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The map label for this gene is lpd [H]

Identifier: 124027929

GI number: 124027929

Start: 1077706

End: 1079073

Strand: Reverse

Name: lpd [H]

Synonym: Hbut_1061

Alternate gene names: 124027929

Gene position: 1079073-1077706 (Counterclockwise)

Preceding gene: 124027930

Following gene: 124027927

Centisome position: 64.73

GC content: 56.14

Gene sequence:

>1368_bases
TTGCCGCGCTTCGACCTCCTAGTCATAGGTGGAGGTTTTGGTGGTTATCCAGCAGCGGTTGTTGCTGCCCAGCGTGGTCT
AAAGACGGCTGTTGTCGAGGCCCGCCTACTCGGCGGCGAGTGTGCGAATTATGCCTGTATCCCAGTTAAGGCCATGCTCT
CGAAGGCATCCGAGATTGCTGCCGTGCTTAGCCGCGGCTTTAGCGTAGACAAGAGGTTCCGCGAGGCCCTAGAGTATGCG
TTGAAGGTGTCCCAGCGGGTTAGGTCGGGCATCGAGACGGTGCTTGAAGGCTACGGTGTCGCAGTCATACGTGGTCGCGC
GAAGATCCGTGCACCTGGTGTAGTACACGTTGAAGGCTACGGAGATGTGGAATACGAGAAACTCGTTATCGCTACTGGCA
CCGATCCCGGTTATCCTCCCGGCCTAGAGCCTGACGGCAAGCTAGTCCATGATAATCGTACGATACTGAGCTACGATGGT
GAGCCCTCGAAAGTCGTTGTTGTCGGTGGAGGCCCAGCAGGGGTCGAGTACGCGGATCTATTTGCCAGACTTGGCGCCGA
GGTACACCTCGTAGAAGTTCTCGACCGCATACTACCATTCATGGATGTCGACCTCTCTCGGGCTGTAGCCCGGTACCTGC
GCAGCATAGGTGTAAAACTACACACGAAGACTACTATCGGTAGACTCGAAAAACTAGCCAACGGCGTGGAGGTTGTTCTC
TCAAGCGGCGACAGGATCAAGGCTGACATTGTAGTTGTTGCCACGGGCCGCCGTCCCGCAACTAGTGGTCTAGGTCTTGA
TGTTCTTGGTGTTAAGCTTGACGAGAAGGGCTACATTATTGTTGACGAGTACCTCAGGGCTGCAAAGGATGTCTACGCCT
CTGGTGATGTAGCAGGGCCGCCTCTACTCGCCCACAAGGCGTACTCCCAGGCAGTCACGGTGGGACTCAACGTATCCGGC
GAGGAGAGGAAATGGAGCCCCAAGGCTATACCTCTAGTGGTCTATACAGGGCTTGAAGCTGTACAGGTGGGTTACACGCT
GGATGAGGCTCGGAGGAGGGGCTACAACGCGCAGGAGGCACGCATAAGGCTAGGCGCAATCTCCATGGCGGTGATCAAGG
GTGCCGAATATGGTGTTGCAAAGATAGTCTATGATGCTAGTAGCGGGAGGGTCCTAGGCTTACACCTTGCTGCTCATGGC
GCTAGCGAGGTGGCGGGGGAAGCAGCTCTAGCCGTGGAGAGGGGTGTCACAGTGGAAGAGCTAGCAGACCTAATCCACCC
GCATCCGTCAATATCTGAGGCAATAGCGCTGGCAGCTGAAGTGGCTGTTGGACGGCCGGTAAACTATCTTGCAAAAAACA
AGCCGTAG

Upstream 100 bases:

>100_bases
GCGGTGCAACACCTAGGCTGACCCACCTGCCCCTATCCTCTGCAAGCTAGTAGTTTTGTAGCCTCAAACCCCTAGGTTTA
GTTCCCGGGTTCAGAACCCC

Downstream 100 bases:

>100_bases
ATAGCTTTGAAGCTGGAGGGTGTAAGGCCAAGCTAGTGGAACCATGGTAGTAAAACCGTGTACATGGCAATAGTACGATG
TGGCTGTCTATGTTGACCCC

Product: dihydrolipoyl dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPRFDLLVIGGGFGGYPAAVVAAQRGLKTAVVEARLLGGECANYACIPVKAMLSKASEIAAVLSRGFSVDKRFREALEYA
LKVSQRVRSGIETVLEGYGVAVIRGRAKIRAPGVVHVEGYGDVEYEKLVIATGTDPGYPPGLEPDGKLVHDNRTILSYDG
EPSKVVVVGGGPAGVEYADLFARLGAEVHLVEVLDRILPFMDVDLSRAVARYLRSIGVKLHTKTTIGRLEKLANGVEVVL
SSGDRIKADIVVVATGRRPATSGLGLDVLGVKLDEKGYIIVDEYLRAAKDVYASGDVAGPPLLAHKAYSQAVTVGLNVSG
EERKWSPKAIPLVVYTGLEAVQVGYTLDEARRRGYNAQEARIRLGAISMAVIKGAEYGVAKIVYDASSGRVLGLHLAAHG
ASEVAGEAALAVERGVTVEELADLIHPHPSISEAIALAAEVAVGRPVNYLAKNKP

Sequences:

