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The map label for this gene is mvk [H]

Identifier: 125623292

GI number: 125623292

Start: 415627

End: 416559

Strand: Reverse

Name: mvk [H]

Synonym: llmg_0425

Alternate gene names: 125623292

Gene position: 416559-415627 (Counterclockwise)

Preceding gene: 125623298

Following gene: 125623290

Centisome position: 16.47

GC content: 37.94

Gene sequence:

>933_bases
ATGACTATCAATAAAATGGGGACGGGAATTGCCCATTCCAAACTAATCTTAATTGGAGAACATTCCGTTGTATATGGTCA
GCCAGCAATTGCCTTACCTGTAACAATTCTTAAAACTACAGTGACAATTACTTCATCAAAATATGGCCAATACATTGAAA
ATAATGAATTTCGTCGAAGACTTGATTTAATGGGAGATGAATTTGAAGGAATTCGTCAACTCATCATGCGTTTACTCGCT
AAATTTCATTCTTCAAAAATGCCTTTTTCTTTAGAAATTGATTCAAACATTCCTCAAGGACGTGGTTTAGGTGCCTCTGC
TTCTTTGGCAACAGCCATCATCAGAGCCTTTTATGATTTCTTTGATGCTGAACTTCCACAAAAAGACTTACTTTTTTATG
CCAATTTTTCTGAAAATATTACCCATGGTAAATCTTCTGGAATTGATGTCGCGACAGTTAATTCTGAGCACCCTTTGTGG
TTTATTAAAGACAGCACAATTGAACCCTTTGAACTAAATCTTCATGGTTTTATCGTCATTGGCGATACTGGTGTGCATGG
CTTTACTAGTCAAGCCATCAATATTGTTCGGGAAAAACTTGTTGAGGAAAATGAAAAAACTCAAAACTCAATTAATGACC
TCGGGCAATTAGCCACAGACTCAAAAGCCTTTTTAATGACCGATAAACTCAAAGAGTTTGGTCACGTCATGAATAAAGCT
CATGAAAGACTTTCAGAACTCGGTGTTTCTCACCCCCGGCTAGACAATTTAGTTGATACGGCTCGAAAAAATGGAGCACT
TGGCGCTAAATTGACTGGTTCTGGACTTGGTGGTGTCATGGTTGCTCTGGCTGAAAATGAAAAAGATGCGATTCGCATCA
GTCAACACCTCCTAAAAAATGGGGCTAAAAACACGTGGATTTACTCCTTTTAA

Upstream 100 bases:

>100_bases
GTATTTTTGCCTCAATCTGACTTAATTTAACCAAAAATATGCTAATTTTCAGTTTACATTTATCAAATGACAAACTAATC
TAGCAGGAGAATTGTTAAAA

Downstream 100 bases:

>100_bases
GATGGTTAATCGCCATCTTTTTTTATAAAGTGACACCTCCAATAATTAATCCTGTCACTTTTATAGTTGATTAATAAAAA
AATCGAGATCATATAATCTC

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTINKMGTGIAHSKLILIGEHSVVYGQPAIALPVTILKTTVTITSSKYGQYIENNEFRRRLDLMGDEFEGIRQLIMRLLA
KFHSSKMPFSLEIDSNIPQGRGLGASASLATAIIRAFYDFFDAELPQKDLLFYANFSENITHGKSSGIDVATVNSEHPLW
FIKDSTIEPFELNLHGFIVIGDTGVHGFTSQAINIVREKLVEENEKTQNSINDLGQLATDSKAFLMTDKLKEFGHVMNKA
HERLSELGVSHPRLDNLVDTARKNGALGAKLTGSGLGGVMVALAENEKDAIRISQHLLKNGAKNTWIYSF

Sequences:

>Translated_310_residues
MTINKMGTGIAHSKLILIGEHSVVYGQPAIALPVTILKTTVTITSSKYGQYIENNEFRRRLDLMGDEFEGIRQLIMRLLA
KFHSSKMPFSLEIDSNIPQGRGLGASASLATAIIRAFYDFFDAELPQKDLLFYANFSENITHGKSSGIDVATVNSEHPLW
FIKDSTIEPFELNLHGFIVIGDTGVHGFTSQAINIVREKLVEENEKTQNSINDLGQLATDSKAFLMTDKLKEFGHVMNKA
HERLSELGVSHPRLDNLVDTARKNGALGAKLTGSGLGGVMVALAENEKDAIRISQHLLKNGAKNTWIYSF
>Mature_309_residues
TINKMGTGIAHSKLILIGEHSVVYGQPAIALPVTILKTTVTITSSKYGQYIENNEFRRRLDLMGDEFEGIRQLIMRLLAK
FHSSKMPFSLEIDSNIPQGRGLGASASLATAIIRAFYDFFDAELPQKDLLFYANFSENITHGKSSGIDVATVNSEHPLWF
IKDSTIEPFELNLHGFIVIGDTGVHGFTSQAINIVREKLVEENEKTQNSINDLGQLATDSKAFLMTDKLKEFGHVMNKAH
ERLSELGVSHPRLDNLVDTARKNGALGAKLTGSGLGGVMVALAENEKDAIRISQHLLKNGAKNTWIYSF

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34219; Mature: 34087

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINKMGTGIAHSKLILIGEHSVVYGQPAIALPVTILKTTVTITSSKYGQYIENNEFRRR
CCCCCCCCCCCCCEEEEEECCEEEECCCCHHHHHEEHEEEEEEECCHHCCHHCCHHHHHH
LDLMGDEFEGIRQLIMRLLAKFHSSKMPFSLEIDSNIPQGRGLGASASLATAIIRAFYDF
HHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
FDAELPQKDLLFYANFSENITHGKSSGIDVATVNSEHPLWFIKDSTIEPFELNLHGFIVI
HHCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCEEECEEEEEEE
GDTGVHGFTSQAINIVREKLVEENEKTQNSINDLGQLATDSKAFLMTDKLKEFGHVMNKA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HERLSELGVSHPRLDNLVDTARKNGALGAKLTGSGLGGVMVALAENEKDAIRISQHLLKN
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHC
GAKNTWIYSF
CCCCCEEEEC
>Mature Secondary Structure 
TINKMGTGIAHSKLILIGEHSVVYGQPAIALPVTILKTTVTITSSKYGQYIENNEFRRR
CCCCCCCCCCCCEEEEEECCEEEECCCCHHHHHEEHEEEEEEECCHHCCHHCCHHHHHH
LDLMGDEFEGIRQLIMRLLAKFHSSKMPFSLEIDSNIPQGRGLGASASLATAIIRAFYDF
HHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
FDAELPQKDLLFYANFSENITHGKSSGIDVATVNSEHPLWFIKDSTIEPFELNLHGFIVI
HHCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCEEECEEEEEEE
GDTGVHGFTSQAINIVREKLVEENEKTQNSINDLGQLATDSKAFLMTDKLKEFGHVMNKA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HERLSELGVSHPRLDNLVDTARKNGALGAKLTGSGLGGVMVALAENEKDAIRISQHLLKN
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHC
GAKNTWIYSF
CCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]