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The map label for this gene is rmlB [H]

Identifier: 125623086

GI number: 125623086

Start: 197217

End: 198269

Strand: Direct

Name: rmlB [H]

Synonym: llmg_0209

Alternate gene names: 125623086

Gene position: 197217-198269 (Clockwise)

Preceding gene: 125623085

Following gene: 125623087

Centisome position: 7.8

GC content: 38.75

Gene sequence:

>1053_bases
ATGACTGAATTTAAAAATATCGTTGTGACAGGTGGAGCGGGATTTATTGGCTCAAACTTTGTACACTATGTTTATAACAA
TCATCCAGATGTGCATATCACAGTGTTGGATAAATTAACTTATGCAGGGAATGTCAACAACATTAATATGTTGTTTGACA
GCGGACGTGTCGAACTTGTGGTGGGTGACATTGCAGACCCTGAAATTGTTGATCAAGTGGCTTCTAAAGCGGATGCAATT
GTTCACTATGCGGCTGAATCTCATAATGATAATTCACTTAAGTCTCAAGATGAATTTATCCAAACTAACTTTATCGGAAC
TTATACTTTGATTCAAGCGGCTCGTAAATACGATTTACGTTTCCACCATGTTTCTACTGACGAAGTTTATGGTGATTTAC
CTTATCGTGAAGATTTGCCAGGTCATGGCGAAGGTGAAGGTGAAAAATTTACTGACAAAACACCTTACAATCCATCAAGC
CCTTACTCTTCAACTAAAGCGGCTTCTGATTTGATTGTTCGTGCTTGGGTACGTTCATTTGGGCTTAAAGCAACAATTTC
AAACTGCTCAAATAACTACGGGCCTTTCCAACACATCGAAAAATTTATTCCTCGTCAAATTACTAATATTCTTTCAGGAA
TCAAACCAAAACTTTACGGTGATGGTAAAAACGTTCGTGACTGGATTCATACAGAAGACCATTCATCAGGTGTTTGGACA
ATTTTGACTAAAGGTCAGATGGGTGAAACTTACCTCATCGGTGCTGATGGCGAAAAAAATAACAAAGAAGTGCTTGAAGA
TATCTTGACTCGTATGGGCAAAGATAAGGACGATTACGACCGCGTAACTGACCGTGCTGGTCATGACCTTCGTTATGCGA
TTGACAATAGCAAATTACGTACAGAACTTGGTTGGACTCCAAAACATACTGACTTTGAATCTGGTTTGCAAGCAACAATC
GACTGGTATCGTGAAAACGAAAACTGGTGGAAAGCCGAAAAAGATGCTGTTGAAGCAAAATATGCTGAAACACAAAAGGT
TTTGGATAAATAA

Upstream 100 bases:

>100_bases
TGGGAAGTATTTAAAGGCTGTGCCAAAGGCAAAATTTGTAAGAGAGTATCGAGTGGATTAATTGCAAAGCTTGCTTATAA
ATTATCAAAAAGGAAATAAC

Downstream 100 bases:

>100_bases
AAATTCATTCTAATTAGAGTGCCCAAAATTTGCTGATGAAATCCTAAGATGTCTGTAGACTACAAAATTAGTGAAGGTCA
TCTCATGAGGAAAAAGAGTC

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTEFKNIVVTGGAGFIGSNFVHYVYNNHPDVHITVLDKLTYAGNVNNINMLFDSGRVELVVGDIADPEIVDQVASKADAI
VHYAAESHNDNSLKSQDEFIQTNFIGTYTLIQAARKYDLRFHHVSTDEVYGDLPYREDLPGHGEGEGEKFTDKTPYNPSS
PYSSTKAASDLIVRAWVRSFGLKATISNCSNNYGPFQHIEKFIPRQITNILSGIKPKLYGDGKNVRDWIHTEDHSSGVWT
ILTKGQMGETYLIGADGEKNNKEVLEDILTRMGKDKDDYDRVTDRAGHDLRYAIDNSKLRTELGWTPKHTDFESGLQATI
DWYRENENWWKAEKDAVEAKYAETQKVLDK

Sequences:

>Translated_350_residues
MTEFKNIVVTGGAGFIGSNFVHYVYNNHPDVHITVLDKLTYAGNVNNINMLFDSGRVELVVGDIADPEIVDQVASKADAI
VHYAAESHNDNSLKSQDEFIQTNFIGTYTLIQAARKYDLRFHHVSTDEVYGDLPYREDLPGHGEGEGEKFTDKTPYNPSS
PYSSTKAASDLIVRAWVRSFGLKATISNCSNNYGPFQHIEKFIPRQITNILSGIKPKLYGDGKNVRDWIHTEDHSSGVWT
ILTKGQMGETYLIGADGEKNNKEVLEDILTRMGKDKDDYDRVTDRAGHDLRYAIDNSKLRTELGWTPKHTDFESGLQATI
DWYRENENWWKAEKDAVEAKYAETQKVLDK
>Mature_349_residues
TEFKNIVVTGGAGFIGSNFVHYVYNNHPDVHITVLDKLTYAGNVNNINMLFDSGRVELVVGDIADPEIVDQVASKADAIV
HYAAESHNDNSLKSQDEFIQTNFIGTYTLIQAARKYDLRFHHVSTDEVYGDLPYREDLPGHGEGEGEKFTDKTPYNPSSP
YSSTKAASDLIVRAWVRSFGLKATISNCSNNYGPFQHIEKFIPRQITNILSGIKPKLYGDGKNVRDWIHTEDHSSGVWTI
LTKGQMGETYLIGADGEKNNKEVLEDILTRMGKDKDDYDRVTDRAGHDLRYAIDNSKLRTELGWTPKHTDFESGLQATID
WYRENENWWKAEKDAVEAKYAETQKVLDK

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=343, Percent_Identity=32.6530612244898, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI42516563, Length=350, Percent_Identity=23.1428571428571, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI48994969, Length=355, Percent_Identity=45.3521126760563, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1788353, Length=342, Percent_Identity=45.0292397660819, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1788366, Length=285, Percent_Identity=24.2105263157895, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=337, Percent_Identity=32.0474777448071, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=33.0275229357798, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17539532, Length=340, Percent_Identity=22.9411764705882, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356223, Length=333, Percent_Identity=25.2252252252252, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24158427, Length=362, Percent_Identity=24.0331491712707, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 39577; Mature: 39446

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKNIVVTGGAGFIGSNFVHYVYNNHPDVHITVLDKLTYAGNVNNINMLFDSGRVELV
CCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCHHCCCCCCEEEEEECCCEEEE
VGDIADPEIVDQVASKADAIVHYAAESHNDNSLKSQDEFIQTNFIGTYTLIQAARKYDLR
ECCCCCHHHHHHHHHHHHHEEEEHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCEE
FHHVSTDEVYGDLPYREDLPGHGEGEGEKFTDKTPYNPSSPYSSTKAASDLIVRAWVRSF
EEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GLKATISNCSNNYGPFQHIEKFIPRQITNILSGIKPKLYGDGKNVRDWIHTEDHSSGVWT
CCEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCEEE
ILTKGQMGETYLIGADGEKNNKEVLEDILTRMGKDKDDYDRVTDRAGHDLRYAIDNSKLR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHH
TELGWTPKHTDFESGLQATIDWYRENENWWKAEKDAVEAKYAETQKVLDK
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEFKNIVVTGGAGFIGSNFVHYVYNNHPDVHITVLDKLTYAGNVNNINMLFDSGRVELV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCHHCCCCCCEEEEEECCCEEEE
VGDIADPEIVDQVASKADAIVHYAAESHNDNSLKSQDEFIQTNFIGTYTLIQAARKYDLR
ECCCCCHHHHHHHHHHHHHEEEEHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCEE
FHHVSTDEVYGDLPYREDLPGHGEGEGEKFTDKTPYNPSSPYSSTKAASDLIVRAWVRSF
EEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GLKATISNCSNNYGPFQHIEKFIPRQITNILSGIKPKLYGDGKNVRDWIHTEDHSSGVWT
CCEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCCCCCCCCEEE
ILTKGQMGETYLIGADGEKNNKEVLEDILTRMGKDKDDYDRVTDRAGHDLRYAIDNSKLR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHH
TELGWTPKHTDFESGLQATIDWYRENENWWKAEKDAVEAKYAETQKVLDK
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 11796113 [H]