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The map label for this gene is mvaD

Identifier: 125623293

GI number: 125623293

Start: 416868

End: 417824

Strand: Direct

Name: mvaD

Synonym: llmg_0426

Alternate gene names: NA

Gene position: 416868-417824 (Clockwise)

Preceding gene: 125623291

Following gene: 125623294

Centisome position: 16.48

GC content: 38.56

Gene sequence:

>957_bases
ATGAAAAATATTGTTACTGCACGGGCGCATACGAATATCGCCTTGATTAAATATTGGGGAAAAACGGATATTGCTCTAAA
TATCCCGACGACATCTTCTTTGTCAATGACCTTGGAGCCATTTTATACAACAACCTCGGTTGAATTTACTGACAATGAGT
CTGACTCATTAATCTTAAATTCAGCGATGGAAGATAGCAGTCGTGTCAGCAAATTTTTGGAAATGATGCGTGGACAATAT
GGAAATTTCCCTAAAGTAATGATTCAATCAGAAAATCATGTTCCAACAGCGGCTGGATTAGCGTCAAGTGCTTCAAGTTT
TGCTGCACTTACAGCTGCTATGTTTGGACTTTTAGACTTAGAAAAAGATGATTCCGAAATGTCACGGATTGCCAGACGGG
GTTCGGGTTCCGCTTCTCGTTCAATTTTTGGAAATTTTGCTGTTTGGAATAAAGGGGAGAATCATCAGTCTTCCTTTGCC
GAATCTTTTTACAATAAAGACATTGGGCTTTCAATGATTGTTGCCGAAATTTCTTCCGAAAAGAAAAAAATGTCATCAAC
AAAAGGAATGCAATTGGCTCAAACAGCGCCAACTTATGGAGCTTGGGTCGAAAAATCAGCAATTCAACTTGCAGAAATGA
AACAAGCAATCCTCCAAGCTGATATTGAAAAAGTGGGTCTAATTGCTCAAGATAATGCTCTTGGCATGCATGAACAAAAT
CGTCTATGTCTTGAACCATTTGACTATTTTACCTCTGAAACGCAACGTGTTGTAGACTTTACAAAAGAATGTTATAAAGC
GGGCTTACTCGCCTTTGTGACCATTGATGCTGGACCAAATGTAAAAATTATTACTGACCATGCGACAGAAAAAATCTTGT
TAACCAAGTTAAAAGCAGAGTTTCCAGAATTAACTTTTGATATTGCACGTGCTGGAGGCGCTTATGAGTATCTCTGA

Upstream 100 bases:

>100_bases
AATTATGATTTATGATAAAAATAAGTATTTTTTAGACAGAAAATTATCTTTGAGAATGATAAGAGATAAGAAAGAATTGT
TTTTTTGATATAATAGTTTC

Downstream 100 bases:

>100_bases
GAAGAAAATTAAGACAAAGATACCGGGGAAACTTTTTTTTGCAGGTGAATATGCGGTCACAAAAGAAGGAAATCTTGCCC
TCATTACGACAATTGAAACA

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKNIVTARAHTNIALIKYWGKTDIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILNSAMEDSSRVSKFLEMMRGQY
GNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDLEKDDSEMSRIARRGSGSASRSIFGNFAVWNKGENHQSSFA
ESFYNKDIGLSMIVAEISSEKKKMSSTKGMQLAQTAPTYGAWVEKSAIQLAEMKQAILQADIEKVGLIAQDNALGMHEQN
RLCLEPFDYFTSETQRVVDFTKECYKAGLLAFVTIDAGPNVKIITDHATEKILLTKLKAEFPELTFDIARAGGAYEYL

Sequences:

>Translated_318_residues
MKNIVTARAHTNIALIKYWGKTDIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILNSAMEDSSRVSKFLEMMRGQY
GNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDLEKDDSEMSRIARRGSGSASRSIFGNFAVWNKGENHQSSFA
ESFYNKDIGLSMIVAEISSEKKKMSSTKGMQLAQTAPTYGAWVEKSAIQLAEMKQAILQADIEKVGLIAQDNALGMHEQN
RLCLEPFDYFTSETQRVVDFTKECYKAGLLAFVTIDAGPNVKIITDHATEKILLTKLKAEFPELTFDIARAGGAYEYL
>Mature_318_residues
MKNIVTARAHTNIALIKYWGKTDIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILNSAMEDSSRVSKFLEMMRGQY
GNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDLEKDDSEMSRIARRGSGSASRSIFGNFAVWNKGENHQSSFA
ESFYNKDIGLSMIVAEISSEKKKMSSTKGMQLAQTAPTYGAWVEKSAIQLAEMKQAILQADIEKVGLIAQDNALGMHEQN
RLCLEPFDYFTSETQRVVDFTKECYKAGLLAFVTIDAGPNVKIITDHATEKILLTKLKAEFPELTFDIARAGGAYEYL

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=311, Percent_Identity=33.1189710610932, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537201, Length=313, Percent_Identity=28.7539936102236, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17537203, Length=176, Percent_Identity=27.8409090909091, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324371, Length=304, Percent_Identity=36.1842105263158, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28571205, Length=336, Percent_Identity=31.25, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 34991; Mature: 34991

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIVTARAHTNIALIKYWGKTDIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILN
CCCEEEECCCCCEEEEEEECCCEEEEECCCCCCCEEEEECEEEEEEEEECCCCCCCEEEE
SAMEDSSRVSKFLEMMRGQYGNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDL
HHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
EKDDSEMSRIARRGSGSASRSIFGNFAVWNKGENHQSSFAESFYNKDIGLSMIVAEISSE
CCCHHHHHHHHHCCCCCCCHHHHCCEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
KKKMSSTKGMQLAQTAPTYGAWVEKSAIQLAEMKQAILQADIEKVGLIAQDNALGMHEQN
HHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCC
RLCLEPFDYFTSETQRVVDFTKECYKAGLLAFVTIDAGPNVKIITDHATEKILLTKLKAE
CEEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
FPELTFDIARAGGAYEYL
CCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNIVTARAHTNIALIKYWGKTDIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILN
CCCEEEECCCCCEEEEEEECCCEEEEECCCCCCCEEEEECEEEEEEEEECCCCCCCEEEE
SAMEDSSRVSKFLEMMRGQYGNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDL
HHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
EKDDSEMSRIARRGSGSASRSIFGNFAVWNKGENHQSSFAESFYNKDIGLSMIVAEISSE
CCCHHHHHHHHHCCCCCCCHHHHCCEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
KKKMSSTKGMQLAQTAPTYGAWVEKSAIQLAEMKQAILQADIEKVGLIAQDNALGMHEQN
HHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCC
RLCLEPFDYFTSETQRVVDFTKECYKAGLLAFVTIDAGPNVKIITDHATEKILLTKLKAE
CEEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
FPELTFDIARAGGAYEYL
CCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA