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The map label for this gene is pepQ [H]

Identifier: 124027342

GI number: 124027342

Start: 434936

End: 436060

Strand: Direct

Name: pepQ [H]

Synonym: Hbut_0451

Alternate gene names: 124027342

Gene position: 434936-436060 (Clockwise)

Preceding gene: 124027341

Following gene: 124027343

Centisome position: 26.09

GC content: 50.58

Gene sequence:

>1125_bases
TTGTACCGTTCCAGGCTTAGGAAGCTCGAAGGCCTGGCAGAGGAGAAGAATGTCTGCGGAGCACTAATAGTCTCAGCCTC
TAACGTGTTCTACTTCACCGGGTTTAAGGGCGGTTTCCTCCTCTATAGCAGGAATGTAGGGTTTAGGCTGCTCGTACCAG
CCCTGGAGTATCTACGCGCCTATGACACTGTACGAGAGAATGCGCTTGATGACCTGGTCACTGTTGTAGCTTACAAGCCA
TACGGCTTACCAGGCGAACTAAAACTAGACATTGAAGGCGAAGAGATTGTTGAGGGTAAGGCTATAGACGCTATTGCGAA
ATTTGTTGGCAAGGGGTGTATATTACTAACTGATGCTGATTCGAAACAGTTCATCTCGGAGCTTGAGGCTAAGGAGTTGA
AACTTCAAGATGCTTCTAAAGACATAGCTCTAATGAGGGCGCTGAAGGAGCCCTGGGAGATTGAGCGCATGACGGAGGCG
GCAAGAATTGCTGAGGCAGCTCTCAACGAGGCACTTGCAAACCTCGAGCCCGGGGTTACGGAGCTTGAAATAGCCGCAAT
CATAGAACGGGAGATACGGGTAAGAGGGGCTGAGGACCACTCCTTCCCACCAATAGTAGCGTTTGGAAAGAACACGGTCT
ACCCTCACGCCATACCCTCTGCTAGGCGAAGACTCGAGGATGGCCAACCAGTGCTCATAGACCTCGGAGCGGTGTATAAG
GGGTACTGCAGCGACATGACTAGAACGGTTGACTTTGGCGGTGTTGGCGACGAGTTTACAGCCGCGCTGAGAACTGTTAT
AGATGCTGTTGAAGCTGCAATAGACGCTATAGAGCCCGGTAAGAAGATAGGAGAGGTAGATGCTGCTGCTAGGAGAATTC
TTGAGAAGCACGGCTATGCCAAGTACTTTATACATAGCCTGGGCCACGGAGTTGGAATAGACGTACATGAATACCCGCGA
GTATCAAGCGACAACAATGACGAACTAAAGCCAGGCATGGTGATAACAATAGAGCCAGGAGTGTATATACCCGGTAAGTT
CGGAGTTAGAGTCGAAGAGATGGTGCTAGTGACAGAGCGGGGTCCAAGACTGCTAACAAGGTTCCCACGAGAGCTATGGG
TCTAG

Upstream 100 bases:

>100_bases
CCCGAAGCTCCTTGGTGCTGAGGCCTGCCGAGTTGCGAGGAGGAAGGCTAAGTAGTCTCTCCACCAACAGTGTATAAGCG
GCTCCAGCGGGTGTATAACC

Downstream 100 bases:

>100_bases
AGAATATGGTAGACATGCTACACCCTATATTCCTCCCATTACCTATTAGTCTTTCTCATCAAAACAAGAACCAGCCATGT
AGCTAATTCATGACATTTTG

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MYRSRLRKLEGLAEEKNVCGALIVSASNVFYFTGFKGGFLLYSRNVGFRLLVPALEYLRAYDTVRENALDDLVTVVAYKP
YGLPGELKLDIEGEEIVEGKAIDAIAKFVGKGCILLTDADSKQFISELEAKELKLQDASKDIALMRALKEPWEIERMTEA
ARIAEAALNEALANLEPGVTELEIAAIIEREIRVRGAEDHSFPPIVAFGKNTVYPHAIPSARRRLEDGQPVLIDLGAVYK
GYCSDMTRTVDFGGVGDEFTAALRTVIDAVEAAIDAIEPGKKIGEVDAAARRILEKHGYAKYFIHSLGHGVGIDVHEYPR
VSSDNNDELKPGMVITIEPGVYIPGKFGVRVEEMVLVTERGPRLLTRFPRELWV

Sequences:

>Translated_374_residues
MYRSRLRKLEGLAEEKNVCGALIVSASNVFYFTGFKGGFLLYSRNVGFRLLVPALEYLRAYDTVRENALDDLVTVVAYKP
YGLPGELKLDIEGEEIVEGKAIDAIAKFVGKGCILLTDADSKQFISELEAKELKLQDASKDIALMRALKEPWEIERMTEA
ARIAEAALNEALANLEPGVTELEIAAIIEREIRVRGAEDHSFPPIVAFGKNTVYPHAIPSARRRLEDGQPVLIDLGAVYK
GYCSDMTRTVDFGGVGDEFTAALRTVIDAVEAAIDAIEPGKKIGEVDAAARRILEKHGYAKYFIHSLGHGVGIDVHEYPR
VSSDNNDELKPGMVITIEPGVYIPGKFGVRVEEMVLVTERGPRLLTRFPRELWV
>Mature_374_residues
MYRSRLRKLEGLAEEKNVCGALIVSASNVFYFTGFKGGFLLYSRNVGFRLLVPALEYLRAYDTVRENALDDLVTVVAYKP
YGLPGELKLDIEGEEIVEGKAIDAIAKFVGKGCILLTDADSKQFISELEAKELKLQDASKDIALMRALKEPWEIERMTEA
ARIAEAALNEALANLEPGVTELEIAAIIEREIRVRGAEDHSFPPIVAFGKNTVYPHAIPSARRRLEDGQPVLIDLGAVYK
GYCSDMTRTVDFGGVGDEFTAALRTVIDAVEAAIDAIEPGKKIGEVDAAARRILEKHGYAKYFIHSLGHGVGIDVHEYPR
VSSDNNDELKPGMVITIEPGVYIPGKFGVRVEEMVLVTERGPRLLTRFPRELWV

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=287, Percent_Identity=32.7526132404181, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI264681563, Length=382, Percent_Identity=28.5340314136126, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI149589008, Length=313, Percent_Identity=27.7955271565495, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI260593665, Length=313, Percent_Identity=27.7955271565495, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI93141226, Length=250, Percent_Identity=31.6, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=29.5546558704453, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI164420681, Length=244, Percent_Identity=30.327868852459, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI260593663, Length=318, Percent_Identity=27.0440251572327, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI264681565, Length=380, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=41.1764705882353, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1789275, Length=253, Percent_Identity=32.4110671936759, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=28.2258064516129, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790282, Length=301, Percent_Identity=23.2558139534884, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71989583, Length=297, Percent_Identity=24.9158249158249, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=381, Percent_Identity=24.9343832020997, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=236, Percent_Identity=32.6271186440678, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=245, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=281, Percent_Identity=26.6903914590747, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321118, Length=283, Percent_Identity=27.208480565371, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323273, Length=244, Percent_Identity=27.0491803278689, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920384, Length=253, Percent_Identity=32.4110671936759, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355531, Length=242, Percent_Identity=26.8595041322314, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357079, Length=290, Percent_Identity=26.551724137931, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=24.8979591836735, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137632, Length=252, Percent_Identity=28.1746031746032, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 41353; Mature: 41353

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRSRLRKLEGLAEEKNVCGALIVSASNVFYFTGFKGGFLLYSRNVGFRLLVPALEYLRA
CCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCEEEEECCCCCEEHHHHHHHHHH
YDTVRENALDDLVTVVAYKPYGLPGELKLDIEGEEIVEGKAIDAIAKFVGKGCILLTDAD
HHHHHHHHHHHHHHHHEECCCCCCCCEEEEECCHHHHCCHHHHHHHHHHCCCEEEEECCC
SKQFISELEAKELKLQDASKDIALMRALKEPWEIERMTEAARIAEAALNEALANLEPGVT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ELEIAAIIEREIRVRGAEDHSFPPIVAFGKNTVYPHAIPSARRRLEDGQPVLIDLGAVYK
HHHHHHHHHHHHHEECCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHH
GYCSDMTRTVDFGGVGDEFTAALRTVIDAVEAAIDAIEPGKKIGEVDAAARRILEKHGYA
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
KYFIHSLGHGVGIDVHEYPRVSSDNNDELKPGMVITIEPGVYIPGKFGVRVEEMVLVTER
HHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCEEEEEEEEECC
GPRLLTRFPRELWV
CCHHHHHCHHHHCC
>Mature Secondary Structure
MYRSRLRKLEGLAEEKNVCGALIVSASNVFYFTGFKGGFLLYSRNVGFRLLVPALEYLRA
CCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCEEEEECCCCCEEHHHHHHHHHH
YDTVRENALDDLVTVVAYKPYGLPGELKLDIEGEEIVEGKAIDAIAKFVGKGCILLTDAD
HHHHHHHHHHHHHHHHEECCCCCCCCEEEEECCHHHHCCHHHHHHHHHHCCCEEEEECCC
SKQFISELEAKELKLQDASKDIALMRALKEPWEIERMTEAARIAEAALNEALANLEPGVT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ELEIAAIIEREIRVRGAEDHSFPPIVAFGKNTVYPHAIPSARRRLEDGQPVLIDLGAVYK
HHHHHHHHHHHHHEECCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCEEEEEHHHHHH
GYCSDMTRTVDFGGVGDEFTAALRTVIDAVEAAIDAIEPGKKIGEVDAAARRILEKHGYA
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
KYFIHSLGHGVGIDVHEYPRVSSDNNDELKPGMVITIEPGVYIPGKFGVRVEEMVLVTER
HHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCEEEEEEEEECC
GPRLLTRFPRELWV
CCHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]