BacMap

Definition	Lactococcus lactis subsp. cremoris MG1363, complete genome.
Accession	NC_009004
Length	2,529,478

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The map label for this gene is yvgN [H]

Identifier: 125623222

GI number: 125623222

Start: 339453

End: 340271

Strand: Reverse

Name: yvgN [H]

Synonym: llmg_0352

Alternate gene names: 125623222

Gene position: 340271-339453 (Counterclockwise)

Preceding gene: 125623239

Following gene: 125623221

Centisome position: 13.45

GC content: 33.7

Gene sequence:

>819_bases
ATGAAACTTAATAATCAAATTGAAATTCCAGAACTCGGTTTAGGAGTCTTTCAAATTCCGAATGAAGAAACTGCTGAAGT
GGTAAAGAACGGAATTATCAATGGATATCGTTTAATTGATACAGCTAAAATTTATGAAAATGAAGAAGGGACTGGTCAAG
GAATAAAAGAAGGTTTGGCCTCGACAGGGCTTACTCGTGAAGATCTCTTTGTCACATCAAAACTTTGGGGAGACAATCAT
TCTTATAAAGAAACAATTCAAAGCTTTGAAGAAAGTTTGAAAAAATTAGATTTGGATTATCTTGATTTATATCTTATCCA
TTGGCCTGGCACTAATTATGCTTACAAAGAAGCTTGGAAAGCAATGGAAGATTTATATAAAGCGGGAAAAGTTAAAGCGA
TTGGTGTCAGCAACTTTCAAAAACATCATTTAGAAGAACTTCTTAGCTATGCTGAAATAAAACCAGTATTAAATCAAATT
GAACTTCACCCTAAGCTTTCACAAAAAGAACTTCGTGAATTTTTGAAACTTCATGATATTAAGGTTCAAGCTTGGTCTCC
TTTGATGCAAGGTCAACTATTAGACAATGAAATGCTCAAAAAAATTGCTGACAAACATGGAAAATCTGTTGCCCAAATTA
TTCTTCGTTGGGATATTCAACAAGAGATTTTAGTCAATGTCAAATCAATCAAGAGTGAGCGAATGATTGCTAATCGACAA
ATATTTGATTTTGCACTTGACCAAGAAGATATGGAGGCCCTAAACTCATTAAATGAAGCCCTTCGTGTTGGCCCTAACCC
AGATACTTTTAATTTTTAA

Upstream 100 bases:

>100_bases
CTTTTTAGTACGTATGACACAAAAAAGTAGGTACTGTTCAAGAGGTTTTATTTATTATATACTAATTTTCTGCCAAAACA
AAATAGATGAGGAGCAAAAA

Downstream 100 bases:

>100_bases
GAAAGAAATATAATGAAAAAAATCTCTCCTAGTCTTACACTTCTTGCTTTAGCGATTAATGCTTTTGCAATTGGTTCAAC
CGAATTTATCAGCGTTGGTT

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKLNNQIEIPELGLGVFQIPNEETAEVVKNGIINGYRLIDTAKIYENEEGTGQGIKEGLASTGLTREDLFVTSKLWGDNH
SYKETIQSFEESLKKLDLDYLDLYLIHWPGTNYAYKEAWKAMEDLYKAGKVKAIGVSNFQKHHLEELLSYAEIKPVLNQI
ELHPKLSQKELREFLKLHDIKVQAWSPLMQGQLLDNEMLKKIADKHGKSVAQIILRWDIQQEILVNVKSIKSERMIANRQ
IFDFALDQEDMEALNSLNEALRVGPNPDTFNF

Sequences:

>Translated_272_residues
MKLNNQIEIPELGLGVFQIPNEETAEVVKNGIINGYRLIDTAKIYENEEGTGQGIKEGLASTGLTREDLFVTSKLWGDNH
SYKETIQSFEESLKKLDLDYLDLYLIHWPGTNYAYKEAWKAMEDLYKAGKVKAIGVSNFQKHHLEELLSYAEIKPVLNQI
ELHPKLSQKELREFLKLHDIKVQAWSPLMQGQLLDNEMLKKIADKHGKSVAQIILRWDIQQEILVNVKSIKSERMIANRQ
IFDFALDQEDMEALNSLNEALRVGPNPDTFNF
>Mature_272_residues
MKLNNQIEIPELGLGVFQIPNEETAEVVKNGIINGYRLIDTAKIYENEEGTGQGIKEGLASTGLTREDLFVTSKLWGDNH
SYKETIQSFEESLKKLDLDYLDLYLIHWPGTNYAYKEAWKAMEDLYKAGKVKAIGVSNFQKHHLEELLSYAEIKPVLNQI
ELHPKLSQKELREFLKLHDIKVQAWSPLMQGQLLDNEMLKKIADKHGKSVAQIILRWDIQQEILVNVKSIKSERMIANRQ
IFDFALDQEDMEALNSLNEALRVGPNPDTFNF

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=37.4149659863946, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI93277124, Length=308, Percent_Identity=37.987012987013, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=36.2068965517241, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=36.2068965517241, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=38.4892086330935, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=36.241610738255, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI5453543, Length=297, Percent_Identity=36.026936026936, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=36.3636363636364, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=36.3636363636364, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=36.3636363636364, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI24497583, Length=305, Percent_Identity=36.3934426229508, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI291291012, Length=269, Percent_Identity=37.546468401487, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=36.7003367003367, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=38.6986301369863, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=35.3790613718412, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI300116271, Length=277, Percent_Identity=33.2129963898917, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=37.012987012987, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI310109926, Length=112, Percent_Identity=42.8571428571429, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI207028673, Length=112, Percent_Identity=42.8571428571429, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI87082198, Length=274, Percent_Identity=43.0656934306569, Blast_Score=238, Evalue=2e-64,
Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=35.2941176470588, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1788081, Length=253, Percent_Identity=32.0158102766798, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87081735, Length=219, Percent_Identity=25.1141552511416, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788070, Length=282, Percent_Identity=25.886524822695, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994888, Length=234, Percent_Identity=27.3504273504274, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537075, Length=299, Percent_Identity=37.4581939799331, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17561298, Length=272, Percent_Identity=35.2941176470588, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=36.734693877551, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=36.5771812080537, Blast_Score=183, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=38.5767790262172, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=34.2281879194631, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=36.3970588235294, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=36.1216730038023, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17550248, Length=283, Percent_Identity=35.6890459363958, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17566692, Length=284, Percent_Identity=33.8028169014084, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562292, Length=277, Percent_Identity=32.4909747292419, Blast_Score=147, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17561300, Length=271, Percent_Identity=31.3653136531365, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17550246, Length=75, Percent_Identity=45.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324694, Length=305, Percent_Identity=36.3934426229508, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320576, Length=290, Percent_Identity=36.551724137931, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321896, Length=310, Percent_Identity=33.5483870967742, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=36.5384615384615, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319625, Length=300, Percent_Identity=36.6666666666667, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320079, Length=291, Percent_Identity=34.3642611683849, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24662789, Length=288, Percent_Identity=37.1527777777778, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24663317, Length=293, Percent_Identity=36.1774744027304, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129731, Length=288, Percent_Identity=34.375, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24657054, Length=293, Percent_Identity=36.1774744027304, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21356425, Length=294, Percent_Identity=35.7142857142857, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=34.1059602649007, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=39.4557823129252, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24662785, Length=287, Percent_Identity=40.0696864111498, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45553081, Length=290, Percent_Identity=34.1379310344828, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221378297, Length=322, Percent_Identity=31.9875776397516, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=34.375, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31257; Mature: 31257

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNNQIEIPELGLGVFQIPNEETAEVVKNGIINGYRLIDTAKIYENEEGTGQGIKEGLA
CCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
STGLTREDLFVTSKLWGDNHSYKETIQSFEESLKKLDLDYLDLYLIHWPGTNYAYKEAWK
HCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
AMEDLYKAGKVKAIGVSNFQKHHLEELLSYAEIKPVLNQIELHPKLSQKELREFLKLHDI
HHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
KVQAWSPLMQGQLLDNEMLKKIADKHGKSVAQIILRWDIQQEILVNVKSIKSERMIANRQ
HHHHHCHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IFDFALDQEDMEALNSLNEALRVGPNPDTFNF
HHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKLNNQIEIPELGLGVFQIPNEETAEVVKNGIINGYRLIDTAKIYENEEGTGQGIKEGLA
CCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
STGLTREDLFVTSKLWGDNHSYKETIQSFEESLKKLDLDYLDLYLIHWPGTNYAYKEAWK
HCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHH
AMEDLYKAGKVKAIGVSNFQKHHLEELLSYAEIKPVLNQIELHPKLSQKELREFLKLHDI
HHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
KVQAWSPLMQGQLLDNEMLKKIADKHGKSVAQIILRWDIQQEILVNVKSIKSERMIANRQ
HHHHHCHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IFDFALDQEDMEALNSLNEALRVGPNPDTFNF
HHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]