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The map label for this gene is gnd [H]

Identifier: 125623448

GI number: 125623448

Start: 573365

End: 574783

Strand: Direct

Name: gnd [H]

Synonym: llmg_0586

Alternate gene names: 125623448

Gene position: 573365-574783 (Clockwise)

Preceding gene: 125623447

Following gene: 125623449

Centisome position: 22.67

GC content: 39.82

Gene sequence:

>1419_bases
ATGGCACAAGCAAACTTTGGTGTTGTCGGAATGGCTGTAATGGGTAAAAACCTTGCACTCAATGTTGAGTCACGTGGTTA
TACCGTTGCTATCTACAACCGTACGACTTCAAAAACTGAAGAAGTTTATAAAGAACATCAAGATAAAAATCTTGTTTTCA
CAAAAACACTTGAAGAATTTGTCGGAAGTCTTGAAAAACCACGTCGTATCATGCTCATGGTTCAAGCGGGAGCTGCTACT
GATGCAACCATCAAATCACTCTTACCACTTTTGGACATAGGCGACATCTTGATTGATGGTGGGAATACTCATTTCCCAGA
TACAATGCGTCGTAATGCTGAACTTGCTGACTCAGGAATCAACTTCATTGGTACTGGTGTTTCAGGTGGAGAAAAAGGAG
CGCTCTTGGGCCCTTCTATGATGCCTGGTGGACAAAAAGAAGCTTATGATTTAGTAGCTCCAATTTTTGAACAAATCGCA
GCTAAAGCTCCTCAAGACGGTAAACCATGTGTTGCTTATATGGGAGCCAATGGTGCGGGACATTACGTTAAAATGGTTCA
TAACGGAATTGAGTATGGCGACATGCAATTGATTGCTGAATCTTATGACCTTTTGAAACGTATTCTTGGACTTAGCAACG
CAGAAATTCAAGCCATTTTTGAAGAATGGAATGAAGGCGAACTTGATAGCTACCTCATCGAAATCACAAAAGAAGTATTG
AAACGTAAAGATGATGAAGGCGAAGGCTATATCGTTGATAAAATTCTTGATAAAGCAGGAAATAAAGGAACTGGTAAATG
GACTTCAGAATCTGCCCTTGACCTTGGTGTACCACTTCCATTGATTACAGAATCAGTATTTGCTCGTTACATTTCAACCT
ATAAAGATGAACGTGTTAAAGCAAGCAAAGTTTTGTCTGGCCCAGCTCTTGATTTCTCAGGCGATAAAAAAGAAGTAATC
GAAAAAATCCGCAAAGCACTTTATTTCTCAAAAATTATGAGTTATGCTCAAGGATTTGCTCAACTTCGCAAAGCTTCTGA
AGAATTTGATTGGGACTTGCCATACGGTACAATTGCTCAAATTTGGCGTGCTGGATGTATCATCCGTGCAGAATTCCTCC
AAAACATTACTGATGCTTTCGATAAAGATAGCGAACTTGAAAACCTCTTGCTTGATGACTACTTTGTAGACATCACAAAA
CGTTATCAAGAAGCTGTTCGTGATGTGGTTTCACTTGCTGTTCAAGCAGGAACTCCAATTCCAACATTCACCTCAGCAAT
TAGCTACTACGATAGCTATCGCTCTGAAAATCTTCCTGCAAACTTGATTCAAGCTCAACGTGACTATTTCGGTGCTCACA
CTTATGAACGGACTGATAAAGCAGGAATTTTCCATTACGACTGGTATACAGAAGATTAA

Upstream 100 bases:

>100_bases
GCTATGTAAAACATTTACACACCTAACTATGGTAATTGGAAATAAATTGCGTTATACTATATAATATATAAAATAAAAGA
AATACTCTGGAGGATTTCAA

Downstream 100 bases:

>100_bases
TTTAAAAATATTCAATCAAAAGCTAGAGTTTTCTAGCTTTTTTTCTTTTAAAGATTAGTAGTATTCTTTGGACCATTTTT
TAACAAAAAATGGATAAAAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVFTKTLEEFVGSLEKPRRIMLMVQAGAAT
DATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIA
AKAPQDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRILGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPALDFSGDKKEVI
EKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITK
RYQEAVRDVVSLAVQAGTPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED

Sequences:

>Translated_472_residues
MAQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVFTKTLEEFVGSLEKPRRIMLMVQAGAAT
DATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIA
AKAPQDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRILGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPALDFSGDKKEVI
EKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITK
RYQEAVRDVVSLAVQAGTPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED
>Mature_471_residues
AQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVFTKTLEEFVGSLEKPRRIMLMVQAGAATD
ATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSGINFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAA
KAPQDGKPCVAYMGANGAGHYVKMVHNGIEYGDMQLIAESYDLLKRILGLSNAEIQAIFEEWNEGELDSYLIEITKEVLK
RKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVKASKVLSGPALDFSGDKKEVIE
KIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQIWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKR
YQEAVRDVVSLAVQAGTPIPTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=56.2632696390658, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=68.3760683760684, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=50.3171247357294, Blast_Score=493, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=458, Percent_Identity=52.6200873362445, Blast_Score=501, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6321977, Length=456, Percent_Identity=52.4122807017544, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=51.9148936170213, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52461; Mature: 52330

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00461 6PGD ; PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVFTKTLEEF
CCCCCCCEEEHEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCCEEHHHHHHHH
VGSLEKPRRIMLMVQAGAATDATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHCCHHHHCCC
NFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAAKAPQDGKPCVAYMGANGAG
CEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYDLLKRILGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVK
HCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASKVLSGPALDFSGDKKEVIEKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQ
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKRYQEAVRDVVSLAVQAGTPI
HHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEECC
>Mature Secondary Structure 
AQANFGVVGMAVMGKNLALNVESRGYTVAIYNRTTSKTEEVYKEHQDKNLVFTKTLEEF
CCCCCCEEEHEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCCEEHHHHHHHH
VGSLEKPRRIMLMVQAGAATDATIKSLLPLLDIGDILIDGGNTHFPDTMRRNAELADSGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHCCHHHHCCC
NFIGTGVSGGEKGALLGPSMMPGGQKEAYDLVAPIFEQIAAKAPQDGKPCVAYMGANGAG
CEEECCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYDLLKRILGLSNAEIQAIFEEWNEGELDSYLIEITKEVL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRKDDEGEGYIVDKILDKAGNKGTGKWTSESALDLGVPLPLITESVFARYISTYKDERVK
HCCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASKVLSGPALDFSGDKKEVIEKIRKALYFSKIMSYAQGFAQLRKASEEFDWDLPYGTIAQ
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IWRAGCIIRAEFLQNITDAFDKDSELENLLLDDYFVDITKRYQEAVRDVVSLAVQAGTPI
HHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTFTSAISYYDSYRSENLPANLIQAQRDYFGAHTYERTDKAGIFHYDWYTED
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]