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The map label for this gene is ywlC [H]

Identifier: 124486054

GI number: 124486054

Start: 1265726

End: 1266322

Strand: Reverse

Name: ywlC [H]

Synonym: Mlab_1234

Alternate gene names: 124486054

Gene position: 1266322-1265726 (Counterclockwise)

Preceding gene: 124486055

Following gene: 124486053

Centisome position: 70.16

GC content: 53.6

Gene sequence:

>597_bases
ATGATAACACCAACCGAAGAGAGCAGAATAGAAAAAGCCGTCCGCGTTTTATCCCGCGACGGCCTTGTAGTATATCCGAC
GGAAACCGTGTACGGGCTTGGGGCCGACGCGTTGTCGGATACTGCCGTCATCAAAGTCTATGAAGCAAAACAGCGGCCTC
TTGGAAAACCGATCTCGGTCGCCGTTTCCGATATCGAAATGATCTACGGCATTGCAGACGTCAGCCCGTTTGCAGAACGG
TTCATCAGCAAATTCCTGCCGGGTCCGGTCACGATCGTTCTCCCGGTGAAAAACTGTCTGCCTGGCGACCTTTCCGGAGG
GACGGGCACGATCGGGATACGGTATCCGGATCACACCCTCGCTCTTGAACTGATCTCCATGTTCGACTGTCCGATAACCG
CGACCTCGGCAAACATCTCAGGCGAAATATCTCCTGTAAGCGTCGACCAGGTCAACGTACCTCATGATTATCTGCTTGAC
GGCGGCGTTCTTCCAGGAATCCCGAGCACGGTCGTCAATCTCGAAACAAGAAATATCGAGCGTCCAGGCGCGATGCTGGA
CGACATCGCCCGTTTCTTTATAGAAAACGCGAAATGA

Upstream 100 bases:

>100_bases
TTGTGGTCACCGATCCGATCCAGGCCGGGGTCATGGCCGTGATGCATATCAGCACGATCGGCGTATTCGATATTGCAAAA
GTGAAAGGGGAAGAGTTCTG

Downstream 100 bases:

>100_bases
AAAAAACCTACTCAGTATCCGGCATGACCTGTTCGGCATGCTCTCTTCATGTTGAAAAGGCCGCAAAAAGTGTAGAGGGC
GTGAACTCCGCGTCAGTGAA

Product: translation factor SUA5

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MITPTEESRIEKAVRVLSRDGLVVYPTETVYGLGADALSDTAVIKVYEAKQRPLGKPISVAVSDIEMIYGIADVSPFAER
FISKFLPGPVTIVLPVKNCLPGDLSGGTGTIGIRYPDHTLALELISMFDCPITATSANISGEISPVSVDQVNVPHDYLLD
GGVLPGIPSTVVNLETRNIERPGAMLDDIARFFIENAK

Sequences:

>Translated_198_residues
MITPTEESRIEKAVRVLSRDGLVVYPTETVYGLGADALSDTAVIKVYEAKQRPLGKPISVAVSDIEMIYGIADVSPFAER
FISKFLPGPVTIVLPVKNCLPGDLSGGTGTIGIRYPDHTLALELISMFDCPITATSANISGEISPVSVDQVNVPHDYLLD
GGVLPGIPSTVVNLETRNIERPGAMLDDIARFFIENAK
>Mature_198_residues
MITPTEESRIEKAVRVLSRDGLVVYPTETVYGLGADALSDTAVIKVYEAKQRPLGKPISVAVSDIEMIYGIADVSPFAER
FISKFLPGPVTIVLPVKNCLPGDLSGGTGTIGIRYPDHTLALELISMFDCPITATSANISGEISPVSVDQVNVPHDYLLD
GGVLPGIPSTVVNLETRNIERPGAMLDDIARFFIENAK

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=192, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI2367210, Length=166, Percent_Identity=31.9277108433735, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI87081864, Length=175, Percent_Identity=26.8571428571429, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17537239, Length=185, Percent_Identity=32.972972972973, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321269, Length=193, Percent_Identity=37.3056994818653, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI78707274, Length=147, Percent_Identity=31.9727891156463, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 21227; Mature: 21227

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPTEESRIEKAVRVLSRDGLVVYPTETVYGLGADALSDTAVIKVYEAKQRPLGKPISV
CCCCCHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCCEEEEEEECCCCCCCCCHHH
AVSDIEMIYGIADVSPFAERFISKFLPGPVTIVLPVKNCLPGDLSGGTGTIGIRYPDHTL
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCHHH
ALELISMFDCPITATSANISGEISPVSVDQVNVPHDYLLDGGVLPGIPSTVVNLETRNIE
HHHHHHHHCCCCEEECCCCCCCCCCEEECEECCCHHHHCCCCCCCCCCCCEEEEECCCCC
RPGAMLDDIARFFIENAK
CCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITPTEESRIEKAVRVLSRDGLVVYPTETVYGLGADALSDTAVIKVYEAKQRPLGKPISV
CCCCCHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCCEEEEEEECCCCCCCCCHHH
AVSDIEMIYGIADVSPFAERFISKFLPGPVTIVLPVKNCLPGDLSGGTGTIGIRYPDHTL
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCHHH
ALELISMFDCPITATSANISGEISPVSVDQVNVPHDYLLDGGVLPGIPSTVVNLETRNIE
HHHHHHHHCCCCEEECCCCCCCCCCEEECEECCCHHHHCCCCCCCCCCCCEEEEECCCCC
RPGAMLDDIARFFIENAK
CCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]