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The map label for this gene is hmgA [H]

Identifier: 124486467

GI number: 124486467

Start: 1683629

End: 1684843

Strand: Reverse

Name: hmgA [H]

Synonym: Mlab_1655

Alternate gene names: 124486467

Gene position: 1684843-1683629 (Counterclockwise)

Preceding gene: 124486472

Following gene: 124486466

Centisome position: 93.35

GC content: 54.49

Gene sequence:

>1215_bases
ATGGATGAATATATCTCAAAGATCCGTTCCGGCGATCTGAAACTTTATGCCCTGGAAAAGAGTCTGCCGGCAGATGATGC
CGTCTCTCTTCGCCGAAAATATATCGAAGAGGAGACCGGCGCGGATCTTTCCGCTGTTGGAACCTATACGATACCCATCG
ACCGCGTAGTGACCAGAAATATCGAGAATATGATCGGCTGTGTTCAGATCCCGCTTGGGGTTGCGGGACCTCTGACGGTT
AAAGGTGAGTATGCGAACGGCAGCTTCTGGCTTCCGCTGGCAACGACCGAAGGTGCTTTGGTCGCTTCAATCAACAGGGG
GTGCAGTGCTATCACGAAAGCGGGCGGTACCGAGGTACGTATTCTCAGGGACGGAATGACCCGTGCTCCTATTTTTGCGG
CGAAAAGCGTGGCCCACGCAGCCGAGGTTGCCAGATGGGCCGAGGACAATCTCCTTCTTTTAAAAGTCGCCGCCGAGGAA
ACCACAAACCACGGCGAGCTGATTGGACTAACCACGTATACGGCAGGTACGAGCGTCTTTATCCGCTTTGAGTTCGACAC
GAAGGATGCGATGGGCATGAACATGGCGACCATCGCCTCTGAAGCCGCGGCTCATTTAATCGAAGAAGAAACGAAAGCAA
AACTTATCGCCGTTTCAGGAAACATGTGCTGCGACAAAAAACCCTCCGCGATCAACATTATCGAAGGCCGGGGGAAAACG
GTTTCAGCCGGTGTTTTTCTCTCTGATGAACTTGTATCCATGGTTTTTAAAACAAACTCGGCTACCCTTGCCGAGGTCAA
CACCCGGAAAAACCTGACAGGTTCTGCCCGGGCGGCCTCCTTTGGATTCAATGCCCAGGCAGCGAACGTGGTCGCCGCCA
TGTTCATCGCCTGCGGGCAGGATCCGGCACATGTGGTTGAGGGAAGCAATGCGATCACGACCGTGGATCTGGTCGAAGGG
GGAGTATATGTCTCGGTTACGCTTCCCTCGCTTCAGGTCGGAACGATCGGCGGAGGAACGAGTATTGCCACCCAGAATGC
ATGTCTCTCAACGCTGGGTGTGGCCGGCGGAGCGGAAAATCCGGGAGACAATGCAAAAGCATTTGCCGAGATCGTAGCTT
CCGGGGTTCTCGCCGGCGAATTGTCGCTTCTTGGAGCACTTGGGGCCCAGCATCTCGGCAAAGCTCACCGGGAACTTGGA
AGGGGCGAAAAGTAA

Upstream 100 bases:

>100_bases
GACAAGGTCCAGAATCTGAGCGTATTTCTGCATATGCCTGAATACTATTTGCCCGTTTGACAGAAAAATGTATTAGTCCC
CTCTGAACTATTCTATAATT

Downstream 100 bases:

>100_bases
TCTATCAAATCCTCCTTTCTCCATTTTTATTATAATGTTCTTTTTTCTGCGTTCTTCACTGGTTTTATGCGCGGAGATTC
TCTTACTCTCGCCTTGGAAG

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDEYISKIRSGDLKLYALEKSLPADDAVSLRRKYIEEETGADLSAVGTYTIPIDRVVTRNIENMIGCVQIPLGVAGPLTV
KGEYANGSFWLPLATTEGALVASINRGCSAITKAGGTEVRILRDGMTRAPIFAAKSVAHAAEVARWAEDNLLLLKVAAEE
TTNHGELIGLTTYTAGTSVFIRFEFDTKDAMGMNMATIASEAAAHLIEEETKAKLIAVSGNMCCDKKPSAINIIEGRGKT
VSAGVFLSDELVSMVFKTNSATLAEVNTRKNLTGSARAASFGFNAQAANVVAAMFIACGQDPAHVVEGSNAITTVDLVEG
GVYVSVTLPSLQVGTIGGGTSIATQNACLSTLGVAGGAENPGDNAKAFAEIVASGVLAGELSLLGALGAQHLGKAHRELG
RGEK

Sequences:

>Translated_404_residues
MDEYISKIRSGDLKLYALEKSLPADDAVSLRRKYIEEETGADLSAVGTYTIPIDRVVTRNIENMIGCVQIPLGVAGPLTV
KGEYANGSFWLPLATTEGALVASINRGCSAITKAGGTEVRILRDGMTRAPIFAAKSVAHAAEVARWAEDNLLLLKVAAEE
TTNHGELIGLTTYTAGTSVFIRFEFDTKDAMGMNMATIASEAAAHLIEEETKAKLIAVSGNMCCDKKPSAINIIEGRGKT
VSAGVFLSDELVSMVFKTNSATLAEVNTRKNLTGSARAASFGFNAQAANVVAAMFIACGQDPAHVVEGSNAITTVDLVEG
GVYVSVTLPSLQVGTIGGGTSIATQNACLSTLGVAGGAENPGDNAKAFAEIVASGVLAGELSLLGALGAQHLGKAHRELG
RGEK
>Mature_404_residues
MDEYISKIRSGDLKLYALEKSLPADDAVSLRRKYIEEETGADLSAVGTYTIPIDRVVTRNIENMIGCVQIPLGVAGPLTV
KGEYANGSFWLPLATTEGALVASINRGCSAITKAGGTEVRILRDGMTRAPIFAAKSVAHAAEVARWAEDNLLLLKVAAEE
TTNHGELIGLTTYTAGTSVFIRFEFDTKDAMGMNMATIASEAAAHLIEEETKAKLIAVSGNMCCDKKPSAINIIEGRGKT
VSAGVFLSDELVSMVFKTNSATLAEVNTRKNLTGSARAASFGFNAQAANVVAAMFIACGQDPAHVVEGSNAITTVDLVEG
GVYVSVTLPSLQVGTIGGGTSIATQNACLSTLGVAGGAENPGDNAKAFAEIVASGVLAGELSLLGALGAQHLGKAHRELG
RGEK

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=405, Percent_Identity=42.7160493827161, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI196049380, Length=290, Percent_Identity=45.8620689655172, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI25144592, Length=409, Percent_Identity=40.0977995110024, Blast_Score=273, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6323565, Length=404, Percent_Identity=44.0594059405941, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323483, Length=405, Percent_Identity=43.7037037037037, Blast_Score=283, Evalue=3e-77,
Organism=Drosophila melanogaster, GI281362379, Length=420, Percent_Identity=42.1428571428571, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45553469, Length=420, Percent_Identity=42.1428571428571, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24649399, Length=420, Percent_Identity=42.1428571428571, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 41965; Mature: 41965

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEYISKIRSGDLKLYALEKSLPADDAVSLRRKYIEEETGADLSAVGTYTIPIDRVVTRN
CCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHH
IENMIGCVQIPLGVAGPLTVKGEYANGSFWLPLATTEGALVASINRGCSAITKAGGTEVR
HHHHHEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCHHHHHHCCCCEEE
ILRDGMTRAPIFAAKSVAHAAEVARWAEDNLLLLKVAAEETTNHGELIGLTTYTAGTSVF
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEEECCCEEE
IRFEFDTKDAMGMNMATIASEAAAHLIEEETKAKLIAVSGNMCCDKKPSAINIIEGRGKT
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCE
VSAGVFLSDELVSMVFKTNSATLAEVNTRKNLTGSARAASFGFNAQAANVVAAMFIACGQ
EEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DPAHVVEGSNAITTVDLVEGGVYVSVTLPSLQVGTIGGGTSIATQNACLSTLGVAGGAEN
CHHHEECCCCCEEEEEEECCCEEEEEEECCEEEEECCCCCCEEEHHHHHHHHHCCCCCCC
PGDNAKAFAEIVASGVLAGELSLLGALGAQHLGKAHRELGRGEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDEYISKIRSGDLKLYALEKSLPADDAVSLRRKYIEEETGADLSAVGTYTIPIDRVVTRN
CCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHH
IENMIGCVQIPLGVAGPLTVKGEYANGSFWLPLATTEGALVASINRGCSAITKAGGTEVR
HHHHHEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCEEEEECCCCHHHHHHCCCCEEE
ILRDGMTRAPIFAAKSVAHAAEVARWAEDNLLLLKVAAEETTNHGELIGLTTYTAGTSVF
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEEECCCEEE
IRFEFDTKDAMGMNMATIASEAAAHLIEEETKAKLIAVSGNMCCDKKPSAINIIEGRGKT
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCE
VSAGVFLSDELVSMVFKTNSATLAEVNTRKNLTGSARAASFGFNAQAANVVAAMFIACGQ
EEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DPAHVVEGSNAITTVDLVEGGVYVSVTLPSLQVGTIGGGTSIATQNACLSTLGVAGGAEN
CHHHEECCCCCEEEEEEECCCEEEEEEECCEEEEECCCCCCEEEHHHHHHHHHCCCCCCC
PGDNAKAFAEIVASGVLAGELSLLGALGAQHLGKAHRELGRGEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1556098 [H]