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The map label for this gene is recQ [H]

Identifier: 124265301

GI number: 124265301

Start: 110768

End: 112555

Strand: Reverse

Name: recQ [H]

Synonym: Mpe_A0108

Alternate gene names: 124265301

Gene position: 112555-110768 (Counterclockwise)

Preceding gene: 124265302

Following gene: 124265298

Centisome position: 2.78

GC content: 71.53

Gene sequence:

>1788_bases
GTGAGCGCCGGCGGCGACGCGCTGGTGCTGATGCCCACCGGCGGTGGCAAGAGCCTGTGCTACCAGGTGCCGGCGATCGC
GCGCCACCGCGCCGGCCACGGCGTGGCCGTGGTGGTGAGCCCGCTGATCGCGCTGATGCACGACCAGGTCGGCGCGCTCG
AGGAAGCCGGCGTGCATGCGGCCTTCCTCAACTCCTCGCTCGAACTCGCCGACGTGCAGCGCATCGAGCGCGAGATGATG
AGCGGCCGCCTGGTGCTGCTGTACGCTGCGCCGGAGCGGCTGACCACGCCGCGCATGCTGGGTCAGCTCGACTCGCTGCA
CGAGCGCGGACTGCTGAGCCTGTTCGCGATCGACGAGGCGCACTGCGTGAGCCAGTGGGGCCACGACTTCCGCGAGGACT
ACCTGGGCCTGCACGTGCTGCACGAGCGCTATGCCGACGTGCCGCGCATCGCGCTCACCGCGACGGCCGACGAGCACACG
CGCGCCGACATCGTGTCGCGCCTGCAGCTCGAGGACGCGCGCGTCTTCATCAGCAGCTTCGATCGGCCGAACATCCGCTA
CCGCGTGGTCGAAAAGGACGATCCGCGCAAGCAGCTGCTGCGCTTCATCGGCGACGAGCACGAGGGCGATGCCGGCATCG
TGTACTGCCAGTCGCGCAAGAAGGTCGACGAGACCGCGGCCTGGCTCGAGACGGAGGGCATCACCGCGCTGCCCTACCAC
GCCGGGCTCGACGCCGCGGTGCGGCAGCGGCACCAGAACCGCTTCCTGCGCGAGGACGGCATCGTGATGGTCGCGACCAT
CGCGTTCGGCATGGGCATCGACAAGCCCGACGTGCGCTTCGTCGCCCACCTCGACCTGCCGAAGAACATCGAGAGCTACT
ACCAGGAGACCGGCCGCGCCGGCCGCGACGGCGAGCCCGCCGAGGCCTGGATGGCCTACGGCCTGGCCGACGTGGTGAAC
CAGCGCCGCATGATCGACGACAGCCCGGCCGGCGAGGAGTTCAAGCGCGCCCAGCGCGGCAAGCTCGACGCGCTGCTGGC
GCTGGCCGAGGCGCACGACTGCCGCCGCATGCGGTTGCTCGATTACTTCGGCGAGCCCAGTCGGTCCTGCGGAAACTGCG
ACAACTGCCTGAATCCGCCGGCGGTGTGGGACGCCACCGAGGCCGCGCGCAAGCTGCTGTCGTGCATCTACCGCTTCGGT
CAGCACGGCCGCGGGCCGCGCAGCTTCGGCGCCGCTCACCTGATCGACGTGCTGCGCGGCAAGGCCACCGAGAAGGTCGC
ACAGTACGGCCACGACGGCCTGTCGACCTTCGGCGTCGGCGCCGACCTGTCCGAGCAGCAGTGGCGAGGCGTGCTGCGCC
AGCTGGTCGCGCTGGGCCATGTGGTGTCCGAGGGCGAATACAACACGCTGGCGCTGACCGACGGCGCGCGCGCGGTGCTC
AAGGGCGAGGTGCAGTTGCTGCTGCGCGTGCCGAGCGACACACCGAAGCGCGGACGCCTCGCCCGCGGCGGTGGCAGCGC
CGGCCGGGGTGCGAAGGGCAGCGGCGCGCCAGCCGACCTGGACGCCGCCGCGCAGGTTCGCTTCGAGGCCTTGCGCGCCT
GGCGCGGCGAGGTGGCGCGTGAGCACAACCTGCCCACCTACATCATCTTCTCGAACGCCACGCTGGCCGAGATGGCGCGC
CGTGCGCCGGCCACGCTGGGCGACCTGGGCGAGGTCAGCGGGGTCGGCGCGAAGAAGCTCGAGGCCTACGGGCGCGAGAT
CCTGCGGGTGCTGGACGCGGGGCGCTGA

Upstream 100 bases:

>100_bases
AACCGACCCGACCCTGCCCGCCACCGACCCGCTGAACGTGCTGCAGCAGGTGTTCGGCTACACCGCCTTCCGCGGACACT
AGGCCGAGATCGTCGACCAC

Downstream 100 bases:

>100_bases
GCGTCGGCACGAGGCCGGCAGCTGCAGCGTCTCCGTCTCCCGATCGTCTCTCGTCGACGACGCCCCGCTCAGGGACCGAT
GCCGACCGACACGACCGCAC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSAGGDALVLMPTGGGKSLCYQVPAIARHRAGHGVAVVVSPLIALMHDQVGALEEAGVHAAFLNSSLELADVQRIEREMM
SGRLVLLYAAPERLTTPRMLGQLDSLHERGLLSLFAIDEAHCVSQWGHDFREDYLGLHVLHERYADVPRIALTATADEHT
RADIVSRLQLEDARVFISSFDRPNIRYRVVEKDDPRKQLLRFIGDEHEGDAGIVYCQSRKKVDETAAWLETEGITALPYH
AGLDAAVRQRHQNRFLREDGIVMVATIAFGMGIDKPDVRFVAHLDLPKNIESYYQETGRAGRDGEPAEAWMAYGLADVVN
QRRMIDDSPAGEEFKRAQRGKLDALLALAEAHDCRRMRLLDYFGEPSRSCGNCDNCLNPPAVWDATEAARKLLSCIYRFG
QHGRGPRSFGAAHLIDVLRGKATEKVAQYGHDGLSTFGVGADLSEQQWRGVLRQLVALGHVVSEGEYNTLALTDGARAVL
KGEVQLLLRVPSDTPKRGRLARGGGSAGRGAKGSGAPADLDAAAQVRFEALRAWRGEVAREHNLPTYIIFSNATLAEMAR
RAPATLGDLGEVSGVGAKKLEAYGREILRVLDAGR

Sequences:

>Translated_595_residues
MSAGGDALVLMPTGGGKSLCYQVPAIARHRAGHGVAVVVSPLIALMHDQVGALEEAGVHAAFLNSSLELADVQRIEREMM
SGRLVLLYAAPERLTTPRMLGQLDSLHERGLLSLFAIDEAHCVSQWGHDFREDYLGLHVLHERYADVPRIALTATADEHT
RADIVSRLQLEDARVFISSFDRPNIRYRVVEKDDPRKQLLRFIGDEHEGDAGIVYCQSRKKVDETAAWLETEGITALPYH
AGLDAAVRQRHQNRFLREDGIVMVATIAFGMGIDKPDVRFVAHLDLPKNIESYYQETGRAGRDGEPAEAWMAYGLADVVN
QRRMIDDSPAGEEFKRAQRGKLDALLALAEAHDCRRMRLLDYFGEPSRSCGNCDNCLNPPAVWDATEAARKLLSCIYRFG
QHGRGPRSFGAAHLIDVLRGKATEKVAQYGHDGLSTFGVGADLSEQQWRGVLRQLVALGHVVSEGEYNTLALTDGARAVL
KGEVQLLLRVPSDTPKRGRLARGGGSAGRGAKGSGAPADLDAAAQVRFEALRAWRGEVAREHNLPTYIIFSNATLAEMAR
RAPATLGDLGEVSGVGAKKLEAYGREILRVLDAGR
>Mature_594_residues
SAGGDALVLMPTGGGKSLCYQVPAIARHRAGHGVAVVVSPLIALMHDQVGALEEAGVHAAFLNSSLELADVQRIEREMMS
GRLVLLYAAPERLTTPRMLGQLDSLHERGLLSLFAIDEAHCVSQWGHDFREDYLGLHVLHERYADVPRIALTATADEHTR
ADIVSRLQLEDARVFISSFDRPNIRYRVVEKDDPRKQLLRFIGDEHEGDAGIVYCQSRKKVDETAAWLETEGITALPYHA
GLDAAVRQRHQNRFLREDGIVMVATIAFGMGIDKPDVRFVAHLDLPKNIESYYQETGRAGRDGEPAEAWMAYGLADVVNQ
RRMIDDSPAGEEFKRAQRGKLDALLALAEAHDCRRMRLLDYFGEPSRSCGNCDNCLNPPAVWDATEAARKLLSCIYRFGQ
HGRGPRSFGAAHLIDVLRGKATEKVAQYGHDGLSTFGVGADLSEQQWRGVLRQLVALGHVVSEGEYNTLALTDGARAVLK
GEVQLLLRVPSDTPKRGRLARGGGSAGRGAKGSGAPADLDAAAQVRFEALRAWRGEVAREHNLPTYIIFSNATLAEMARR
APATLGDLGEVSGVGAKKLEAYGREILRVLDAGR

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=636, Percent_Identity=34.748427672956, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI14591902, Length=437, Percent_Identity=35.9267734553776, Blast_Score=275, Evalue=9e-74,
Organism=Homo sapiens, GI14591904, Length=437, Percent_Identity=35.9267734553776, Blast_Score=275, Evalue=9e-74,
Organism=Homo sapiens, GI148612816, Length=409, Percent_Identity=40.3422982885086, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI110735439, Length=568, Percent_Identity=32.3943661971831, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI169218196, Length=568, Percent_Identity=32.3943661971831, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI51242947, Length=370, Percent_Identity=41.0810810810811, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI51242943, Length=370, Percent_Identity=41.0810810810811, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI284005309, Length=323, Percent_Identity=36.8421052631579, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI48994977, Length=593, Percent_Identity=46.2057335581787, Blast_Score=505, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI25145561, Length=483, Percent_Identity=39.7515527950311, Blast_Score=310, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71987997, Length=383, Percent_Identity=40.2088772845953, Blast_Score=291, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI71987993, Length=383, Percent_Identity=40.2088772845953, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI32564293, Length=648, Percent_Identity=31.4814814814815, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17552866, Length=420, Percent_Identity=36.1904761904762, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17555296, Length=334, Percent_Identity=23.6526946107784, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=466, Percent_Identity=37.1244635193133, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6321360, Length=352, Percent_Identity=25.2840909090909, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24646066, Length=613, Percent_Identity=36.5415986949429, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24664226, Length=414, Percent_Identity=37.9227053140097, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24664230, Length=414, Percent_Identity=37.9227053140097, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI62472181, Length=414, Percent_Identity=37.9227053140097, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI21358123, Length=329, Percent_Identity=36.1702127659575, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 65127; Mature: 64996

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGGDALVLMPTGGGKSLCYQVPAIARHRAGHGVAVVVSPLIALMHDQVGALEEAGVHA
CCCCCCEEEEEECCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AFLNSSLELADVQRIEREMMSGRLVLLYAAPERLTTPRMLGQLDSLHERGLLSLFAIDEA
HHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCHH
HCVSQWGHDFREDYLGLHVLHERYADVPRIALTATADEHTRADIVSRLQLEDARVFISSF
HHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
DRPNIRYRVVEKDDPRKQLLRFIGDEHEGDAGIVYCQSRKKVDETAAWLETEGITALPYH
CCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEECCCC
AGLDAAVRQRHQNRFLREDGIVMVATIAFGMGIDKPDVRFVAHLDLPKNIESYYQETGRA
CCCCHHHHHHHHHHHHHHCCEEEEEEHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCC
GRDGEPAEAWMAYGLADVVNQRRMIDDSPAGEEFKRAQRGKLDALLALAEAHDCRRMRLL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DYFGEPSRSCGNCDNCLNPPAVWDATEAARKLLSCIYRFGQHGRGPRSFGAAHLIDVLRG
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
KATEKVAQYGHDGLSTFGVGADLSEQQWRGVLRQLVALGHVVSEGEYNTLALTDGARAVL
CHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHH
KGEVQLLLRVPSDTPKRGRLARGGGSAGRGAKGSGAPADLDAAAQVRFEALRAWRGEVAR
HCCEEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EHNLPTYIIFSNATLAEMARRAPATLGDLGEVSGVGAKKLEAYGREILRVLDAGR
HCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAGGDALVLMPTGGGKSLCYQVPAIARHRAGHGVAVVVSPLIALMHDQVGALEEAGVHA
CCCCCEEEEEECCCCCCCEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AFLNSSLELADVQRIEREMMSGRLVLLYAAPERLTTPRMLGQLDSLHERGLLSLFAIDEA
HHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCHH
HCVSQWGHDFREDYLGLHVLHERYADVPRIALTATADEHTRADIVSRLQLEDARVFISSF
HHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
DRPNIRYRVVEKDDPRKQLLRFIGDEHEGDAGIVYCQSRKKVDETAAWLETEGITALPYH
CCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEECCCC
AGLDAAVRQRHQNRFLREDGIVMVATIAFGMGIDKPDVRFVAHLDLPKNIESYYQETGRA
CCCCHHHHHHHHHHHHHHCCEEEEEEHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCC
GRDGEPAEAWMAYGLADVVNQRRMIDDSPAGEEFKRAQRGKLDALLALAEAHDCRRMRLL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
DYFGEPSRSCGNCDNCLNPPAVWDATEAARKLLSCIYRFGQHGRGPRSFGAAHLIDVLRG
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
KATEKVAQYGHDGLSTFGVGADLSEQQWRGVLRQLVALGHVVSEGEYNTLALTDGARAVL
CHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHH
KGEVQLLLRVPSDTPKRGRLARGGGSAGRGAKGSGAPADLDAAAQVRFEALRAWRGEVAR
HCCEEEEEECCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EHNLPTYIIFSNATLAEMARRAPATLGDLGEVSGVGAKKLEAYGREILRVLDAGR
HCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]