGELNSGIIVAETYDDEVIEKIYHAYDNRFLSVTMKSDGTFDKELIASVSESFYFNSE
HCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHEECCC
NTEGWAHLTKVFENPSLQFTTFSITEKGYSLRDSKDQLTPLALEDMQGRSKPKTNMGAIT
CCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHH
YLLYARFKAGKFPIAMVSTDNFSENGLKLQEAILTIAKAWVENEIVEQDFYDYLINPKRV
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
SFPWSMIDRITPNPSEKVAGLLTADGFEDTEILHSQKHTNIAPFGNTEEVHYLVIEDAFP
CCCHHHHHCCCCCCHHHHHEEHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCC
NGRPALEKAGVILTDRETVNDADQMKVTACLNPLHTALAIFGSLLDYHSIWEEVANPDLL
CCCCCHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALIKNLGYGEALPVVKNPKIINPTEFIDQLLTKRLPNKNIPDTPQRIAADSSQKIPVRYG
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEC
VTIGHYIANPRFSVKELEFIPLVIAAWCRYLIGINDELESFSPSPDPLLEELQSYLTKVK
CEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHEE
LDGSQKEIHEILKPILSNHQIFPHEMYQTGLAEKIETYFEEMIQGKGAVLATLQIALKKH
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GKNY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA