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The map label for this gene is mtlD

Identifier: 125622906

GI number: 125622906

Start: 30938

End: 32104

Strand: Direct

Name: mtlD

Synonym: llmg_0025

Alternate gene names: 125622906

Gene position: 30938-32104 (Clockwise)

Preceding gene: 125622905

Following gene: 125622920

Centisome position: 1.22

GC content: 35.39

Gene sequence:

>1167_bases
ATGAAAAAAGCAGTACATTTTGGTGCAGGAAATATTGGTCGTGGTTTTATTGGGGAAATTCTAAGTAAAAATGGCTTTGA
GATTTACTTCGTTGACACGAATAAGGCGATAATTGATGAACTTAATACTCGTCATTCTTATGAAATTGGTATCGCAAGTA
GTAGTCCTGAAAAAATTTCTGTTTCAGGAGTATTTGGGATTAACAATGGTGAAAATCCTAAGGATGTAATTGAGGCAATT
GCTCAAGCTGATATAGTAACGACAGCAATTGGACCAAATATTTTGCCTTATATTGCTGAGCTTGTTGCCAAAGGCATTCA
AAAACGTAAAGAAGAGAATAAGCAAGTCCAAATAGATATTATTGCTTGTGAAAATATGATTGGGGGCTCAGAGTTTTTAG
AAAAGAAGGTGGCTGAATATTTATCAGACTCTGATAAAGTTTACCTTGCAAACTACATAGGGTTTCCCAATGCTGCTGTT
GACCGCATTGTACCTGGTCAAAAGCATGAAGATCTTCTTTATGTTGAAGTAGAGCCCTTTTGTGAGTGGGTGATTGACGA
GAGTCAGATAAAAAATAAAAGTTTTAAACTTGAAGGCGTTCATTATGCCAGTAATCTTGAACCTTTCATAGAGCGTAAAC
TTTTCTCTGTAAACTCAGGACACGCTACAGTCGCTTATTCTAGCGCATATAAAGGTTATAAAACAATTTTGGAAGGTTTA
CAGCACAAAGAGATTTTAAGTGCTTTAAAGGGTGTACAGAAAGAAACACGCGCTTTACTTTTAGCCAAATGGCCCCAATA
TTTTACGGAAGAAGATTTGATGAGCTATCATCAAATGATTATCTCTCGCTTTGCTAATCCAAAAATTATTGATGAGGTGA
CACGGGTTGCACGAACACCTATTCGAAAGTTAGGTTATGACGAACGCTTTATTCGACCTATTCGTGAATTAAATGAACGT
GGTCTCTCTTATCAAAATCATTTAGATATTGTTGGAAAAATTTTTGCTTACCAGGATGAAAATGATAGTCAGTCGGTTCA
ACTTCAAGAAAAGCTTAGCACAATGGATTTTCAAAGGCTTATTGAAGAAGTCACGGGTCTATCAAATAAAAAAATAATTT
TGGAAATCGAACTAGTGATTAAGAAATATAAAAATGACAGCAAGTAG

Upstream 100 bases:

>100_bases
TTACCACCACAATGTAAAAGCTTACAATTGCTTATGTAAAGGGATTTTAGAAGATTCTATTTGAACTTTTTACTTTCTAA
ATAAAGGAGCAGTAAGTAAG

Downstream 100 bases:

>100_bases
ACAGAGAATATTTTATCAATGGATTTTCTGACTTGAAATTTAACCGCTTTCTCTTGAAAAAAAAGATAAAAAGTGTTATT
ATAGAACCATAGAAAAAGCA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKKAVHFGAGNIGRGFIGEILSKNGFEIYFVDTNKAIIDELNTRHSYEIGIASSSPEKISVSGVFGINNGENPKDVIEAI
AQADIVTTAIGPNILPYIAELVAKGIQKRKEENKQVQIDIIACENMIGGSEFLEKKVAEYLSDSDKVYLANYIGFPNAAV
DRIVPGQKHEDLLYVEVEPFCEWVIDESQIKNKSFKLEGVHYASNLEPFIERKLFSVNSGHATVAYSSAYKGYKTILEGL
QHKEILSALKGVQKETRALLLAKWPQYFTEEDLMSYHQMIISRFANPKIIDEVTRVARTPIRKLGYDERFIRPIRELNER
GLSYQNHLDIVGKIFAYQDENDSQSVQLQEKLSTMDFQRLIEEVTGLSNKKIILEIELVIKKYKNDSK

Sequences:

