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The map label for this gene is tctD [H]

Identifier: 124265269

GI number: 124265269

Start: 70626

End: 71297

Strand: Direct

Name: tctD [H]

Synonym: Mpe_A0076

Alternate gene names: 124265269

Gene position: 70626-71297 (Clockwise)

Preceding gene: 124265266

Following gene: 124265270

Centisome position: 1.75

GC content: 67.86

Gene sequence:

>672_bases
ATGAGGATCCTCATCGCCGAAGACGACCAGGTGCTGGCCGACGGTCTGTTGCGCACCTTGCGCAAGGGTGGCTATGCGGT
GGATCAGGTCGGAAGCGGCAGCGAGGCCGATGCGGCGCTGGCCGACCACGAGTTCGACCTGGTGATCCTCGATCTCGGAC
TGCCCAAGCTGCACGGCCTGGAGGTGCTGCGCAAGATGCGCGCGCGCGGCACCGTGACGCCAGTGCTGATCCTGACCGCG
GCCGACAGCGTGGAGCAGCGCGTGAAGGGGCTGGACCTGGGGGCCGACGACTACATGGCCAAGCCCTTCGCGCTGCAGGA
ACTGGAGGCGCGCGTGCGAGCGCTGACGCGGCGTGGCCTGGGCACCGCCTCGGCCATCATCAAGCACGGCCCGCTGTCGT
TCGATGCAACTGGGCGCGTGGCCTACCTGAACGACCAGATGATCGAGCTGTCGGCTCGCGAGCTCTCGCTGCTCGAGGTG
CTGCTGCAGCGTGCCGGCCGGCTGGTCAGCAAGGATCAGCTGGTCGAGCGCCTGTGCGAATGGGGCGACGAGGTCAGCAA
CAACGCGATCGAGGTCTACATCCACCGCCTGCGCAAGAAGATCGAGCAGGGCCCGGTGCGCATCGCCACCGTGCGCGGCC
TGGGCTACTGCCTCGAGAAGATCGCGGGCTGA

Upstream 100 bases:

>100_bases
TATTTGTACAGTAGTTTTTGGCTCTTCCGAAGCCCCTCCCTACAATGAACCCGGCGCTGACCACAACGAAACCCATGGCG
CCGCCGAGGGAGACACGTCC

Downstream 100 bases:

>100_bases
GCCGGCATGCTGCGCGGCGCGCGCCTTCGGGCATGAACACGCTGCGCGGACAACGCTCGCTGTTCGGCGAGATCCTCGAC
TGGATGCTCGCGCCGCTGCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILIAEDDQVLADGLLRTLRKGGYAVDQVGSGSEADAALADHEFDLVILDLGLPKLHGLEVLRKMRARGTVTPVLILTA
ADSVEQRVKGLDLGADDYMAKPFALQELEARVRALTRRGLGTASAIIKHGPLSFDATGRVAYLNDQMIELSARELSLLEV
LLQRAGRLVSKDQLVERLCEWGDEVSNNAIEVYIHRLRKKIEQGPVRIATVRGLGYCLEKIAG

Sequences:

>Translated_223_residues
MRILIAEDDQVLADGLLRTLRKGGYAVDQVGSGSEADAALADHEFDLVILDLGLPKLHGLEVLRKMRARGTVTPVLILTA
ADSVEQRVKGLDLGADDYMAKPFALQELEARVRALTRRGLGTASAIIKHGPLSFDATGRVAYLNDQMIELSARELSLLEV
LLQRAGRLVSKDQLVERLCEWGDEVSNNAIEVYIHRLRKKIEQGPVRIATVRGLGYCLEKIAG
>Mature_223_residues
MRILIAEDDQVLADGLLRTLRKGGYAVDQVGSGSEADAALADHEFDLVILDLGLPKLHGLEVLRKMRARGTVTPVLILTA
ADSVEQRVKGLDLGADDYMAKPFALQELEARVRALTRRGLGTASAIIKHGPLSFDATGRVAYLNDQMIELSARELSLLEV
LLQRAGRLVSKDQLVERLCEWGDEVSNNAIEVYIHRLRKKIEQGPVRIATVRGLGYCLEKIAG

Specific function: Transcriptional activator of the tctI tricarboxylate transport system operon [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=45.8715596330275, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=42.2018348623853, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=40.2714932126697, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=37.7777777777778, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.4545454545455, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=34.841628959276, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.1877729257642, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=33.9366515837104, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=33.1838565022422, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.3008849557522, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.5309734513274, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.4561403508772, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=33.0434782608696, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24450; Mature: 24450

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIAEDDQVLADGLLRTLRKGGYAVDQVGSGSEADAALADHEFDLVILDLGLPKLHGL
CEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHCCCCCCEEEEECCCCCHHHH
EVLRKMRARGTVTPVLILTAADSVEQRVKGLDLGADDYMAKPFALQELEARVRALTRRGL
HHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
GTASAIIKHGPLSFDATGRVAYLNDQMIELSARELSLLEVLLQRAGRLVSKDQLVERLCE
CHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
WGDEVSNNAIEVYIHRLRKKIEQGPVRIATVRGLGYCLEKIAG
HCHHHCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MRILIAEDDQVLADGLLRTLRKGGYAVDQVGSGSEADAALADHEFDLVILDLGLPKLHGL
CEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHCCCCCCEEEEECCCCCHHHH
EVLRKMRARGTVTPVLILTAADSVEQRVKGLDLGADDYMAKPFALQELEARVRALTRRGL
HHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCC
GTASAIIKHGPLSFDATGRVAYLNDQMIELSARELSLLEVLLQRAGRLVSKDQLVERLCE
CHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
WGDEVSNNAIEVYIHRLRKKIEQGPVRIATVRGLGYCLEKIAG
HCHHHCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666399; 11083839; 11677609 [H]