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The map label for this gene is metC [H]

Identifier: 124027696

GI number: 124027696

Start: 811309

End: 812502

Strand: Direct

Name: metC [H]

Synonym: Hbut_0818

Alternate gene names: 124027696

Gene position: 811309-812502 (Clockwise)

Preceding gene: 124027691

Following gene: 124027698

Centisome position: 48.66

GC content: 52.43

Gene sequence:

>1194_bases
ATGAGTACAAGACGTGATAGCCGTGAAAAGGGCCCTACCACGAAGGTTATCCAGGCACTGTCTTCAGCTCTGGGCAGCGA
CCCCTATGCTCCAATAGTTACCCCGATATATCGTACCGCGCCATTCATGTTTCCTAGAGAAGATTCGCCAATGATACGTG
GTAGGCCCTACAAGTACTCTAGGGAGGATAACCCAACCATAGTTACCCTAGAGAAGGCTATTACGATTCTCGAGGAGGGC
GAAGACACGCTTGTATTTAACACCGGGATGGCTGCAATCTCGACTCTATTATTTGCATTACTTGGCCCTGGCGACCGTGT
AGTAGCGACACGGGAAGCCTATGGATCGACACTACACCTCCTCAAGGAGCTGGAGAGGTGGGGCGTCAAAGTCGTCCTAG
CAGGCCCGGACAGCGGGGATATCGCCTCCGAGGCTAGCAAGCCTGGAACGAAACTCGTGTTTGTCGAGACTATTACTAAC
CCACTTCTACATGTTACGGATGTACCAGAGGTTGCCAAGGCTGCAAGAGAGTCGGGGGCCATACTCGTAGTGGACAATAC
TTTTGCAACGCCAATCCTCTTCCGGCCCCTACGCCACGGAGCTACGCTTGTAGTACACAGTCTAACCAAGTACATGGCTG
GCCACAACGATGTAATGGGTGGCTCGGTAACCGGGCCAGCCAGCATAGTGTCTGACAGGCTCTGGGAGTGGAGGAAGATC
ATGGGTACAACTATGGATCCCGAGCAGGCATTCCTCGTGGCGAGGGGCTTGAAAACACTTGAAATCCGGGTGAAGAGGCA
TTGCGAGAACGCGCTCAAAATAGCTGAGTTCCTAGCTGAACACCCCAAGATACGCGAAGTGTACTATCCCGGCCTGCCTG
GCAACCCATCTCACAGTGTTGCAAAACGCCTATTCCCATCCGGTATGTATGGCGGAGTTGTAAGCTTTAGAGTTAGGGGA
GGAAGAAACGAGGTACTGAAGCTGATGAGGAGGCTCACACTAGTAAAGCCTTCACCAAGCCTTGGAGCTCCAGAGAGCCT
ACTAGCATACCCTGTTGAGAGTAGCCATTCATCACTATCGCCGGAGGAGAGGAAAGCTCTCGGGATAACGGAGGACCTTG
TCAGGCTCAGTGTAGGCCTTGAAAACTATGAAGATATAATAGAGGACCTCGACCAGGCACTATCGGCGTTATAG

Upstream 100 bases:

>100_bases
AGGGCAATGATTGTAGATAGCATACTGCCCGTATGCTGACACGTGCTATCCTCATAAAAACATCTAGATAACCTATGCAC
CAGTGTAACCGGTGGCAGGC

Downstream 100 bases:

>100_bases
CTCGATCAATGTTTTACACACTAGCCGGAGAGGCTAGCTCACATACATACATACATCAAGCATTGTGTTTGGGGATTGTT
AAACCTAGGGCGTATCCACC

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSTRRDSREKGPTTKVIQALSSALGSDPYAPIVTPIYRTAPFMFPREDSPMIRGRPYKYSREDNPTIVTLEKAITILEEG
EDTLVFNTGMAAISTLLFALLGPGDRVVATREAYGSTLHLLKELERWGVKVVLAGPDSGDIASEASKPGTKLVFVETITN
PLLHVTDVPEVAKAARESGAILVVDNTFATPILFRPLRHGATLVVHSLTKYMAGHNDVMGGSVTGPASIVSDRLWEWRKI
MGTTMDPEQAFLVARGLKTLEIRVKRHCENALKIAEFLAEHPKIREVYYPGLPGNPSHSVAKRLFPSGMYGGVVSFRVRG
GRNEVLKLMRRLTLVKPSPSLGAPESLLAYPVESSHSSLSPEERKALGITEDLVRLSVGLENYEDIIEDLDQALSAL

Sequences:

>Translated_397_residues
MSTRRDSREKGPTTKVIQALSSALGSDPYAPIVTPIYRTAPFMFPREDSPMIRGRPYKYSREDNPTIVTLEKAITILEEG
EDTLVFNTGMAAISTLLFALLGPGDRVVATREAYGSTLHLLKELERWGVKVVLAGPDSGDIASEASKPGTKLVFVETITN
PLLHVTDVPEVAKAARESGAILVVDNTFATPILFRPLRHGATLVVHSLTKYMAGHNDVMGGSVTGPASIVSDRLWEWRKI
MGTTMDPEQAFLVARGLKTLEIRVKRHCENALKIAEFLAEHPKIREVYYPGLPGNPSHSVAKRLFPSGMYGGVVSFRVRG
GRNEVLKLMRRLTLVKPSPSLGAPESLLAYPVESSHSSLSPEERKALGITEDLVRLSVGLENYEDIIEDLDQALSAL
>Mature_396_residues
STRRDSREKGPTTKVIQALSSALGSDPYAPIVTPIYRTAPFMFPREDSPMIRGRPYKYSREDNPTIVTLEKAITILEEGE
DTLVFNTGMAAISTLLFALLGPGDRVVATREAYGSTLHLLKELERWGVKVVLAGPDSGDIASEASKPGTKLVFVETITNP
LLHVTDVPEVAKAARESGAILVVDNTFATPILFRPLRHGATLVVHSLTKYMAGHNDVMGGSVTGPASIVSDRLWEWRKIM
GTTMDPEQAFLVARGLKTLEIRVKRHCENALKIAEFLAEHPKIREVYYPGLPGNPSHSVAKRLFPSGMYGGVVSFRVRGG
RNEVLKLMRRLTLVKPSPSLGAPESLLAYPVESSHSSLSPEERKALGITEDLVRLSVGLENYEDIIEDLDQALSAL

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=400, Percent_Identity=35.5, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI299473759, Length=341, Percent_Identity=34.8973607038123, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI25453487, Length=398, Percent_Identity=31.6582914572864, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1790375, Length=383, Percent_Identity=37.597911227154, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789383, Length=346, Percent_Identity=32.0809248554913, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=35.5614973262032, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17560056, Length=374, Percent_Identity=37.7005347593583, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538055, Length=369, Percent_Identity=37.3983739837398, Blast_Score=218, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319307, Length=374, Percent_Identity=37.4331550802139, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323333, Length=422, Percent_Identity=29.8578199052133, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6321254, Length=395, Percent_Identity=30.126582278481, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=372, Percent_Identity=28.494623655914, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321170, Length=312, Percent_Identity=28.2051282051282, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323557, Length=337, Percent_Identity=25.8160237388724, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19922554, Length=369, Percent_Identity=37.940379403794, Blast_Score=238, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43452; Mature: 43320

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRRDSREKGPTTKVIQALSSALGSDPYAPIVTPIYRTAPFMFPREDSPMIRGRPYKYS
CCCCCCCHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
REDNPTIVTLEKAITILEEGEDTLVFNTGMAAISTLLFALLGPGDRVVATREAYGSTLHL
CCCCCEEEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
LKELERWGVKVVLAGPDSGDIASEASKPGTKLVFVETITNPLLHVTDVPEVAKAARESGA
HHHHHHCCEEEEEECCCCCCCHHHCCCCCCEEEEEEECCCCCEEECCCHHHHHHHHHCCC
ILVVDNTFATPILFRPLRHGATLVVHSLTKYMAGHNDVMGGSVTGPASIVSDRLWEWRKI
EEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MGTTMDPEQAFLVARGLKTLEIRVKRHCENALKIAEFLAEHPKIREVYYPGLPGNPSHSV
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHH
AKRLFPSGMYGGVVSFRVRGGRNEVLKLMRRLTLVKPSPSLGAPESLLAYPVESSHSSLS
HHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCCCC
PEERKALGITEDLVRLSVGLENYEDIIEDLDQALSAL
HHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STRRDSREKGPTTKVIQALSSALGSDPYAPIVTPIYRTAPFMFPREDSPMIRGRPYKYS
CCCCCCHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
REDNPTIVTLEKAITILEEGEDTLVFNTGMAAISTLLFALLGPGDRVVATREAYGSTLHL
CCCCCEEEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHH
LKELERWGVKVVLAGPDSGDIASEASKPGTKLVFVETITNPLLHVTDVPEVAKAARESGA
HHHHHHCCEEEEEECCCCCCCHHHCCCCCCEEEEEEECCCCCEEECCCHHHHHHHHHCCC
ILVVDNTFATPILFRPLRHGATLVVHSLTKYMAGHNDVMGGSVTGPASIVSDRLWEWRKI
EEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MGTTMDPEQAFLVARGLKTLEIRVKRHCENALKIAEFLAEHPKIREVYYPGLPGNPSHSV
HCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHH
AKRLFPSGMYGGVVSFRVRGGRNEVLKLMRRLTLVKPSPSLGAPESLLAYPVESSHSSLS
HHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCCCC
PEERKALGITEDLVRLSVGLENYEDIIEDLDQALSAL
HHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]