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The map label for this gene is aqpM [H]

Identifier: 124486104

GI number: 124486104

Start: 1310920

End: 1311666

Strand: Reverse

Name: aqpM [H]

Synonym: Mlab_1284

Alternate gene names: 124486104

Gene position: 1311666-1310920 (Counterclockwise)

Preceding gene: 124486105

Following gene: 124486102

Centisome position: 72.67

GC content: 54.89

Gene sequence:

>747_bases
ATGGATCTCGCAAGACGGTGTTTTGCGGAATTAATCGGGACGATGATCCTTGTGTTCATCGGGTGTGGCTCCGTCGTGAT
CATGCTGATGCTTGCGGCAGGCACGACCCCGTCGACCTCATTCGACATAGGGATAGGTGCCCTTGGCGGAATGGGTGACT
GGTTCGGCATCAGTGCGGCCTTCGGTCTTGCCGTAGCGGCAGTAATCTATGCTCTAGGCACGGTGTCTGGAGCCCACATC
AATCCGGCAGTCAGCATCGCGCTTTGTTCGATTCGGAAATTCCCAGTAAAAGATACGATCGCATACGTGATTGCCCAGTG
TATCGGAGCAGGAATTGGAGCAGCTTTGCTGTTTTTCATCATCGGCCCCGAATCCCTTAGCGTTGGCGGGCTCGGTGCGA
CCGCTCCTTTCCCGGGGATCTCTCTCTGGCAGGCTCTTCTGGCCGAAATCGTCGGCACCTTCATCTTAATGCTCGTCATT
ATGGGTGTTGCTGTTGACAAGAAAGCTCCCGCAGGATTTGCCGGACTTGCGATCGGCGCCGCCGTTACTGCCGTCATCCT
TGCCACAGGGAATATCTCCGGCGGTTCGATCAATCCGGCTCGATCATTCGGTCCGGATATTATGAGACTGATACTTTCAG
GTTCTGATGCCCTTTGGACAACATACCCGATCTATGTGGTCGGACCGATCGTCGGTGCCGTACTCGCTGCGTTCTTCTAT
GTTTTCGTAGCGGGAAAACGGGAGTGA

Upstream 100 bases:

>100_bases
CTTGGGAGGGGGGATATCCCTTCCCTGCAAAGAAACTGAAGCATCCGATCCCCCGGATACTTTGTCCTGAATGCAGTAAA
GCCTGGAACGGAGAGAAATA

Downstream 100 bases:

>100_bases
TCCGATCACTTATTTTTTTAAATTATTTCAGTGCCTGGCACAGTGTGAAAAAAAAGTTATGACCGTTCGCCGTAGACTCT
CTTGATCTCGTGCGCCTCGG

Product: hypothetical protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MDLARRCFAELIGTMILVFIGCGSVVIMLMLAAGTTPSTSFDIGIGALGGMGDWFGISAAFGLAVAAVIYALGTVSGAHI
NPAVSIALCSIRKFPVKDTIAYVIAQCIGAGIGAALLFFIIGPESLSVGGLGATAPFPGISLWQALLAEIVGTFILMLVI
MGVAVDKKAPAGFAGLAIGAAVTAVILATGNISGGSINPARSFGPDIMRLILSGSDALWTTYPIYVVGPIVGAVLAAFFY
VFVAGKRE

Sequences:

>Translated_248_residues
MDLARRCFAELIGTMILVFIGCGSVVIMLMLAAGTTPSTSFDIGIGALGGMGDWFGISAAFGLAVAAVIYALGTVSGAHI
NPAVSIALCSIRKFPVKDTIAYVIAQCIGAGIGAALLFFIIGPESLSVGGLGATAPFPGISLWQALLAEIVGTFILMLVI
MGVAVDKKAPAGFAGLAIGAAVTAVILATGNISGGSINPARSFGPDIMRLILSGSDALWTTYPIYVVGPIVGAVLAAFFY
VFVAGKRE
>Mature_248_residues
MDLARRCFAELIGTMILVFIGCGSVVIMLMLAAGTTPSTSFDIGIGALGGMGDWFGISAAFGLAVAAVIYALGTVSGAHI
NPAVSIALCSIRKFPVKDTIAYVIAQCIGAGIGAALLFFIIGPESLSVGGLGATAPFPGISLWQALLAEIVGTFILMLVI
MGVAVDKKAPAGFAGLAIGAAVTAVILATGNISGGSINPARSFGPDIMRLILSGSDALWTTYPIYVVGPIVGAVLAAFFY
VFVAGKRE

Specific function: Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=188, Percent_Identity=39.8936170212766, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4502181, Length=188, Percent_Identity=39.8936170212766, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI157266307, Length=265, Percent_Identity=32.0754716981132, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4826645, Length=264, Percent_Identity=29.9242424242424, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI37694062, Length=246, Percent_Identity=32.1138211382114, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4502183, Length=241, Percent_Identity=35.6846473029046, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI6912506, Length=244, Percent_Identity=31.5573770491803, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI45446752, Length=207, Percent_Identity=35.2657004830918, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI22538420, Length=260, Percent_Identity=28.8461538461538, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4502179, Length=241, Percent_Identity=32.3651452282158, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4502187, Length=268, Percent_Identity=25.3731343283582, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI86792455, Length=241, Percent_Identity=31.5352697095436, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI310133356, Length=175, Percent_Identity=28, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI310114181, Length=175, Percent_Identity=28, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787101, Length=206, Percent_Identity=41.2621359223301, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790362, Length=271, Percent_Identity=34.3173431734317, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71993722, Length=249, Percent_Identity=32.9317269076305, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17558372, Length=240, Percent_Identity=35.4166666666667, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71994009, Length=271, Percent_Identity=30.2583025830258, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17531431, Length=261, Percent_Identity=30.6513409961686, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17531429, Length=261, Percent_Identity=30.6513409961686, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71992966, Length=263, Percent_Identity=28.8973384030418, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564052, Length=265, Percent_Identity=27.9245283018868, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17533613, Length=265, Percent_Identity=27.9245283018868, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17544068, Length=266, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992961, Length=250, Percent_Identity=27.6, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=216, Percent_Identity=33.7962962962963, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24652747, Length=245, Percent_Identity=33.469387755102, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45551084, Length=245, Percent_Identity=33.469387755102, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24762344, Length=245, Percent_Identity=34.2857142857143, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24762346, Length=245, Percent_Identity=34.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24762348, Length=245, Percent_Identity=34.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20130305, Length=245, Percent_Identity=34.2857142857143, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550503, Length=248, Percent_Identity=31.0483870967742, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24652751, Length=235, Percent_Identity=31.4893617021277, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762342, Length=255, Percent_Identity=30.9803921568627, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922038, Length=235, Percent_Identity=31.4893617021277, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136672, Length=191, Percent_Identity=32.4607329842932, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25105; Mature: 25105

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCC
>Mature Secondary Structure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HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]