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The map label for this gene is treR [H]

Identifier: 125623319

GI number: 125623319

Start: 446110

End: 446826

Strand: Reverse

Name: treR [H]

Synonym: llmg_0452

Alternate gene names: 125623319

Gene position: 446826-446110 (Counterclockwise)

Preceding gene: 125623324

Following gene: 125623298

Centisome position: 17.66

GC content: 35.98

Gene sequence:

>717_bases
ATGAAGAAATATGAAGTGATTTTGCAAGATTTAGAAAAAAAGATTTTTAATGATATCTATAAAACGAACGATATTCTTCC
AAGCGAGAATGAACTTTCTATTAGTTATGAAAGTAGCCGTTCAACCGTCAGACAAGCTTTAAAAATTTTAGAAGAAAAAG
GGCTCATCCAAAGAAGACATGGCTATGGCAGCATTGTCCTCGCTCACGATCGGCTCCTTTTCCCTATTTCCGGCTTAACT
TCATATAAAGAATTGCAAACTTCAATGGGTTTTCACAGTGAAACTGAAGTAATAAAATTTGAAAGTATAAAAATTACCCC
AGCTCTTTCAGAAACTACTGGATTCGCCATCGGCGACCAAGCCCTTAGTATTCTTAGAAGAAGAAAAGTAGATGGTAAAT
TTTCCATTTTGGATTGGGATTTATTTTTAGAAAAATACGCTGATGGTTTGACCCCCGCACATGCCCAAAATTCTACTTAC
GATTATTTAGAAGGGGCTTTGGGACTTGATATTGCCTATGCCCAAAAAGAAGTTACCATTGATTTTGCTTGTGAAGATGA
TTTTACATATCTTGATTTAAATCCGAAGGACCATCATGTTGTTTCCGTGAAATCTCATGTCTATCTTGCCGATAATACAC
TTTTCCAGTATACTGAATCACGACATCAGGTTGACCGTTTTCGTTTTACAGAGTTTGCTAGACGCCAAAAAAGATAA

Upstream 100 bases:

>100_bases
TATCTTTTACAGTTGTACGTACAAGTTAACAAAATCATTGTATCACATAAAAACGTTTTCAGCAAGCGTTAACAATTATT
TTTATGATAAAATATAAAGT

Downstream 100 bases:

>100_bases
AAAAACTCTACCACAGTAGGTAGAGTTTTAGGATATGAAAAAAGACAAGAAGAATATTCTCCTTGTCTTTTCTTTATTTC
ACACCAATTTCCTCTTCAAC

Product: trehalose operon transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKKYEVILQDLEKKIFNDIYKTNDILPSENELSISYESSRSTVRQALKILEEKGLIQRRHGYGSIVLAHDRLLFPISGLT
SYKELQTSMGFHSETEVIKFESIKITPALSETTGFAIGDQALSILRRRKVDGKFSILDWDLFLEKYADGLTPAHAQNSTY
DYLEGALGLDIAYAQKEVTIDFACEDDFTYLDLNPKDHHVVSVKSHVYLADNTLFQYTESRHQVDRFRFTEFARRQKR

Sequences:

>Translated_238_residues
MKKYEVILQDLEKKIFNDIYKTNDILPSENELSISYESSRSTVRQALKILEEKGLIQRRHGYGSIVLAHDRLLFPISGLT
SYKELQTSMGFHSETEVIKFESIKITPALSETTGFAIGDQALSILRRRKVDGKFSILDWDLFLEKYADGLTPAHAQNSTY
DYLEGALGLDIAYAQKEVTIDFACEDDFTYLDLNPKDHHVVSVKSHVYLADNTLFQYTESRHQVDRFRFTEFARRQKR
>Mature_238_residues
MKKYEVILQDLEKKIFNDIYKTNDILPSENELSISYESSRSTVRQALKILEEKGLIQRRHGYGSIVLAHDRLLFPISGLT
SYKELQTSMGFHSETEVIKFESIKITPALSETTGFAIGDQALSILRRRKVDGKFSILDWDLFLEKYADGLTPAHAQNSTY
DYLEGALGLDIAYAQKEVTIDFACEDDFTYLDLNPKDHHVVSVKSHVYLADNTLFQYTESRHQVDRFRFTEFARRQKR

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790118, Length=169, Percent_Identity=28.4023668639053, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786950, Length=235, Percent_Identity=26.8085106382979, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790540, Length=241, Percent_Identity=23.6514522821577, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27501; Mature: 27501

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYEVILQDLEKKIFNDIYKTNDILPSENELSISYESSRSTVRQALKILEEKGLIQRRH
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCHHEECC
GYGSIVLAHDRLLFPISGLTSYKELQTSMGFHSETEVIKFESIKITPALSETTGFAIGDQ
CCCEEEEECCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCEECHH
ALSILRRRKVDGKFSILDWDLFLEKYADGLTPAHAQNSTYDYLEGALGLDIAYAQKEVTI
HHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCEEEEECEEEEE
DFACEDDFTYLDLNPKDHHVVSVKSHVYLADNTLFQYTESRHQVDRFRFTEFARRQKR
EEEECCCCEEEECCCCCCEEEEEECEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKYEVILQDLEKKIFNDIYKTNDILPSENELSISYESSRSTVRQALKILEEKGLIQRRH
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCHHEECC
GYGSIVLAHDRLLFPISGLTSYKELQTSMGFHSETEVIKFESIKITPALSETTGFAIGDQ
CCCEEEEECCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCEECHH
ALSILRRRKVDGKFSILDWDLFLEKYADGLTPAHAQNSTYDYLEGALGLDIAYAQKEVTI
HHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCEEEEECEEEEE
DFACEDDFTYLDLNPKDHHVVSVKSHVYLADNTLFQYTESRHQVDRFRFTEFARRQKR
EEEECCCCEEEECCCCCCEEEEEECEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]