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The map label for this gene is fhuB [H]

Identifier: 125623217

GI number: 125623217

Start: 334322

End: 335272

Strand: Direct

Name: fhuB [H]

Synonym: llmg_0347

Alternate gene names: 125623217

Gene position: 334322-335272 (Clockwise)

Preceding gene: 125623216

Following gene: 125623218

Centisome position: 13.22

GC content: 38.49

Gene sequence:

>951_bases
ATGCCTAAAAAACATTTTCTGACAATCTTTTTTGCCCTAGTTTTTTCTTTACTTTTTTTGTCAGTTCTTTATCTGATGTT
AGGAAACAAAAATGTTCCACTGACAGAGTTATCCACAAATAAAATGGTTTTACAATTACGCTTACCACGATTGATAAGTC
TTTTTCTAACTGGATTTCTCCTGTCGGTCAGTGGATTTCTAGTTCAAATTATGACCAGAAATCCAATTACTGAAATGTCT
ACTCTAGGAATTTCTGGCGGTTCAAGTCTGGCTTTATCTCTTTTGTTGACTTTGGGTTGGTCGACAAATGATGGAATTTC
AGTCATGGTTTCATCACTAGGAGCATTTATTGCTCTAGCCGTCGTCATGCTTTTGACTGCCAGGACACATTTTCAACCCT
TAAAAGTTGTTTTAGTTGGAACATCAGTCGGACTTTTTGCAACGAGTTTAGCGAGCTCAATGACTTTTGCTAGTCATGAT
AAGCAGGCTTATTTTCGCTGGATTGTCGGGTCTTTTTCTGGTATAACCAATACTAAAGTTCTTTTAATGGCAGTCGTGAG
TCTGATTTTTCTCCTACTCTTGCTCCTATTCTCTAAACAAATTTATTTATTAAACTTTGGAGACGAGCTGGCCCAATCTT
TCGGAGTTTCCGTAAATTTTGTCCGTCTACTCATTATGTTTTTAGTTGCTCTTGCTTCGGGTGTGACCGTTGCCTCAGTT
GGAGTGGTTAGCTTTGTTGGTCTGATAGCTCCACATATTGCCAAGAAAATTGTTAGAACGAATTTTTGGCAAAATGTGAT
TTTGTCCGTGCTGACAGGGATGCTTTTGCTTGTTTTGGCAGATTTGGCGGCTAGGAATTTATTTAAACCATACGAATTTC
CAGCAGGAAGTTTAACCATGCTTCTGGGGGCTCCTTTCTTTTTGTGGGTCATTACAAAGGAGGCGAAATAA

Upstream 100 bases:

>100_bases
GACTTATTTACTCAAAAAACCTTGAAAGAATGCTTTGGATTGGACGTTACTTTAGGATGTGATACCTTTACCAAAAAATT
AATGATTACTGGGGTGAAAG

Downstream 100 bases:

>100_bases
ATGAAAAGAAAATTCACTTTACTTTTTGTCCTTCTTTTGGTTTTGATTGTGGCTGATTTGACACAATTTTCGACTAATTC
TCAAATCCTATCTATTTTGA

Product: ferrichrome ABC transporter permease protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPKKHFLTIFFALVFSLLFLSVLYLMLGNKNVPLTELSTNKMVLQLRLPRLISLFLTGFLLSVSGFLVQIMTRNPITEMS
TLGISGGSSLALSLLLTLGWSTNDGISVMVSSLGAFIALAVVMLLTARTHFQPLKVVLVGTSVGLFATSLASSMTFASHD
KQAYFRWIVGSFSGITNTKVLLMAVVSLIFLLLLLLFSKQIYLLNFGDELAQSFGVSVNFVRLLIMFLVALASGVTVASV
GVVSFVGLIAPHIAKKIVRTNFWQNVILSVLTGMLLLVLADLAARNLFKPYEFPAGSLTMLLGAPFFLWVITKEAK

Sequences:

>Translated_316_residues
MPKKHFLTIFFALVFSLLFLSVLYLMLGNKNVPLTELSTNKMVLQLRLPRLISLFLTGFLLSVSGFLVQIMTRNPITEMS
TLGISGGSSLALSLLLTLGWSTNDGISVMVSSLGAFIALAVVMLLTARTHFQPLKVVLVGTSVGLFATSLASSMTFASHD
KQAYFRWIVGSFSGITNTKVLLMAVVSLIFLLLLLLFSKQIYLLNFGDELAQSFGVSVNFVRLLIMFLVALASGVTVASV
GVVSFVGLIAPHIAKKIVRTNFWQNVILSVLTGMLLLVLADLAARNLFKPYEFPAGSLTMLLGAPFFLWVITKEAK
>Mature_315_residues
PKKHFLTIFFALVFSLLFLSVLYLMLGNKNVPLTELSTNKMVLQLRLPRLISLFLTGFLLSVSGFLVQIMTRNPITEMST
LGISGGSSLALSLLLTLGWSTNDGISVMVSSLGAFIALAVVMLLTARTHFQPLKVVLVGTSVGLFATSLASSMTFASHDK
QAYFRWIVGSFSGITNTKVLLMAVVSLIFLLLLLLFSKQIYLLNFGDELAQSFGVSVNFVRLLIMFLVALASGVTVASVG
VVSFVGLIAPHIAKKIVRTNFWQNVILSVLTGMLLLVLADLAARNLFKPYEFPAGSLTMLLGAPFFLWVITKEAK

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=317, Percent_Identity=29.0220820189274, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790740, Length=321, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790741, Length=288, Percent_Identity=32.6388888888889, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788004, Length=297, Percent_Identity=29.96632996633, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786804, Length=283, Percent_Identity=30.0353356890459, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786805, Length=308, Percent_Identity=26.6233766233766, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34393; Mature: 34262

Theoretical pI: Translated: 10.91; Mature: 10.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKHFLTIFFALVFSLLFLSVLYLMLGNKNVPLTELSTNKMVLQLRLPRLISLFLTGFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEHHHHHHHHHHHHHHH
LSVSGFLVQIMTRNPITEMSTLGISGGSSLALSLLLTLGWSTNDGISVMVSSLGAFIALA
HHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VVMLLTARTHFQPLKVVLVGTSVGLFATSLASSMTFASHDKQAYFRWIVGSFSGITNTKV
HHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
LLMAVVSLIFLLLLLLFSKQIYLLNFGDELAQSFGVSVNFVRLLIMFLVALASGVTVASV
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHH
GVVSFVGLIAPHIAKKIVRTNFWQNVILSVLTGMLLLVLADLAARNLFKPYEFPAGSLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLGAPFFLWVITKEAK
HHCCHHHEEEEECCCC
>Mature Secondary Structure 
PKKHFLTIFFALVFSLLFLSVLYLMLGNKNVPLTELSTNKMVLQLRLPRLISLFLTGFL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEHHHHHHHHHHHHHHH
LSVSGFLVQIMTRNPITEMSTLGISGGSSLALSLLLTLGWSTNDGISVMVSSLGAFIALA
HHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
VVMLLTARTHFQPLKVVLVGTSVGLFATSLASSMTFASHDKQAYFRWIVGSFSGITNTKV
HHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
LLMAVVSLIFLLLLLLFSKQIYLLNFGDELAQSFGVSVNFVRLLIMFLVALASGVTVASV
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHH
GVVSFVGLIAPHIAKKIVRTNFWQNVILSVLTGMLLLVLADLAARNLFKPYEFPAGSLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLGAPFFLWVITKEAK
HHCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]