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The map label for this gene is dut [H]

Identifier: 124027733

GI number: 124027733

Start: 860698

End: 861180

Strand: Direct

Name: dut [H]

Synonym: Hbut_0857

Alternate gene names: 124027733

Gene position: 860698-861180 (Clockwise)

Preceding gene: 124027728

Following gene: 124027734

Centisome position: 51.63

GC content: 54.24

Gene sequence:

>483_bases
ATGGCTCTACCAGGCATCTATGCTGCTTTAACGCTCCTCGGCAGAGTTGATGATGTGCAAGTGCAGCCGGCTGGTGTGGA
TCTCCGTGTTGGAGAGATACACCGCTTCTTGTCCGAAGGAATGTTGGCTCCCAAGCGTGTGCTGCCAGAGACCGAGCCCG
TTGAAGCTAGGGATGGCTTCTGGTTTTTGGAGCCGGGCTTCTACAAGGTTGTCTTTGCCGATGCTGTCTACGTGCCACCC
AGTGCTGTGGGTATCTGTCTCCCACGTAGTAGTCTCCTCAGGATGGGAGCCACGCTGTCTTGCGCTGTATGGGATCCAGG
GTATATGGGACGCGGTGAAGCACTGCTTATAGTTGGTAATCCTCACGGTATCAGAATAGCTGTCGGAGAGAGGATTGCAC
AGATGCTATATATCCGTGTTGAGCCGCCACCAGCTAGCCTCTATGCTGGATTCTATCAAGGGGAAAGGCTGGGTACACGC
TAG

Upstream 100 bases:

>100_bases
CCCAGCATTCGCAAGCCCTCTGTGCTTGTTTAGGCCTTGCAACCTCCAAGGCTTTAAGACGAGTGTTCATCCAGACCGTT
CCCAGCGGTGGCGCCTCTCC

Downstream 100 bases:

>100_bases
TGTTTTATTAGCTGGCTCCCCGGTGAAGCGGAATGGGTGGTACATGTAATGGTGCTTGAACGCCTTGAGGAAGCTGCAGC
TACCCTCGACTCTATAGCCT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MALPGIYAALTLLGRVDDVQVQPAGVDLRVGEIHRFLSEGMLAPKRVLPETEPVEARDGFWFLEPGFYKVVFADAVYVPP
SAVGICLPRSSLLRMGATLSCAVWDPGYMGRGEALLIVGNPHGIRIAVGERIAQMLYIRVEPPPASLYAGFYQGERLGTR

Sequences:

>Translated_160_residues
MALPGIYAALTLLGRVDDVQVQPAGVDLRVGEIHRFLSEGMLAPKRVLPETEPVEARDGFWFLEPGFYKVVFADAVYVPP
SAVGICLPRSSLLRMGATLSCAVWDPGYMGRGEALLIVGNPHGIRIAVGERIAQMLYIRVEPPPASLYAGFYQGERLGTR
>Mature_159_residues
ALPGIYAALTLLGRVDDVQVQPAGVDLRVGEIHRFLSEGMLAPKRVLPETEPVEARDGFWFLEPGFYKVVFADAVYVPPS
AVGICLPRSSLLRMGATLSCAVWDPGYMGRGEALLIVGNPHGIRIAVGERIAQMLYIRVEPPPASLYAGFYQGERLGTR

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0717

COG function: function code F; Deoxycytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 17427; Mature: 17295

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPGIYAALTLLGRVDDVQVQPAGVDLRVGEIHRFLSEGMLAPKRVLPETEPVEARDGF
CCCCHHHHHHHHHCCCCCEEECCCCCEEEHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCE
WFLEPGFYKVVFADAVYVPPSAVGICLPRSSLLRMGATLSCAVWDPGYMGRGEALLIVGN
EEECCCEEEEEEEEEEECCCCCEEEEECCHHHHHCCCEEEEEEECCCCCCCCCEEEEEEC
PHGIRIAVGERIAQMLYIRVEPPPASLYAGFYQGERLGTR
CCCEEEEHHHHHCEEEEEEECCCCHHEEECCCCCCCCCCC
>Mature Secondary Structure 
ALPGIYAALTLLGRVDDVQVQPAGVDLRVGEIHRFLSEGMLAPKRVLPETEPVEARDGF
CCCHHHHHHHHHCCCCCEEECCCCCEEEHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCE
WFLEPGFYKVVFADAVYVPPSAVGICLPRSSLLRMGATLSCAVWDPGYMGRGEALLIVGN
EEECCCEEEEEEEEEEECCCCCEEEEECCHHHHHCCCEEEEEEECCCCCCCCCEEEEEEC
PHGIRIAVGERIAQMLYIRVEPPPASLYAGFYQGERLGTR
CCCEEEEHHHHHCEEEEEEECCCCHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]