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The map label for this gene is pcp [H]

Identifier: 124028457

GI number: 124028457

Start: 1615846

End: 1616478

Strand: Direct

Name: pcp [H]

Synonym: Hbut_1614

Alternate gene names: 124028457

Gene position: 1615846-1616478 (Clockwise)

Preceding gene: 124028455

Following gene: 124028459

Centisome position: 96.92

GC content: 56.08

Gene sequence:

>633_bases
ATGCAGGGCAGGGTGCTCGTTACAGGCTTCATGGTTTTCGCAGGCTACCAGTTCAATCCGAGCGAATGGATAGCAGCTAC
CCTAGACGGCCAAGTGATTGAGGGTTATCGTGTCCACAGCCTAGTCCTACCCGTATCACTCCGAAGGGCCCTCCCCATCC
TCAAAGAGCACCTTGAGACTCTGAAGCCACAAGTTGTGCTGGGTCTAGGGCTAGCACCACGGGCGAGAAAAGTGACTGTT
GAACTTGTAGCAGTGAGCCTAGCGCACTACCCTGACTATCCTGACGAGGACGGTTACCGAGCAGATCTTCAACTTCTGGA
CAATGGCGGCTTGAGGACGTACACTACACGGATTCCACTCGAAGCGGTGCGTGCATGCCGCGGGAAAGGCTACCCTGTCA
CCGTGTCGGTTAGCGTTGGCACCTACCTATGCAACGCCGTTGCCTACGCGATACACCGTTACGCCCACCACAACAATGCT
ATTGGGGGCTTCCTGCACCTGCCCCCCACAACCGAGCTAGCCCACCGTCACGGGCTCACAAACACGACGCCACTCTGGTT
GGAGCTAGAAACAGTCAAGTGCATATTGAGGGAGACTATCCGCCTTCTCCACAAAGCTCCCGGAAAGCTTTAG

Upstream 100 bases:

>100_bases
GAGCTGTAAATACAGCTACCACTAGCGGCACCGAACACACTGCAAAAGCTAGGGCCTGAACACCACTAGAAGCGGGGTAG
GCGAGGGGGTCTACGACTCC

Downstream 100 bases:

>100_bases
CAACAACATCAGCTATATCCTCCAGGGAGACCCCGACAAACACGCCTCGAGACCCAGCATCTAGGATTCTCCCACGGATG
CATCCCACACTATCACAGCC

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MQGRVLVTGFMVFAGYQFNPSEWIAATLDGQVIEGYRVHSLVLPVSLRRALPILKEHLETLKPQVVLGLGLAPRARKVTV
ELVAVSLAHYPDYPDEDGYRADLQLLDNGGLRTYTTRIPLEAVRACRGKGYPVTVSVSVGTYLCNAVAYAIHRYAHHNNA
IGGFLHLPPTTELAHRHGLTNTTPLWLELETVKCILRETIRLLHKAPGKL

Sequences:

>Translated_210_residues
MQGRVLVTGFMVFAGYQFNPSEWIAATLDGQVIEGYRVHSLVLPVSLRRALPILKEHLETLKPQVVLGLGLAPRARKVTV
ELVAVSLAHYPDYPDEDGYRADLQLLDNGGLRTYTTRIPLEAVRACRGKGYPVTVSVSVGTYLCNAVAYAIHRYAHHNNA
IGGFLHLPPTTELAHRHGLTNTTPLWLELETVKCILRETIRLLHKAPGKL
>Mature_210_residues
MQGRVLVTGFMVFAGYQFNPSEWIAATLDGQVIEGYRVHSLVLPVSLRRALPILKEHLETLKPQVVLGLGLAPRARKVTV
ELVAVSLAHYPDYPDEDGYRADLQLLDNGGLRTYTTRIPLEAVRACRGKGYPVTVSVSVGTYLCNAVAYAIHRYAHHNNA
IGGFLHLPPTTELAHRHGLTNTTPLWLELETVKCILRETIRLLHKAPGKL

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23278; Mature: 23278

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGRVLVTGFMVFAGYQFNPSEWIAATLDGQVIEGYRVHSLVLPVSLRRALPILKEHLET
CCCCEEEEEEEHHCCCCCCHHHEEEEECCCCEECCEEEEEEEECHHHHHHHHHHHHHHHH
LKPQVVLGLGLAPRARKVTVELVAVSLAHYPDYPDEDGYRADLQLLDNGGLRTYTTRIPL
HCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCH
EAVRACRGKGYPVTVSVSVGTYLCNAVAYAIHRYAHHNNAIGGFLHLPPTTELAHRHGLT
HHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCC
NTTPLWLELETVKCILRETIRLLHKAPGKL
CCCCEEEEHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQGRVLVTGFMVFAGYQFNPSEWIAATLDGQVIEGYRVHSLVLPVSLRRALPILKEHLET
CCCCEEEEEEEHHCCCCCCHHHEEEEECCCCEECCEEEEEEEECHHHHHHHHHHHHHHHH
LKPQVVLGLGLAPRARKVTVELVAVSLAHYPDYPDEDGYRADLQLLDNGGLRTYTTRIPL
HCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCH
EAVRACRGKGYPVTVSVSVGTYLCNAVAYAIHRYAHHNNAIGGFLHLPPTTELAHRHGLT
HHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCC
NTTPLWLELETVKCILRETIRLLHKAPGKL
CCCCEEEEHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11057915; 10089475; 10368293 [H]