>Translated_455_residues
MPRFDLLVIGGGFGGYPAAVVAAQRGLKTAVVEARLLGGECANYACIPVKAMLSKASEIAAVLSRGFSVDKRFREALEYA
LKVSQRVRSGIETVLEGYGVAVIRGRAKIRAPGVVHVEGYGDVEYEKLVIATGTDPGYPPGLEPDGKLVHDNRTILSYDG
EPSKVVVVGGGPAGVEYADLFARLGAEVHLVEVLDRILPFMDVDLSRAVARYLRSIGVKLHTKTTIGRLEKLANGVEVVL
SSGDRIKADIVVVATGRRPATSGLGLDVLGVKLDEKGYIIVDEYLRAAKDVYASGDVAGPPLLAHKAYSQAVTVGLNVSG
EERKWSPKAIPLVVYTGLEAVQVGYTLDEARRRGYNAQEARIRLGAISMAVIKGAEYGVAKIVYDASSGRVLGLHLAAHG
ASEVAGEAALAVERGVTVEELADLIHPHPSISEAIALAAEVAVGRPVNYLAKNKP
>Mature_454_residues
PRFDLLVIGGGFGGYPAAVVAAQRGLKTAVVEARLLGGECANYACIPVKAMLSKASEIAAVLSRGFSVDKRFREALEYAL
KVSQRVRSGIETVLEGYGVAVIRGRAKIRAPGVVHVEGYGDVEYEKLVIATGTDPGYPPGLEPDGKLVHDNRTILSYDGE
PSKVVVVGGGPAGVEYADLFARLGAEVHLVEVLDRILPFMDVDLSRAVARYLRSIGVKLHTKTTIGRLEKLANGVEVVLS
SGDRIKADIVVVATGRRPATSGLGLDVLGVKLDEKGYIIVDEYLRAAKDVYASGDVAGPPLLAHKAYSQAVTVGLNVSGE
ERKWSPKAIPLVVYTGLEAVQVGYTLDEARRRGYNAQEARIRLGAISMAVIKGAEYGVAKIVYDASSGRVLGLHLAAHGA
SEVAGEAALAVERGVTVEELADLIHPHPSISEAIALAAEVAVGRPVNYLAKNKP

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=32.8421052631579, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI50301238, Length=455, Percent_Identity=29.6703296703297, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI291045266, Length=468, Percent_Identity=27.7777777777778, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI148277065, Length=449, Percent_Identity=24.9443207126949, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI148277071, Length=450, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI291045268, Length=464, Percent_Identity=27.1551724137931, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI22035672, Length=451, Percent_Identity=23.9467849223947, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI21389617, Length=237, Percent_Identity=29.957805907173, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI65787454, Length=237, Percent_Identity=29.957805907173, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI226437568, Length=237, Percent_Identity=29.957805907173, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=30.5676855895196, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=29.3361884368308, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081717, Length=446, Percent_Identity=27.8026905829596, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=29.0322580645161, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789065, Length=188, Percent_Identity=32.4468085106383, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=31.6129032258064, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=28.0082987551867, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=459, Percent_Identity=30.2832244008715, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=459, Percent_Identity=30.2832244008715, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=30.168776371308, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=28, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=27.645788336933, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21358499, Length=466, Percent_Identity=31.3304721030043, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640553, Length=486, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640551, Length=486, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=26.5560165975104, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48102; Mature: 47971

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFDLLVIGGGFGGYPAAVVAAQRGLKTAVVEARLLGGECANYACIPVKAMLSKASEIA
CCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
AVLSRGFSVDKRFREALEYALKVSQRVRSGIETVLEGYGVAVIRGRAKIRAPGVVHVEGY
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEECC
GDVEYEKLVIATGTDPGYPPGLEPDGKLVHDNRTILSYDGEPSKVVVVGGGPAGVEYADL
CCCEEEEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCCEEEEECCCCCCCHHHHH
FARLGAEVHLVEVLDRILPFMDVDLSRAVARYLRSIGVKLHTKTTIGRLEKLANGVEVVL
HHHHCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCEEEE
SSGDRIKADIVVVATGRRPATSGLGLDVLGVKLDEKGYIIVDEYLRAAKDVYASGDVAGP
CCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCC
PLLAHKAYSQAVTVGLNVSGEERKWSPKAIPLVVYTGLEAVQVGYTLDEARRRGYNAQEA
CHHHHHHHCCEEEEEEECCCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHCCCCCHHH
RIRLGAISMAVIKGAEYGVAKIVYDASSGRVLGLHLAAHGASEVAGEAALAVERGVTVEE
EEEEHHEEEEECCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHCCHHHHHHHCCCCHHH
LADLIHPHPSISEAIALAAEVAVGRPVNYLAKNKP
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCC
>Mature Secondary Structure 
PRFDLLVIGGGFGGYPAAVVAAQRGLKTAVVEARLLGGECANYACIPVKAMLSKASEIA
CCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
AVLSRGFSVDKRFREALEYALKVSQRVRSGIETVLEGYGVAVIRGRAKIRAPGVVHVEGY
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEECC
GDVEYEKLVIATGTDPGYPPGLEPDGKLVHDNRTILSYDGEPSKVVVVGGGPAGVEYADL
CCCEEEEEEEEECCCCCCCCCCCCCCCEEECCCEEEEECCCCCEEEEECCCCCCCHHHHH
FARLGAEVHLVEVLDRILPFMDVDLSRAVARYLRSIGVKLHTKTTIGRLEKLANGVEVVL
HHHHCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCEEEE
SSGDRIKADIVVVATGRRPATSGLGLDVLGVKLDEKGYIIVDEYLRAAKDVYASGDVAGP
CCCCEEEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCC
PLLAHKAYSQAVTVGLNVSGEERKWSPKAIPLVVYTGLEAVQVGYTLDEARRRGYNAQEA
CHHHHHHHCCEEEEEEECCCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHCCCCCHHH
RIRLGAISMAVIKGAEYGVAKIVYDASSGRVLGLHLAAHGASEVAGEAALAVERGVTVEE
EEEEHHEEEEECCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHCCHHHHHHHCCCCHHH
LADLIHPHPSISEAIALAAEVAVGRPVNYLAKNKP
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA