Click here to switch to the map view.

The map label for this gene is mcrA [H]

Identifier: 124486376

GI number: 124486376

Start: 1593986

End: 1595692

Strand: Reverse

Name: mcrA [H]

Synonym: Mlab_1561

Alternate gene names: 124486376

Gene position: 1595692-1593986 (Counterclockwise)

Preceding gene: 124486377

Following gene: 124486375

Centisome position: 88.41

GC content: 55.54

Gene sequence:

>1707_bases
ATGGCAAAAGTAGAAAAGACCCAGAAACTTTTCCTTGATGCACTCAAGCAGAAGTTCCCAAAACAGGACGTTGCATCCAC
CACCGCCGAGTTCTATAAATTCAATGGTCTTGAGCAGTCTCCTCGTAAGAGAGAGTTCATGGCCGAGAACAAGAAGATCG
AAGCTGCACGCGGCATCTCCATGTACGACCCGAACCGCTGCCACCTTGGCGGTATCCCGATGGGTCAGCGCCAGCTGATG
ACCTACGAACTCTCCGGCACCGGAACCTTCGTTGAGGGTGATGACCTTCACTTCGTCAACAATGCTGCCATGCAGCAGAT
GTGGGATGATATCCGCAGAACCGTAATCGTGTCCATGGACATGGCCCACCAGACCCTGCAGAAGCGTCTCGGCAAGGAAG
TTACTCCTGAAACCATCAACGAGTATCTCCACGTCGTCAACCACGCAATGCCCGGAGGCGCCGTCGTTCAGGAACACATG
GTCGAGACCCACCCGGGACTTACCGACGACTGTTACGTCCGTGTGTTTACTGGTGACCAGGAACTCGCCGACAACCTTGA
ACCCCAGTTCGTCATCGACGTCGAGAAGCTCTTCCCGAAGAAGCAGGCAGAGGCCCTCCAGGCAGCAGTCGGTAAATCCC
TCTGGCAGTGCGTCCACATGCCGACCATCGTCGGCCGTACCTGCGATGGAGGAACTACCTCCCGCTGGTCCGCCATGCAG
ATCGGTATGTCCTTCATTGCCGCATACCGTATGTGCGCCGGTGAAGCAGCAGTCGCTGACCTGTCCTTTGCAGCAAAGCA
CGCTGGTGTCATCAACATGGCCCACCACCTGCCTGCACGCCGTGCACGCGGTCCGAACGAGCCCGGAGGAATGCTCTTTG
GTAACTTCTCCGATATGATCCAGGCAGACCGTGTCAACCCGAACGACCCGGCAAAAGCATCCCTGGAAAATGTCGCAGCA
GGAGCCATGCTCTTCGACCAGATCTGGCTCGGATCCTACATGTCCGGCGGTGTCGGTTTCACCCAGTACGCAACTGCAGC
ATACACGGATAACATCCTTGATGATTTCACCTACTACGGAATGGACTACATCCACGACAAGTACAAGGTTGACATCAAGA
ACCCGAACCCGAAAGACAAAGTTAAAGCAACTCAGGAAGTTGTCAACGACATCGCAACCGAAGTTAACCTTTACGGTATG
GAACAGTATGAACAGTTCCCGACCATGATGGAAGACCACTTCGGCGGTTCCCAGCGTGCAGCAGTTCTTGCAGCAGCATC
CGGTATCACCACCTCCATTGGAACCGGAAACTCCAACGCCGGTCTCAACGGCTGGTATCTGTCCATGCTTATGCACAAAG
ACGGATGGTCCAGACTTGGTTTCTTCGGCTACGACCTGCAGGACCAGTGCGGTTCCGCAAACTCACTCTCCATCAGACCC
GACGAGGGCTGTATCGGCGAGTTCCGTGGACCGAACTACCCGAACTATGCAATGAACGTCGGTCACCAGGGAGAATACGC
AGCAATTGCAGCCTCTGCCCACTTCGGCCGCGGCGACGCATGGACGCTCTCCCCGCTGATCAAGATCTGTTTCGCAGACC
CGGCCCTGAAGTTCGACTTCGCTCACCCGCGTGCAGAATTCGCCAAAGGAGCAATCCGCGAATTTATGCCTGCTGGTGAG
AGATCCCTCATCATCCCGGCACAGTAA

Upstream 100 bases:

>100_bases
GAACTGCATTCCGCTCCGACAGTGAATATGTTGCATACGTTCAGCGTATCCACGCCCTCCGTACCAAATACGGATTCATG
CCCAAGGAGGCCTGAGTAAT

Downstream 100 bases:

>100_bases
GTGGTTCATTAACCACTCACTTTTTTCTTTTTTTCTATGAAACGCGCAGACTAGTTCTTTATTTATATACTGCTCCAAAA
AATCACGACAACAAAGGTAT

Product: methyl-coenzyme M reductase, alpha subunit

Products: NA

Alternate protein names: Coenzyme-B sulfoethylthiotransferase alpha [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MAKVEKTQKLFLDALKQKFPKQDVASTTAEFYKFNGLEQSPRKREFMAENKKIEAARGISMYDPNRCHLGGIPMGQRQLM
TYELSGTGTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHM
VETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQ
IGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLPARRARGPNEPGGMLFGNFSDMIQADRVNPNDPAKASLENVAA
GAMLFDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYYGMDYIHDKYKVDIKNPNPKDKVKATQEVVNDIATEVNLYGM
EQYEQFPTMMEDHFGGSQRAAVLAAASGITTSIGTGNSNAGLNGWYLSMLMHKDGWSRLGFFGYDLQDQCGSANSLSIRP
DEGCIGEFRGPNYPNYAMNVGHQGEYAAIAASAHFGRGDAWTLSPLIKICFADPALKFDFAHPRAEFAKGAIREFMPAGE
RSLIIPAQ

Sequences:

>Translated_568_residues
MAKVEKTQKLFLDALKQKFPKQDVASTTAEFYKFNGLEQSPRKREFMAENKKIEAARGISMYDPNRCHLGGIPMGQRQLM
TYELSGTGTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHM
VETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQ
IGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLPARRARGPNEPGGMLFGNFSDMIQADRVNPNDPAKASLENVAA
GAMLFDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYYGMDYIHDKYKVDIKNPNPKDKVKATQEVVNDIATEVNLYGM
EQYEQFPTMMEDHFGGSQRAAVLAAASGITTSIGTGNSNAGLNGWYLSMLMHKDGWSRLGFFGYDLQDQCGSANSLSIRP
DEGCIGEFRGPNYPNYAMNVGHQGEYAAIAASAHFGRGDAWTLSPLIKICFADPALKFDFAHPRAEFAKGAIREFMPAGE
RSLIIPAQ
>Mature_567_residues
AKVEKTQKLFLDALKQKFPKQDVASTTAEFYKFNGLEQSPRKREFMAENKKIEAARGISMYDPNRCHLGGIPMGQRQLMT
YELSGTGTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMDMAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMV
ETHPGLTDDCYVRVFTGDQELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQI
GMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLPARRARGPNEPGGMLFGNFSDMIQADRVNPNDPAKASLENVAAG
AMLFDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYYGMDYIHDKYKVDIKNPNPKDKVKATQEVVNDIATEVNLYGME
QYEQFPTMMEDHFGGSQRAAVLAAASGITTSIGTGNSNAGLNGWYLSMLMHKDGWSRLGFFGYDLQDQCGSANSLSIRPD
EGCIGEFRGPNYPNYAMNVGHQGEYAAIAASAHFGRGDAWTLSPLIKICFADPALKFDFAHPRAEFAKGAIREFMPAGER
SLIIPAQ

Specific function: Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide [H]

COG id: COG4058

COG function: function code H; Methyl coenzyme M reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022681
- InterPro:   IPR016212
- InterPro:   IPR008924
- InterPro:   IPR009047
- InterPro:   IPR003183
- InterPro:   IPR015811
- InterPro:   IPR015823
- InterPro:   IPR009024 [H]

Pfam domain/function: PF02249 MCR_alpha; PF02745 MCR_alpha_N [H]

EC number: =2.8.4.1 [H]

Molecular weight: Translated: 62669; Mature: 62538

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVEKTQKLFLDALKQKFPKQDVASTTAEFYKFNGLEQSPRKREFMAENKKIEAARGIS
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHCCCC
MYDPNRCHLGGIPMGQRQLMTYELSGTGTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMD
CCCCCCCEECCCCCCCCEEEEEEECCCEEEECCCCEEEHHHHHHHHHHHHHHHHEEEHHH
MAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMVETHPGLTDDCYVRVFTGDQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCH
ELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQ
HHHHCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHH
IGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLPARRARGPNEPGGMLFGNFSDMI
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCCCCCEEECCHHHHH
QADRVNPNDPAKASLENVAAGAMLFDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYYG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
MDYIHDKYKVDIKNPNPKDKVKATQEVVNDIATEVNLYGMEQYEQFPTMMEDHFGGSQRA
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHH
AVLAAASGITTSIGTGNSNAGLNGWYLSMLMHKDGWSRLGFFGYDLQDQCGSANSLSIRP
EEEEECCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCHHHHCCCCCCEEECC
DEGCIGEFRGPNYPNYAMNVGHQGEYAAIAASAHFGRGDAWTLSPLIKICFADPALKFDF
CCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHCCCCCEEEC
AHPRAEFAKGAIREFMPAGERSLIIPAQ
CCCHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
AKVEKTQKLFLDALKQKFPKQDVASTTAEFYKFNGLEQSPRKREFMAENKKIEAARGIS
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHCCCC
MYDPNRCHLGGIPMGQRQLMTYELSGTGTFVEGDDLHFVNNAAMQQMWDDIRRTVIVSMD
CCCCCCCEECCCCCCCCEEEEEEECCCEEEECCCCEEEHHHHHHHHHHHHHHHHEEEHHH
MAHQTLQKRLGKEVTPETINEYLHVVNHAMPGGAVVQEHMVETHPGLTDDCYVRVFTGDQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCH
ELADNLEPQFVIDVEKLFPKKQAEALQAAVGKSLWQCVHMPTIVGRTCDGGTTSRWSAMQ
HHHHCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHH
IGMSFIAAYRMCAGEAAVADLSFAAKHAGVINMAHHLPARRARGPNEPGGMLFGNFSDMI
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCCCCCEEECCHHHHH
QADRVNPNDPAKASLENVAAGAMLFDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYYG
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
MDYIHDKYKVDIKNPNPKDKVKATQEVVNDIATEVNLYGMEQYEQFPTMMEDHFGGSQRA
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHH
AVLAAASGITTSIGTGNSNAGLNGWYLSMLMHKDGWSRLGFFGYDLQDQCGSANSLSIRP
EEEEECCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEECCCHHHHCCCCCCEEECC
DEGCIGEFRGPNYPNYAMNVGHQGEYAAIAASAHFGRGDAWTLSPLIKICFADPALKFDF
CCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHCCCCCEEEC
AHPRAEFAKGAIREFMPAGERSLIIPAQ
CCCHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3502709; 11023796 [H]