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The map label for this gene is ctaB

Identifier: 124028061

GI number: 124028061

Start: 1212570

End: 1213466

Strand: Reverse

Name: ctaB

Synonym: Hbut_1202

Alternate gene names: 124028061

Gene position: 1213466-1212570 (Counterclockwise)

Preceding gene: 124028063

Following gene: 124028059

Centisome position: 72.79

GC content: 47.49

Gene sequence:

>897_bases
ATGCAGCTCAGCCGTGTGCGATCCGTGTTGCTGGACGTGTTTGCCCTAGCTAAGGTTAAGCAGACACTCCTACTACTATT
TACAATGTATACAGCATATATTGTTGGGGGCGGGCTCGGAAAGCCCTATGAGAGACACCTAGTGGTGCTCACTCTAGGGT
TTATCACTATAGCTGCGGTTACAGCGCTAAACATGTATTTTGACAGGGACATAGACGCACTTATGGAGAGGACTAGGGAT
AGGCCACTACCAGCTGGAAGGCTTGACCCTCTAAAGGTGTTTATAGCAACCGTAGCAGCCACAATTGTATCCGTAATCCT
CGCTTGGCGCATTATAAACCCTCACTTTGCTCTTGCAATAGTTATTGGTTTCCTCTTTGACATAGTAGCTTACACCTATC
TCCTCAAGAGGAGAACACCACTCAGCATTATAGCTGGAGCTGTTGCTGGTGGTGCACCGGCTCTTGGTGGCTGGGCAGCC
GCTGCGGGAAGAATCGATGTTAATGCGCTTCTGTTCTCACTTATTGTCGCTACATGGGTTCCCTCACACATATGGTTCCT
AGCAACATACTACCGCGATGATTATAGGCGCGCAAATGTGCCAATGCTGCCAGTTGTAGCTGATACCCCTATAGCTGTTG
CATCCGGCATAGGACTAGGCTCGCTCGTAATGGGCTACTCTATTGTTGGGCTTTGGGTCAACAATGTCATAGGTACGGTG
TCACTCATAGTAGGCGTTATTGCCGCCATAGCAATCTTTCATCTTGCAGTAAAATATGCAGAACTCGGAGGAGATCCGAA
TTACAGCAGAACGGCATTCAAGAAAACAAACATGATGCTAGGCCTTGTATTCCTCGTAATGATGCTTGAAAAGGTTGTAT
CATACATCATCAGCTAG

Upstream 100 bases:

>100_bases
AGAGATTTTATCCGCTTTAACAGTTAAATAGTTTTGAGCCTCGCTATAGGCTCTAACTAGGGTGTCTACGTAAATTTTCG
GCGAACGAGGTGCACATGTG

Downstream 100 bases:

>100_bases
CTTGTAGATACTTACCCCACTCTCCGAGTAGCAGGGCTAGAACCTTCTCGCGTCGCTGCCCTGTTATTGATAAGCTACCG
TCGCGCCGAGGTATGCCAAG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQLSRVRSVLLDVFALAKVKQTLLLLFTMYTAYIVGGGLGKPYERHLVVLTLGFITIAAVTALNMYFDRDIDALMERTRD
RPLPAGRLDPLKVFIATVAATIVSVILAWRIINPHFALAIVIGFLFDIVAYTYLLKRRTPLSIIAGAVAGGAPALGGWAA
AAGRIDVNALLFSLIVATWVPSHIWFLATYYRDDYRRANVPMLPVVADTPIAVASGIGLGSLVMGYSIVGLWVNNVIGTV
SLIVGVIAAIAIFHLAVKYAELGGDPNYSRTAFKKTNMMLGLVFLVMMLEKVVSYIIS

Sequences:

>Translated_298_residues
MQLSRVRSVLLDVFALAKVKQTLLLLFTMYTAYIVGGGLGKPYERHLVVLTLGFITIAAVTALNMYFDRDIDALMERTRD
RPLPAGRLDPLKVFIATVAATIVSVILAWRIINPHFALAIVIGFLFDIVAYTYLLKRRTPLSIIAGAVAGGAPALGGWAA
AAGRIDVNALLFSLIVATWVPSHIWFLATYYRDDYRRANVPMLPVVADTPIAVASGIGLGSLVMGYSIVGLWVNNVIGTV
SLIVGVIAAIAIFHLAVKYAELGGDPNYSRTAFKKTNMMLGLVFLVMMLEKVVSYIIS
>Mature_298_residues
MQLSRVRSVLLDVFALAKVKQTLLLLFTMYTAYIVGGGLGKPYERHLVVLTLGFITIAAVTALNMYFDRDIDALMERTRD
RPLPAGRLDPLKVFIATVAATIVSVILAWRIINPHFALAIVIGFLFDIVAYTYLLKRRTPLSIIAGAVAGGAPALGGWAA
AAGRIDVNALLFSLIVATWVPSHIWFLATYYRDDYRRANVPMLPVVADTPIAVASGIGLGSLVMGYSIVGLWVNNVIGTV
SLIVGVIAAIAIFHLAVKYAELGGDPNYSRTAFKKTNMMLGLVFLVMMLEKVVSYIIS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=198, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1786631, Length=158, Percent_Identity=31.6455696202532, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921064, Length=192, Percent_Identity=29.6875, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_HYPBU (A2BM25)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013381.1
- STRING:   A2BM25
- GeneID:   4781436
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1202
- eggNOG:   arNOG12403
- OMA:   VILAWRI
- ProtClustDB:   CLSK2747798
- BioCyc:   HBUT415426:HBUT_1202-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32361; Mature: 32361

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1637ad20)-; HASH(0x18a683b4)-; HASH(0x189dcfd0)-; HASH(0x18a68588)-; HASH(0x18545170)-; HASH(0x18a59268)-; HASH(0x1861b224)-; HASH(0x18a5bb68)-; HASH(0x186bf7c0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSRVRSVLLDVFALAKVKQTLLLLFTMYTAYIVGGGLGKPYERHLVVLTLGFITIAAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TALNMYFDRDIDALMERTRDRPLPAGRLDPLKVFIATVAATIVSVILAWRIINPHFALAI
HHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VIGFLFDIVAYTYLLKRRTPLSIIAGAVAGGAPALGGWAAAAGRIDVNALLFSLIVATWV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
PSHIWFLATYYRDDYRRANVPMLPVVADTPIAVASGIGLGSLVMGYSIVGLWVNNVIGTV
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SLIVGVIAAIAIFHLAVKYAELGGDPNYSRTAFKKTNMMLGLVFLVMMLEKVVSYIIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MQLSRVRSVLLDVFALAKVKQTLLLLFTMYTAYIVGGGLGKPYERHLVVLTLGFITIAAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
TALNMYFDRDIDALMERTRDRPLPAGRLDPLKVFIATVAATIVSVILAWRIINPHFALAI
HHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VIGFLFDIVAYTYLLKRRTPLSIIAGAVAGGAPALGGWAAAAGRIDVNALLFSLIVATWV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
PSHIWFLATYYRDDYRRANVPMLPVVADTPIAVASGIGLGSLVMGYSIVGLWVNNVIGTV
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SLIVGVIAAIAIFHLAVKYAELGGDPNYSRTAFKKTNMMLGLVFLVMMLEKVVSYIIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA