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The map label for this gene is guaA

Identifier: 124485953

GI number: 124485953

Start: 1145912

End: 1147438

Strand: Reverse

Name: guaA

Synonym: Mlab_1133

Alternate gene names: 124485953

Gene position: 1147438-1145912 (Counterclockwise)

Preceding gene: 124485954

Following gene: 124485952

Centisome position: 63.57

GC content: 54.62

Gene sequence:

>1527_bases
ATGGAATCGATATTAGTCCTTGATTTCGGCGGCCAGTACAACCAGCTGATCTCCCGCCGCGTCAGAGAAGCACATGTTTT
CTGCGAAGTAAAGCCCTGCACGATCCCCCTTTCGGAAATAAAAGAAGGAAACTATGCGGGAATTATTTTCACCGGCGGAC
CGGCGAGCGTGTATGCGAAGAACGCTCCGACCGTTGATGCCGGTATCTTCGAGCTAGGAATCCCGATTCTCGGGATCTGC
TACGGCGCACAGCTCACGGCATATCTCCTTGGAGGAAACGTCGCTTCTGCGACGACCCGCGAGTACGGCAAAACTTCCAT
TTCAACGGAAGAGTCCCCTATCTTCAAAAATGTCCCAAGAGAGACGACCTGCTGGATGAGCCACACGGATTACATCAGCG
AGGTCCCTGCCGGATTCGTCAAGGTCGCCCACACGAGTGTGTGCCCGGTCGCCGCCATGGCAAACCCCGCAAAGAAGATC
TACGCGGTCCAGTTCCACCCCGAGGTCATGCACACCCCTGAGGGCATGACGATGATCAAAAACTTCCTTTACGATGTCTG
CGGGTGCAAAGGAACCTGGCATATGTCCTCTTTTGTCGAGGATCAGGTCCTGCAGCTTCGCGAGAAGATCGGCGACAAAA
AAGTCCTCTGTGCCCTCTCCGGCGGCGTCGACTCATCCGTTGCCGCTGTTTTGATCAACAAAGCGGTCGGCAAACAACTG
ACCTGCATCTTTGTCGATCACGGTCTTCTCAGAAAGAACGAGGGTAACGAGGTCGAAGAGATCTTCAGAAATCAGTTCGA
TATCAATCTGATCCGCGTCAATGTCGAGGACCAGTTCCTCGGAAAACTCGCCGGCGTTTCCGACCCTGAAAAGAAACGCA
AGATCATCGGCGAGGAGTTCATCCGCGTCTTCGAAGCAGAGGCAAAAAAGATCGGCACGGTCGATTTCCTTGTGCAGGGA
ACGATCTATCCCGATGTGATAGAGTCAGGACCGGGCGCGGCTGCCGTGATCAAAAGCCACCACAATGTCGGCGGTCTGCC
GGACAATGTGGATTTCAAGGAGATCATCGAGCCGCTTCGTATCCTTTTCAAGGATGAGGTCCGCCGGGCCGGTCTCGAAC
TCGGCATCCCTGAGAAGCTTGTCTGGCGTCAGCCGTTCCCGGGCCCGGGTCTTGCTATCCGGGTGATCGGCGACATCACA
AAAGAAAAACTCGAGATCGTCCGCGACGCCGATGCGATCTACCGCGAGGAGATCGCCAAAGCCGGAATCGATCGGGACAT
CAATCAGTATTTTGCGGCCTTAACGAATATGCGCAGCGTCGGTGTGATGGGCGATGAGAGGACATATGACTACGCCGTCG
TTTTGCGGGCCGTAACAACGACCGATTTCATGACTGCCGACTGGGCCCAGATCCCGTTTGCGGTGCTTGAAAAGGTTTCA
AGCCGGATCATCAACGAAGTCAGGCACGTGAACCGGGTCTTATACGACATTACAAGCAAGCCTCCGGCAACGATCGAGTA
CGAATAA

Upstream 100 bases:

>100_bases
ACCCAGTTCCACCCGGAGTTCAGATCACGTCCGGCCCGTCCGTCGGCCCCGTTCATCGGTTTTGTAAAAGCCTGCCGTGA
GATGAAGAGAAAGGAGTAAC

Downstream 100 bases:

>100_bases
ATTACCTGATGCTGCAGAGACTAATCTTTGCAGATATCCATCCCGGGATTAAAATCCGGGAAGATGATTAGATGGTGTAA
CGTATGAAAATAATCGGATT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MESILVLDFGGQYNQLISRRVREAHVFCEVKPCTIPLSEIKEGNYAGIIFTGGPASVYAKNAPTVDAGIFELGIPILGIC
YGAQLTAYLLGGNVASATTREYGKTSISTEESPIFKNVPRETTCWMSHTDYISEVPAGFVKVAHTSVCPVAAMANPAKKI
YAVQFHPEVMHTPEGMTMIKNFLYDVCGCKGTWHMSSFVEDQVLQLREKIGDKKVLCALSGGVDSSVAAVLINKAVGKQL
TCIFVDHGLLRKNEGNEVEEIFRNQFDINLIRVNVEDQFLGKLAGVSDPEKKRKIIGEEFIRVFEAEAKKIGTVDFLVQG
TIYPDVIESGPGAAAVIKSHHNVGGLPDNVDFKEIIEPLRILFKDEVRRAGLELGIPEKLVWRQPFPGPGLAIRVIGDIT
KEKLEIVRDADAIYREEIAKAGIDRDINQYFAALTNMRSVGVMGDERTYDYAVVLRAVTTTDFMTADWAQIPFAVLEKVS
SRIINEVRHVNRVLYDITSKPPATIEYE

Sequences:

>Translated_508_residues
MESILVLDFGGQYNQLISRRVREAHVFCEVKPCTIPLSEIKEGNYAGIIFTGGPASVYAKNAPTVDAGIFELGIPILGIC
YGAQLTAYLLGGNVASATTREYGKTSISTEESPIFKNVPRETTCWMSHTDYISEVPAGFVKVAHTSVCPVAAMANPAKKI
YAVQFHPEVMHTPEGMTMIKNFLYDVCGCKGTWHMSSFVEDQVLQLREKIGDKKVLCALSGGVDSSVAAVLINKAVGKQL
TCIFVDHGLLRKNEGNEVEEIFRNQFDINLIRVNVEDQFLGKLAGVSDPEKKRKIIGEEFIRVFEAEAKKIGTVDFLVQG
TIYPDVIESGPGAAAVIKSHHNVGGLPDNVDFKEIIEPLRILFKDEVRRAGLELGIPEKLVWRQPFPGPGLAIRVIGDIT
KEKLEIVRDADAIYREEIAKAGIDRDINQYFAALTNMRSVGVMGDERTYDYAVVLRAVTTTDFMTADWAQIPFAVLEKVS
SRIINEVRHVNRVLYDITSKPPATIEYE
>Mature_508_residues
MESILVLDFGGQYNQLISRRVREAHVFCEVKPCTIPLSEIKEGNYAGIIFTGGPASVYAKNAPTVDAGIFELGIPILGIC
YGAQLTAYLLGGNVASATTREYGKTSISTEESPIFKNVPRETTCWMSHTDYISEVPAGFVKVAHTSVCPVAAMANPAKKI
YAVQFHPEVMHTPEGMTMIKNFLYDVCGCKGTWHMSSFVEDQVLQLREKIGDKKVLCALSGGVDSSVAAVLINKAVGKQL
TCIFVDHGLLRKNEGNEVEEIFRNQFDINLIRVNVEDQFLGKLAGVSDPEKKRKIIGEEFIRVFEAEAKKIGTVDFLVQG
TIYPDVIESGPGAAAVIKSHHNVGGLPDNVDFKEIIEPLRILFKDEVRRAGLELGIPEKLVWRQPFPGPGLAIRVIGDIT
KEKLEIVRDADAIYREEIAKAGIDRDINQYFAALTNMRSVGVMGDERTYDYAVVLRAVTTTDFMTADWAQIPFAVLEKVS
SRIINEVRHVNRVLYDITSKPPATIEYE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=552, Percent_Identity=36.7753623188406, Blast_Score=310, Evalue=3e-84,
Organism=Escherichia coli, GI1788854, Length=517, Percent_Identity=49.9032882011605, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI133901714, Length=567, Percent_Identity=36.331569664903, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=567, Percent_Identity=36.331569664903, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=567, Percent_Identity=36.331569664903, Blast_Score=299, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=50.965250965251, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322638, Length=169, Percent_Identity=34.9112426035503, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365319, Length=546, Percent_Identity=36.996336996337, Blast_Score=297, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56149; Mature: 56149

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESILVLDFGGQYNQLISRRVREAHVFCEVKPCTIPLSEIKEGNYAGIIFTGGPASVYAK
CCCEEEEECCCCHHHHHHHHHHHHEEEEEECCCCCCHHHCCCCCEEEEEEECCCCEEEEC
NAPTVDAGIFELGIPILGICYGAQLTAYLLGGNVASATTREYGKTSISTEESPIFKNVPR
CCCCCCCHHHHHCCHHHHHHHHHHHEEHEECCCCCHHHHHHHCCCCCCCCCCCHHHCCCC
ETTCWMSHTDYISEVPAGFVKVAHTSVCPVAAMANPAKKIYAVQFHPEVMHTPEGMTMIK
CCEEECCCHHHHHHCCHHHHHHHHCCCCCHHHHCCCCHHEEEEEECCHHHCCCCHHHHHH
NFLYDVCGCKGTWHMSSFVEDQVLQLREKIGDKKVLCALSGGVDSSVAAVLINKAVGKQL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCEE
TCIFVDHGLLRKNEGNEVEEIFRNQFDINLIRVNVEDQFLGKLAGVSDPEKKRKIIGEEF
EEEEECCCCEECCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHH
IRVFEAEAKKIGTVDFLVQGTIYPDVIESGPGAAAVIKSHHNVGGLPDNVDFKEIIEPLR
HHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHH
ILFKDEVRRAGLELGIPEKLVWRQPFPGPGLAIRVIGDITKEKLEIVRDADAIYREEIAK
HHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
AGIDRDINQYFAALTNMRSVGVMGDERTYDYAVVLRAVTTTDFMTADWAQIPFAVLEKVS
CCCCCHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHH
SRIINEVRHVNRVLYDITSKPPATIEYE
HHHHHHHHHHHHHHHHHCCCCCCEEECC
>Mature Secondary Structure
MESILVLDFGGQYNQLISRRVREAHVFCEVKPCTIPLSEIKEGNYAGIIFTGGPASVYAK
CCCEEEEECCCCHHHHHHHHHHHHEEEEEECCCCCCHHHCCCCCEEEEEEECCCCEEEEC
NAPTVDAGIFELGIPILGICYGAQLTAYLLGGNVASATTREYGKTSISTEESPIFKNVPR
CCCCCCCHHHHHCCHHHHHHHHHHHEEHEECCCCCHHHHHHHCCCCCCCCCCCHHHCCCC
ETTCWMSHTDYISEVPAGFVKVAHTSVCPVAAMANPAKKIYAVQFHPEVMHTPEGMTMIK
CCEEECCCHHHHHHCCHHHHHHHHCCCCCHHHHCCCCHHEEEEEECCHHHCCCCHHHHHH
NFLYDVCGCKGTWHMSSFVEDQVLQLREKIGDKKVLCALSGGVDSSVAAVLINKAVGKQL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCEE
TCIFVDHGLLRKNEGNEVEEIFRNQFDINLIRVNVEDQFLGKLAGVSDPEKKRKIIGEEF
EEEEECCCCEECCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHH
IRVFEAEAKKIGTVDFLVQGTIYPDVIESGPGAAAVIKSHHNVGGLPDNVDFKEIIEPLR
HHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHH
ILFKDEVRRAGLELGIPEKLVWRQPFPGPGLAIRVIGDITKEKLEIVRDADAIYREEIAK
HHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
AGIDRDINQYFAALTNMRSVGVMGDERTYDYAVVLRAVTTTDFMTADWAQIPFAVLEKVS
CCCCCHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHH
SRIINEVRHVNRVLYDITSKPPATIEYE
HHHHHHHHHHHHHHHHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA