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The map label for this gene is tbp1 [H]

Identifier: 124485267

GI number: 124485267

Start: 424244

End: 424810

Strand: Reverse

Name: tbp1 [H]

Synonym: Mlab_0440

Alternate gene names: 124485267

Gene position: 424810-424244 (Counterclockwise)

Preceding gene: 124485268

Following gene: 124485264

Centisome position: 23.54

GC content: 49.21

Gene sequence:

>567_bases
ATGGATGGGAAAACATACTCCTCTCTGAAGATTGAAAATATCGTCGCCTCCGGCGTAATTGCCGAAGAAATTGATCTTGC
AGAGATCTCCGAAAAAATTGACGGGTGTGAACTCAATACAAAACGTTTCCCCGGTGCAGTGTATCGTATCGACAGTCCGA
AAATGGCATCGCTGATCTTCTCGTCGGGAAAGGTCGTGCTTACCGGAATCAGAAATGAAGAGTCGCTGGGAGAAGGTCTC
GCAAAGGTGCTTGCCTCCCTGAAAGAAGCAGGCGTAAACGTGCTGGATGTCCCGCGGGTCGCCGTGACCAACATAGTCTG
TTCCTACGACATCGGTCGGTTTATCAACCTGAACCGTGTGGTCGCAACCCTCTCTCTCGAAGCCATCGAGTATGAACCCG
AGCAGTTTCCGGGTCTCGTATACCGTATCAAAGATCCGAAAATCGTTGCACTGCTCTTCTCGTCTGGAAAGATCATCTTA
ACCGGCGGTAAGAATCTTGACGATGTCAGAAAAGGTCTGGACTTCCTCGAAGAGAGTCTCAAAGACGTCCTGACCGAACA
AAAATAA

Upstream 100 bases:

>100_bases
CCTTGAAATGATATTATATAAACCGCCGCGCATTTACAGATGAAACCACACCCGCATCTAACGCGAAGTATTATGCTTGT
CCGTGCTCCATTTAATAAAG

Downstream 100 bases:

>100_bases
TCCTAATACTTTTTTTCCGGCCGTCTTAGTAATGGAAGACGATGTCCCGGCCGTCTTTGACGGACTCGGCATACCGGTTT
ACATTCTCTTCGATCAGCGT

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein 1; BAP 1; TATA sequence-binding protein 1; TBP 1; TATA-box factor 1 [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MDGKTYSSLKIENIVASGVIAEEIDLAEISEKIDGCELNTKRFPGAVYRIDSPKMASLIFSSGKVVLTGIRNEESLGEGL
AKVLASLKEAGVNVLDVPRVAVTNIVCSYDIGRFINLNRVVATLSLEAIEYEPEQFPGLVYRIKDPKIVALLFSSGKIIL
TGGKNLDDVRKGLDFLEESLKDVLTEQK

Sequences:

>Translated_188_residues
MDGKTYSSLKIENIVASGVIAEEIDLAEISEKIDGCELNTKRFPGAVYRIDSPKMASLIFSSGKVVLTGIRNEESLGEGL
AKVLASLKEAGVNVLDVPRVAVTNIVCSYDIGRFINLNRVVATLSLEAIEYEPEQFPGLVYRIKDPKIVALLFSSGKIIL
TGGKNLDDVRKGLDFLEESLKDVLTEQK
>Mature_188_residues
MDGKTYSSLKIENIVASGVIAEEIDLAEISEKIDGCELNTKRFPGAVYRIDSPKMASLIFSSGKVVLTGIRNEESLGEGL
AKVLASLKEAGVNVLDVPRVAVTNIVCSYDIGRFINLNRVVATLSLEAIEYEPEQFPGLVYRIKDPKIVALLFSSGKIIL
TGGKNLDDVRKGLDFLEESLKDVLTEQK

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation [H]

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family [H]

Homologues:

Organism=Homo sapiens, GI39930602, Length=174, Percent_Identity=36.2068965517241, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI285026520, Length=174, Percent_Identity=35.632183908046, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI4507379, Length=174, Percent_Identity=35.632183908046, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI4759234, Length=184, Percent_Identity=29.8913043478261, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555358, Length=171, Percent_Identity=35.0877192982456, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320996, Length=176, Percent_Identity=35.2272727272727, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136834, Length=172, Percent_Identity=38.3720930232558, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647997, Length=167, Percent_Identity=35.9281437125749, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294 [H]

Pfam domain/function: PF00352 TBP [H]

EC number: NA

Molecular weight: Translated: 20491; Mature: 20491

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGKTYSSLKIENIVASGVIAEEIDLAEISEKIDGCELNTKRFPGAVYRIDSPKMASLIF
CCCCCCCCEEHHHHHHHCHHHHHCCHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHH
SSGKVVLTGIRNEESLGEGLAKVLASLKEAGVNVLDVPRVAVTNIVCSYDIGRFINLNRV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCEEHHHH
VATLSLEAIEYEPEQFPGLVYRIKDPKIVALLFSSGKIILTGGKNLDDVRKGLDFLEESL
HHHEEHHHEECCCCCCCCEEEEECCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHH
KDVLTEQK
HHHHCCCC
>Mature Secondary Structure
MDGKTYSSLKIENIVASGVIAEEIDLAEISEKIDGCELNTKRFPGAVYRIDSPKMASLIF
CCCCCCCCEEHHHHHHHCHHHHHCCHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHH
SSGKVVLTGIRNEESLGEGLAKVLASLKEAGVNVLDVPRVAVTNIVCSYDIGRFINLNRV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCEEHHHH
VATLSLEAIEYEPEQFPGLVYRIKDPKIVALLFSSGKIILTGGKNLDDVRKGLDFLEESL
HHHEEHHHEECCCCCCCCEEEEECCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHH
KDVLTEQK
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]