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The map label for this gene is eIF-1A [H]

Identifier: 124028248

GI number: 124028248

Start: 1398154

End: 1398408

Strand: Direct

Name: eIF-1A [H]

Synonym: Hbut_1399

Alternate gene names: 124028248

Gene position: 1398154-1398408 (Clockwise)

Preceding gene: 124028247

Following gene: 124028249

Centisome position: 83.86

GC content: 58.82

Gene sequence:

>255_bases
GTGGTAAGGCTGCTCGGCGCAGACCACCTGCTGATAAGGTGCCAGGACGGGGTTGAACGGAAGGCAAGGATACCCGGCAG
CATGAGGCGCAGGGTCTGGATAAGGGAGGGCGACATAGTCCTAGCAGCCCCATGGGACTTCAAGCCAGACCGCGCCGACG
TGGTGTACAGATACTCCAGGGAGGAGCTAAGGAAGCTCGTGGAGAAGGGCATAGTGCCACAAGAGCTTCTAGAGCTAGCA
GAGGAGTATGCATAG

Upstream 100 bases:

>100_bases
GGGTGAATAAGCCCTGGCGAGGAAGAAGAGGCGCGCCGAGGAGGAGGCTCGGAAGGAGCCACCACTACCAAGCGAGGAGG
AGGGCACCCAGCTCTGCGTA

Downstream 100 bases:

>100_bases
GCACCGTTAATGTGTGAAGGCTACACGTGGAGAGAGGCTGGAAGTTTGACGAGCCTTTTGTCATCATTTTTAGCTGTCAT
CACCGGGTTCACAGCAGCAT

Product: translation initiation factor 1A

Products: NA

Alternate protein names: aIF-1A [H]

Number of amino acids: Translated: 84; Mature: 84

Protein sequence:

>84_residues
MVRLLGADHLLIRCQDGVERKARIPGSMRRRVWIREGDIVLAAPWDFKPDRADVVYRYSREELRKLVEKGIVPQELLELA
EEYA

Sequences:

>Translated_84_residues
MVRLLGADHLLIRCQDGVERKARIPGSMRRRVWIREGDIVLAAPWDFKPDRADVVYRYSREELRKLVEKGIVPQELLELA
EEYA
>Mature_84_residues
MVRLLGADHLLIRCQDGVERKARIPGSMRRRVWIREGDIVLAAPWDFKPDRADVVYRYSREELRKLVEKGIVPQELLELA
EEYA

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits [H]

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17540984, Length=74, Percent_Identity=35.1351351351351, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323916, Length=75, Percent_Identity=37.3333333333333, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553405, Length=76, Percent_Identity=36.8421052631579, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24647907, Length=76, Percent_Identity=36.8421052631579, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- InterPro:   IPR018104
- ProDom:   PD005579 [H]

Pfam domain/function: PF01176 eIF-1a [H]

EC number: NA

Molecular weight: Translated: 9862; Mature: 9862

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50832 S1_IF1_TYPE ; PS01262 IF1A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRLLGADHLLIRCQDGVERKARIPGSMRRRVWIREGDIVLAAPWDFKPDRADVVYRYSR
CEEECCCCEEEEEECCCCCHHHCCCCCHHHEEEEECCCEEEECCCCCCCCCCHHEEECCH
EELRKLVEKGIVPQELLELAEEYA
HHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVRLLGADHLLIRCQDGVERKARIPGSMRRRVWIREGDIVLAAPWDFKPDRADVVYRYSR
CEEECCCCEEEEEECCCCCHHHCCCCCHHHEEEEECCCEEEECCCCCCCCCCHHEEECCH
EELRKLVEKGIVPQELLELAEEYA
HHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA