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The map label for this gene is glmU [H]

Identifier: 124027905

GI number: 124027905

Start: 1049837

End: 1051165

Strand: Direct

Name: glmU [H]

Synonym: Hbut_1036

Alternate gene names: 124027905

Gene position: 1049837-1051165 (Clockwise)

Preceding gene: 124027904

Following gene: 124027907

Centisome position: 62.97

GC content: 61.32

Gene sequence:

>1329_bases
ATGTCCCGTTACGCCATAGTATTGGCCGCCGGGCGTGGGGAGAGGCTCTGGCCTCTAACCTCCACGAGGCCCAAACCACT
GCTACCCCTACCGGGCGGCGAGACACTACTATCGAGAATCATGGGACAGCTTAGACGGCTAGTCGACGGCTTCGTGGTCG
TCGTAGGGCCGGGCTGGGCTGGCGACACGGTTAAGAGGCACCTAGAGGAGAAAGGCTACAGCGTCATCTACGCTGTGCAG
GAGAGTCCCCGGGGTACCGGTGATGCTGTCCGCGCAGCAGTGGAGAAACTGCCCCGTAGCGTCGACGAGGTCCTCATCGT
TTATGGCGACCTCCTAGTGTCGGGCAAGCTTCTCGAGGACGTGGCTGCTGCTGGTGCACCTGCGTTAGCCGCCAAGAGGC
ACGAGAGACCATGGGACTATGGCGTGGTAAGGGTTAACGGTAGGGGCTGCCTCTCGGGGCTCGTGGAGAAGCCAGCCGAC
GCCAAGCCGGGAGAGCTGGTGAACACTGGAGTCTACCTGCTGCCCAGGGAGATTCTCGAGGAGTCCCTCGAAGTCCTGAA
GCCGAGTCCCCGGGGCGAGCTAGAGTTCACCGATGCCGTGGCACGGATTGCCGGGAAGGCCTGCCTCAGGGTGGTATCTG
GAGACTGGCTATGGATGGACGTGGGGAGGCCATGGGACTTATTTGACGCCTATCGTGCTGTCTGGGAGGAGCGCTTCCCG
GGGCTCCGGGAGCCCCTGGTTGAGGGCGAGGTTGAGCCCGGGGCAACTCTGAAAGGTCCCGTCTACGTCGCCAGGGGCGC
TGTTGTGAGGAGCTACAGCTACGTGGAGGGGCCCGCGTGGATAGAGGGCGAGGTGGGCCCCTTTGCCAGGATTAGGCCGT
GGAGCTTCCTCCACCCGGGCAGCAGGGCTGCAACACACACCGAGGTTAAGGCATCAATACTCATGAGGGGTGCCCGGGCT
CCACACCTAAACTATGTGGGCGACAGCATCCTCGGCGAAGGCGTAAACCTCGGCGCTGGCACGGTGACTGCGAACCTCCG
CTTCGACCATGCAACAGTCAGGATGAGGCTTAAGGGGAAACTGGTGGATACTGGGAGAAACAAGCTCGGCGCAATAATCG
GCGATTATGCACAGACAGGCATCAATGTCTCGACACTTCCGGGCTTAAGGATAGGAGCCTACAGCTGGGTCTACCCCGGC
ATGACTGTGGCAAAGGATGTGCCGGACTGTGTGCTAGCAAGGCCTAAGCCTGGCGGCGGAGTAGAGTATGTTGATATAGC
AGAGCGTGTTGGCTGTCCAGAACACCTGCGGCGTAGCCGTAGGTACTAG

Upstream 100 bases:

>100_bases
TGTTCACCCGTTGACCCGGAAACAGGCAAGGTTGAGCTGATCTACGAGAGGTACCGCCTCGTAAAAGTGGCCGAGGCCAG
TGCCGCCGGCGGTGTCTAAC

Downstream 100 bases:

>100_bases
CCTGTTATTAGGCTGCCAAGCTCTTCTCCAAGCACTACCCTTTTCACGTTCTCCGGATCCGAACCATTAACTACTCTTAC
CGGTATATTGCTCCTCTCAA

Product: acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSRYAIVLAAGRGERLWPLTSTRPKPLLPLPGGETLLSRIMGQLRRLVDGFVVVVGPGWAGDTVKRHLEEKGYSVIYAVQ
ESPRGTGDAVRAAVEKLPRSVDEVLIVYGDLLVSGKLLEDVAAAGAPALAAKRHERPWDYGVVRVNGRGCLSGLVEKPAD
AKPGELVNTGVYLLPREILEESLEVLKPSPRGELEFTDAVARIAGKACLRVVSGDWLWMDVGRPWDLFDAYRAVWEERFP
GLREPLVEGEVEPGATLKGPVYVARGAVVRSYSYVEGPAWIEGEVGPFARIRPWSFLHPGSRAATHTEVKASILMRGARA
PHLNYVGDSILGEGVNLGAGTVTANLRFDHATVRMRLKGKLVDTGRNKLGAIIGDYAQTGINVSTLPGLRIGAYSWVYPG
MTVAKDVPDCVLARPKPGGGVEYVDIAERVGCPEHLRRSRRY

Sequences:

>Translated_442_residues
MSRYAIVLAAGRGERLWPLTSTRPKPLLPLPGGETLLSRIMGQLRRLVDGFVVVVGPGWAGDTVKRHLEEKGYSVIYAVQ
ESPRGTGDAVRAAVEKLPRSVDEVLIVYGDLLVSGKLLEDVAAAGAPALAAKRHERPWDYGVVRVNGRGCLSGLVEKPAD
AKPGELVNTGVYLLPREILEESLEVLKPSPRGELEFTDAVARIAGKACLRVVSGDWLWMDVGRPWDLFDAYRAVWEERFP
GLREPLVEGEVEPGATLKGPVYVARGAVVRSYSYVEGPAWIEGEVGPFARIRPWSFLHPGSRAATHTEVKASILMRGARA
PHLNYVGDSILGEGVNLGAGTVTANLRFDHATVRMRLKGKLVDTGRNKLGAIIGDYAQTGINVSTLPGLRIGAYSWVYPG
MTVAKDVPDCVLARPKPGGGVEYVDIAERVGCPEHLRRSRRY
>Mature_441_residues
SRYAIVLAAGRGERLWPLTSTRPKPLLPLPGGETLLSRIMGQLRRLVDGFVVVVGPGWAGDTVKRHLEEKGYSVIYAVQE
SPRGTGDAVRAAVEKLPRSVDEVLIVYGDLLVSGKLLEDVAAAGAPALAAKRHERPWDYGVVRVNGRGCLSGLVEKPADA
KPGELVNTGVYLLPREILEESLEVLKPSPRGELEFTDAVARIAGKACLRVVSGDWLWMDVGRPWDLFDAYRAVWEERFPG
LREPLVEGEVEPGATLKGPVYVARGAVVRSYSYVEGPAWIEGEVGPFARIRPWSFLHPGSRAATHTEVKASILMRGARAP
HLNYVGDSILGEGVNLGAGTVTANLRFDHATVRMRLKGKLVDTGRNKLGAIIGDYAQTGINVSTLPGLRIGAYSWVYPGM
TVAKDVPDCVLARPKPGGGVEYVDIAERVGCPEHLRRSRRY

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=457, Percent_Identity=26.9146608315098, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788351, Length=251, Percent_Identity=29.4820717131474, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=345, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=320, Percent_Identity=25.9375, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355443, Length=234, Percent_Identity=25.2136752136752, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24644084, Length=234, Percent_Identity=25.2136752136752, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48034; Mature: 47903

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYAIVLAAGRGERLWPLTSTRPKPLLPLPGGETLLSRIMGQLRRLVDGFVVVVGPGWA
CCCEEEEEEECCCCEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCC
GDTVKRHLEEKGYSVIYAVQESPRGTGDAVRAAVEKLPRSVDEVLIVYGDLLVSGKLLED
CHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VAAAGAPALAAKRHERPWDYGVVRVNGRGCLSGLVEKPADAKPGELVNTGVYLLPREILE
HHHCCCCHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCEECCCHHEECHHHHH
ESLEVLKPSPRGELEFTDAVARIAGKACLRVVSGDWLWMDVGRPWDLFDAYRAVWEERFP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCC
GLREPLVEGEVEPGATLKGPVYVARGAVVRSYSYVEGPAWIEGEVGPFARIRPWSFLHPG
CHHHHHHCCCCCCCCCCCCCEEEECCHHEECCCCCCCCCEECCCCCCCCEECCCCEECCC
SRAATHTEVKASILMRGARAPHLNYVGDSILGEGVNLGAGTVTANLRFDHATVRMRLKGK
CCCCHHHHHHHHHHHHCCCCCCCHHCCHHHHCCCCCCCCCEEEEEEEECCEEEEEEEECE
LVDTGRNKLGAIIGDYAQTGINVSTLPGLRIGAYSWVYPGMTVAKDVPDCVLARPKPGGG
EEECCCHHHHHHHHHHHHCCCCEECCCCCEECCCCEECCCCHHHHCCCHHEEECCCCCCC
VEYVDIAERVGCPEHLRRSRRY
CHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
SRYAIVLAAGRGERLWPLTSTRPKPLLPLPGGETLLSRIMGQLRRLVDGFVVVVGPGWA
CCEEEEEEECCCCEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCC
GDTVKRHLEEKGYSVIYAVQESPRGTGDAVRAAVEKLPRSVDEVLIVYGDLLVSGKLLED
CHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VAAAGAPALAAKRHERPWDYGVVRVNGRGCLSGLVEKPADAKPGELVNTGVYLLPREILE
HHHCCCCHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCEECCCHHEECHHHHH
ESLEVLKPSPRGELEFTDAVARIAGKACLRVVSGDWLWMDVGRPWDLFDAYRAVWEERFP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCC
GLREPLVEGEVEPGATLKGPVYVARGAVVRSYSYVEGPAWIEGEVGPFARIRPWSFLHPG
CHHHHHHCCCCCCCCCCCCCEEEECCHHEECCCCCCCCCEECCCCCCCCEECCCCEECCC
SRAATHTEVKASILMRGARAPHLNYVGDSILGEGVNLGAGTVTANLRFDHATVRMRLKGK
CCCCHHHHHHHHHHHHCCCCCCCHHCCHHHHCCCCCCCCCEEEEEEEECCEEEEEEEECE
LVDTGRNKLGAIIGDYAQTGINVSTLPGLRIGAYSWVYPGMTVAKDVPDCVLARPKPGGG
EEECCCHHHHHHHHHHHHCCCCEECCCCCEECCCCEECCCCHHHHCCCHHEEECCCCCCC
VEYVDIAERVGCPEHLRRSRRY
CHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]