Definition Hyperthermus butylicus DSM 5456 chromosome, complete genome.
Accession NC_008818
Length 1,667,163

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The map label for this gene is hflB [C]

Identifier: 124028210

GI number: 124028210

Start: 1347502

End: 1349712

Strand: Direct

Name: hflB [C]

Synonym: Hbut_1358

Alternate gene names: 124028210

Gene position: 1347502-1349712 (Clockwise)

Preceding gene: 124028209

Following gene: 124028214

Centisome position: 80.83

GC content: 56.81

Gene sequence:

>2211_bases
GTGGCGGCCATGACGTCTAGGCGTAGGAAGGAGGTCGTGCTGAGGGTCGCTGAGGCTAAGCAGCGAGACGTAGGCAAGGG
CAAGGTCAGGATAGACGTCGACATACTCCGTATGATAGATGCAGAGCCGGGCGACGTTGTGGAGATCGAGGGCCGGAAGA
AGACTGCAGCTGTCGCGTGGCCGAGCTACCCGGAGGACCGGGGCCAGGACATAATTAGGATGGACGGGCTGATTAGGAAG
AACGCCGGCGTCAGCATAGGAGAGAAAGTCATCGTCCGCAAGGCTGAGGTACAACCAGCCATAACCGTCAAGCTTGCACC
TGCAAACTTCTCGATAACCATTGATGCCGGCTTTGTAAACTACGTGAAGAAAAAGTTGGCAGACTACCCGGTAGTCGAGG
GCGACACGGTTCTTGTGCCAGTTCTAAACCAGTCCATACCCTTCGTTGTAATCCAGACAAAGCCCCACGGCGTAGTAACA
ATAACACACGATACCAACATAATCGTGTTAGAGAGGCCTGTGGAGCAGGGTAGGATACCAAGAGTCACGTACGAGGATAT
CGGTGGAATGAGGGATATAATCCAGAAGGTGCGTGAACTAGTCGAGCTGCCCCTAAAGCACCCAGAGATATTCAAGAGGC
TCGGCATCGAGCCGCCGAAGGGTATACTGCTCTATGGCCCGCCGGGCGTGGGCAAGACCCTGCTGGCAAAGGCGATAGCG
AACGAGACCAACGCGTACTTCATCGCTATTAACGGCCCAGAGATCATGAGCAAGTACTATGGCGAGAGCGAGCAGAGGCT
GAGAGAAATCTTCGAGGAGGCAAAGAAGCACGCTCCAGCCATAATATTCATAGACGAGATTGACGCTATCGCGCCGAAGA
GGGACGAGGTTATAGGCGAGGTTGAGAGGCGAGTCGTAGCCCAGCTCCTAGCGCTGATGGATGGCCTTGAGAGCCGCGGC
GACGTGATAGTGATAGCCGCTACTAATAGGCCGAATGCTCTCGACCCCGCGCTGCGCAGGCCAGGCAGGTTCGACAGGGA
GATAGAGATACCGTTGCCCGACAAGCAGGGCCGCCTGGAGATACTCCAGATACACACCCGGAACATGCCGCTAGCCGAGG
ACGTCGACCTGGAGAGGCTCGCGGAGCTAACCCGCGGCTTCACAGGCGCAGACCTAGCAGCCCTCGTCAGAGAGGCAGCG
ATGCACGCGCTGCGCCGCTACCTGCCAAAGATAGACCTGAACCAGGACCGTATACCGCCCGAGGTCCTAGAGGAGATGGA
GATAAGAATGGAGGACTTCATGGCAGCGCTGAGGGAGATAGTGCCCAGCGGCCTCAGGGAGATATATATCGAGGTACCAG
AGGTACGCTGGGACGATATCGGAGGGCTTGAGGAGGCTAAGCAGCAGCTAAGGGAGGCTGTCGAATGGCCACTAAAGAAC
CCAGACATCTTCCGCCGCATGGGCGTCGAGCCGCCGAAGGGTATACTGCTCTTTGGCCCACCTGGTACGGGTAAGACGCT
CCTCGCTAAGGCTGCTGCGACGGAGAGTGGAGCCAACTTCATAGCGGTAAGAGGACCCGAAATACTCAGCAAATGGGTAG
GCGAAAGCGAGAAGATGATAAGGGAGATATTCAGGAAGGCCCGGCAGCACGCGCCCGCGATAATCTTCTTCGACGAGATA
GACGCGATAGCCCAGACAAGGGGAGTATACGATACCAGCGGGGTAACCTACCGTATCGTGAACCAGCTGCTGGCAGAGCT
AGACGGCATAGTCCCCCTGAGCAACGTTGTCGTGATAGCTGCCACTAATAGGCCAGACATCCTCGACCCAGCACTGCTGA
GGCCAGGCAGGTTCGACAAGATAATCTATGTGCCACCACCCGACACCAAGGCCAGGCTCGAGATACTGAGGATACACACG
AGGAGGATGCCGCTGGCAGAGGACGTAGACCTCGAGCTAATCGCGCTGAGGACAGAGGGCTACAGCGGTGCAGACCTAGC
AGCACTAGTGAGAGAGGCAGCGATGTTAGCGCTGAGGGAGGACATAAACGCCACCAAGGTACACATGAGGCACTTCCTCA
AAGCTCTGGAGATCGTGAGGCCAAGCATAACACCCGAGATGGTGAAGTTCTACGAGGAGTGGTACCAGCAGGCGCGCCAG
CAGCTACCAGGCAGCAGGCTGGTAAAGGTAAAGCCGACACTCTTCACTTAA

Upstream 100 bases:

>100_bases
GGTATATGCTCTCAAAAGTTCTACCAGGGGTTCCCCATCACAGAAAATCCAGGCTCATAAGGGTGCCTAATGGTCTCCGG
CAGGCTATAGGGTGAAGACC

Downstream 100 bases:

>100_bases
CCCCTATCCGTCACACATTCTTTATCTGGGTTTCCGTCAAGCCCTAAACCATATATGATCTTTTACCAGGGCGGTGGGTC
GAGTCTCATTATTCTCGTAG

Product: ATP-dependent protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 736; Mature: 735

Protein sequence:

>736_residues
MAAMTSRRRKEVVLRVAEAKQRDVGKGKVRIDVDILRMIDAEPGDVVEIEGRKKTAAVAWPSYPEDRGQDIIRMDGLIRK
NAGVSIGEKVIVRKAEVQPAITVKLAPANFSITIDAGFVNYVKKKLADYPVVEGDTVLVPVLNQSIPFVVIQTKPHGVVT
ITHDTNIIVLERPVEQGRIPRVTYEDIGGMRDIIQKVRELVELPLKHPEIFKRLGIEPPKGILLYGPPGVGKTLLAKAIA
NETNAYFIAINGPEIMSKYYGESEQRLREIFEEAKKHAPAIIFIDEIDAIAPKRDEVIGEVERRVVAQLLALMDGLESRG
DVIVIAATNRPNALDPALRRPGRFDREIEIPLPDKQGRLEILQIHTRNMPLAEDVDLERLAELTRGFTGADLAALVREAA
MHALRRYLPKIDLNQDRIPPEVLEEMEIRMEDFMAALREIVPSGLREIYIEVPEVRWDDIGGLEEAKQQLREAVEWPLKN
PDIFRRMGVEPPKGILLFGPPGTGKTLLAKAAATESGANFIAVRGPEILSKWVGESEKMIREIFRKARQHAPAIIFFDEI
DAIAQTRGVYDTSGVTYRIVNQLLAELDGIVPLSNVVVIAATNRPDILDPALLRPGRFDKIIYVPPPDTKARLEILRIHT
RRMPLAEDVDLELIALRTEGYSGADLAALVREAAMLALREDINATKVHMRHFLKALEIVRPSITPEMVKFYEEWYQQARQ
QLPGSRLVKVKPTLFT

Sequences:

>Translated_736_residues
MAAMTSRRRKEVVLRVAEAKQRDVGKGKVRIDVDILRMIDAEPGDVVEIEGRKKTAAVAWPSYPEDRGQDIIRMDGLIRK
NAGVSIGEKVIVRKAEVQPAITVKLAPANFSITIDAGFVNYVKKKLADYPVVEGDTVLVPVLNQSIPFVVIQTKPHGVVT
ITHDTNIIVLERPVEQGRIPRVTYEDIGGMRDIIQKVRELVELPLKHPEIFKRLGIEPPKGILLYGPPGVGKTLLAKAIA
NETNAYFIAINGPEIMSKYYGESEQRLREIFEEAKKHAPAIIFIDEIDAIAPKRDEVIGEVERRVVAQLLALMDGLESRG
DVIVIAATNRPNALDPALRRPGRFDREIEIPLPDKQGRLEILQIHTRNMPLAEDVDLERLAELTRGFTGADLAALVREAA
MHALRRYLPKIDLNQDRIPPEVLEEMEIRMEDFMAALREIVPSGLREIYIEVPEVRWDDIGGLEEAKQQLREAVEWPLKN
PDIFRRMGVEPPKGILLFGPPGTGKTLLAKAAATESGANFIAVRGPEILSKWVGESEKMIREIFRKARQHAPAIIFFDEI
DAIAQTRGVYDTSGVTYRIVNQLLAELDGIVPLSNVVVIAATNRPDILDPALLRPGRFDKIIYVPPPDTKARLEILRIHT
RRMPLAEDVDLELIALRTEGYSGADLAALVREAAMLALREDINATKVHMRHFLKALEIVRPSITPEMVKFYEEWYQQARQ
QLPGSRLVKVKPTLFT
>Mature_735_residues
AAMTSRRRKEVVLRVAEAKQRDVGKGKVRIDVDILRMIDAEPGDVVEIEGRKKTAAVAWPSYPEDRGQDIIRMDGLIRKN
AGVSIGEKVIVRKAEVQPAITVKLAPANFSITIDAGFVNYVKKKLADYPVVEGDTVLVPVLNQSIPFVVIQTKPHGVVTI
THDTNIIVLERPVEQGRIPRVTYEDIGGMRDIIQKVRELVELPLKHPEIFKRLGIEPPKGILLYGPPGVGKTLLAKAIAN
ETNAYFIAINGPEIMSKYYGESEQRLREIFEEAKKHAPAIIFIDEIDAIAPKRDEVIGEVERRVVAQLLALMDGLESRGD
VIVIAATNRPNALDPALRRPGRFDREIEIPLPDKQGRLEILQIHTRNMPLAEDVDLERLAELTRGFTGADLAALVREAAM
HALRRYLPKIDLNQDRIPPEVLEEMEIRMEDFMAALREIVPSGLREIYIEVPEVRWDDIGGLEEAKQQLREAVEWPLKNP
DIFRRMGVEPPKGILLFGPPGTGKTLLAKAAATESGANFIAVRGPEILSKWVGESEKMIREIFRKARQHAPAIIFFDEID
AIAQTRGVYDTSGVTYRIVNQLLAELDGIVPLSNVVVIAATNRPDILDPALLRPGRFDKIIYVPPPDTKARLEILRIHTR
RMPLAEDVDLELIALRTEGYSGADLAALVREAAMLALREDINATKVHMRHFLKALEIVRPSITPEMVKFYEEWYQQARQQ
LPGSRLVKVKPTLFT

Specific function: Seems To Act As An ATP-Dependent Zinc Metallopeptidase. Involved In The Degradation Of Sigma-32. Degrades Carboxy- Terminal-Tagged Cytoplasmic Proteins. These Proteins Are Tagged With An 11-Amino-Acid Nonpolar Destabilizing Tail VIa A Mechanism Involving

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family. CDC48 subfamily [H]

Homologues:

Organism=Homo sapiens, GI6005942, Length=717, Percent_Identity=47.6987447698745, Blast_Score=654, Evalue=0.0,
Organism=Homo sapiens, GI157671927, Length=550, Percent_Identity=53.6363636363636, Blast_Score=593, Evalue=1e-169,
Organism=Homo sapiens, GI45643123, Length=593, Percent_Identity=46.0370994940978, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI45643125, Length=593, Percent_Identity=46.0370994940978, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI229577436, Length=754, Percent_Identity=38.9920424403183, Blast_Score=468, Evalue=1e-131,
Organism=Homo sapiens, GI4505725, Length=479, Percent_Identity=38.4133611691023, Blast_Score=306, Evalue=6e-83,
Organism=Homo sapiens, GI194018488, Length=518, Percent_Identity=35.5212355212355, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI24430151, Length=272, Percent_Identity=49.2647058823529, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI24497618, Length=274, Percent_Identity=45.2554744525547, Blast_Score=251, Evalue=3e-66,
Organism=Homo sapiens, GI153792536, Length=274, Percent_Identity=45.985401459854, Blast_Score=245, Evalue=1e-64,
Organism=Homo sapiens, GI4506209, Length=229, Percent_Identity=50.6550218340611, Blast_Score=234, Evalue=3e-61,
Organism=Homo sapiens, GI24497435, Length=231, Percent_Identity=48.9177489177489, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI195539395, Length=250, Percent_Identity=47.2, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI5729991, Length=269, Percent_Identity=46.4684014869888, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI24430155, Length=269, Percent_Identity=46.4684014869888, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI89064750, Length=269, Percent_Identity=46.4684014869888, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI21361144, Length=265, Percent_Identity=45.2830188679245, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI300192933, Length=254, Percent_Identity=46.4566929133858, Blast_Score=216, Evalue=9e-56,
Organism=Homo sapiens, GI5901990, Length=318, Percent_Identity=40.5660377358491, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI14149767, Length=300, Percent_Identity=41.3333333333333, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI62177112, Length=300, Percent_Identity=41.3333333333333, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI156564401, Length=387, Percent_Identity=36.9509043927649, Blast_Score=206, Evalue=6e-53,
Organism=Homo sapiens, GI31742536, Length=309, Percent_Identity=38.1877022653722, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI112789543, Length=309, Percent_Identity=38.1877022653722, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI7657689, Length=228, Percent_Identity=46.0526315789474, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI21327685, Length=228, Percent_Identity=46.0526315789474, Blast_Score=199, Evalue=9e-51,
Organism=Homo sapiens, GI4507173, Length=230, Percent_Identity=46.5217391304348, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI7019569, Length=265, Percent_Identity=41.8867924528302, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226371754, Length=310, Percent_Identity=36.1290322580645, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI17865802, Length=251, Percent_Identity=42.6294820717131, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI310125280, Length=241, Percent_Identity=45.2282157676349, Blast_Score=183, Evalue=6e-46,
Organism=Homo sapiens, GI310125282, Length=241, Percent_Identity=45.2282157676349, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI11875211, Length=346, Percent_Identity=33.5260115606936, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI40806170, Length=346, Percent_Identity=33.5260115606936, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI31377644, Length=234, Percent_Identity=41.4529914529915, Blast_Score=170, Evalue=6e-42,
Organism=Homo sapiens, GI64084766, Length=282, Percent_Identity=34.7517730496454, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI40806173, Length=138, Percent_Identity=45.6521739130435, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI116292174, Length=265, Percent_Identity=29.811320754717, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI11321607, Length=271, Percent_Identity=27.3062730627306, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI40255052, Length=203, Percent_Identity=25.1231527093596, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1789568, Length=239, Percent_Identity=48.5355648535565, Blast_Score=219, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17532375, Length=715, Percent_Identity=44.8951048951049, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17531535, Length=717, Percent_Identity=44.0725244072524, Blast_Score=617, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17537217, Length=604, Percent_Identity=41.7218543046358, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17508053, Length=535, Percent_Identity=38.1308411214953, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17562804, Length=491, Percent_Identity=33.6048879837067, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17563250, Length=297, Percent_Identity=43.4343434343434, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI193206116, Length=279, Percent_Identity=44.8028673835125, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI193206114, Length=279, Percent_Identity=44.8028673835125, Blast_Score=235, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI133931034, Length=279, Percent_Identity=44.8028673835125, Blast_Score=235, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI71987364, Length=244, Percent_Identity=47.5409836065574, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71987372, Length=244, Percent_Identity=47.5409836065574, Blast_Score=232, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI25153574, Length=479, Percent_Identity=32.3590814196242, Blast_Score=232, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17554786, Length=232, Percent_Identity=47.8448275862069, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17563248, Length=229, Percent_Identity=49.7816593886463, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17505546, Length=260, Percent_Identity=46.1538461538462, Blast_Score=228, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25144281, Length=231, Percent_Identity=47.6190476190476, Blast_Score=226, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI25144278, Length=252, Percent_Identity=44.8412698412698, Blast_Score=226, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17508701, Length=301, Percent_Identity=41.8604651162791, Blast_Score=223, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI193209502, Length=224, Percent_Identity=46.4285714285714, Blast_Score=212, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17554784, Length=233, Percent_Identity=46.7811158798283, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71994521, Length=263, Percent_Identity=46.3878326996198, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI86561515, Length=248, Percent_Identity=44.3548387096774, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25146157, Length=279, Percent_Identity=40.5017921146953, Blast_Score=185, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI133901658, Length=427, Percent_Identity=33.0210772833724, Blast_Score=182, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI133901662, Length=461, Percent_Identity=32.1041214750542, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17508421, Length=286, Percent_Identity=40.2097902097902, Blast_Score=178, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32563584, Length=290, Percent_Identity=40, Blast_Score=178, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17554264, Length=233, Percent_Identity=40.7725321888412, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI115534323, Length=255, Percent_Identity=40.7843137254902, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17560432, Length=278, Percent_Identity=39.2086330935252, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17541224, Length=219, Percent_Identity=37.4429223744292, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17541226, Length=219, Percent_Identity=37.4429223744292, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17570397, Length=103, Percent_Identity=43.6893203883495, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566590, Length=103, Percent_Identity=43.6893203883495, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71990294, Length=195, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320077, Length=765, Percent_Identity=44.9673202614379, Blast_Score=650, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323429, Length=743, Percent_Identity=41.5881561238223, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322994, Length=579, Percent_Identity=42.832469775475, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321709, Length=272, Percent_Identity=48.1617647058824, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6324000, Length=589, Percent_Identity=32.937181663837, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322651, Length=494, Percent_Identity=32.7935222672065, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321390, Length=232, Percent_Identity=48.2758620689655, Blast_Score=237, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6324833, Length=246, Percent_Identity=47.1544715447154, Blast_Score=231, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6322704, Length=229, Percent_Identity=50.2183406113537, Blast_Score=231, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6320197, Length=231, Percent_Identity=50.2164502164502, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324691, Length=313, Percent_Identity=41.5335463258786, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6325281, Length=247, Percent_Identity=45.748987854251, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320602, Length=234, Percent_Identity=46.1538461538462, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323736, Length=293, Percent_Identity=41.9795221843003, Blast_Score=210, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6319554, Length=411, Percent_Identity=35.2798053527981, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6325183, Length=312, Percent_Identity=37.5, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320854, Length=256, Percent_Identity=42.578125, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6325431, Length=247, Percent_Identity=43.3198380566802, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320887, Length=343, Percent_Identity=35.5685131195335, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321465, Length=276, Percent_Identity=38.768115942029, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI9755327, Length=185, Percent_Identity=30.2702702702703, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320583, Length=146, Percent_Identity=30.8219178082192, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137560, Length=713, Percent_Identity=46.5638148667602, Blast_Score=645, Evalue=0.0,
