Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 124027987

GI number: 124027987

Start: 1137155

End: 1137580

Strand: Reverse

Name: trxA [H]

Synonym: Hbut_1122

Alternate gene names: 124027987

Gene position: 1137580-1137155 (Counterclockwise)

Preceding gene: 124027990

Following gene: 124027986

Centisome position: 68.23

GC content: 45.77

Gene sequence:

>426_bases
TTGAGCAACGACATAGTAAGAGAGCTGAGAAGCCTAATCGAGAAAAAGGTTAACGAGCTAGACAAGGAACTCGGTGACCC
TCTAATTTACCTAAACAAGGACAACTTCGATGAAGTCCTCAAAAATTACAAGGTTGTAGTCGTAGAGTTCTCGGCACCCT
GGTGCAACCCTTGCAAAGCCTATACACCTGTATTCAAACGGGTAGCTCGCCGCCTCGCGGACCCTGAAAAGGGCATAGTC
TTTGCATACCTAGACACGGACGAAGCTCCTGACATAGCCGATAGATATTCCGTGGACAATATACCAACAACAATAATATT
CGTAAACGGTCACGTAGCAGATGTCATACTCGGCGTAACCCAGGAATCCAAGCTAACAGAGAGAGTACAGAACATAGTCA
AGGAATTACTACGCGGTGAGAAATAG

Upstream 100 bases:

>100_bases
AAGCTGGAAGCCACGGGTAGACAAGCGCTATAGTTGTCCTGGCTAAAACCGATTTAAGGGCATTACAAATCAGCGGTATT
AAGCAGGGCTGGTGGTAGGA

Downstream 100 bases:

>100_bases
CCGCTTGCTTAGGAATAGTTGTTTCGGCAAAGGGGGAGGCTACGTCATCCCATACGCCGGTCCTTTCGGGGACAGCGACT
CCACACCCATCAGGGAAGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MSNDIVRELRSLIEKKVNELDKELGDPLIYLNKDNFDEVLKNYKVVVVEFSAPWCNPCKAYTPVFKRVARRLADPEKGIV
FAYLDTDEAPDIADRYSVDNIPTTIIFVNGHVADVILGVTQESKLTERVQNIVKELLRGEK

Sequences:

>Translated_141_residues
MSNDIVRELRSLIEKKVNELDKELGDPLIYLNKDNFDEVLKNYKVVVVEFSAPWCNPCKAYTPVFKRVARRLADPEKGIV
FAYLDTDEAPDIADRYSVDNIPTTIIFVNGHVADVILGVTQESKLTERVQNIVKELLRGEK
>Mature_140_residues
SNDIVRELRSLIEKKVNELDKELGDPLIYLNKDNFDEVLKNYKVVVVEFSAPWCNPCKAYTPVFKRVARRLADPEKGIVF
AYLDTDEAPDIADRYSVDNIPTTIIFVNGHVADVILGVTQESKLTERVQNIVKELLRGEK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI20070125, Length=88, Percent_Identity=39.7727272727273, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI4758304, Length=84, Percent_Identity=38.0952380952381, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=34.2857142857143, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI1788936, Length=98, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=107, Percent_Identity=33.6448598130841, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=99, Percent_Identity=34.3434343434343, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=106, Percent_Identity=40.5660377358491, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=83, Percent_Identity=36.144578313253, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=83, Percent_Identity=36.144578313253, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=83, Percent_Identity=36.144578313253, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=135, Percent_Identity=27.4074074074074, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17647799, Length=99, Percent_Identity=34.3434343434343, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584105, Length=116, Percent_Identity=30.1724137931034, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 16096; Mature: 15964

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDIVRELRSLIEKKVNELDKELGDPLIYLNKDNFDEVLKNYKVVVVEFSAPWCNPCKA
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCEEEEEEECCCCCCCHHH
YTPVFKRVARRLADPEKGIVFAYLDTDEAPDIADRYSVDNIPTTIIFVNGHVADVILGVT
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHCC
QESKLTERVQNIVKELLRGEK
CHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNDIVRELRSLIEKKVNELDKELGDPLIYLNKDNFDEVLKNYKVVVVEFSAPWCNPCKA
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCEEEEEEECCCCCCCHHH
YTPVFKRVARRLADPEKGIVFAYLDTDEAPDIADRYSVDNIPTTIIFVNGHVADVILGVT
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHCC
QESKLTERVQNIVKELLRGEK
CHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11959450; 12949158 [H]