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The map label for this gene is apt [H]

Identifier: 125623468

GI number: 125623468

Start: 595890

End: 596402

Strand: Direct

Name: apt [H]

Synonym: llmg_0607

Alternate gene names: 125623468

Gene position: 595890-596402 (Clockwise)

Preceding gene: 125623467

Following gene: 125623469

Centisome position: 23.56

GC content: 40.35

Gene sequence:

>513_bases
ATGGAATTAAAAGACTATATTGCAACCATCGAAAACTATCCTAAAGAAGGCGTAGTTTTTCGCGACATCAGCCCTTTGAT
GGCAGATGGGAATGCCTATAACTATGCTGCTACCGAAATTGTTCAGTATGCCAGAGATAAAGAAATTGATATGGTTGTAG
GACCTGAAGCACGTGGCTTCATCATTGGTTGCCCAGTCGCATTTGCACTTGGTGTAGGTTTTGCGCCAGTTCGTAAACCT
GGAAAATTACCTCGTGAAGTTATTGAAGCAACTTACGAAAAAGAGTATGGTACAGATACACTTACAATGCACTCAGATAG
TATCAAACCAGGACAACGCGTCTTGATTGTTGATGATTTGCTTGCAACAGGTGGAACCATTGCTGCAACAATTGAACTTG
TTGAAAAAATGGGTGGAGTTGTTGTCGGTTGTGCCTTCCTTATCGAACTTGACGAGCTTAAAGGTCGCGAAAAAATCGGA
AATTACGACTATAAAGTTTTAATGCATTATTAA

Upstream 100 bases:

>100_bases
TGACAGAAAATAATTAGACTGTTAATGTTAATTCTGTCAGTAAAAACAACGGACTTATGTTAGAAAAAGGAGCACTGACA
ATTCTGTCAGTAACAAAAAC

Downstream 100 bases:

>100_bases
TTTCTGTCAGCCAGTTACCCAATAATTTCTGTCAGTATTCCTTTACTAAAAGTTAAAGGATACATTCGAGCTAATGGCAA
GAGGACAGAGGTTTTTTGGT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCPVAFALGVGFAPVRKP
GKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGVVVGCAFLIELDELKGREKIG
NYDYKVLMHY

Sequences:

>Translated_170_residues
MELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCPVAFALGVGFAPVRKP
GKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGVVVGCAFLIELDELKGREKIG
NYDYKVLMHY
>Mature_170_residues
MELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCPVAFALGVGFAPVRKP
GKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGVVVGCAFLIELDELKGREKIG
NYDYKVLMHY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=40.7185628742515, Blast_Score=133, Evalue=8e-32,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=41.3223140495868, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=54.140127388535, Blast_Score=178, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=43.2748538011696, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=42.9447852760736, Blast_Score=121, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=32.9411764705882, Blast_Score=88, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=44.0251572327044, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18698; Mature: 18698

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGF
CCHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCE
IIGCPVAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDL
EEECHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTIAATIELVEKMGGVVVGCAFLIELDELKGREKIGNYDYKVLMHY
HHCCCHHHHHHHHHHHHCCHHEEHHHEEEHHHHCCHHHCCCCCEEEEEEC
>Mature Secondary Structure
MELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGF
CCHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCE
IIGCPVAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDL
EEECHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTIAATIELVEKMGGVVVGCAFLIELDELKGREKIGNYDYKVLMHY
HHCCCHHHHHHHHHHHHCCHHEEHHHEEEHHHHCCHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]