Organism=Drosophila melanogaster, GI161076486, Length=713, Percent_Identity=46.5638148667602, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI161076488, Length=713, Percent_Identity=46.5638148667602, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921202, Length=594, Percent_Identity=41.4141414141414, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45552965, Length=310, Percent_Identity=47.0967741935484, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI281365776, Length=295, Percent_Identity=48.4745762711864, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24660075, Length=295, Percent_Identity=48.4745762711864, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24656825, Length=518, Percent_Identity=34.9420849420849, Blast_Score=286, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24656820, Length=537, Percent_Identity=33.8919925512104, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI21355121, Length=526, Percent_Identity=32.6996197718631, Blast_Score=277, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24649446, Length=272, Percent_Identity=48.8970588235294, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI281363136, Length=505, Percent_Identity=33.6633663366337, Blast_Score=247, Evalue=3e-65,
Organism=Drosophila melanogaster, GI78707192, Length=505, Percent_Identity=33.6633663366337, Blast_Score=247, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24652279, Length=259, Percent_Identity=45.1737451737452, Blast_Score=239, Evalue=6e-63,
Organism=Drosophila melanogaster, GI18860063, Length=250, Percent_Identity=50, Blast_Score=235, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24640100, Length=262, Percent_Identity=46.9465648854962, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI19920408, Length=231, Percent_Identity=48.9177489177489, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI17137738, Length=229, Percent_Identity=49.7816593886463, Blast_Score=233, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24651451, Length=230, Percent_Identity=48.695652173913, Blast_Score=232, Evalue=9e-61,
Organism=Drosophila melanogaster, GI17738151, Length=299, Percent_Identity=43.1438127090301, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281361487, Length=271, Percent_Identity=44.280442804428, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24663015, Length=272, Percent_Identity=43.3823529411765, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24665814, Length=250, Percent_Identity=46.4, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28574878, Length=250, Percent_Identity=46.4, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17864540, Length=451, Percent_Identity=33.7028824833703, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI18859657, Length=248, Percent_Identity=44.3548387096774, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28573010, Length=384, Percent_Identity=37.5, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24644145, Length=318, Percent_Identity=37.7358490566038, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24658770, Length=239, Percent_Identity=42.6778242677824, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24581396, Length=277, Percent_Identity=41.8772563176895, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24639391, Length=241, Percent_Identity=44.8132780082988, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281360146, Length=292, Percent_Identity=34.9315068493151, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281360138, Length=292, Percent_Identity=34.9315068493151, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281360142, Length=292, Percent_Identity=34.9315068493151, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21357333, Length=292, Percent_Identity=34.9315068493151, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281360144, Length=292, Percent_Identity=34.9315068493151, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281360140, Length=292, Percent_Identity=34.9315068493151, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281360136, Length=292, Percent_Identity=34.9315068493151, Blast_Score=179, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24644411, Length=292, Percent_Identity=34.9315068493151, Blast_Score=179, Evalue=6e-45,
Organism=Drosophila melanogaster, GI20129423, Length=236, Percent_Identity=39.8305084745763, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI28571849, Length=287, Percent_Identity=39.3728222996516, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571847, Length=287, Percent_Identity=39.3728222996516, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129529, Length=273, Percent_Identity=37.3626373626374, Blast_Score=172, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24639486, Length=234, Percent_Identity=36.3247863247863, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45554047, Length=166, Percent_Identity=42.1686746987952, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28573181, Length=237, Percent_Identity=26.5822784810127, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR003593
- InterPro:   IPR005938
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR003338
- InterPro:   IPR004201
- InterPro:   IPR015415 [H]

Pfam domain/function: PF00004 AAA; PF02933 CDC48_2; PF02359 CDC48_N; PF09336 Vps4_C [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 82532; Mature: 82401

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00674 AAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MAAMTSRRRKEVVLRVAEAKQRDVGKGKVRIDVDILRMIDAEPGDVVEIEGRKKTAAVAW
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCEEEECCCCCEEEEEC
PSYPEDRGQDIIRMDGLIRKNAGVSIGEKVIVRKAEVQPAITVKLAPANFSITIDAGFVN
CCCCCHHCCCEEHHCCHHCCCCCCCCCHHHHEEECCCCCEEEEEEECCCEEEEEECHHHH
YVKKKLADYPVVEGDTVLVPVLNQSIPFVVIQTKPHGVVTITHDTNIIVLERPVEQGRIP
HHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEECCCEEEEEEECCEEEEEECCHHCCCCC
RVTYEDIGGMRDIIQKVRELVELPLKHPEIFKRLGIEPPKGILLYGPPGVGKTLLAKAIA
EEEHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHH
NETNAYFIAINGPEIMSKYYGESEQRLREIFEEAKKHAPAIIFIDEIDAIAPKRDEVIGE
CCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHH
VERRVVAQLLALMDGLESRGDVIVIAATNRPNALDPALRRPGRFDREIEIPLPDKQGRLE
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCEEECCCCCCCCCEE
ILQIHTRNMPLAEDVDLERLAELTRGFTGADLAALVREAAMHALRRYLPKIDLNQDRIPP
EEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EVLEEMEIRMEDFMAALREIVPSGLREIYIEVPEVRWDDIGGLEEAKQQLREAVEWPLKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PDIFRRMGVEPPKGILLFGPPGTGKTLLAKAAATESGANFIAVRGPEILSKWVGESEKMI
CHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCHHHHH
REIFRKARQHAPAIIFFDEIDAIAQTRGVYDTSGVTYRIVNQLLAELDGIVPLSNVVVIA
HHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEE
ATNRPDILDPALLRPGRFDKIIYVPPPDTKARLEILRIHTRRMPLAEDVDLELIALRTEG
ECCCCCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
YSGADLAALVREAAMLALREDINATKVHMRHFLKALEIVRPSITPEMVKFYEEWYQQARQ
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QLPGSRLVKVKPTLFT
HCCCCCEEEECCCCCC
>Mature Secondary Structure 
AAMTSRRRKEVVLRVAEAKQRDVGKGKVRIDVDILRMIDAEPGDVVEIEGRKKTAAVAW
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCEEEECCCCCEEEEEC
PSYPEDRGQDIIRMDGLIRKNAGVSIGEKVIVRKAEVQPAITVKLAPANFSITIDAGFVN
CCCCCHHCCCEEHHCCHHCCCCCCCCCHHHHEEECCCCCEEEEEEECCCEEEEEECHHHH
YVKKKLADYPVVEGDTVLVPVLNQSIPFVVIQTKPHGVVTITHDTNIIVLERPVEQGRIP
HHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEECCCEEEEEEECCEEEEEECCHHCCCCC
RVTYEDIGGMRDIIQKVRELVELPLKHPEIFKRLGIEPPKGILLYGPPGVGKTLLAKAIA
EEEHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHH
NETNAYFIAINGPEIMSKYYGESEQRLREIFEEAKKHAPAIIFIDEIDAIAPKRDEVIGE
CCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHH
VERRVVAQLLALMDGLESRGDVIVIAATNRPNALDPALRRPGRFDREIEIPLPDKQGRLE
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCCEEECCCCCCCCCEE
ILQIHTRNMPLAEDVDLERLAELTRGFTGADLAALVREAAMHALRRYLPKIDLNQDRIPP
EEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
EVLEEMEIRMEDFMAALREIVPSGLREIYIEVPEVRWDDIGGLEEAKQQLREAVEWPLKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
PDIFRRMGVEPPKGILLFGPPGTGKTLLAKAAATESGANFIAVRGPEILSKWVGESEKMI
CHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCHHHHH
REIFRKARQHAPAIIFFDEIDAIAQTRGVYDTSGVTYRIVNQLLAELDGIVPLSNVVVIA
HHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEE
ATNRPDILDPALLRPGRFDKIIYVPPPDTKARLEILRIHTRRMPLAEDVDLELIALRTEG
ECCCCCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
YSGADLAALVREAAMLALREDINATKVHMRHFLKALEIVRPSITPEMVKFYEEWYQQARQ
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QLPGSRLVKVKPTLFT
HCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]