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The map label for this gene is trxB [H]

Identifier: 124265205

GI number: 124265205

Start: 15560

End: 17260

Strand: Direct

Name: trxB [H]

Synonym: Mpe_A0012

Alternate gene names: 124265205

Gene position: 15560-17260 (Clockwise)

Preceding gene: 124265204

Following gene: 124265206

Centisome position: 0.38

GC content: 74.78

Gene sequence:

>1701_bases
ATGGCCGCAGACCTGCCGACCGACGGCGCCCCCAATCGCCGCCACCAGATGTTCCCGGTGCTGAGCGACACCGAGATCGC
GCGCATCAGCCGCTTCGGCAGCGTGTGCCGCTATGCGCGCGGCGAGCGGTTGTTCACGTCGGGCGAGGTGGGCCCGGGCA
TGTTCGTGCTGCTGTCCGGTGTGGTGTCGGTCACCCACCGCGACGGCCTGGGCCACGTGCTGCCGCTGGTGCGCCAGGGG
CCGGGCGAGTTCCTGGCCGAAGTGGGCCAGCTCTCGGGCCGCCCGGCGCTGGTGGACGGCACGGCCGAAGAGGCGGTGGA
GGCGCTGCTGGTGCCGCCCGGTCAGCTGCGCGCGCTGCTGGTGGCCGAGGCCGAACTGGGCGAGCGCATCACCCGCGCGC
TGATCCTGCGGCGCGTGTCGCTCATCGAATCGGGGGCTAGCGGCCCGGTCCTGATCGGCCCGTCGACCGCGCCCGACATG
CTGCGCCTGCAGGCCTTCCTGCGCCGCAACGGCCAGCCCTACCAGATGGTCTGCGCGCGCAAGGACGCCGACGCGGCGGC
GCTGATCGCGCAGTACGGCGCGGCCGCGGACGAGGTGGTGGTGGTCTGCCCCGACGGCTCGGTGTTGCTCAATCCCGGCG
AGGACGCGCTGGCGCGCTGCATCGGCATGGTCGACACGGCCGAGCGCGACGAGCTGTTCGACGTGGTGGTGGTCGGTGCG
GGCCCGGCGGGGCTGGCCACCGCGGTCTACGCGGCCTCGGAAGGCCTGAGCGTGGTGGTGCTCGACTGCCGCGCCTACGG
CGGCCAGGCCGGCGCCAGCGCGCGCATCGAGAACTACCTCGGTTTTCCCACGGGCATCTCGGGTCAGGCGCTGGCCGGGC
GGGCCTTCGTGCAGGCGCAAAAGTTCGGCGCGGAGATGCTGATCCCGGCGCAGGCCGTCGGTCTGGACTGCAGCCGCGCG
AAGGACGGCCCGGCGGCCGAGCTGCACGTGAAGCTCGCCGACGGGCGGAGGCTGCGCGGGCGCAGCGTGGTCGTGGCCAG
CGGCGCGCGCTACCGCCGCCCGGCCGTGCCGCGCCTGGCCGAGTTCGAGGGCCGGGGCGTCTGGTACTGGGCCTCGGCGG
TGGAGGCGCGCCTGTGCGCGCAGGCCGAGGTGGCGCTCATCGGCGGCGGCAACTCGGCGGGCCAGGCGGCGGTGTTCCTG
GCCCAGCATGCCGTGGCCGTGCACATGCTGGTGCGCAGCGCCGGCCTCGCGGCCAGTATGTCGCGCTACCTCATCGACCG
CATCGAGGCCACGCCCAACATCCACCTGCGTTCGCACACCGAGCTGTCGCGGCTGGACGGCTGCACCGCCGAGGGCCTGG
AAGGCCTGGCCTGGCGCGACCACCGCAGCGGCGCCGAGGAGGCGCGTCGCATCCGCCACCTGTTCCTGTTCGTCGGCGCC
GATCCGGAGGCGGCGTGGCTGCAGGGCTGCGGCGTGGCGGTCGACGCGCACGGCTTCGTGCGCACCGGCCAGGCGATCGA
AGGCGCGGCCGGCGACGGCTACCGGCCGGCCGCGCTGGAGTCCAACGTGCCCGGCGTGTTCGCGGTGGGCGACGTGCGCT
CGGGCTCCGTCAAGCGCGTCGGCGGCGCCATCGGCGAAGGCGCCGCGGCGGTGGCGATGATTCACCAGTTCCTGGCGGCG
CGGGCGCCGGTCGCCGTCTAG

Upstream 100 bases:

>100_bases
CGCGCGCTCGGAGATCCGACTCCGCGCCAGAATCAAGCCGCGCTCTTGCCGAGGTCAGGCCCGCTCCGGCCGCCTCCCTG
AAGCGCCCTCGGAGGTGAAG

Downstream 100 bases:

>100_bases
CGTCGCGACCGACCGCCTCGCGCGGCGGGCCTGCGCCACCGGCGCAAACGCCCTTGTGCGAGAGCGTGGTGCGTGGTCTA
TTGGTCCGAGGAGGACACCA

Product: cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MAADLPTDGAPNRRHQMFPVLSDTEIARISRFGSVCRYARGERLFTSGEVGPGMFVLLSGVVSVTHRDGLGHVLPLVRQG
PGEFLAEVGQLSGRPALVDGTAEEAVEALLVPPGQLRALLVAEAELGERITRALILRRVSLIESGASGPVLIGPSTAPDM
LRLQAFLRRNGQPYQMVCARKDADAAALIAQYGAAADEVVVVCPDGSVLLNPGEDALARCIGMVDTAERDELFDVVVVGA
GPAGLATAVYAASEGLSVVVLDCRAYGGQAGASARIENYLGFPTGISGQALAGRAFVQAQKFGAEMLIPAQAVGLDCSRA
KDGPAAELHVKLADGRRLRGRSVVVASGARYRRPAVPRLAEFEGRGVWYWASAVEARLCAQAEVALIGGGNSAGQAAVFL
AQHAVAVHMLVRSAGLAASMSRYLIDRIEATPNIHLRSHTELSRLDGCTAEGLEGLAWRDHRSGAEEARRIRHLFLFVGA
DPEAAWLQGCGVAVDAHGFVRTGQAIEGAAGDGYRPAALESNVPGVFAVGDVRSGSVKRVGGAIGEGAAAVAMIHQFLAA
RAPVAV

Sequences:

>Translated_566_residues
MAADLPTDGAPNRRHQMFPVLSDTEIARISRFGSVCRYARGERLFTSGEVGPGMFVLLSGVVSVTHRDGLGHVLPLVRQG
PGEFLAEVGQLSGRPALVDGTAEEAVEALLVPPGQLRALLVAEAELGERITRALILRRVSLIESGASGPVLIGPSTAPDM
LRLQAFLRRNGQPYQMVCARKDADAAALIAQYGAAADEVVVVCPDGSVLLNPGEDALARCIGMVDTAERDELFDVVVVGA
GPAGLATAVYAASEGLSVVVLDCRAYGGQAGASARIENYLGFPTGISGQALAGRAFVQAQKFGAEMLIPAQAVGLDCSRA
KDGPAAELHVKLADGRRLRGRSVVVASGARYRRPAVPRLAEFEGRGVWYWASAVEARLCAQAEVALIGGGNSAGQAAVFL
AQHAVAVHMLVRSAGLAASMSRYLIDRIEATPNIHLRSHTELSRLDGCTAEGLEGLAWRDHRSGAEEARRIRHLFLFVGA
DPEAAWLQGCGVAVDAHGFVRTGQAIEGAAGDGYRPAALESNVPGVFAVGDVRSGSVKRVGGAIGEGAAAVAMIHQFLAA
RAPVAV
>Mature_565_residues
AADLPTDGAPNRRHQMFPVLSDTEIARISRFGSVCRYARGERLFTSGEVGPGMFVLLSGVVSVTHRDGLGHVLPLVRQGP
GEFLAEVGQLSGRPALVDGTAEEAVEALLVPPGQLRALLVAEAELGERITRALILRRVSLIESGASGPVLIGPSTAPDML
RLQAFLRRNGQPYQMVCARKDADAAALIAQYGAAADEVVVVCPDGSVLLNPGEDALARCIGMVDTAERDELFDVVVVGAG
PAGLATAVYAASEGLSVVVLDCRAYGGQAGASARIENYLGFPTGISGQALAGRAFVQAQKFGAEMLIPAQAVGLDCSRAK
DGPAAELHVKLADGRRLRGRSVVVASGARYRRPAVPRLAEFEGRGVWYWASAVEARLCAQAEVALIGGGNSAGQAAVFLA
QHAVAVHMLVRSAGLAASMSRYLIDRIEATPNIHLRSHTELSRLDGCTAEGLEGLAWRDHRSGAEEARRIRHLFLFVGAD
PEAAWLQGCGVAVDAHGFVRTGQAIEGAAGDGYRPAALESNVPGVFAVGDVRSGSVKRVGGAIGEGAAAVAMIHQFLAAR
APVAV

