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The map label for this gene is psmA [H]

Identifier: 124486159

GI number: 124486159

Start: 1365868

End: 1366686

Strand: Reverse

Name: psmA [H]

Synonym: Mlab_1341

Alternate gene names: 124486159

Gene position: 1366686-1365868 (Counterclockwise)

Preceding gene: 124486160

Following gene: 124486158

Centisome position: 75.72

GC content: 54.33

Gene sequence:

>819_bases
ATGCAGCCACAACAATATCAAATGGGCGGGTACGATCGTGCCATCACGATGTTCTCCCCCGACGGACGTCTGTATCAGGT
TGAATATGCACGTGAAGCGGTAAAACGGGGAACGACCGCGGTTGGTATCAAATGTAAGACGGGAGTCGTACTTCTCGTTG
ACAAACGGGTCAACTCCCGTCTTCTGGAACCATCGTCGATCGAGAAGATCTTTCGGATCGACGAACACATCGGTGTCGCC
TCCTCCGGCCTTGTCGGCGATGCCCGGATCCTTGTCGACCGTGCCCGGATCGAGGCTCAGATCAACCGGGTAAGCTACGG
CGAACCGGTCGATGTGGAGACGCTGGCAAAGAAACTCTGCGACCACATGCAGAGCTACACCCTGTTCGGCGGGGCACGCC
CTTACGGTACGGCGCTTCTGATCGCCGGTGCCGAGTCGTCACCGACCGGTACAAAGTATCATCTCTTCGAGACCGATCCC
TCAGGAACCCTTCTCGAGTACTCCGCCACCGGTATTGGTATCGGCAGACCTGCCGTCATCAAACTCTTCGAACAGGAGTA
CAAAGAAACCTGCTCGGCAGAAGAAGCCGTCCTGCTTGGCCTTAAAGCCCTGCACACCGCGACCGAAGGCAAGTTCGATA
TGAACACCGTCGAGATCGGTATAGCAGGCGAGTATTCCAAGAAACACTCCTCCAAAAAGGAGAGCGAGACCGCGAACGGA
ACAAAAATATCGACCATCGCATTTAGAAAACTGAATGTGGATGAAGTAAAGGCAGCTGTTGCCAAATTTTCCAAGACGAC
TCCTGCGAAAAAGGAGTGA

Upstream 100 bases:

>100_bases
CATATCCGGGGTATTTGTGCGCAGGTAAGAAGGTTAATAATCTCTCAAAAGAGAATGGGCATAGATATCTAACTAGAGAT
GATATAATTAAGGAGTAACA

Downstream 100 bases:

>100_bases
GTTAATCTATGATTTCCCTTGATGATGCAGTAACCGCCCGTCTGGAGACACACGGGCTGAAATTTGAACTGTTGGTTGAT
CCCGAACTTGCCGACAAAAT

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MQPQQYQMGGYDRAITMFSPDGRLYQVEYAREAVKRGTTAVGIKCKTGVVLLVDKRVNSRLLEPSSIEKIFRIDEHIGVA
SSGLVGDARILVDRARIEAQINRVSYGEPVDVETLAKKLCDHMQSYTLFGGARPYGTALLIAGAESSPTGTKYHLFETDP
SGTLLEYSATGIGIGRPAVIKLFEQEYKETCSAEEAVLLGLKALHTATEGKFDMNTVEIGIAGEYSKKHSSKKESETANG
TKISTIAFRKLNVDEVKAAVAKFSKTTPAKKE

Sequences:

>Translated_272_residues
MQPQQYQMGGYDRAITMFSPDGRLYQVEYAREAVKRGTTAVGIKCKTGVVLLVDKRVNSRLLEPSSIEKIFRIDEHIGVA
SSGLVGDARILVDRARIEAQINRVSYGEPVDVETLAKKLCDHMQSYTLFGGARPYGTALLIAGAESSPTGTKYHLFETDP
SGTLLEYSATGIGIGRPAVIKLFEQEYKETCSAEEAVLLGLKALHTATEGKFDMNTVEIGIAGEYSKKHSSKKESETANG
TKISTIAFRKLNVDEVKAAVAKFSKTTPAKKE
>Mature_272_residues
MQPQQYQMGGYDRAITMFSPDGRLYQVEYAREAVKRGTTAVGIKCKTGVVLLVDKRVNSRLLEPSSIEKIFRIDEHIGVA
SSGLVGDARILVDRARIEAQINRVSYGEPVDVETLAKKLCDHMQSYTLFGGARPYGTALLIAGAESSPTGTKYHLFETDP
SGTLLEYSATGIGIGRPAVIKLFEQEYKETCSAEEAVLLGLKALHTATEGKFDMNTVEIGIAGEYSKKHSSKKESETANG
TKISTIAFRKLNVDEVKAAVAKFSKTTPAKKE

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI23110942, Length=233, Percent_Identity=39.9141630901288, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI68303563, Length=196, Percent_Identity=42.3469387755102, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI4506189, Length=179, Percent_Identity=43.0167597765363, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI68303561, Length=202, Percent_Identity=41.0891089108911, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4506181, Length=216, Percent_Identity=38.4259259259259, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI156713442, Length=213, Percent_Identity=37.5586854460094, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4506185, Length=213, Percent_Identity=37.5586854460094, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4506183, Length=169, Percent_Identity=42.0118343195266, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI23110939, Length=169, Percent_Identity=41.4201183431953, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI23110935, Length=218, Percent_Identity=37.1559633027523, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4506179, Length=218, Percent_Identity=37.1559633027523, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI23110944, Length=218, Percent_Identity=33.0275229357798, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI68303565, Length=196, Percent_Identity=36.734693877551, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI221316716, Length=105, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI156713444, Length=146, Percent_Identity=34.2465753424658, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17508491, Length=194, Percent_Identity=43.8144329896907, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25143215, Length=212, Percent_Identity=38.6792452830189, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17508493, Length=213, Percent_Identity=38.0281690140845, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17562790, Length=231, Percent_Identity=33.7662337662338, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17562792, Length=220, Percent_Identity=34.0909090909091, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71998965, Length=248, Percent_Identity=30.241935483871, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562788, Length=204, Percent_Identity=31.8627450980392, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321692, Length=218, Percent_Identity=44.4954128440367, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324535, Length=204, Percent_Identity=42.6470588235294, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321574, Length=200, Percent_Identity=39.5, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324938, Length=203, Percent_Identity=38.9162561576355, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323547, Length=248, Percent_Identity=33.4677419354839, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323974, Length=163, Percent_Identity=40.4907975460123, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321427, Length=222, Percent_Identity=32.4324324324324, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654391, Length=216, Percent_Identity=40.2777777777778, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24654389, Length=216, Percent_Identity=40.2777777777778, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17933602, Length=214, Percent_Identity=41.1214953271028, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356137, Length=201, Percent_Identity=39.8009950248756, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19922898, Length=187, Percent_Identity=41.1764705882353, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17737927, Length=214, Percent_Identity=35.981308411215, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17136420, Length=179, Percent_Identity=40.2234636871508, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24651571, Length=176, Percent_Identity=35.2272727272727, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360341, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24586406, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24586400, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24586402, Length=216, Percent_Identity=32.8703703703704, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24652204, Length=166, Percent_Identity=35.5421686746988, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17737405, Length=219, Percent_Identity=35.6164383561644, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI19921232, Length=217, Percent_Identity=32.7188940092166, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 29660; Mature: 29660

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPQQYQMGGYDRAITMFSPDGRLYQVEYAREAVKRGTTAVGIKCKTGVVLLVDKRVNSR
CCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCC
LLEPSSIEKIFRIDEHIGVASSGLVGDARILVDRARIEAQINRVSYGEPVDVETLAKKLC
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
DHMQSYTLFGGARPYGTALLIAGAESSPTGTKYHLFETDPSGTLLEYSATGIGIGRPAVI
HHHHHEEEECCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHH
KLFEQEYKETCSAEEAVLLGLKALHTATEGKFDMNTVEIGIAGEYSKKHSSKKESETANG
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEECEEEEEEECCCCHHHHCCCHHHHCCCC
TKISTIAFRKLNVDEVKAAVAKFSKTTPAKKE
CEEEEEEEEECCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQPQQYQMGGYDRAITMFSPDGRLYQVEYAREAVKRGTTAVGIKCKTGVVLLVDKRVNSR
CCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCC
LLEPSSIEKIFRIDEHIGVASSGLVGDARILVDRARIEAQINRVSYGEPVDVETLAKKLC
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
DHMQSYTLFGGARPYGTALLIAGAESSPTGTKYHLFETDPSGTLLEYSATGIGIGRPAVI
HHHHHEEEECCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHH
KLFEQEYKETCSAEEAVLLGLKALHTATEGKFDMNTVEIGIAGEYSKKHSSKKESETANG
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEECEEEEEEECCCCHHHHCCCHHHHCCCC
TKISTIAFRKLNVDEVKAAVAKFSKTTPAKKE
CEEEEEEEEECCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA