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The map label for this gene is cpdC [H]

Identifier: 125623187

GI number: 125623187

Start: 301611

End: 303173

Strand: Direct

Name: cpdC [H]

Synonym: llmg_0316

Alternate gene names: 125623187

Gene position: 301611-303173 (Clockwise)

Preceding gene: 125623186

Following gene: 125623188

Centisome position: 11.92

GC content: 36.53

Gene sequence:

>1563_bases
ATGATGAAGATAAGAATTCTTGAAACAAGTGACTTGCATGGCTTTGTTCTTCCCACAAATTTTACAGAAAAAGACATGGA
TTTACCTTTTTCGATTGCTAAAGCTCGAACTAAAATGGACGAACTGACAAGCTCCTCTGAACAAAAAGGAGAAATCGTCA
TAAAAATTGAAAATGGCGACATCTTGCAAGGGTCTGCTCTGGCTTACTATCTGGCAAAAAAAGCAAAGGAAGGCATCAAA
GATTTAGTCAATGTCACAAATTCTTTTGGATATGACGTTGGCTTACTAGGGAATCATGAGTTTAATTATGGACTGGAGTA
TTTAGAAACGTATGTCAAGCAAGTCAATTATCCTATTTTAGCAGCCAATGTTTTAGATAAAAAAGGACAACCAGTTTTTG
GACCAACTTATCAAATCATTGAAAAACATGGGCTGAAAATTGGAATTGTTGGTTTCTTGACTCAGTATATTCCTCATTGG
GAACAGCCAGCTACAATTAAGGATTTAACTTTTCAATCAATTGTTGAAGCTGCCAAAGAAATTTTACCCGACTTACGTCA
GCGCGTTGATGTGCTTCTTGTAGCTTATCATGGGGGATTTGAACGAGATTTACTGACAGGAATTCCTACGGAAAGCTTAA
CAGGAGAAAATGAAGCCTACCAATTATTATTGGAATATGGAGAATTGATTGACGCTCTAGTCACAGGACATCAGCATCGG
GAAATTGCTCAACATGTTTTAGGAGTTCCCGTGATTCAGCCCGGATTTCGAGGGGATTTTGTTGGGGAAATTGAGCTAGA
ATTAGATAAGCAAAAAAAAATTACCCATTCAAAAGCCAAAATTCATAGAACAGCCGAGTCAAAAGTTTCGACAGATGTGG
TTGAACTTATTTCTGATATCAGTAAGGAAACAGAAGAATGGTTAGACCAGCCAATGGGAAAAATATTGGGGAACATGAAA
ATTCTGGATCCAATGGCCGCGCGCATTAGTGAGCATCCTTATATTGAATTGATAAATAAAATACAAATGGAAGCAACAGC
TGCCAAAATTTCGGGGACAGCGCTTTTTAACAATGAAGCCAAAGGTTTTGATGAACAAATTACAATGCGCTCAATTTTGA
CAAATTATATTTATCCTAATACTTTAGCTGTTTTAAGAGTGACAGGGTCTGATTTAAAAGCTGCCTTAGAACGAACGGCT
GAACATCTTGAAATTAATGATGAGGGAGAAATTATTTTTAGTCCTCGCTTTGTTGAACCTAAACCTGAGTATTATAATTA
TGATATGTATGAAGGCATTGATTATACTATTGATTTGAAGAAAAAGATTGGTCAGCGAATTGTGAACTTAAGTTTTGAGG
GACGTCCAGTTGCCAGTGAGGAGTTTTTAGAAATTGTAGTCAATCAGTATCGAGCAGTCGGTGGTGGAAATTATCCAATG
TTTTCTGCTGACAAGATTGTCAGAGAAATAACAGTGGACATGACAGAATTGATTGCGGCTTATTTGAAAAATCATCCTGT
GATTCAAGCGACTGTCAATCATAATTTTATGATTTTAAAATAA

Upstream 100 bases:

>100_bases
GTCGTCTGTTGGAGCAATTTTACTCGGACTTTTAGTATTAATCATTTTTGTTGAACTCATTTCATCAAGAATTAGAAAAA
AATTAGCGAAAGGATAAAGG

Downstream 100 bases:

>100_bases
TAATTACTGACAGCTTTTTTAGCATTAATAAAGCGCTAAAAATTACTGTCAGTAATTTTTTTATTAAGTTTTGCTTTAGA
ATAAGCTAAGTTATTCTAAA

Product: 2',3'-cyclic-nucleotide 2'-phosphodiesterase

Products: NA

Alternate protein names: 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase; 5'-nucleotidase [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MMKIRILETSDLHGFVLPTNFTEKDMDLPFSIAKARTKMDELTSSSEQKGEIVIKIENGDILQGSALAYYLAKKAKEGIK
DLVNVTNSFGYDVGLLGNHEFNYGLEYLETYVKQVNYPILAANVLDKKGQPVFGPTYQIIEKHGLKIGIVGFLTQYIPHW
EQPATIKDLTFQSIVEAAKEILPDLRQRVDVLLVAYHGGFERDLLTGIPTESLTGENEAYQLLLEYGELIDALVTGHQHR
EIAQHVLGVPVIQPGFRGDFVGEIELELDKQKKITHSKAKIHRTAESKVSTDVVELISDISKETEEWLDQPMGKILGNMK
ILDPMAARISEHPYIELINKIQMEATAAKISGTALFNNEAKGFDEQITMRSILTNYIYPNTLAVLRVTGSDLKAALERTA
EHLEINDEGEIIFSPRFVEPKPEYYNYDMYEGIDYTIDLKKKIGQRIVNLSFEGRPVASEEFLEIVVNQYRAVGGGNYPM
FSADKIVREITVDMTELIAAYLKNHPVIQATVNHNFMILK

Sequences:

>Translated_520_residues
MMKIRILETSDLHGFVLPTNFTEKDMDLPFSIAKARTKMDELTSSSEQKGEIVIKIENGDILQGSALAYYLAKKAKEGIK
DLVNVTNSFGYDVGLLGNHEFNYGLEYLETYVKQVNYPILAANVLDKKGQPVFGPTYQIIEKHGLKIGIVGFLTQYIPHW
EQPATIKDLTFQSIVEAAKEILPDLRQRVDVLLVAYHGGFERDLLTGIPTESLTGENEAYQLLLEYGELIDALVTGHQHR
EIAQHVLGVPVIQPGFRGDFVGEIELELDKQKKITHSKAKIHRTAESKVSTDVVELISDISKETEEWLDQPMGKILGNMK
ILDPMAARISEHPYIELINKIQMEATAAKISGTALFNNEAKGFDEQITMRSILTNYIYPNTLAVLRVTGSDLKAALERTA
EHLEINDEGEIIFSPRFVEPKPEYYNYDMYEGIDYTIDLKKKIGQRIVNLSFEGRPVASEEFLEIVVNQYRAVGGGNYPM
FSADKIVREITVDMTELIAAYLKNHPVIQATVNHNFMILK
>Mature_520_residues
MMKIRILETSDLHGFVLPTNFTEKDMDLPFSIAKARTKMDELTSSSEQKGEIVIKIENGDILQGSALAYYLAKKAKEGIK
DLVNVTNSFGYDVGLLGNHEFNYGLEYLETYVKQVNYPILAANVLDKKGQPVFGPTYQIIEKHGLKIGIVGFLTQYIPHW
EQPATIKDLTFQSIVEAAKEILPDLRQRVDVLLVAYHGGFERDLLTGIPTESLTGENEAYQLLLEYGELIDALVTGHQHR
EIAQHVLGVPVIQPGFRGDFVGEIELELDKQKKITHSKAKIHRTAESKVSTDVVELISDISKETEEWLDQPMGKILGNMK
ILDPMAARISEHPYIELINKIQMEATAAKISGTALFNNEAKGFDEQITMRSILTNYIYPNTLAVLRVTGSDLKAALERTA
EHLEINDEGEIIFSPRFVEPKPEYYNYDMYEGIDYTIDLKKKIGQRIVNLSFEGRPVASEEFLEIVVNQYRAVGGGNYPM
FSADKIVREITVDMTELIAAYLKNHPVIQATVNHNFMILK

Specific function: Catalyzes the release of inorganic phosphate from 2',3'- cyclic nucleotides through consecutive 2',3'-phosphodiesterase and 3'- (or 2') nucleotidase activities. Also possesses a 5'- nucleotidase activity. Does not catalyze the release of inorganic phospha

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=550, Percent_Identity=28, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786687, Length=556, Percent_Identity=20.6834532374101, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR019931
- InterPro:   IPR004843
- InterPro:   IPR001899 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16; =3.1.3.5 [H]

Molecular weight: Translated: 58601; Mature: 58601

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00785 5_NUCLEOTIDASE_1 ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKIRILETSDLHGFVLPTNFTEKDMDLPFSIAKARTKMDELTSSSEQKGEIVIKIENGD
CEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
ILQGSALAYYLAKKAKEGIKDLVNVTNSFGYDVGLLGNHEFNYGLEYLETYVKQVNYPIL
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEE
AANVLDKKGQPVFGPTYQIIEKHGLKIGIVGFLTQYIPHWEQPATIKDLTFQSIVEAAKE
EEHHHCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ILPDLRQRVDVLLVAYHGGFERDLLTGIPTESLTGENEAYQLLLEYGELIDALVTGHQHR
HHHHHHHHHHEEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
EIAQHVLGVPVIQPGFRGDFVGEIELELDKQKKITHSKAKIHRTAESKVSTDVVELISDI
HHHHHHHCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKETEEWLDQPMGKILGNMKILDPMAARISEHPYIELINKIQMEATAAKISGTALFNNEA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCC
KGFDEQITMRSILTNYIYPNTLAVLRVTGSDLKAALERTAEHLEINDEGEIIFSPRFVEP
CCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCEECCCCCEEECCCCCCC
KPEYYNYDMYEGIDYTIDLKKKIGQRIVNLSFEGRPVASEEFLEIVVNQYRAVGGGNYPM
CCCCCCCHHHCCCCEEEEHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
FSADKIVREITVDMTELIAAYLKNHPVIQATVNHNFMILK
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
>Mature Secondary Structure
MMKIRILETSDLHGFVLPTNFTEKDMDLPFSIAKARTKMDELTSSSEQKGEIVIKIENGD
CEEEEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
ILQGSALAYYLAKKAKEGIKDLVNVTNSFGYDVGLLGNHEFNYGLEYLETYVKQVNYPIL
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEE
AANVLDKKGQPVFGPTYQIIEKHGLKIGIVGFLTQYIPHWEQPATIKDLTFQSIVEAAKE
EEHHHCCCCCCCCCCHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ILPDLRQRVDVLLVAYHGGFERDLLTGIPTESLTGENEAYQLLLEYGELIDALVTGHQHR
HHHHHHHHHHEEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
EIAQHVLGVPVIQPGFRGDFVGEIELELDKQKKITHSKAKIHRTAESKVSTDVVELISDI
HHHHHHHCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKETEEWLDQPMGKILGNMKILDPMAARISEHPYIELINKIQMEATAAKISGTALFNNEA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCC
KGFDEQITMRSILTNYIYPNTLAVLRVTGSDLKAALERTAEHLEINDEGEIIFSPRFVEP
CCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCEECCCCCEEECCCCCCC
KPEYYNYDMYEGIDYTIDLKKKIGQRIVNLSFEGRPVASEEFLEIVVNQYRAVGGGNYPM
CCCCCCCHHHCCCCEEEEHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
FSADKIVREITVDMTELIAAYLKNHPVIQATVNHNFMILK
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]