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The map label for this gene is lhgO [H]

Identifier: 124266223

GI number: 124266223

Start: 1100292

End: 1101413

Strand: Direct

Name: lhgO [H]

Synonym: Mpe_A1030

Alternate gene names: 124266223

Gene position: 1100292-1101413 (Clockwise)

Preceding gene: 124266222

Following gene: 124266224

Centisome position: 27.21

GC content: 74.33

Gene sequence:

>1122_bases
ATGGATCAGGTCGATGCGGTGGTTGTCGGGGCCGGGGTCGTGGGGCTGGCGGTCGGTCGCGCGCTGGCGCGGCGCGGCTT
CGAGACCGTGGTGCTTGAAAGCGAGACCGCGATCGGCACCGTCACCAGCGCGCGCAACAGCGAGGTGATCCATGCCGGCC
TCTACTACCCCTCCGGTTCGCTGAAGGCGCGGCTGTGCGTGGCCGGCAAGGCGGCGCTCTACGCCTACTGCGCCGAGCGC
GGCATCGCGCACCGGCGCTGCGGCAAGCTGATCGTCGCGACCGGGCCGACGCAGCATGCGGCGCTGCACGCGCTGAGCCG
GCGTGCGGCCGACAACGGCGTCGACGACCTGCAACTCCTGACGCCGGACGCTGCGCGTGCGCTCGAACCCGCGCTCGCCT
GCAGCGAGGCACTGCTGTCGCCGTCGACCGGCATCGTCGACAGCCACGGCCTGATGCTCGCGCTGCAGGGCGACCTGGAG
TCGGCCGGCGGCGCGGTGGCGCTGGCCTCGCGCGTCGAGCGCATCGAGGTCGGGCGACCGCACCGTGTGCAGGCAGCCGG
CATGACGCTGGGCGCGCGCATCGTCGTCAATGCCGCCGGGCTGTGGGCGCCGGCGCTCGCACGGCGCACCGAGGGGCTGG
CGCCGGCCTTCCAGCCGCCGGGCCGGTTCGCGAAGGGCAGCTACTTCGCGTTGCCGGGCCGGGCGCCGTTCTCGCATCTC
ATCTACCCGATGCCGGAGGTGGCCGGCCTCGGCGTCCACCTGACGCTCGATCTCGGCGGCCAGGCGCGCTTCGGGCCCGA
TGTGGAATGGGTCGAGCCCGGTCCCGCCGCCGCGGGCGGTGACGGCACGCTCGACTACCGCGTCGACGTTCGGCGCGCCG
ATGGCTTCTATGCGGAGATCCGCCGCTACTGGCCGGCGCTTCCCGACGGCGCGCTGCAGCCGGCCTACAGCGGCGTGCGA
CCCAAGCTGTCGGGCCCGGGCGAGCCGGCGGCCGACTTCCGCATCGACGGCCCGGCCGAGCACGGCATCGAGGGCCTGGT
GAACCTGCTCGGCATCGAGTCGCCGGGCCTGACGGCCAGCCTCGCGCTGGCCGACGAGACGCTGCGGCGCCTGGCTGCGT
GA

Upstream 100 bases:

>100_bases
CTCGGCCAAGAAGACGAGCCGGCGCTGAGTCGCCAGGCACCGGCGTGGCCGGCCGTAGCATCTCAGGCCGGGGCACCCGG
CGGGCGGGGAGGGCGCGCGG

Downstream 100 bases:

>100_bases
GCCGCTGCCTCGAGCAGAACCGGCCCGGAAGGCCGCGGCTCCGCCGGAAAGTATCCTCTGCACCATGTACGCGCAATTCT
TCGGCCTGAGCCAGGAGCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDQVDAVVVGAGVVGLAVGRALARRGFETVVLESETAIGTVTSARNSEVIHAGLYYPSGSLKARLCVAGKAALYAYCAER
GIAHRRCGKLIVATGPTQHAALHALSRRAADNGVDDLQLLTPDAARALEPALACSEALLSPSTGIVDSHGLMLALQGDLE
SAGGAVALASRVERIEVGRPHRVQAAGMTLGARIVVNAAGLWAPALARRTEGLAPAFQPPGRFAKGSYFALPGRAPFSHL
IYPMPEVAGLGVHLTLDLGGQARFGPDVEWVEPGPAAAGGDGTLDYRVDVRRADGFYAEIRRYWPALPDGALQPAYSGVR
PKLSGPGEPAADFRIDGPAEHGIEGLVNLLGIESPGLTASLALADETLRRLAA

Sequences:

>Translated_373_residues
MDQVDAVVVGAGVVGLAVGRALARRGFETVVLESETAIGTVTSARNSEVIHAGLYYPSGSLKARLCVAGKAALYAYCAER
GIAHRRCGKLIVATGPTQHAALHALSRRAADNGVDDLQLLTPDAARALEPALACSEALLSPSTGIVDSHGLMLALQGDLE
SAGGAVALASRVERIEVGRPHRVQAAGMTLGARIVVNAAGLWAPALARRTEGLAPAFQPPGRFAKGSYFALPGRAPFSHL
IYPMPEVAGLGVHLTLDLGGQARFGPDVEWVEPGPAAAGGDGTLDYRVDVRRADGFYAEIRRYWPALPDGALQPAYSGVR
PKLSGPGEPAADFRIDGPAEHGIEGLVNLLGIESPGLTASLALADETLRRLAA
>Mature_373_residues
MDQVDAVVVGAGVVGLAVGRALARRGFETVVLESETAIGTVTSARNSEVIHAGLYYPSGSLKARLCVAGKAALYAYCAER
GIAHRRCGKLIVATGPTQHAALHALSRRAADNGVDDLQLLTPDAARALEPALACSEALLSPSTGIVDSHGLMLALQGDLE
SAGGAVALASRVERIEVGRPHRVQAAGMTLGARIVVNAAGLWAPALARRTEGLAPAFQPPGRFAKGSYFALPGRAPFSHL
IYPMPEVAGLGVHLTLDLGGQARFGPDVEWVEPGPAAAGGDGTLDYRVDVRRADGFYAEIRRYWPALPDGALQPAYSGVR
PKLSGPGEPAADFRIDGPAEHGIEGLVNLLGIESPGLTASLALADETLRRLAA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=271, Percent_Identity=33.9483394833948, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082148, Length=335, Percent_Identity=30.7462686567164, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17565764, Length=280, Percent_Identity=32.8571428571429, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585081, Length=380, Percent_Identity=30.5263157894737, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38688; Mature: 38688

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQVDAVVVGAGVVGLAVGRALARRGFETVVLESETAIGTVTSARNSEVIHAGLYYPSGS
CCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCEEEEEEECCCCC
LKARLCVAGKAALYAYCAERGIAHRRCGKLIVATGPTQHAALHALSRRAADNGVDDLQLL
CEEEEEECCHHHHHHHHHHCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEE
TPDAARALEPALACSEALLSPSTGIVDSHGLMLALQGDLESAGGAVALASRVERIEVGRP
CCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCC
HRVQAAGMTLGARIVVNAAGLWAPALARRTEGLAPAFQPPGRFAKGSYFALPGRAPFSHL
CEEEECCCEECEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCHHHH
IYPMPEVAGLGVHLTLDLGGQARFGPDVEWVEPGPAAAGGDGTLDYRVDVRRADGFYAEI
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEECCCHHHHH
RRYWPALPDGALQPAYSGVRPKLSGPGEPAADFRIDGPAEHGIEGLVNLLGIESPGLTAS
HHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEEE
LALADETLRRLAA
EHHHHHHHHHHCC
>Mature Secondary Structure
MDQVDAVVVGAGVVGLAVGRALARRGFETVVLESETAIGTVTSARNSEVIHAGLYYPSGS
CCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCEEEEEEECCCCC
LKARLCVAGKAALYAYCAERGIAHRRCGKLIVATGPTQHAALHALSRRAADNGVDDLQLL
CEEEEEECCHHHHHHHHHHCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEE
TPDAARALEPALACSEALLSPSTGIVDSHGLMLALQGDLESAGGAVALASRVERIEVGRP
CCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCC
HRVQAAGMTLGARIVVNAAGLWAPALARRTEGLAPAFQPPGRFAKGSYFALPGRAPFSHL
CEEEECCCEECEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCHHHH
IYPMPEVAGLGVHLTLDLGGQARFGPDVEWVEPGPAAAGGDGTLDYRVDVRRADGFYAEI
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEECCCHHHHH
RRYWPALPDGALQPAYSGVRPKLSGPGEPAADFRIDGPAEHGIEGLVNLLGIESPGLTAS
HHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEEE
LALADETLRRLAA
EHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]