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The map label for this gene is lepB [H]

Identifier: 124265841

GI number: 124265841

Start: 682378

End: 683346

Strand: Direct

Name: lepB [H]

Synonym: Mpe_A0648

Alternate gene names: 124265841

Gene position: 682378-683346 (Clockwise)

Preceding gene: 124265840

Following gene: 124265842

Centisome position: 16.87

GC content: 62.64

Gene sequence:

>969_bases
ATGAGTGCATTGACCGGGCTGCTCTATGGCGCCCTCGTGGTTTACCTGGGCGGCTGGTATCTCGGCTCCTGGAGCGGCAA
CTTCTCGCTGCTGCTCTTCATCCTGACGCTGGCGACCTTCGGCTACTGGCTGGCCGAGCGCCTGCACTTCCTGCCGCGAC
GCGTGGCGGCAGCCTCGGCACTGGAGGCGCAGGACGCGCAGCGGCGCAGCGAACTGCAGCGCCAGGGCATCCAGCAGGTC
GATGGCAACGTGGCCGTGGCGCGGGAGCGCGTGTTGGCCCAGCCGTGGTGGCTGGACTGGACCGCGGGCCTGTTCCCGGT
GATCCTGGCGGTCTTCCTGCTGCGCTCCTTCCTGTTCGAACCGTTCAAGATTCCGTCAGGCTCCATGATCCCCACGCTGG
CGATCGGCGATCTCATCCTCGTGAACAAGTTCCACTATGGGGTGAGGCTGCCGGTGATCAACAAGAAGATCCTCGCCAAC
AATGAGCCCCAGCGTGGCGACGTGATGGTGTTTCGCTATCCGGTCGAGCCAGGTGTCGACTACATCAAGCGCGTGGTCGG
TCTGCCGGGTGATGAAGTGGCCTACCTGAACAAGAAGCTCTCGATCAATGGTCAGCCGGTGGAAACACGGCCGCTGCCGG
ATTTCTATGACGAGGACTCGCTGCGCTATGCCCAGCAGGCAAGTGAAAAGCTCGGCGCCGTCGAGCACCGCATCCTGACC
GACAAGGACCGTCCCGGCTTCGTGATCCCGATGCCCCAGTTCCAGAACTTCCGCGACAACTGCCGCTACAACGCCGAAGG
CGTGGTGTGCACCGTGCCCCCGGGCCACTACTTCATGATGGGCGACAACCGGGACAATTCGCAGGATTCGCGCTACTGGG
GCTTCGTGCCCAACGAGAACATCGTCGGCAAGGCCTTCTTTGTCTGGATGAATTTCGGTAACCTCAGGCGAATCGGCTCC
TTCCATTGA

Upstream 100 bases:

>100_bases
AAACAGAAGGCTGGCAAGAAACGCATGAAGCAGATCGGCTCCGTCGAGGTGCCGCAGGAAGCGTTCCTGGCCATCCTCCA
AGTGGACGACTGAACACTTC

Downstream 100 bases:

>100_bases
GCCGGCGCTTCACCAGGAGAACAACGATGGCCTTCGCAGCGTCGGCAACATCGGGTGCGGTCCGCGCGCGCCCTGCCCAG
AGAGGCGTCACCCTGATCGG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSALTGLLYGALVVYLGGWYLGSWSGNFSLLLFILTLATFGYWLAERLHFLPRRVAAASALEAQDAQRRSELQRQGIQQV
DGNVAVARERVLAQPWWLDWTAGLFPVILAVFLLRSFLFEPFKIPSGSMIPTLAIGDLILVNKFHYGVRLPVINKKILAN
NEPQRGDVMVFRYPVEPGVDYIKRVVGLPGDEVAYLNKKLSINGQPVETRPLPDFYDEDSLRYAQQASEKLGAVEHRILT
DKDRPGFVIPMPQFQNFRDNCRYNAEGVVCTVPPGHYFMMGDNRDNSQDSRYWGFVPNENIVGKAFFVWMNFGNLRRIGS
FH

Sequences:

>Translated_322_residues
MSALTGLLYGALVVYLGGWYLGSWSGNFSLLLFILTLATFGYWLAERLHFLPRRVAAASALEAQDAQRRSELQRQGIQQV
DGNVAVARERVLAQPWWLDWTAGLFPVILAVFLLRSFLFEPFKIPSGSMIPTLAIGDLILVNKFHYGVRLPVINKKILAN
NEPQRGDVMVFRYPVEPGVDYIKRVVGLPGDEVAYLNKKLSINGQPVETRPLPDFYDEDSLRYAQQASEKLGAVEHRILT
DKDRPGFVIPMPQFQNFRDNCRYNAEGVVCTVPPGHYFMMGDNRDNSQDSRYWGFVPNENIVGKAFFVWMNFGNLRRIGS
FH
>Mature_321_residues
SALTGLLYGALVVYLGGWYLGSWSGNFSLLLFILTLATFGYWLAERLHFLPRRVAAASALEAQDAQRRSELQRQGIQQVD
GNVAVARERVLAQPWWLDWTAGLFPVILAVFLLRSFLFEPFKIPSGSMIPTLAIGDLILVNKFHYGVRLPVINKKILANN
EPQRGDVMVFRYPVEPGVDYIKRVVGLPGDEVAYLNKKLSINGQPVETRPLPDFYDEDSLRYAQQASEKLGAVEHRILTD
KDRPGFVIPMPQFQNFRDNCRYNAEGVVCTVPPGHYFMMGDNRDNSQDSRYWGFVPNENIVGKAFFVWMNFGNLRRIGSF
H

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=343, Percent_Identity=38.4839650145773, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36567; Mature: 36435

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALTGLLYGALVVYLGGWYLGSWSGNFSLLLFILTLATFGYWLAERLHFLPRRVAAASA
CCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEAQDAQRRSELQRQGIQQVDGNVAVARERVLAQPWWLDWTAGLFPVILAVFLLRSFLFE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PFKIPSGSMIPTLAIGDLILVNKFHYGVRLPVINKKILANNEPQRGDVMVFRYPVEPGVD
CCCCCCCCCCHHHHHCCEEEEEEECCCEECCEECHHHHCCCCCCCCCEEEEEECCCCCHH
YIKRVVGLPGDEVAYLNKKLSINGQPVETRPLPDFYDEDSLRYAQQASEKLGAVEHRILT
HHHHHHCCCCCCEEECCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
DKDRPGFVIPMPQFQNFRDNCRYNAEGVVCTVPPGHYFMMGDNRDNSQDSRYWGFVPNEN
CCCCCCEEEECHHHHCHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCEECCCCCCC
IVGKAFFVWMNFGNLRRIGSFH
CCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SALTGLLYGALVVYLGGWYLGSWSGNFSLLLFILTLATFGYWLAERLHFLPRRVAAASA
CHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEAQDAQRRSELQRQGIQQVDGNVAVARERVLAQPWWLDWTAGLFPVILAVFLLRSFLFE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
PFKIPSGSMIPTLAIGDLILVNKFHYGVRLPVINKKILANNEPQRGDVMVFRYPVEPGVD
CCCCCCCCCCHHHHHCCEEEEEEECCCEECCEECHHHHCCCCCCCCCEEEEEECCCCCHH
YIKRVVGLPGDEVAYLNKKLSINGQPVETRPLPDFYDEDSLRYAQQASEKLGAVEHRILT
HHHHHHCCCCCCEEECCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
DKDRPGFVIPMPQFQNFRDNCRYNAEGVVCTVPPGHYFMMGDNRDNSQDSRYWGFVPNEN
CCCCCCEEEECHHHHCHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCEECCCCCCC
IVGKAFFVWMNFGNLRRIGSFH
CCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]