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The map label for this gene is pepA [H]

Identifier: 124027381

GI number: 124027381

Start: 474192

End: 475664

Strand: Reverse

Name: pepA [H]

Synonym: Hbut_0494

Alternate gene names: 124027381

Gene position: 475664-474192 (Counterclockwise)

Preceding gene: 124027382

Following gene: 124027378

Centisome position: 28.53

GC content: 54.38

Gene sequence:

>1473_bases
TTGTCGACCCTTCTCCGCGTTGGCAACGCCCGTAATGGCGTGGATGCTATAGCCTATGTTGCTGGCGAGAAGCAGCTAGA
ATGGCTTAAGGGCTTTGGCGATACCGTGCGGACCGTTATTGAACTCGGCGACTTTAAAGGGAAGCTTGAGGAGACGATTC
TGATCTACGAGTCTAGTGCTACTGTTAAGAGGGTTATACTTGCCGGTGCCGGGGGTAACGAGTGGTTCGGCGATGCTGAG
AGATTAAGGGTTGCCGTCGCCTCTGCAGTCAAGCTTGCAAGGAGCAAGAAGAGCATAAAGAGGCTCGGTGTCGTAGTGCA
CGAGGAGTTGCTAGAGAAGGCTGCTGAGACAGCCGGCAGGGATACTGTTTGGAGTGTTGAACAAGCCCTCGTGGCAGCGG
ACATGGCAAACTACGTATACAGCCTACGGGAGAGGGAGGAGAAGCCGCACATCCTCGAGGAGGTAAGGCTAGAGCCCGGC
GACGAGAAAGCTGTTGAGACTGCTAAGGCTATAGCGGAGGCTGTAAGGGTAGCTAGGGATATAGCAAATGCGCCAGCCAA
TAGGCTGAGCCCAGAGAAGCTTGAGGAGAAGGCTAGAGAGCTTGCATCCCGGCTGGGCCTCACTATAAGGGTTCTATATA
GGTCAGACTTGGAGAGCCTTGGCATGGGTGGCATACTAGCTGTTGGCTCTGGCAGCAATGTAGAGCCACGCCTCATAATA
CTAGAGTACAACAGTGGTGGCAAGAGGATAGCCGTTGTGGGCAAGGCGGTAGTCTTCGATGCTGGCGGCTTAGATCTCAA
ACCGCCACAGGCTATGCAGGAGATGAAGTTTGATAAGAGCGGTGGTGCTGCCGCTATAGGTGCCGTGGTTGCAGCTGCTC
TGCTTAGACTGCCAGTAAACATGGTAGCCCTCGTACCAGCCGTGGAGAACCTACCAAGCGGCCGTGCTTACAAACCACTC
GATGTTATAAGAATGTACAACGGCACCACCGTGGAGATAGGCAACACCGATGCCGAGGGCAGACTCATAATGGCTGACGC
ACTCGCCTATGCTGCAGAGAAGTATAAGCCAGACTACATGTTCGACTTCGCAACACTAACCGGTGCAGCAGTAGTAGCCC
TAGGCAACCACGCAGCAGCACTATTCAGCAACAACGACCAGCTAGCCTCAATGGTCGAAAGAGCAGCATGGATCGCAGGC
GAGCCCGTATGGAAAATGCCGCTATGGCCTGTCTACGCCAAACAACTCGAAAGCCATGTAGCCGACACAAACAACGTTGG
GGGCCGGCCAGCAGGCGCAATAACGGCTGCAAAGTTCCTCGAAAAGTTCGTCGGCGACAGACCATGGGCACATTTGGACA
TCGCTGGCACAGCCTGGGTTCAGGAGAAGGGGCCCTGGAAACCATACTACGAGAAGGGCGCCACCGGATGGGGCGTAAGA
ACACTAGTCGAATTCCTAAGACTCTTGATATAA

Upstream 100 bases:

>100_bases
GGAGTTAGTCCCGCTCCTCACAATCCAATCTCCGGCATAGCCCGTAGTTCTATTTTTAAAGAATTAGGGTGATTCTTCCA
GATACCTGGTGCTAGACCCC

Downstream 100 bases:

>100_bases
TTGATATAATCTAACATAAAACAACTTCAACCCATTTGCCATCAATACAAAATGTTCACCTACAGTTATCATTTTATTTT
AGCTTGAGAGCAAGTGTATA

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSTLLRVGNARNGVDAIAYVAGEKQLEWLKGFGDTVRTVIELGDFKGKLEETILIYESSATVKRVILAGAGGNEWFGDAE
RLRVAVASAVKLARSKKSIKRLGVVVHEELLEKAAETAGRDTVWSVEQALVAADMANYVYSLREREEKPHILEEVRLEPG
DEKAVETAKAIAEAVRVARDIANAPANRLSPEKLEEKARELASRLGLTIRVLYRSDLESLGMGGILAVGSGSNVEPRLII
LEYNSGGKRIAVVGKAVVFDAGGLDLKPPQAMQEMKFDKSGGAAAIGAVVAAALLRLPVNMVALVPAVENLPSGRAYKPL
DVIRMYNGTTVEIGNTDAEGRLIMADALAYAAEKYKPDYMFDFATLTGAAVVALGNHAAALFSNNDQLASMVERAAWIAG
EPVWKMPLWPVYAKQLESHVADTNNVGGRPAGAITAAKFLEKFVGDRPWAHLDIAGTAWVQEKGPWKPYYEKGATGWGVR
TLVEFLRLLI

Sequences:

>Translated_490_residues
MSTLLRVGNARNGVDAIAYVAGEKQLEWLKGFGDTVRTVIELGDFKGKLEETILIYESSATVKRVILAGAGGNEWFGDAE
RLRVAVASAVKLARSKKSIKRLGVVVHEELLEKAAETAGRDTVWSVEQALVAADMANYVYSLREREEKPHILEEVRLEPG
DEKAVETAKAIAEAVRVARDIANAPANRLSPEKLEEKARELASRLGLTIRVLYRSDLESLGMGGILAVGSGSNVEPRLII
LEYNSGGKRIAVVGKAVVFDAGGLDLKPPQAMQEMKFDKSGGAAAIGAVVAAALLRLPVNMVALVPAVENLPSGRAYKPL
DVIRMYNGTTVEIGNTDAEGRLIMADALAYAAEKYKPDYMFDFATLTGAAVVALGNHAAALFSNNDQLASMVERAAWIAG
EPVWKMPLWPVYAKQLESHVADTNNVGGRPAGAITAAKFLEKFVGDRPWAHLDIAGTAWVQEKGPWKPYYEKGATGWGVR
TLVEFLRLLI
>Mature_489_residues
STLLRVGNARNGVDAIAYVAGEKQLEWLKGFGDTVRTVIELGDFKGKLEETILIYESSATVKRVILAGAGGNEWFGDAER
LRVAVASAVKLARSKKSIKRLGVVVHEELLEKAAETAGRDTVWSVEQALVAADMANYVYSLREREEKPHILEEVRLEPGD
EKAVETAKAIAEAVRVARDIANAPANRLSPEKLEEKARELASRLGLTIRVLYRSDLESLGMGGILAVGSGSNVEPRLIIL
EYNSGGKRIAVVGKAVVFDAGGLDLKPPQAMQEMKFDKSGGAAAIGAVVAAALLRLPVNMVALVPAVENLPSGRAYKPLD
VIRMYNGTTVEIGNTDAEGRLIMADALAYAAEKYKPDYMFDFATLTGAAVVALGNHAAALFSNNDQLASMVERAAWIAGE
PVWKMPLWPVYAKQLESHVADTNNVGGRPAGAITAAKFLEKFVGDRPWAHLDIAGTAWVQEKGPWKPYYEKGATGWGVRT
LVEFLRLLI

