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The map label for this gene is cysO [H]

Identifier: 124028430

GI number: 124028430

Start: 1594065

End: 1595285

Strand: Direct

Name: cysO [H]

Synonym: Hbut_1585

Alternate gene names: 124028430

Gene position: 1594065-1595285 (Clockwise)

Preceding gene: 124028429

Following gene: 124028433

Centisome position: 95.62

GC content: 49.06

Gene sequence:

>1221_bases
GTGGTCGTAATAGGGTATAAGATCGTTGATATAAAGTCGATAACACCTCTTAAACCTGTTGAGCTTCAGGACGTTCTAGA
CACTATTACTGCCTTACTTTCAGCAGGAAATGTTTACAGAACTATTGCCGTCGATGCAAGCTATAGAGTTGCCGAAGAAG
ATTCCAACATGCTCTACTGGGCGCTCAACTACATTGGGGTGAAACGCGTACCCATATCGTATAGCACACCTATCAACATC
ACCATCAGCCTTGAGGAGCTAGGATTCTATGACGACATAAACCCCGAGCCATTACGCGTGTTTAAGAGCAGCCTAGAACT
CCTCTACCGTAACTGGCCGACGCCGCTTGTTAGGCTAGAGAGCCTCTCAACGGACGGATATCGAGTATGGGCTAAGCTCG
AGTGGTATAACCCGTACAGTATGAGCGTGAAAGATAGAATCGGCTGGTACATGATTGTACGCGCCCTTGAAACTGGCTGG
AGAGGCAGAGAAGTCTACGAAACCACGTCAACCAATACGGGTATGGCGCTCGCCGCAATGGGCGCTATTCATGGATTCAG
GGTTAAGCTGTGGATACCAAAGACTATACAGAAGGCTAGCGATGTTCTCCTTAAAGCGCTTGGAGCCGAAGTTATTAGAA
CCGATAAACAGCTAACGGTAGACCTCATAGAGGATGTTAAGACAGAGGCTAAGCGTAGCAACGCACTACACGTGGACCAG
TTCAATAATGATGCCAACTTCCTCGTGCATTTGAAGTACACAGCTAAAGAGCTTGAGCTACAACTAAAGCATGCAGGAGT
AAAACCGAAAGGCATCATTGGCGGGCTAGGAACCTCAGGGCATCTCGCAGCGCTCACGCTCTACTTCCGCTCACGCATGA
GCGGCATAAGAGTCTATGGCGTACAGCCAGCTAGGGGCGAGGTTATACCTGGTATACGCCGTATCGAAACCGGCATGAAA
TGGGTTCACTGGGCAAAGCCTGACAATATAGTCGAAGTTAAACGTTGCGAAGCTATTGAAGCGCTGCTACGTGTTGCACG
GCGTGATGGTATACTACCTGGCCTAAGTAGTGGTGCCGTAGCTGCAGCCTTCCTAAAACTCTTGGAGAAGGGCGAAATCG
AGCCAGGAGACTATATCCTGATATTCCCCGATAACGGGTTCAAGTATGTTGAGCAGCTCAGCGAGTACTTTGCCGGAAAA
GGCGGAGATTGCAGCTCCTAA

Upstream 100 bases:

>100_bases
AAGCTTTTTCCTCCAAAGACCAGCCGACACCGCGTCTGCTTCGAAATCCCCCGCTTGAACATACCATTATATAAGCTTAT
GTGAAATATCTCGTTAGGGG

Downstream 100 bases:

>100_bases
CATCCTTTTGCTGGTATCCATACTCCAGTTCGCCCAAGCCGCGCAAACCTACAGTTTTTAATTCTGTACGATAACCTCAA
CTAACAGACGATTCGTCTAG

Product: cysteine synthase

Products: NA

Alternate protein names: Cystathionine beta-synthase; Cysteine synthase; O-acetylserine sulfhydrylase; O-phosphoserine sulfhydrylase; Serine sulfhydrase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVVIGYKIVDIKSITPLKPVELQDVLDTITALLSAGNVYRTIAVDASYRVAEEDSNMLYWALNYIGVKRVPISYSTPINI
TISLEELGFYDDINPEPLRVFKSSLELLYRNWPTPLVRLESLSTDGYRVWAKLEWYNPYSMSVKDRIGWYMIVRALETGW
RGREVYETTSTNTGMALAAMGAIHGFRVKLWIPKTIQKASDVLLKALGAEVIRTDKQLTVDLIEDVKTEAKRSNALHVDQ
FNNDANFLVHLKYTAKELELQLKHAGVKPKGIIGGLGTSGHLAALTLYFRSRMSGIRVYGVQPARGEVIPGIRRIETGMK
WVHWAKPDNIVEVKRCEAIEALLRVARRDGILPGLSSGAVAAAFLKLLEKGEIEPGDYILIFPDNGFKYVEQLSEYFAGK
GGDCSS

Sequences:

>Translated_406_residues
MVVIGYKIVDIKSITPLKPVELQDVLDTITALLSAGNVYRTIAVDASYRVAEEDSNMLYWALNYIGVKRVPISYSTPINI
TISLEELGFYDDINPEPLRVFKSSLELLYRNWPTPLVRLESLSTDGYRVWAKLEWYNPYSMSVKDRIGWYMIVRALETGW
RGREVYETTSTNTGMALAAMGAIHGFRVKLWIPKTIQKASDVLLKALGAEVIRTDKQLTVDLIEDVKTEAKRSNALHVDQ
FNNDANFLVHLKYTAKELELQLKHAGVKPKGIIGGLGTSGHLAALTLYFRSRMSGIRVYGVQPARGEVIPGIRRIETGMK
WVHWAKPDNIVEVKRCEAIEALLRVARRDGILPGLSSGAVAAAFLKLLEKGEIEPGDYILIFPDNGFKYVEQLSEYFAGK
GGDCSS
>Mature_406_residues
MVVIGYKIVDIKSITPLKPVELQDVLDTITALLSAGNVYRTIAVDASYRVAEEDSNMLYWALNYIGVKRVPISYSTPINI
TISLEELGFYDDINPEPLRVFKSSLELLYRNWPTPLVRLESLSTDGYRVWAKLEWYNPYSMSVKDRIGWYMIVRALETGW
RGREVYETTSTNTGMALAAMGAIHGFRVKLWIPKTIQKASDVLLKALGAEVIRTDKQLTVDLIEDVKTEAKRSNALHVDQ
FNNDANFLVHLKYTAKELELQLKHAGVKPKGIIGGLGTSGHLAALTLYFRSRMSGIRVYGVQPARGEVIPGIRRIETGMK
WVHWAKPDNIVEVKRCEAIEALLRVARRDGILPGLSSGAVAAAFLKLLEKGEIEPGDYILIFPDNGFKYVEQLSEYFAGK
GGDCSS

Specific function: Cysteine synthase that can also catalyze the synthesis of S-sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=219, Percent_Identity=30.5936073059361, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI295821200, Length=219, Percent_Identity=30.5936073059361, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557415, Length=219, Percent_Identity=30.5936073059361, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=32.5423728813559, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788754, Length=298, Percent_Identity=32.8859060402685, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562970, Length=279, Percent_Identity=32.9749103942652, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32566674, Length=279, Percent_Identity=32.9749103942652, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17535051, Length=274, Percent_Identity=32.1167883211679, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115535073, Length=293, Percent_Identity=30.7167235494881, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17561720, Length=278, Percent_Identity=32.0143884892086, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25147552, Length=332, Percent_Identity=25.9036144578313, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32566672, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17534315, Length=178, Percent_Identity=29.2134831460674, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=310, Percent_Identity=29.0322580645161, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321449, Length=184, Percent_Identity=34.2391304347826, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643623, Length=200, Percent_Identity=32, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20129101, Length=200, Percent_Identity=32, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.22; =2.5.1.47; =2.5.1.65 [H]

Molecular weight: Translated: 45431; Mature: 45431

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVIGYKIVDIKSITPLKPVELQDVLDTITALLSAGNVYRTIAVDASYRVAEEDSNMLYW
CEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCEEEE
ALNYIGVKRVPISYSTPINITISLEELGFYDDINPEPLRVFKSSLELLYRNWPTPLVRLE
EEEECCEEECCEEECCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
SLSTDGYRVWAKLEWYNPYSMSVKDRIGWYMIVRALETGWRGREVYETTSTNTGMALAAM
CCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
GAIHGFRVKLWIPKTIQKASDVLLKALGAEVIRTDKQLTVDLIEDVKTEAKRSNALHVDQ
HHHCCEEEEEECCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEE
FNNDANFLVHLKYTAKELELQLKHAGVKPKGIIGGLGTSGHLAALTLYFRSRMSGIRVYG
CCCCCCEEEEEEEEHHHHHEEHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEE
VQPARGEVIPGIRRIETGMKWVHWAKPDNIVEVKRCEAIEALLRVARRDGILPGLSSGAV
CCCCCCCCCCCHHHHHHCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AAAFLKLLEKGEIEPGDYILIFPDNGFKYVEQLSEYFAGKGGDCSS
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVVIGYKIVDIKSITPLKPVELQDVLDTITALLSAGNVYRTIAVDASYRVAEEDSNMLYW
CEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCEEEE
ALNYIGVKRVPISYSTPINITISLEELGFYDDINPEPLRVFKSSLELLYRNWPTPLVRLE
EEEECCEEECCEEECCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEE
SLSTDGYRVWAKLEWYNPYSMSVKDRIGWYMIVRALETGWRGREVYETTSTNTGMALAAM
CCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
GAIHGFRVKLWIPKTIQKASDVLLKALGAEVIRTDKQLTVDLIEDVKTEAKRSNALHVDQ
HHHCCEEEEEECCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEE
FNNDANFLVHLKYTAKELELQLKHAGVKPKGIIGGLGTSGHLAALTLYFRSRMSGIRVYG
CCCCCCEEEEEEEEHHHHHEEHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEE
VQPARGEVIPGIRRIETGMKWVHWAKPDNIVEVKRCEAIEALLRVARRDGILPGLSSGAV
CCCCCCCCCCCHHHHHHCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AAAFLKLLEKGEIEPGDYILIFPDNGFKYVEQLSEYFAGKGGDCSS
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12644499 [H]