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The map label for this gene is dfpB [H]

Identifier: 125623410

GI number: 125623410

Start: 541219

End: 541914

Strand: Reverse

Name: dfpB [H]

Synonym: llmg_0544

Alternate gene names: 125623410

Gene position: 541914-541219 (Counterclockwise)

Preceding gene: 125623411

Following gene: 125623409

Centisome position: 21.42

GC content: 36.06

Gene sequence:

>696_bases
ATGAAAGTTTTGATTACTTCTGGTGGAACAACAGAACCAATTGATGAGGTTCGAGGCATCAGTAATTTTGCGACAGGAAG
TCTTGGTAAATTAGCCGCCGAAAAATTTTTACAGGCCGGTCATGAAGTCTTTTTATTGGCTGGATTACAGGCAGTTCTCC
CAGAAAATGATGCTCATCTTACTCATATTCCAATTGAAGGAACCAAAGACCTTTATCAGCAAATGGAAAAATTAGTTCCT
AAAATGGACGTGGTTATCCACAGTATGGCTGTCAGTGACTATCGACCAGTATACATGACTGGACTTGAAAATTTTTCTGG
AAGCCTCTCTGTAGATGAACTTCTTGATTACCGTCCTGAGCAGGTCGGGAAAATTTCTTCTAAATCTGATCATCAAATCA
TGCTCTTAGAAAAAACGCCAAAGATTATTTCTTATATCAAAAAATGGAATCCTAAAGTTTTACTTTTCGGCTTTAAATTG
TTGGTAGGTGTGGAAAATTCTGAACTTCTTCATGTTGCTAGAGAAAAATTACTGACAACAGAGGCTGATTTTATCCTTGC
TAATGACTTGAAAAATATTGAAGGTCAAAAGCACAAAGCACTTTTGGTCAGTAAAAATGAAGTAACTGCTTTAGATACAA
AGTCAGAAATTGCTGACAGTCTTCTAAAAATATCGGAGGAATTAAAAAATGACTAA

Upstream 100 bases:

>100_bases
TATATCAGCTGTCAGTAATTTTTTTAGTAAATAAACTTCTCTTGAAAAAACATTTTTAATAGGATAAAATGAAAGCAACT
CTAAAAGAAACTGGTGAAAA

Downstream 100 bases:

>100_bases
AATTACACTTGCGGTAACAGGTTCAATTGCAGCTTATAAAGCGGCTGATTTGACTTCATTACTGACAAAAGAGGGACATA
ATGTGACGGTCTTAATGACA

Product: phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKVLITSGGTTEPIDEVRGISNFATGSLGKLAAEKFLQAGHEVFLLAGLQAVLPENDAHLTHIPIEGTKDLYQQMEKLVP
KMDVVIHSMAVSDYRPVYMTGLENFSGSLSVDELLDYRPEQVGKISSKSDHQIMLLEKTPKIISYIKKWNPKVLLFGFKL
LVGVENSELLHVAREKLLTTEADFILANDLKNIEGQKHKALLVSKNEVTALDTKSEIADSLLKISEELKND

Sequences:

>Translated_231_residues
MKVLITSGGTTEPIDEVRGISNFATGSLGKLAAEKFLQAGHEVFLLAGLQAVLPENDAHLTHIPIEGTKDLYQQMEKLVP
KMDVVIHSMAVSDYRPVYMTGLENFSGSLSVDELLDYRPEQVGKISSKSDHQIMLLEKTPKIISYIKKWNPKVLLFGFKL
LVGVENSELLHVAREKLLTTEADFILANDLKNIEGQKHKALLVSKNEVTALDTKSEIADSLLKISEELKND
>Mature_231_residues
MKVLITSGGTTEPIDEVRGISNFATGSLGKLAAEKFLQAGHEVFLLAGLQAVLPENDAHLTHIPIEGTKDLYQQMEKLVP
KMDVVIHSMAVSDYRPVYMTGLENFSGSLSVDELLDYRPEQVGKISSKSDHQIMLLEKTPKIISYIKKWNPKVLLFGFKL
LVGVENSELLHVAREKLLTTEADFILANDLKNIEGQKHKALLVSKNEVTALDTKSEIADSLLKISEELKND

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 25626; Mature: 25626

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLITSGGTTEPIDEVRGISNFATGSLGKLAAEKFLQAGHEVFLLAGLQAVLPENDAHL
CEEEEECCCCCCCHHHHHCCHHHCCCCHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCEE
THIPIEGTKDLYQQMEKLVPKMDVVIHSMAVSDYRPVYMTGLENFSGSLSVDELLDYRPE
EEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHCCCCH
QVGKISSKSDHQIMLLEKTPKIISYIKKWNPKVLLFGFKLLVGVENSELLHVAREKLLTT
HHCCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHC
EADFILANDLKNIEGQKHKALLVSKNEVTALDTKSEIADSLLKISEELKND
CCCEEEECCHHHCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVLITSGGTTEPIDEVRGISNFATGSLGKLAAEKFLQAGHEVFLLAGLQAVLPENDAHL
CEEEEECCCCCCCHHHHHCCHHHCCCCHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCEE
THIPIEGTKDLYQQMEKLVPKMDVVIHSMAVSDYRPVYMTGLENFSGSLSVDELLDYRPE
EEECCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHCCCCH
QVGKISSKSDHQIMLLEKTPKIISYIKKWNPKVLLFGFKLLVGVENSELLHVAREKLLTT
HHCCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHC
EADFILANDLKNIEGQKHKALLVSKNEVTALDTKSEIADSLLKISEELKND
CCCEEEECCHHHCCCCCCEEEEEECCCEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]