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The map label for this gene is serA [H]

Identifier: 124486358

GI number: 124486358

Start: 1576272

End: 1577855

Strand: Reverse

Name: serA [H]

Synonym: Mlab_1543

Alternate gene names: 124486358

Gene position: 1577855-1576272 (Counterclockwise)

Preceding gene: 124486361

Following gene: 124486349

Centisome position: 87.42

GC content: 54.29

Gene sequence:

>1584_bases
GTGAGCTTCAAAGTACTGGTATCTGATCCTCTTGCAGCAGAGGGTATTGCTATATTAAAGGATTTTTGCGAAGTCGATGA
GAAAGCTGATCTCTCTGAAGACGAACTCGTTAAAATCATCGGTGAATATGACGCGTTGATCGTTCGCTCGGGGACCCAGG
TTACTGCCAGGATCATCGAAGCGGCTGATAAAATGAAGTACATCGGCCGTGCCGGTGTTGGAGTCGACAATATCGACTGC
GAAGCAGCGACCAAAAAAGGCATCATTGTTTCCAATGCGCCGGAGGGAAACACTCTCGCAGCGACCGAACACACGATCGC
GATGATGATGGCAATGGCGAGAAATATCCCGCAGGCAAGCGCGTCCCTGAAAAAGGGCGAGTGGAAACGCTCCAAATTCA
TGGGCAACGAAATGAACGGCAAGGTCCTCGGCGTTGTCGGATTCGGACGTATCGGCCGTGAAGTTGCAAAGCGTGCCCAG
GCCCTTCAGATGACGGTCATCGCCTACGACCCGTTCATTCCGGCAGAAGTCGGAGCGGCAATGGGCGTCGAAATGATGAG
CGTTGCCGAGCTCTTCACGAAAGCGGATGTCATCACGGTCCACACCCCCCTTATTCCGTCAACGACCCATCTCGTGAACA
AGGAATCCATCGCGACGATGAAGACCGGCGTTCGGATGATCAACTGTGCCCGCGGCGGAATCATCGATGAGAAAGATCTC
TACGATGCGATCGTCTCCGGGAAAGTTGCCGGAGCCGCTCTTGATGTATTCGAGACCGAGCCGCCGACGGAGTCCCCTCT
TCTGAAACTTGACTCGGTGATCGTTACTCCGCACCTTGGAGCAAGCACGGTCGAAGCCCAGAAGAATGTGGCTATCTCCG
TTGCCCACCAGTGCATTGATGTTCTGAAAGGCGGCTCTGCGAAGAGTGCGGTGAATGCACCGTTAGTAACGCCGGAAGTC
AAGTCGAAGATCGATCCGTATGCGCTTCTCGCCGAGAAGATGGGAAGCCTTGCTGCCCAGATCGCCGACGGTGCGATCAC
GGAAGTGGAGTTTGCCTATCTCGGTGAGATCGCCGACCTTAAGCAGAATCTGAAGTATGTGACCCGGCTTGGAATCAAAG
GTATGCTTGAGCAGGTTCTTCATGAGCCGGCCAACATCGTCAATGCCGAGATCATCGCCCAGGGACGCGGTATTACGATC
TTCGAGAAGACCTCGAGCGAAGCAGGCGATTACAAGTCTCTGGTGACGCTCACGTTCAAGACGGAAAAGGGCAGCGAGTC
GATCTCCGGTATCGTAACCCGTGCAGGCCCCCGCATCCTTTCGATCGGCAAATACGCGACCGATCTTGTCCCAAGCGGAT
ACGTTATCCTTGCTGATCATGTGAACCGTCCGGGCGTTGTCGGTCCGGTCGGCATGATCCTCGGCAAGCATAATGTGAAT
ATTTCCAGCATGCAGGTCGGCGGCAGAAATGTCGGTTCCGAGTCTCTGATGATCCTCGCAGTTGACGATATCGTCTCGCC
CGAAGTTATGCAGGAAGTCGCGTCAAGTGACGGGATTACTGCAGCAAAGTTCGTACGGCTGTAA

Upstream 100 bases:

>100_bases
TTCAGCAAATCGGCGGTGTTTTTTTCGCATGCAGGAGGGGTTTTTGGTCAGCACAGAAACATACTAAACGGGTGAATACC
AAATAAGTACTCGATAATCC

Downstream 100 bases:

>100_bases
ATGCAGGGGATATCCCCTTCATTTTCCGGAACAAGTTAAAAAAATTTATATGTGTCCGGTGACAATCTAGTAAGGCACAC
AGGTGCTTAATCCTGGACTC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSFKVLVSDPLAAEGIAILKDFCEVDEKADLSEDELVKIIGEYDALIVRSGTQVTARIIEAADKMKYIGRAGVGVDNIDC
EAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQASASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQ
ALQMTVIAYDPFIPAEVGAAMGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDL
YDAIVSGKVAGAALDVFETEPPTESPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCIDVLKGGSAKSAVNAPLVTPEV
KSKIDPYALLAEKMGSLAAQIADGAITEVEFAYLGEIADLKQNLKYVTRLGIKGMLEQVLHEPANIVNAEIIAQGRGITI
FEKTSSEAGDYKSLVTLTFKTEKGSESISGIVTRAGPRILSIGKYATDLVPSGYVILADHVNRPGVVGPVGMILGKHNVN
ISSMQVGGRNVGSESLMILAVDDIVSPEVMQEVASSDGITAAKFVRL

Sequences:

>Translated_527_residues
MSFKVLVSDPLAAEGIAILKDFCEVDEKADLSEDELVKIIGEYDALIVRSGTQVTARIIEAADKMKYIGRAGVGVDNIDC
EAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQASASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQ
ALQMTVIAYDPFIPAEVGAAMGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDL
YDAIVSGKVAGAALDVFETEPPTESPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCIDVLKGGSAKSAVNAPLVTPEV
KSKIDPYALLAEKMGSLAAQIADGAITEVEFAYLGEIADLKQNLKYVTRLGIKGMLEQVLHEPANIVNAEIIAQGRGITI
FEKTSSEAGDYKSLVTLTFKTEKGSESISGIVTRAGPRILSIGKYATDLVPSGYVILADHVNRPGVVGPVGMILGKHNVN
ISSMQVGGRNVGSESLMILAVDDIVSPEVMQEVASSDGITAAKFVRL
>Mature_526_residues
SFKVLVSDPLAAEGIAILKDFCEVDEKADLSEDELVKIIGEYDALIVRSGTQVTARIIEAADKMKYIGRAGVGVDNIDCE
AATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQASASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQA
LQMTVIAYDPFIPAEVGAAMGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDLY
DAIVSGKVAGAALDVFETEPPTESPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCIDVLKGGSAKSAVNAPLVTPEVK
SKIDPYALLAEKMGSLAAQIADGAITEVEFAYLGEIADLKQNLKYVTRLGIKGMLEQVLHEPANIVNAEIIAQGRGITIF
EKTSSEAGDYKSLVTLTFKTEKGSESISGIVTRAGPRILSIGKYATDLVPSGYVILADHVNRPGVVGPVGMILGKHNVNI
SSMQVGGRNVGSESLMILAVDDIVSPEVMQEVASSDGITAAKFVRL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=407, Percent_Identity=45.945945945946, Blast_Score=348, Evalue=8e-96,
Organism=Homo sapiens, GI6912396, Length=313, Percent_Identity=30.9904153354633, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI145580578, Length=340, Percent_Identity=30.5882352941176, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4557499, Length=340, Percent_Identity=30.5882352941176, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4557497, Length=340, Percent_Identity=30, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI61743967, Length=340, Percent_Identity=30, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI145580575, Length=286, Percent_Identity=31.8181818181818, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI1789279, Length=296, Percent_Identity=37.8378378378378, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=29.6875, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=33.6734693877551, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788660, Length=252, Percent_Identity=30.1587301587302, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87081824, Length=234, Percent_Identity=25.2136752136752, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=47.1947194719472, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI25147481, Length=305, Percent_Identity=29.5081967213115, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=32.8267477203647, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320925, Length=302, Percent_Identity=33.4437086092715, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6324055, Length=267, Percent_Identity=32.2097378277154, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=288, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325144, Length=189, Percent_Identity=31.2169312169312, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=151, Percent_Identity=27.8145695364238, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=44.5482866043614, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=33.0128205128205, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24585516, Length=315, Percent_Identity=27.3015873015873, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=282, Percent_Identity=30.4964539007092, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646448, Length=282, Percent_Identity=30.4964539007092, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646452, Length=282, Percent_Identity=30.4964539007092, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646450, Length=282, Percent_Identity=30.4964539007092, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI62472511, Length=282, Percent_Identity=30.4964539007092, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI28574286, Length=328, Percent_Identity=28.6585365853659, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=25.5591054313099, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=25.5591054313099, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=25.5591054313099, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=25.5591054313099, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI45552429, Length=327, Percent_Identity=25.3822629969419, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55789; Mature: 55658