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=337, Percent_Identity=40.9495548961424, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI47155554, Length=355, Percent_Identity=33.8028169014084, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1790710, Length=467, Percent_Identity=36.1884368308351, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=40.9375, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=305, Percent_Identity=36.0655737704918, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=488, Percent_Identity=26.0245901639344, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129969, Length=319, Percent_Identity=33.2288401253918, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24662227, Length=366, Percent_Identity=31.4207650273224, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24661038, Length=320, Percent_Identity=33.4375, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355645, Length=320, Percent_Identity=32.8125, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24662223, Length=320, Percent_Identity=32.8125, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI161077148, Length=374, Percent_Identity=30.2139037433155, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20130057, Length=374, Percent_Identity=30.2139037433155, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355725, Length=320, Percent_Identity=32.8125, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129963, Length=374, Percent_Identity=31.283422459893, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19922386, Length=382, Percent_Identity=30.6282722513089, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI21357381, Length=337, Percent_Identity=31.7507418397626, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI221379063, Length=340, Percent_Identity=31.4705882352941, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI221379062, Length=340, Percent_Identity=31.4705882352941, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24646701, Length=325, Percent_Identity=31.3846153846154, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646703, Length=325, Percent_Identity=31.3846153846154, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21358201, Length=325, Percent_Identity=31.3846153846154, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52933; Mature: 52802

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLLRVGNARNGVDAIAYVAGEKQLEWLKGFGDTVRTVIELGDFKGKLEETILIYESSA
CCCHHCCCCCCCCHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCC
TVKRVILAGAGGNEWFGDAERLRVAVASAVKLARSKKSIKRLGVVVHEELLEKAAETAGR
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DTVWSVEQALVAADMANYVYSLREREEKPHILEEVRLEPGDEKAVETAKAIAEAVRVARD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
IANAPANRLSPEKLEEKARELASRLGLTIRVLYRSDLESLGMGGILAVGSGSNVEPRLII
HHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHCHHHCCCCCEEEECCCCCCCCEEEE
LEYNSGGKRIAVVGKAVVFDAGGLDLKPPQAMQEMKFDKSGGAAAIGAVVAAALLRLPVN
EEECCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
MVALVPAVENLPSGRAYKPLDVIRMYNGTTVEIGNTDAEGRLIMADALAYAAEKYKPDYM
HHHHHHHHHCCCCCCCCCCHHHHEECCCCEEEECCCCCCCCEEHHHHHHHHHHHCCCCCE
FDFATLTGAAVVALGNHAAALFSNNDQLASMVERAAWIAGEPVWKMPLWPVYAKQLESHV
EEHHHHHHHHEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ADTNNVGGRPAGAITAAKFLEKFVGDRPWAHLDIAGTAWVQEKGPWKPYYEKGATGWGVR
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCHHHCCCCCCCHH
TLVEFLRLLI
HHHHHHHHHC
>Mature Secondary Structure 
STLLRVGNARNGVDAIAYVAGEKQLEWLKGFGDTVRTVIELGDFKGKLEETILIYESSA
CCHHCCCCCCCCHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCC
TVKRVILAGAGGNEWFGDAERLRVAVASAVKLARSKKSIKRLGVVVHEELLEKAAETAGR
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DTVWSVEQALVAADMANYVYSLREREEKPHILEEVRLEPGDEKAVETAKAIAEAVRVARD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
IANAPANRLSPEKLEEKARELASRLGLTIRVLYRSDLESLGMGGILAVGSGSNVEPRLII
HHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHCHHHCCCCCEEEECCCCCCCCEEEE
LEYNSGGKRIAVVGKAVVFDAGGLDLKPPQAMQEMKFDKSGGAAAIGAVVAAALLRLPVN
EEECCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
MVALVPAVENLPSGRAYKPLDVIRMYNGTTVEIGNTDAEGRLIMADALAYAAEKYKPDYM
HHHHHHHHHCCCCCCCCCCHHHHEECCCCEEEECCCCCCCCEEHHHHHHHHHHHCCCCCE
FDFATLTGAAVVALGNHAAALFSNNDQLASMVERAAWIAGEPVWKMPLWPVYAKQLESHV
EEHHHHHHHHEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ADTNNVGGRPAGAITAAKFLEKFVGDRPWAHLDIAGTAWVQEKGPWKPYYEKGATGWGVR
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCHHHCCCCCCCHH
TLVEFLRLLI
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA