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The map label for this gene is estA [H]

Identifier: 124265247

GI number: 124265247

Start: 51426

End: 52172

Strand: Reverse

Name: estA [H]

Synonym: Mpe_A0054

Alternate gene names: 124265247

Gene position: 52172-51426 (Counterclockwise)

Preceding gene: 124265249

Following gene: 124265241

Centisome position: 1.29

GC content: 72.56

Gene sequence:

>747_bases
GTGGTTGCGCGCGAGCGTAACGCAGCCTTGGCCGCGGGCGTGCCACGGGTAGGATCACCGGGAACCCACCGAAAGCCCCT
GATGACGACCCTCGACTGCATCGAGATCCAGACCACCGAACACCCCGCCGCCAGCATCATCGTGCTGCACGGCCTGGGCG
CCGACGGCAACGACTTCGTGCCGATCTGCGAGGAGCTCGACCTCGACGCCGTCGGCGGCGCGCGCTTCGTCTTCCCGCAC
GCGCCGACGCGGCCGGTCACGATCAACGGGGGCTACGTGATGCGCGCCTGGTACGACATCCTCGGCCCCGACGGGCCGCG
CCGCGAGGACGAAGCCGGGCTGCGCGCATCACTGGAGCTGGTGCGCGCGCTGATCGAACGCGAGAACGCGCGCGGCATCC
CCAGCTCGCGCATCGTGCTGGCCGGCTTCTCGCAGGGCTGCGCGATGACGCTGCTGACCGGCCTGCGCCACGGCGAGCGC
CTCGCGGGCCTGGCCGGCCTCTCGGGCTACCTGCCGCTGGCGCCAGTGACCGCCGACGAGCGCAGCGCGGCCAACGCCGA
CGTGCCGATCTTCCTGGCCCACGGCCGCGCCGACCCGGTGATCCCGCTCGCGCGCGCCACCGCCTCGCGCGACGCGCTGC
AGGCGCTGGGCTATGTGGTGGAGTGGCACGAATACCCGATGCCGCACTCGGTGTGCCCGGAGGAGATCGTCGACCTGAAC
CGCTGGCTGCTGCGCGTGCTGGCCTGA

Upstream 100 bases:

>100_bases
GCCAGCGTGCGCGTGCGCCAGGGCTCCGCAAAGATGCGCACCGAGTGCGTGCCGAGAAAGAGAACAAGGCCGAGGATCAG
GACGAGCATGAAGGACTCCG

Downstream 100 bases:

>100_bases
GGCCGCGCGACGGGAGGGGGTCCGCGGCTTATGACACCTCTTCGGTCGTCACCTCGAAGCGCAGCAGCTGGTTCTGCCCG
AAGGCCATCGTGATCGGCAC

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MVARERNAALAAGVPRVGSPGTHRKPLMTTLDCIEIQTTEHPAASIIVLHGLGADGNDFVPICEELDLDAVGGARFVFPH
APTRPVTINGGYVMRAWYDILGPDGPRREDEAGLRASLELVRALIERENARGIPSSRIVLAGFSQGCAMTLLTGLRHGER
LAGLAGLSGYLPLAPVTADERSAANADVPIFLAHGRADPVIPLARATASRDALQALGYVVEWHEYPMPHSVCPEEIVDLN
RWLLRVLA

Sequences:

>Translated_248_residues
MVARERNAALAAGVPRVGSPGTHRKPLMTTLDCIEIQTTEHPAASIIVLHGLGADGNDFVPICEELDLDAVGGARFVFPH
APTRPVTINGGYVMRAWYDILGPDGPRREDEAGLRASLELVRALIERENARGIPSSRIVLAGFSQGCAMTLLTGLRHGER
LAGLAGLSGYLPLAPVTADERSAANADVPIFLAHGRADPVIPLARATASRDALQALGYVVEWHEYPMPHSVCPEEIVDLN
RWLLRVLA
>Mature_248_residues
MVARERNAALAAGVPRVGSPGTHRKPLMTTLDCIEIQTTEHPAASIIVLHGLGADGNDFVPICEELDLDAVGGARFVFPH
APTRPVTINGGYVMRAWYDILGPDGPRREDEAGLRASLELVRALIERENARGIPSSRIVLAGFSQGCAMTLLTGLRHGER
LAGLAGLSGYLPLAPVTADERSAANADVPIFLAHGRADPVIPLARATASRDALQALGYVVEWHEYPMPHSVCPEEIVDLN
RWLLRVLA

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI5453722, Length=213, Percent_Identity=37.5586854460094, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI9966764, Length=232, Percent_Identity=36.6379310344828, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI20270341, Length=209, Percent_Identity=27.7511961722488, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17508057, Length=206, Percent_Identity=37.8640776699029, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323147, Length=213, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=7e-28,
Organism=Drosophila melanogaster, GI45553055, Length=213, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI45553057, Length=213, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21357257, Length=213, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161078179, Length=235, Percent_Identity=28.936170212766, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 26612; Mature: 26612

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARERNAALAAGVPRVGSPGTHRKPLMTTLDCIEIQTTEHPAASIIVLHGLGADGNDFV
CCCCCCCCHHCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCEEEEEEEECCCCCCCCC
PICEELDLDAVGGARFVFPHAPTRPVTINGGYVMRAWYDILGPDGPRREDEAGLRASLEL
HHHHHCCCCCCCCEEEEECCCCCCCEEECCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHH
VRALIERENARGIPSSRIVLAGFSQGCAMTLLTGLRHGERLAGLAGLSGYLPLAPVTADE
HHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
RSAANADVPIFLAHGRADPVIPLARATASRDALQALGYVVEWHEYPMPHSVCPEEIVDLN
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RWLLRVLA
HHHHHHHC
>Mature Secondary Structure
MVARERNAALAAGVPRVGSPGTHRKPLMTTLDCIEIQTTEHPAASIIVLHGLGADGNDFV
CCCCCCCCHHCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCEEEEEEEECCCCCCCCC
PICEELDLDAVGGARFVFPHAPTRPVTINGGYVMRAWYDILGPDGPRREDEAGLRASLEL
HHHHHCCCCCCCCEEEEECCCCCCCEEECCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHH
VRALIERENARGIPSSRIVLAGFSQGCAMTLLTGLRHGERLAGLAGLSGYLPLAPVTADE
HHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
RSAANADVPIFLAHGRADPVIPLARATASRDALQALGYVVEWHEYPMPHSVCPEEIVDLN
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RWLLRVLA
HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA