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The map label for this gene is pyrG [H]

Identifier: 125623334

GI number: 125623334

Start: 461021

End: 462628

Strand: Direct

Name: pyrG [H]

Synonym: llmg_0467

Alternate gene names: 125623334

Gene position: 461021-462628 (Clockwise)

Preceding gene: 125623333

Following gene: 125623335

Centisome position: 18.23

GC content: 40.98

Gene sequence:

>1608_bases
ATGTCAACTAAGTATATTTTCGTCACTGGTGGTGGTACTTCGTCAATGGGTAAAGGGATCGTAGCGGCATCGCTCGGTCG
TTTGCTTAAAAACCGTGGACTTAAAGTCACTGTCCAAAAATTTGACCCATACCTTAACATCGACCCAGGGACAATGAGTC
CTTATCAACATGGTGAAGTCTTTGTTACTGATGATGGTGCTGAAACTGACCTTGACCTTGGTCACTATGAACGTTTCATT
GACATCAATTTAAATAAATATTCAAACGTTACCTCAGGTAAAGTTTACAGTGAGATTCTTCGTAAAGAACGTAAAGGAGA
ATATCTCGGAGCAACTGTCCAAATGGTACCGCATGTGACTAACATGTTGAAAGAAAAAATTAAACGTGCAGCAACAACAA
CTGATGCTGATATTATTATCACTGAGGTTGGTGGGACTGTTGGTGATATGGAAAGCTTGCCATTTATTGAAGCTTTGCGC
CAAATGAAAGCCGAAGTTGGTGCTGACAACGTGATGTACATTCACACTGTTCCAATTCTTCACTTGCGTGCTGCTGGCGA
ATTGAAAACTAAGATCGCACAAAATGCGACTAAGACACTTCGTGAATATGGTATCCAAGCCAACATGCTTGTCTTGCGCA
GTGAAGTGCCAATCACGACAGAAATGCGTGATAAAATTGCAATGTTCTGTGACGTAGCACCTGAAGCAGTGATTCAATCA
CTTGATGTGGAACATCTTTATCAAATTCCATTGAACCTTCAAGCACAAAATATGGACCAAATCGTTTGTGACCATTTGAA
ACTTGATGCACCAAAAGCAGATATGGCAGAATGGTCAGCAATGGTTGACCATGTCATGAATCTTAAGAAAAAAGTGAAAA
TCGCTTTGGTTGGTAAATATGTAGAGTTGCCAGATGCTTATATTTCAGTGACTGAAGCTCTTAAACATGCAGGCTATGCA
TCTGATGCCGAAGTTGATATTAACTGGGTAAATGCCAACGATGTGACCGATGAGAATGTCGCTGAACTTGTTGGAGACGC
AGCTGGAATTATCGTGCCTGGTGGCTTTGGTCAACGTGGAACAGAAGGTAAGATTGCAGCAATCAAATATGCGCGTGAAA
ATGACGTTCCAATGCTTGGGATTTGTCTTGGAATGCAATTGACAGCGGTAGAATTTGCTCGTAATGTTCTTGGACTTGAA
GGAGCTCATTCATTTGAATTGGACCCTGAAACAAAATATCCAGTCATTGACATCATGCGCGACCAAGTTGATGTTGAAGA
CATGGGTGGAACATTACGTCTTGGACTTTACCCAGCAAAATTGAAAAATGGTTCACGCGCTAAAGCAGCCTACAATGATG
CTGAAGTGGTTCAACGTCGTCACCGTCACCGTTATGAATTTAATAACAAATATCGTGAAGACTTTGAAAAAGCTGGTTTC
GTATTCTCAGGAGTTTCGCCAGATAACCGTTTGGTTGAAATCGTTGAACTTTCAGGCAAAAAATTCTTCGTTGCTTGTCA
ATATCACCCAGAGTTACAATCACGTCCAAACCGTCCAGAAGAACTCTACACAGAATTTATTCGTGTAGCTGTTGAAAATA
GTAAATAA

