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The map label for this gene is moaC

Identifier: 124486163

GI number: 124486163

Start: 1368518

End: 1368994

Strand: Reverse

Name: moaC

Synonym: Mlab_1345

Alternate gene names: 124486163

Gene position: 1368994-1368518 (Counterclockwise)

Preceding gene: 124486164

Following gene: 124486162

Centisome position: 75.85

GC content: 57.65

Gene sequence:

>477_bases
ATGCCGGTTTTTACTCATCTGAATGAAAATAACGAAGTCCACATGGTGGATGTGACGCCAAAACCCGACGTATCTCGTGA
AGCGACCGCCAAAGGGCGGATCTATCTGCGGCCGGAGACGCTTGCGGCCATCGCCGAAGGCCGGGTCCTGAAAGGAAATG
TGCTTGCGACCGCTCAGGTTGCCGGGACGCTTGCGGTAAAACAGACCTGGGCTTTGATCCCGATGTGCCACCCACTCCCG
GTCGGCGGGGTAACGATCTGGTTTGAACAGACGGACGAGTACATCGAAGCGTTCTGCCGGGTGAAGACCTACGGGAAGAC
CGGCATCGAGATGGAGGCCCTGACCGGCGTGTCGCTTTCCCTTCTGACGATCTGGGACATGGTCAAGTCCGCGGAAAAGG
ATGAGGCAGGCCAGTATCCGGTGACCCGTATCGACGGGATCTCCGTTATAGAGAAGATCAAGGGCACTCCTGAGTGA

Upstream 100 bases:

>100_bases
GGACTTGCCGGGGAGCTGGCCGATGAAGACACCGGGGACGGTCTAATCGCAACCGATTTACTGAGGCACCTTGCATACAT
AGTGTATAAGGAGAAATAAG

Downstream 100 bases:

>100_bases
AGACCTCTTCGGTCATCACGGAGTATTTATACAACATAGCTCCAATAATATACAGTTTACAGCTAGCCGCATCAAGGTGC
GGTCTGTATATCACAGGAAT

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MPVFTHLNENNEVHMVDVTPKPDVSREATAKGRIYLRPETLAAIAEGRVLKGNVLATAQVAGTLAVKQTWALIPMCHPLP
VGGVTIWFEQTDEYIEAFCRVKTYGKTGIEMEALTGVSLSLLTIWDMVKSAEKDEAGQYPVTRIDGISVIEKIKGTPE

Sequences:

>Translated_158_residues
MPVFTHLNENNEVHMVDVTPKPDVSREATAKGRIYLRPETLAAIAEGRVLKGNVLATAQVAGTLAVKQTWALIPMCHPLP
VGGVTIWFEQTDEYIEAFCRVKTYGKTGIEMEALTGVSLSLLTIWDMVKSAEKDEAGQYPVTRIDGISVIEKIKGTPE
>Mature_157_residues
PVFTHLNENNEVHMVDVTPKPDVSREATAKGRIYLRPETLAAIAEGRVLKGNVLATAQVAGTLAVKQTWALIPMCHPLPV
GGVTIWFEQTDEYIEAFCRVKTYGKTGIEMEALTGVSLSLLTIWDMVKSAEKDEAGQYPVTRIDGISVIEKIKGTPE

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=138, Percent_Identity=48.5507246376812, Blast_Score=132, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32566331, Length=130, Percent_Identity=38.4615384615385, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574490, Length=133, Percent_Identity=36.8421052631579, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28574492, Length=122, Percent_Identity=38.5245901639344, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_METLZ (A2ST56)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030779.1
- ProteinModelPortal:   A2ST56
- SMR:   A2ST56
- STRING:   A2ST56
- GeneID:   4795095
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_1345
- eggNOG:   arNOG11144
- HOGENOM:   HBG605231
- OMA:   RIKEGTI
- PhylomeDB:   A2ST56
- BioCyc:   MLAB410358:MLAB_1345-MONOMER
- HAMAP:   MF_01224_A
- InterPro:   IPR023045
- InterPro:   IPR023047
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 17325; Mature: 17194

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: ACT_SITE 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFTHLNENNEVHMVDVTPKPDVSREATAKGRIYLRPETLAAIAEGRVLKGNVLATAQV
CCEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCEEEECCEEEEEHH
AGTLAVKQTWALIPMCHPLPVGGVTIWFEQTDEYIEAFCRVKTYGKTGIEMEALTGVSLS
HHHHHHHHHEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCHH
LLTIWDMVKSAEKDEAGQYPVTRIDGISVIEKIKGTPE
HHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHCCCCC
>Mature Secondary Structure 
PVFTHLNENNEVHMVDVTPKPDVSREATAKGRIYLRPETLAAIAEGRVLKGNVLATAQV
CEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCEEEECCEEEEEHH
AGTLAVKQTWALIPMCHPLPVGGVTIWFEQTDEYIEAFCRVKTYGKTGIEMEALTGVSLS
HHHHHHHHHEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCHH
LLTIWDMVKSAEKDEAGQYPVTRIDGISVIEKIKGTPE
HHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA