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The map label for this gene is gluP [H]

Identifier: 125623059

GI number: 125623059

Start: 171795

End: 172487

Strand: Direct

Name: gluP [H]

Synonym: llmg_0182

Alternate gene names: 125623059

Gene position: 171795-172487 (Clockwise)

Preceding gene: 125623058

Following gene: 125623060

Centisome position: 6.79

GC content: 37.23

Gene sequence:

>693_bases
ATGAATTTTAATGAAATTAAACGAGATTTTACACGTTACAAAGCCACTTATGTTTTATCAATAATCACTCTTTTAGTATG
GTTATGGCAATTTTTCACTTATGGAACCTCGGCGACCTCAGCATTTAATCTTTTTAAAAGCGGAGCCATACTCGGTCAAG
TAATGGTCTTTGACCCAAGCCAAATGTGGCGTTTACTTACGGCGAACTTTATCCATATTGGTTGGGCGCATGTATTATTA
AATGTGGCAACGCTCTTTTTCATTGGCCGACAAATTGAAAATGTTTTTGGTTGGCTACGTTTTACGCTGATTTACCTTTT
GTCAGGTATTTTTGGAAATGCGATGGTCTTTCTATTGACGCCTCAAGTGGTTTCTGCAGGTGCTTCGACTTCTCTATTTG
GACTGTTCGCGGCAGTTGTTGGATTAGCCTATTTTACAAAACATCCATTTTTACAACAAATCGGTAGAATGTTTACAGTA
TTAATTGTTGCCAACTTAGTGATGAACCTCTTTTCTTTAGGAAATGTAAGTATTTGGGCGCATATCGGGGGAGCAATTGG
AGGACTTTTGTTGTCAGTTATTCTTCCTCCAAAGGCTTTTGTACCCTCCATTCCAAAACAATATCGAGTATTTGCAATTG
GCGCCTTTATCATTTTGTTCTTTCTTTTTATTGGCTTACCATTTATTAAATAG

Upstream 100 bases:

>100_bases
GGCATGACTGCTTCAGTTCTTTATGATTTTCAAAAAATGGATTTCGCTGCTGAAGCACATGATATTGCAGTAAAAAAACT
TTTTATAGGGAGAAAAAATA

Downstream 100 bases:

>100_bases
AAATTTGTTTTGCTATTGAAAACATGAAAGTGCTTGCAAAGAATCTTTAATCTTGCTAGAATAAACTTAGTTAAAAAAAC
TTGATAAGGGAGAAAAAGAT

Product: rhomboid-related protein 1

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNFNEIKRDFTRYKATYVLSIITLLVWLWQFFTYGTSATSAFNLFKSGAILGQVMVFDPSQMWRLLTANFIHIGWAHVLL
NVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLTPQVVSAGASTSLFGLFAAVVGLAYFTKHPFLQQIGRMFTV
LIVANLVMNLFSLGNVSIWAHIGGAIGGLLLSVILPPKAFVPSIPKQYRVFAIGAFIILFFLFIGLPFIK

Sequences:

>Translated_230_residues
MNFNEIKRDFTRYKATYVLSIITLLVWLWQFFTYGTSATSAFNLFKSGAILGQVMVFDPSQMWRLLTANFIHIGWAHVLL
NVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLTPQVVSAGASTSLFGLFAAVVGLAYFTKHPFLQQIGRMFTV
LIVANLVMNLFSLGNVSIWAHIGGAIGGLLLSVILPPKAFVPSIPKQYRVFAIGAFIILFFLFIGLPFIK
>Mature_230_residues
MNFNEIKRDFTRYKATYVLSIITLLVWLWQFFTYGTSATSAFNLFKSGAILGQVMVFDPSQMWRLLTANFIHIGWAHVLL
NVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLTPQVVSAGASTSLFGLFAAVVGLAYFTKHPFLQQIGRMFTV
LIVANLVMNLFSLGNVSIWAHIGGAIGGLLLSVILPPKAFVPSIPKQYRVFAIGAFIILFFLFIGLPFIK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI93352558, Length=176, Percent_Identity=32.9545454545455, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI301069362, Length=176, Percent_Identity=32.9545454545455, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI190341097, Length=149, Percent_Identity=33.5570469798658, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115534507, Length=159, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133901888, Length=161, Percent_Identity=29.8136645962733, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532986, Length=161, Percent_Identity=29.8136645962733, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 25721; Mature: 25721

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNEIKRDFTRYKATYVLSIITLLVWLWQFFTYGTSATSAFNLFKSGAILGQVMVFDPS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECHH
QMWRLLTANFIHIGWAHVLLNVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
PQVVSAGASTSLFGLFAAVVGLAYFTKHPFLQQIGRMFTVLIVANLVMNLFSLGNVSIWA
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
HIGGAIGGLLLSVILPPKAFVPSIPKQYRVFAIGAFIILFFLFIGLPFIK
HHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFNEIKRDFTRYKATYVLSIITLLVWLWQFFTYGTSATSAFNLFKSGAILGQVMVFDPS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECHH
QMWRLLTANFIHIGWAHVLLNVATLFFIGRQIENVFGWLRFTLIYLLSGIFGNAMVFLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
PQVVSAGASTSLFGLFAAVVGLAYFTKHPFLQQIGRMFTVLIVANLVMNLFSLGNVSIWA
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
HIGGAIGGLLLSVILPPKAFVPSIPKQYRVFAIGAFIILFFLFIGLPFIK
HHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]