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKVLVSDPLAAEGIAILKDFCEVDEKADLSEDELVKIIGEYDALIVRSGTQVTARIIE
CCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHH
AADKMKYIGRAGVGVDNIDCEAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQAS
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCHHH
ASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAEVGAA
HHHHCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHH
MGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDL
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHHHHCCCEEECCCCCCCCHHHH
YDAIVSGKVAGAALDVFETEPPTESPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCID
HHHHHCCCCCCCEEEEECCCCCCCCCCEEECCEEECCCCCCCHHHHHHCHHHHHHHHHHH
VLKGGSAKSAVNAPLVTPEVKSKIDPYALLAEKMGSLAAQIADGAITEVEFAYLGEIADL
HHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHH
KQNLKYVTRLGIKGMLEQVLHEPANIVNAEIIAQGRGITIFEKTSSEAGDYKSLVTLTFK
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEEE
TEKGSESISGIVTRAGPRILSIGKYATDLVPSGYVILADHVNRPGVVGPVGMILGKHNVN
CCCCCCHHHHHHHCCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHEECCCCC
ISSMQVGGRNVGSESLMILAVDDIVSPEVMQEVASSDGITAAKFVRL
EEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHHEECC
>Mature Secondary Structure 
SFKVLVSDPLAAEGIAILKDFCEVDEKADLSEDELVKIIGEYDALIVRSGTQVTARIIE
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHH
AADKMKYIGRAGVGVDNIDCEAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQAS
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCHHH
ASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAEVGAA
HHHHCCCHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHH
MGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDL
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHHHHCCCEEECCCCCCCCHHHH
YDAIVSGKVAGAALDVFETEPPTESPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCID
HHHHHCCCCCCCEEEEECCCCCCCCCCEEECCEEECCCCCCCHHHHHHCHHHHHHHHHHH
VLKGGSAKSAVNAPLVTPEVKSKIDPYALLAEKMGSLAAQIADGAITEVEFAYLGEIADL
HHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHH
KQNLKYVTRLGIKGMLEQVLHEPANIVNAEIIAQGRGITIFEKTSSEAGDYKSLVTLTFK
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEECCCCEEEEECCCCCCCCCEEEEEEEEE
TEKGSESISGIVTRAGPRILSIGKYATDLVPSGYVILADHVNRPGVVGPVGMILGKHNVN
CCCCCCHHHHHHHCCCCCEEECCHHHHHCCCCCEEEEEECCCCCCCCCCHHHHEECCCCC
ISSMQVGGRNVGSESLMILAVDDIVSPEVMQEVASSDGITAAKFVRL
EEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]