Upstream 100 bases:

>100_bases
TTTTATTATAAAAAATCAGTAACGGTAGGCTCCCCTCTGGGGAGCTGTTTTTGTTTTTCCCAGTTATTTCTGTTTTGTAA
AAAGATAAGAGGAGATTTAG

Downstream 100 bases:

>100_bases
GCTAAAACTTATAAAACTCTCCTTAACTCAGGAGAGTTTTTTATTTTGTTTAAATAATCAGAATATTACAAATAAATCGT
TGTCTTATATTTTTCTTTGT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALR
QMKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMAEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYA
SDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGQRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLE
GAHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKYREDFEKAGF
VFSGVSPDNRLVEIVELSGKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK

Sequences:

>Translated_535_residues
MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALR
QMKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMAEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYA
SDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGQRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLE
GAHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKYREDFEKAGF
VFSGVSPDNRLVEIVELSGKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
>Mature_534_residues
STKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVTNMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQ
MKAEVGADNVMYIHTVPILHLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQSL
DVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMAEWSAMVDHVMNLKKKVKIALVGKYVELPDAYISVTEALKHAGYAS
DAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGQRGTEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEG
AHSFELDPETKYPVIDIMRDQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKYREDFEKAGFV
FSGVSPDNRLVEIVELSGKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=44.464609800363, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=42.3636363636364, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=42.3636363636364, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=42.3636363636364, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=545, Percent_Identity=48.0733944954128, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI25148299, Length=589, Percent_Identity=37.6910016977929, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319432, Length=556, Percent_Identity=44.2446043165468, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322563, Length=553, Percent_Identity=44.8462929475588, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24664469, Length=549, Percent_Identity=42.2586520947177, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI21357815, Length=494, Percent_Identity=39.8785425101215, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59456; Mature: 59325

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVT
EEECCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQMKAEVGADNVMYIHTVPIL
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECEE
HLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
EEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHH
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMAEWSAMVDHVMNLKKKVKIALVGKY
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECH
VELPDAYISVTEALKHAGYASDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGQRG
HHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCC
TEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEGAHSFELDPETKYPVIDIMR
CCCCEEEEEEECCCCCCEEEHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKYREDFEKAGF
CCCCHHHCCCEEEEEEEHHHCCCCCCCHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCE
VFSGVSPDNRLVEIVELSGKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
EEECCCCCCCEEEEEEECCCEEEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STKYIFVTGGGTSSMGKGIVAASLGRLLKNRGLKVTVQKFDPYLNIDPGTMSPYQHGEV
CCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDINLNKYSNVTSGKVYSEILRKERKGEYLGATVQMVPHVT
EEECCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NMLKEKIKRAATTTDADIIITEVGGTVGDMESLPFIEALRQMKAEVGADNVMYIHTVPIL
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECEE
HLRAAGELKTKIAQNATKTLREYGIQANMLVLRSEVPITTEMRDKIAMFCDVAPEAVIQS
EEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHH
LDVEHLYQIPLNLQAQNMDQIVCDHLKLDAPKADMAEWSAMVDHVMNLKKKVKIALVGKY
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECH
VELPDAYISVTEALKHAGYASDAEVDINWVNANDVTDENVAELVGDAAGIIVPGGFGQRG
HHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCC
TEGKIAAIKYARENDVPMLGICLGMQLTAVEFARNVLGLEGAHSFELDPETKYPVIDIMR
CCCCEEEEEEECCCCCCEEEHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DQVDVEDMGGTLRLGLYPAKLKNGSRAKAAYNDAEVVQRRHRHRYEFNNKYREDFEKAGF
CCCCHHHCCCEEEEEEEHHHCCCCCCCHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCE
VFSGVSPDNRLVEIVELSGKKFFVACQYHPELQSRPNRPEELYTEFIRVAVENSK
EEECCCCCCCEEEEEEECCCEEEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]