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The map label for this gene is rmlA1 [C]

Identifier: 124028272

GI number: 124028272

Start: 1427528

End: 1428229

Strand: Reverse

Name: rmlA1 [C]

Synonym: Hbut_1423

Alternate gene names: 124028272

Gene position: 1428229-1427528 (Counterclockwise)

Preceding gene: 124028273

Following gene: 124028271

Centisome position: 85.67

GC content: 55.56

Gene sequence:

>702_bases
GTGGCTAAAGCTGTCATATTAGCTGGTGGGCTTGGTAAGAGGCTGCGTCCGCTTACGAGCAACAGGCCCAAGCCCCTTGT
AGAGGTTGCAGGGAAGCCTATCATCGAGTGGCAGATTGAATGGCTCAAGCGACACGGGTTCCACGAGTTTGTAGTGCTTG
CTGGCTATCGGTGGGATCGGCTAGTAAAACACCTTGGCAGTGGACAGAAGCTGGGCGTAAGGATAGCCTACGTGGTGGAG
GATGAGCCCCTGGGAACCGGTGGAGCGATAAAGAACGCGGAGCACCTCCTCCGCGGCGAGGACTACTTCGTGGTAATAAA
CGGCGACATCATAACAGACCTGCCCGTATCAAAGCTCGTTGAGGCGCTCCAGGCCGAGCCGAGAGCTGTAGCAGCGATAG
CACTGGTACCCCTACGCAGCCCCTATGGCGTGGTAGAGGTAAACGAGGAAGGCTGGGTTACAGTGTTCCGCGAGAAGCCC
GTGCTCAACTACTGGATAAACGCCGGCGTCTACGCTATGAGACCCGTGGTGCTTGACTACCTTCCCGAGAAGGGTGACAT
AGAGACCACAGCCCTCCCAAGACTCGCCAGCGAGAAGAGGCTACTAGGCGTAAAATTCCGCGACATATACTGGAGAAGCA
TAGACACTGTGAAAGACCTGGAGGAGGTTAGCAAGCAGCTAGCCGAGAAAACAACACTATAA

Upstream 100 bases:

>100_bases
GGGAGAGGCCGTTGCATAGCAGCCAATAGGGCCGCCTCTTTCCGGGCTTGGGTCTATATAGGTGGGCCTATAATCTCCCT
ATTCTGCTGGTGTGGTGGCT

Downstream 100 bases:

>100_bases
CCCACGCTACGCAGCAGATAATGGGATCCAGCGTATCCGTCTGAGGATTGGATAGGAAAAGGCGGGGAGTCCCTCTCCCT
AGGGTTTAGTGGTCCTTGTT

Product: sugar phosphate nucleotidyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MAKAVILAGGLGKRLRPLTSNRPKPLVEVAGKPIIEWQIEWLKRHGFHEFVVLAGYRWDRLVKHLGSGQKLGVRIAYVVE
DEPLGTGGAIKNAEHLLRGEDYFVVINGDIITDLPVSKLVEALQAEPRAVAAIALVPLRSPYGVVEVNEEGWVTVFREKP
VLNYWINAGVYAMRPVVLDYLPEKGDIETTALPRLASEKRLLGVKFRDIYWRSIDTVKDLEEVSKQLAEKTTL

Sequences:

>Translated_233_residues
MAKAVILAGGLGKRLRPLTSNRPKPLVEVAGKPIIEWQIEWLKRHGFHEFVVLAGYRWDRLVKHLGSGQKLGVRIAYVVE
DEPLGTGGAIKNAEHLLRGEDYFVVINGDIITDLPVSKLVEALQAEPRAVAAIALVPLRSPYGVVEVNEEGWVTVFREKP
VLNYWINAGVYAMRPVVLDYLPEKGDIETTALPRLASEKRLLGVKFRDIYWRSIDTVKDLEEVSKQLAEKTTL
>Mature_232_residues
AKAVILAGGLGKRLRPLTSNRPKPLVEVAGKPIIEWQIEWLKRHGFHEFVVLAGYRWDRLVKHLGSGQKLGVRIAYVVED
EPLGTGGAIKNAEHLLRGEDYFVVINGDIITDLPVSKLVEALQAEPRAVAAIALVPLRSPYGVVEVNEEGWVTVFREKPV
LNYWINAGVYAMRPVVLDYLPEKGDIETTALPRLASEKRLLGVKFRDIYWRSIDTVKDLEEVSKQLAEKTTL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=35.8407079646018, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=35.8407079646018, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI31881779, Length=194, Percent_Identity=32.9896907216495, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI45447090, Length=194, Percent_Identity=32.9896907216495, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788351, Length=240, Percent_Identity=28.75, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790224, Length=239, Percent_Identity=27.6150627615063, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=224, Percent_Identity=36.1607142857143, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17509979, Length=220, Percent_Identity=33.6363636363636, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17509981, Length=207, Percent_Identity=32.3671497584541, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=226, Percent_Identity=36.7256637168142, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355443, Length=226, Percent_Identity=36.283185840708, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24644084, Length=226, Percent_Identity=36.283185840708, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653912, Length=192, Percent_Identity=32.2916666666667, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26114; Mature: 25983

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAVILAGGLGKRLRPLTSNRPKPLVEVAGKPIIEWQIEWLKRHGFHEFVVLAGYRWDR
CCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEHHHHHHHHHCCCEEEEEEECCCHHH
LVKHLGSGQKLGVRIAYVVEDEPLGTGGAIKNAEHLLRGEDYFVVINGDIITDLPVSKLV
HHHHHCCCCEEEEEEEEEEECCCCCCCCCHHCHHHHHCCCCEEEEECCCEEECCCHHHHH
EALQAEPRAVAAIALVPLRSPYGVVEVNEEGWVTVFREKPVLNYWINAGVYAMRPVVLDY
HHHHCCCCCEEEEEEEECCCCCCEEEECCCCCEEEEECCCCEEEHHCCCHHHHHHHHHHH
LPEKGDIETTALPRLASEKRLLGVKFRDIYWRSIDTVKDLEEVSKQLAEKTTL
CCCCCCCCHHHHCHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKAVILAGGLGKRLRPLTSNRPKPLVEVAGKPIIEWQIEWLKRHGFHEFVVLAGYRWDR
CCEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEHHHHHHHHHCCCEEEEEEECCCHHH
LVKHLGSGQKLGVRIAYVVEDEPLGTGGAIKNAEHLLRGEDYFVVINGDIITDLPVSKLV
HHHHHCCCCEEEEEEEEEEECCCCCCCCCHHCHHHHHCCCCEEEEECCCEEECCCHHHHH
EALQAEPRAVAAIALVPLRSPYGVVEVNEEGWVTVFREKPVLNYWINAGVYAMRPVVLDY
HHHHCCCCCEEEEEEEECCCCCCEEEECCCCCEEEEECCCCEEEHHCCCHHHHHHHHHHH
LPEKGDIETTALPRLASEKRLLGVKFRDIYWRSIDTVKDLEEVSKQLAEKTTL
CCCCCCCCHHHHCHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA