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The map label for this gene is gppA [H]

Identifier: 124485221

GI number: 124485221

Start: 371368

End: 372279

Strand: Reverse

Name: gppA [H]

Synonym: Mlab_0394

Alternate gene names: 124485221

Gene position: 372279-371368 (Counterclockwise)

Preceding gene: 124485222

Following gene: 124485218

Centisome position: 20.63

GC content: 48.9

Gene sequence:

>912_bases
ATGTACGGTGTAATAGATCTTGGTTCCAACACGGTGCGTCTGGTGTTGTACAAAGTAATCGACAATACCATTGTGCCAAA
GCTCAGCAAAAAACATACGGCGGGGCTGGTCGGGTATGTGAAAAAACGGCGTCTCACCCCGGAAGGTATCCAAAAAGCTG
TAGACGTCCTGAATGATTTCAAGATGATTCTTGAGAACGTCCGGGTCGAACGTCTGTATATATTTGCTACCGCCTCGCTT
CGAAACATAGAAAATACGCTGGAAGTCACGTCAGAGATCAAGAAGCAGACGGGATTCGATGTTGATGTGATAAGCGGCAG
GGAGGAGGCGGTATTCGATTATTACGGAGCGACGCAGACGATCGAAATGCATGACGGTCTTTTGGTGGACATCGGCGGGG
GCAGCACCGAACTGGTTTTTTACAAAGATGATGAGATAATCACCACTGAATCGCTGCCGATCGGCTCATTGAATGCCTAC
ACATCATTTGTCTCCGACCTCCTGCCGACTGCCGAGGAACGAAAGGCTATCGAAAAGGAGGTAACTGCGCAGCTTGCTTC
CATTCCTCTTCCCTGCAAACCTATTCCCACCGATATCATCTGCGGCGTGGGCGGCACGATACGGGCAAGCTGCCGTCTGA
ATCATCTATTGAAAGGAAAAGGATCAACTGGTGCCGAATATTCCTGCCGCGATCTCCAAAAGATGATCGATCTGGCTGAA
ACGAACAGAAAAACCGCGATCTCTCAGATACTCAAGGTTGCTCCCGAAAGAATCCATACACTTGTTCCTGGAATGATCAT
TCAGCAGACGATTGCAGGCTATTATTCCTGCAAAACCGTGATCGTCAGCAGATCGGGAGTGCGTGACGGATATCTCTATC
ATAAACTCGAAACGGCCGGTGTGATTCAATAG

Upstream 100 bases:

>100_bases
GCAACTGATACTCCATACACTCCTTTTTTTCTATAGAATATTATTAAGATGCGTTGCGTGTAAGATAAGAACCAAGTATG
ATTTTGGAGGAATCACCTCG

Downstream 100 bases:

>100_bases
GAATAAAATACTATCCTCAGGCAAAGCGGTGGGCATTGGCAAAACAGTGTTCTGCACGCTCTTTTTCACCAAGGGCAAGA
AGGACAGTTCCTTTTCGTTC

Product: hypothetical protein

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MYGVIDLGSNTVRLVLYKVIDNTIVPKLSKKHTAGLVGYVKKRRLTPEGIQKAVDVLNDFKMILENVRVERLYIFATASL
RNIENTLEVTSEIKKQTGFDVDVISGREEAVFDYYGATQTIEMHDGLLVDIGGGSTELVFYKDDEIITTESLPIGSLNAY
TSFVSDLLPTAEERKAIEKEVTAQLASIPLPCKPIPTDIICGVGGTIRASCRLNHLLKGKGSTGAEYSCRDLQKMIDLAE
TNRKTAISQILKVAPERIHTLVPGMIIQQTIAGYYSCKTVIVSRSGVRDGYLYHKLETAGVIQ

Sequences:

>Translated_303_residues
MYGVIDLGSNTVRLVLYKVIDNTIVPKLSKKHTAGLVGYVKKRRLTPEGIQKAVDVLNDFKMILENVRVERLYIFATASL
RNIENTLEVTSEIKKQTGFDVDVISGREEAVFDYYGATQTIEMHDGLLVDIGGGSTELVFYKDDEIITTESLPIGSLNAY
TSFVSDLLPTAEERKAIEKEVTAQLASIPLPCKPIPTDIICGVGGTIRASCRLNHLLKGKGSTGAEYSCRDLQKMIDLAE
TNRKTAISQILKVAPERIHTLVPGMIIQQTIAGYYSCKTVIVSRSGVRDGYLYHKLETAGVIQ
>Mature_303_residues
MYGVIDLGSNTVRLVLYKVIDNTIVPKLSKKHTAGLVGYVKKRRLTPEGIQKAVDVLNDFKMILENVRVERLYIFATASL
RNIENTLEVTSEIKKQTGFDVDVISGREEAVFDYYGATQTIEMHDGLLVDIGGGSTELVFYKDDEIITTESLPIGSLNAY
TSFVSDLLPTAEERKAIEKEVTAQLASIPLPCKPIPTDIICGVGGTIRASCRLNHLLKGKGSTGAEYSCRDLQKMIDLAE
TNRKTAISQILKVAPERIHTLVPGMIIQQTIAGYYSCKTVIVSRSGVRDGYLYHKLETAGVIQ

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=296, Percent_Identity=24.6621621621622, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI48994966, Length=301, Percent_Identity=24.9169435215947, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 33374; Mature: 33374

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGVIDLGSNTVRLVLYKVIDNTIVPKLSKKHTAGLVGYVKKRRLTPEGIQKAVDVLNDF
CCEEEECCCCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KMILENVRVERLYIFATASLRNIENTLEVTSEIKKQTGFDVDVISGREEAVFDYYGATQT
HHHHHHCCEEEEEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHEECCCCCEE
IEMHDGLLVDIGGGSTELVFYKDDEIITTESLPIGSLNAYTSFVSDLLPTAEERKAIEKE
EEECCCEEEEECCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
VTAQLASIPLPCKPIPTDIICGVGGTIRASCRLNHLLKGKGSTGAEYSCRDLQKMIDLAE
HHHHHHHCCCCCCCCCCHHEECCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
TNRKTAISQILKVAPERIHTLVPGMIIQQTIAGYYSCKTVIVSRSGVRDGYLYHKLETAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEECCCC
VIQ
CCC
>Mature Secondary Structure
MYGVIDLGSNTVRLVLYKVIDNTIVPKLSKKHTAGLVGYVKKRRLTPEGIQKAVDVLNDF
CCEEEECCCCHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KMILENVRVERLYIFATASLRNIENTLEVTSEIKKQTGFDVDVISGREEAVFDYYGATQT
HHHHHHCCEEEEEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHEECCCCCEE
IEMHDGLLVDIGGGSTELVFYKDDEIITTESLPIGSLNAYTSFVSDLLPTAEERKAIEKE
EEECCCEEEEECCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
VTAQLASIPLPCKPIPTDIICGVGGTIRASCRLNHLLKGKGSTGAEYSCRDLQKMIDLAE
HHHHHHHCCCCCCCCCCHHEECCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
TNRKTAISQILKVAPERIHTLVPGMIIQQTIAGYYSCKTVIVSRSGVRDGYLYHKLETAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEECCCC
VIQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA