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The map label for this gene is coaBC [H]

Identifier: 124485744

GI number: 124485744

Start: 917419

End: 918552

Strand: Reverse

Name: coaBC [H]

Synonym: Mlab_0922

Alternate gene names: 124485744

Gene position: 918552-917419 (Counterclockwise)

Preceding gene: 124485745

Following gene: 124485743

Centisome position: 50.89

GC content: 57.58

Gene sequence:

>1134_bases
ATGAAAAGACTCAACAATATCCGCATCGTTCTCGGCGTATGCGGCAGTATCGCCGCTGTCGAGACGATCAAACTCGCCCA
CGAGCTCAGACGCCGGGGAGCGAGAGTGACCGGCATCATCAGCCCCGCGGGGTGCGGGATCATCCATCCCGATGCGCTGA
CCTATGCGTGCCAGAATCCGGCGCTGACAGAGATCACCGGCATGGTCGAGCATGTCAAATACTGCGGCGAAGGAGGCGAG
GCGGATCTTCTTTTGATAGCTCCCGCCACCGCGAACACCGTTGGAAAGATCGCCTGCGGGATCGACGACACCATCATCAC
GACCTTTGCGACCACCGCGATCGGCCGCGGTCTACCGGTCGTCGTCGTTCCGGCGATGCATGAATCGATGTACCGCCACC
CGGCAGTCAGGAAAAATCTGGAGACCCTCAAAGAGTTCGGGATCGATGTTGTTCCCCCGCGAATGGAAGAGGAGAAGGCG
AAGATCGCGGGAATCGACGAGATTTGTCTGTATGCCGAGCGGGCAGTCTCGTCAAAGAAGCTCGCAGGCAAACGCGTCCT
GATCTCCGGCGGGTCCTGCCGCGAAGAACTGGACGATGTCAGGATCCTGACGACGCGATCCAGCGGGACGATGGCAAAGG
AGCTCGCGCTTGAAGCCTTCCGGCTCGGCGCCGAGGTGACCCTCGTGATGAATCCGATGCACGGCATCGTTCCCTGTGTG
AAGAATGTCCCGGTGATCACCGCGGCCGATATGCACGAAGCGGTCCTTCGCGAGGCAGATGGAGCCGATTATTATCTCTC
GGCCGCCGCGATCTCCGACTTTGCCCCGAAAAGGGTGGACGGCAAGATCAAAAGCGGCTCGGCTGTATCCGTGACGCTTG
AACCGCTTGAAAAACTGATAACTAGGATCGCCGCAAAAGGCGTGAAAACCGTCGGCTTCAAGCTCGGCAGGGACGCAGAA
GAAGAGGGGCTCCATCTTCTCGAATACGATAATATCGTCCTTGTTCTTGCAAACAAACCCGAGACTATGGGCTCTCCCTT
CGGCGAGTATGTCTTTTTACGAAAAGACGGGAAAGAAACGGTGTGTGGAACAAAAGACGAGATCGCGGGGAAAGTATGGG
ACGTTCTTGCATAA

Upstream 100 bases:

>100_bases
AGACTCTCGAAGGGGCAGGTTTTACGTATATTATCAGCGAACATAAAGTAAAGAAGTATGCGGGGCGCCTCTGGCACTCG
GTTTGGGATGTGAACCTCAT

Downstream 100 bases:

>100_bases
CTTTTGCTCCGGGTCATATCTCAGGCTACTTTAAGCGGATCGACGGTATCTCTGCCCAGACGACCGGGAGTCTCGGCGCC
GGGATCGTGATCGACAAAGG

Product: phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKRLNNIRIVLGVCGSIAAVETIKLAHELRRRGARVTGIISPAGCGIIHPDALTYACQNPALTEITGMVEHVKYCGEGGE
ADLLLIAPATANTVGKIACGIDDTIITTFATTAIGRGLPVVVVPAMHESMYRHPAVRKNLETLKEFGIDVVPPRMEEEKA
KIAGIDEICLYAERAVSSKKLAGKRVLISGGSCREELDDVRILTTRSSGTMAKELALEAFRLGAEVTLVMNPMHGIVPCV
KNVPVITAADMHEAVLREADGADYYLSAAAISDFAPKRVDGKIKSGSAVSVTLEPLEKLITRIAAKGVKTVGFKLGRDAE
EEGLHLLEYDNIVLVLANKPETMGSPFGEYVFLRKDGKETVCGTKDEIAGKVWDVLA

Sequences:

>Translated_377_residues
MKRLNNIRIVLGVCGSIAAVETIKLAHELRRRGARVTGIISPAGCGIIHPDALTYACQNPALTEITGMVEHVKYCGEGGE
ADLLLIAPATANTVGKIACGIDDTIITTFATTAIGRGLPVVVVPAMHESMYRHPAVRKNLETLKEFGIDVVPPRMEEEKA
KIAGIDEICLYAERAVSSKKLAGKRVLISGGSCREELDDVRILTTRSSGTMAKELALEAFRLGAEVTLVMNPMHGIVPCV
KNVPVITAADMHEAVLREADGADYYLSAAAISDFAPKRVDGKIKSGSAVSVTLEPLEKLITRIAAKGVKTVGFKLGRDAE
EEGLHLLEYDNIVLVLANKPETMGSPFGEYVFLRKDGKETVCGTKDEIAGKVWDVLA
>Mature_377_residues
MKRLNNIRIVLGVCGSIAAVETIKLAHELRRRGARVTGIISPAGCGIIHPDALTYACQNPALTEITGMVEHVKYCGEGGE
ADLLLIAPATANTVGKIACGIDDTIITTFATTAIGRGLPVVVVPAMHESMYRHPAVRKNLETLKEFGIDVVPPRMEEEKA
KIAGIDEICLYAERAVSSKKLAGKRVLISGGSCREELDDVRILTTRSSGTMAKELALEAFRLGAEVTLVMNPMHGIVPCV
KNVPVITAADMHEAVLREADGADYYLSAAAISDFAPKRVDGKIKSGSAVSVTLEPLEKLITRIAAKGVKTVGFKLGRDAE
EEGLHLLEYDNIVLVLANKPETMGSPFGEYVFLRKDGKETVCGTKDEIAGKVWDVLA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=397, Percent_Identity=29.2191435768262, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 40402; Mature: 40402

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLNNIRIVLGVCGSIAAVETIKLAHELRRRGARVTGIISPAGCGIIHPDALTYACQNP
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCHHEEECCCC
ALTEITGMVEHVKYCGEGGEADLLLIAPATANTVGKIACGIDDTIITTFATTAIGRGLPV
CHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCE
VVVPAMHESMYRHPAVRKNLETLKEFGIDVVPPRMEEEKAKIAGIDEICLYAERAVSSKK
EEECHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
LAGKRVLISGGSCREELDDVRILTTRSSGTMAKELALEAFRLGAEVTLVMNPMHGIVPCV
CCCCEEEEECCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
KNVPVITAADMHEAVLREADGADYYLSAAAISDFAPKRVDGKIKSGSAVSVTLEPLEKLI
HCCCEEEECHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHH
TRIAAKGVKTVGFKLGRDAEEEGLHLLEYDNIVLVLANKPETMGSPFGEYVFLRKDGKET
HHHHHCCHHHHHHCCCCCCHHCCCEEEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCC
VCGTKDEIAGKVWDVLA
CCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRLNNIRIVLGVCGSIAAVETIKLAHELRRRGARVTGIISPAGCGIIHPDALTYACQNP
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCHHEEECCCC
ALTEITGMVEHVKYCGEGGEADLLLIAPATANTVGKIACGIDDTIITTFATTAIGRGLPV
CHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCE
VVVPAMHESMYRHPAVRKNLETLKEFGIDVVPPRMEEEKAKIAGIDEICLYAERAVSSKK
EEECHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
LAGKRVLISGGSCREELDDVRILTTRSSGTMAKELALEAFRLGAEVTLVMNPMHGIVPCV
CCCCEEEEECCCCHHHHCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
KNVPVITAADMHEAVLREADGADYYLSAAAISDFAPKRVDGKIKSGSAVSVTLEPLEKLI
HCCCEEEECHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHH
TRIAAKGVKTVGFKLGRDAEEEGLHLLEYDNIVLVLANKPETMGSPFGEYVFLRKDGKET
HHHHHCCHHHHHHCCCCCCHHCCCEEEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCC
VCGTKDEIAGKVWDVLA
CCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]