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=358, Percent_Identity=31.5642458100559, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787114, Length=327, Percent_Identity=28.1345565749235, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321898, Length=342, Percent_Identity=27.1929824561404, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320560, Length=341, Percent_Identity=26.6862170087977, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 59027; Mature: 58896

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADLPTDGAPNRRHQMFPVLSDTEIARISRFGSVCRYARGERLFTSGEVGPGMFVLLSG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
VVSVTHRDGLGHVLPLVRQGPGEFLAEVGQLSGRPALVDGTAEEAVEALLVPPGQLRALL
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCHHHEEEE
VAEAELGERITRALILRRVSLIESGASGPVLIGPSTAPDMLRLQAFLRRNGQPYQMVCAR
EEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEC
KDADAAALIAQYGAAADEVVVVCPDGSVLLNPGEDALARCIGMVDTAERDELFDVVVVGA
CCCHHHHHHHHHCCCCCCEEEECCCCCEEECCCHHHHHHHHHHCCCCCCCCEEEEEEECC
GPAGLATAVYAASEGLSVVVLDCRAYGGQAGASARIENYLGFPTGISGQALAGRAFVQAQ
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHH
KFGAEMLIPAQAVGLDCSRAKDGPAAELHVKLADGRRLRGRSVVVASGARYRRPAVPRLA
HCCCCEECCHHHHCCCHHCCCCCCCEEEEEEECCCCEECCCEEEEECCCCCCCCCCCHHH
EFEGRGVWYWASAVEARLCAQAEVALIGGGNSAGQAAVFLAQHAVAVHMLVRSAGLAASM
HCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
SRYLIDRIEATPNIHLRSHTELSRLDGCTAEGLEGLAWRDHRSGAEEARRIRHLFLFVGA
HHHHHHHHCCCCCEEEECCCHHHHHCCCCHHCCCCCEECCCCCCHHHHHHHEEEEEEEEC
DPEAAWLQGCGVAVDAHGFVRTGQAIEGAAGDGYRPAALESNVPGVFAVGDVRSGSVKRV
CCCHHHHHCCCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHH
GGAIGEGAAAVAMIHQFLAARAPVAV
CCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AADLPTDGAPNRRHQMFPVLSDTEIARISRFGSVCRYARGERLFTSGEVGPGMFVLLSG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
VVSVTHRDGLGHVLPLVRQGPGEFLAEVGQLSGRPALVDGTAEEAVEALLVPPGQLRALL
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCHHHEEEE
VAEAELGERITRALILRRVSLIESGASGPVLIGPSTAPDMLRLQAFLRRNGQPYQMVCAR
EEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEEC
KDADAAALIAQYGAAADEVVVVCPDGSVLLNPGEDALARCIGMVDTAERDELFDVVVVGA
CCCHHHHHHHHHCCCCCCEEEECCCCCEEECCCHHHHHHHHHHCCCCCCCCEEEEEEECC
GPAGLATAVYAASEGLSVVVLDCRAYGGQAGASARIENYLGFPTGISGQALAGRAFVQAQ
CCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHH
KFGAEMLIPAQAVGLDCSRAKDGPAAELHVKLADGRRLRGRSVVVASGARYRRPAVPRLA
HCCCCEECCHHHHCCCHHCCCCCCCEEEEEEECCCCEECCCEEEEECCCCCCCCCCCHHH
EFEGRGVWYWASAVEARLCAQAEVALIGGGNSAGQAAVFLAQHAVAVHMLVRSAGLAASM
HCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
SRYLIDRIEATPNIHLRSHTELSRLDGCTAEGLEGLAWRDHRSGAEEARRIRHLFLFVGA
HHHHHHHHCCCCCEEEECCCHHHHHCCCCHHCCCCCEECCCCCCHHHHHHHEEEEEEEEC
DPEAAWLQGCGVAVDAHGFVRTGQAIEGAAGDGYRPAALESNVPGVFAVGDVRSGSVKRV
CCCHHHHHCCCEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHH
GGAIGEGAAAVAMIHQFLAARAPVAV
CCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]