>Translated_388_residues
MKKAVHFGAGNIGRGFIGEILSKNGFEIYFVDTNKAIIDELNTRHSYEIGIASSSPEKISVSGVFGINNGENPKDVIEAI
AQADIVTTAIGPNILPYIAELVAKGIQKRKEENKQVQIDIIACENMIGGSEFLEKKVAEYLSDSDKVYLANYIGFPNAAV
DRIVPGQKHEDLLYVEVEPFCEWVIDESQIKNKSFKLEGVHYASNLEPFIERKLFSVNSGHATVAYSSAYKGYKTILEGL
QHKEILSALKGVQKETRALLLAKWPQYFTEEDLMSYHQMIISRFANPKIIDEVTRVARTPIRKLGYDERFIRPIRELNER
GLSYQNHLDIVGKIFAYQDENDSQSVQLQEKLSTMDFQRLIEEVTGLSNKKIILEIELVIKKYKNDSK
>Mature_388_residues
MKKAVHFGAGNIGRGFIGEILSKNGFEIYFVDTNKAIIDELNTRHSYEIGIASSSPEKISVSGVFGINNGENPKDVIEAI
AQADIVTTAIGPNILPYIAELVAKGIQKRKEENKQVQIDIIACENMIGGSEFLEKKVAEYLSDSDKVYLANYIGFPNAAV
DRIVPGQKHEDLLYVEVEPFCEWVIDESQIKNKSFKLEGVHYASNLEPFIERKLFSVNSGHATVAYSSAYKGYKTILEGL
QHKEILSALKGVQKETRALLLAKWPQYFTEEDLMSYHQMIISRFANPKIIDEVTRVARTPIRKLGYDERFIRPIRELNER
GLSYQNHLDIVGKIFAYQDENDSQSVQLQEKLSTMDFQRLIEEVTGLSNKKIILEIELVIKKYKNDSK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=376, Percent_Identity=37.7659574468085, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788497, Length=224, Percent_Identity=24.5535714285714, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787823, Length=213, Percent_Identity=25.8215962441315, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790779, Length=292, Percent_Identity=22.9452054794521, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324401, Length=195, Percent_Identity=25.1282051282051, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320765, Length=195, Percent_Identity=25.1282051282051, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_LACLM (A2RH97)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001031389.1
- ProteinModelPortal:   A2RH97
- STRING:   A2RH97
- GeneID:   4797451
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_0025
- eggNOG:   COG0246
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 43947; Mature: 43947

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAVHFGAGNIGRGFIGEILSKNGFEIYFVDTNKAIIDELNTRHSYEIGIASSSPEKIS
CCCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCCEEEEEECCCCCEEE
VSGVFGINNGENPKDVIEAIAQADIVTTAIGPNILPYIAELVAKGIQKRKEENKQVQIDI
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
IACENMIGGSEFLEKKVAEYLSDSDKVYLANYIGFPNAAVDRIVPGQKHEDLLYVEVEPF
EEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCCCCCCCEEEEEECHH
CEWVIDESQIKNKSFKLEGVHYASNLEPFIERKLFSVNSGHATVAYSSAYKGYKTILEGL
HHHHHCHHHHCCCCEEEECEECCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
QHKEILSALKGVQKETRALLLAKWPQYFTEEDLMSYHQMIISRFANPKIIDEVTRVARTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRKLGYDERFIRPIRELNERGLSYQNHLDIVGKIFAYQDENDSQSVQLQEKLSTMDFQRL
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH
IEEVTGLSNKKIILEIELVIKKYKNDSK
HHHHHCCCCCEEEEEHHHHHHHHCCCCC
>Mature Secondary Structure
MKKAVHFGAGNIGRGFIGEILSKNGFEIYFVDTNKAIIDELNTRHSYEIGIASSSPEKIS
CCCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCCEEEEEECCCCCEEE
VSGVFGINNGENPKDVIEAIAQADIVTTAIGPNILPYIAELVAKGIQKRKEENKQVQIDI
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
IACENMIGGSEFLEKKVAEYLSDSDKVYLANYIGFPNAAVDRIVPGQKHEDLLYVEVEPF
EEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCCCCCCCEEEEEECHH
CEWVIDESQIKNKSFKLEGVHYASNLEPFIERKLFSVNSGHATVAYSSAYKGYKTILEGL
HHHHHCHHHHCCCCEEEECEECCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
QHKEILSALKGVQKETRALLLAKWPQYFTEEDLMSYHQMIISRFANPKIIDEVTRVARTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IRKLGYDERFIRPIRELNERGLSYQNHLDIVGKIFAYQDENDSQSVQLQEKLSTMDFQRL
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHH
IEEVTGLSNKKIILEIELVIKKYKNDSK
HHHHHCCCCCEEEEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA